Wwox (WW domain-containing oxidoreductase) - Rat Genome Database

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Gene: Wwox (WW domain-containing oxidoreductase) Rattus norvegicus
Analyze
Symbol: Wwox
Name: WW domain-containing oxidoreductase
RGD ID: 1309927
Description: Predicted to enable enzyme binding activity and identical protein binding activity. Predicted to contribute to transcription coactivator activity. Predicted to be involved in cellular response to transforming growth factor beta stimulus; positive regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including Golgi apparatus; microvillus; and mitochondrion. Predicted to be part of RNA polymerase II transcription regulator complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC292041
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Wwoxlde  
Genetic Models: WIC-Wwoxlde/Fta
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81959,338,402 - 60,269,323 (+)NCBIGRCr8
mRatBN7.21942,432,141 - 43,360,278 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1942,432,152 - 43,359,391 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1949,256,468 - 49,551,669 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01949,909,668 - 50,204,880 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01952,152,685 - 52,447,763 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01946,761,353 - 47,695,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01957,582,172 - 58,503,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41944,516,391 - 44,829,849 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11944,521,372 - 44,611,040 (+)NCBI
Celera1941,740,658 - 42,034,912 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetamidofluorene  (ISO)
2-nitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
quercitrin  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. Kuroki T, etal., Cancer Res. 2002 Apr 15;62(8):2258-60.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Phenotypic characterization of spontaneously mutated rats showing lethal dwarfism and epilepsy. Suzuki H, etal., Comp Med. 2007 Aug;57(4):360-9.
10. A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy. Suzuki H, etal., Genes Brain Behav. 2009 Oct;8(7):650-60. doi: 10.1111/j.1601-183X.2009.00502.x. Epub 2009 May 20.
11. Retarded differentiation of Leydig cells and increased apoptosis of germ cells in the initial round of spermatogenesis of rats with lethal dwarf and epilepsy (lde/lde) phenotypes. Takenaka M, etal., J Androl. 2008 Nov-Dec;29(6):669-78. doi: 10.2164/jandrol.108.005066. Epub 2008 Jul 31.
Additional References at PubMed
PMID:11058590   PMID:14651853   PMID:15064722   PMID:18371080   PMID:18487609   PMID:19366691   PMID:19465938   PMID:19918364   PMID:25416187   PMID:31340538   PMID:33565365   PMID:35984507  


Genomics

Comparative Map Data
Wwox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81959,338,402 - 60,269,323 (+)NCBIGRCr8
mRatBN7.21942,432,141 - 43,360,278 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1942,432,152 - 43,359,391 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1949,256,468 - 49,551,669 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01949,909,668 - 50,204,880 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01952,152,685 - 52,447,763 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01946,761,353 - 47,695,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01957,582,172 - 58,503,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41944,516,391 - 44,829,849 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11944,521,372 - 44,611,040 (+)NCBI
Celera1941,740,658 - 42,034,912 (+)NCBICelera
Cytogenetic Map19q12NCBI
WWOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381678,099,654 - 79,212,667 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1678,099,400 - 79,212,667 (+)EnsemblGRCh38hg38GRCh38
GRCh371678,133,551 - 79,246,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361676,691,052 - 77,804,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 341676,691,051 - 76,691,596NCBI
Celera1662,433,225 - 63,546,286 (+)NCBICelera
Cytogenetic Map16q23.1-q23.2NCBI
HuRef1663,889,774 - 65,003,146 (+)NCBIHuRef
CHM1_11679,544,693 - 80,658,050 (+)NCBICHM1_1
T2T-CHM13v2.01684,155,399 - 85,268,915 (+)NCBIT2T-CHM13v2.0
Wwox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398115,166,377 - 116,079,451 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8115,166,395 - 116,079,447 (+)EnsemblGRCm39 Ensembl
GRCm388114,439,635 - 115,352,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8114,439,655 - 115,352,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv378116,963,552 - 117,876,612 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368117,325,673 - 118,238,685 (+)NCBIMGSCv36mm8
Celera8118,649,907 - 119,566,431 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map860.99NCBI
Wwox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555221,265,404 - 2,184,562 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555221,265,732 - 2,185,372 (+)NCBIChiLan1.0ChiLan1.0
WWOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21887,833,842 - 88,944,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11693,753,157 - 94,863,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01658,689,609 - 59,800,333 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11678,124,887 - 79,232,509 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1678,125,302 - 79,231,546 (+)Ensemblpanpan1.1panPan2
WWOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1572,298,254 - 73,243,667 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl572,299,157 - 73,261,406 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha572,245,508 - 73,191,719 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0572,604,717 - 73,550,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl572,605,629 - 73,567,870 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1572,544,957 - 73,491,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0572,380,513 - 73,326,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0572,857,621 - 73,810,182 (-)NCBIUU_Cfam_GSD_1.0
Wwox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934932,379,557 - 33,246,838 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647526,342,220 - 27,208,711 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647526,342,245 - 27,209,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl68,910,138 - 9,871,053 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.168,910,209 - 9,871,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.269,684,508 - 9,774,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WWOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1563,580,049 - 64,698,212 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl563,580,741 - 63,916,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604712,176,137 - 12,459,672 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wwox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247467,984,671 - 8,924,136 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247467,983,863 - 8,924,312 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wwox
5783 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:23
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000058779
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
D19Mit7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,983,518 - 42,983,632 (+)MAPPERmRatBN7.2
Rnor_6.01947,318,201 - 47,318,314NCBIRnor6.0
Rnor_5.01958,132,164 - 58,132,277UniSTSRnor5.0
RGSC_v3.41945,090,802 - 45,090,916RGDRGSC3.4
RGSC_v3.41945,090,803 - 45,090,916UniSTSRGSC3.4
RGSC_v3.11945,095,501 - 45,095,902RGD
Celera1942,291,103 - 42,291,216UniSTS
RH 3.4 Map19581.1UniSTS
RH 3.4 Map19581.1RGD
RH 2.0 Map19607.0RGD
SHRSP x BN Map1934.6298RGD
FHH x ACI Map1935.68RGD
Cytogenetic Map19q12UniSTS
D19Rat66  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,899,669 - 42,899,812 (+)MAPPERmRatBN7.2
Rnor_6.01947,231,083 - 47,231,225NCBIRnor6.0
Rnor_5.01958,046,185 - 58,046,327UniSTSRnor5.0
RGSC_v3.41945,001,545 - 45,001,687RGDRGSC3.4
RGSC_v3.41945,001,546 - 45,001,688UniSTSRGSC3.4
RGSC_v3.11945,006,426 - 45,006,568RGD
Celera1942,206,578 - 42,206,720UniSTS
RH 3.4 Map19575.2RGD
RH 3.4 Map19575.2UniSTS
RH 2.0 Map19617.3RGD
SHRSP x BN Map1936.9799RGD
Cytogenetic Map19q12UniSTS
D19Got41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,482,491 - 42,482,688 (+)MAPPERmRatBN7.2
mRatBN7.21942,482,277 - 42,482,688 (+)MAPPERmRatBN7.2
Rnor_6.01946,812,501 - 46,812,909NCBIRnor6.0
Rnor_6.01946,812,715 - 46,812,909NCBIRnor6.0
Rnor_5.01957,631,948 - 57,632,356UniSTSRnor5.0
Rnor_5.01957,632,162 - 57,632,356UniSTSRnor5.0
RGSC_v3.41944,566,511 - 44,566,705UniSTSRGSC3.4
RGSC_v3.41944,566,510 - 44,566,705RGDRGSC3.4
RGSC_v3.41944,566,297 - 44,566,705UniSTSRGSC3.4
RGSC_v3.11944,571,392 - 44,571,586RGD
Celera1941,790,706 - 41,791,019UniSTS
Celera1941,790,920 - 41,791,019UniSTS
RH 3.4 Map19566.0RGD
RH 3.4 Map19566.0UniSTS
RH 2.0 Map19575.4RGD
Cytogenetic Map19q12UniSTS
D19Got43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,596,759 - 42,596,944 (+)MAPPERmRatBN7.2
Rnor_6.01946,927,922 - 46,928,106NCBIRnor6.0
Rnor_5.01957,746,512 - 57,746,696UniSTSRnor5.0
RGSC_v3.41944,681,934 - 44,682,117RGDRGSC3.4
RGSC_v3.41944,681,935 - 44,682,119UniSTSRGSC3.4
RGSC_v3.11944,686,815 - 44,686,998RGD
Celera1941,905,166 - 41,905,350UniSTS
RH 3.4 Map19565.5UniSTS
RH 3.4 Map19565.5RGD
RH 2.0 Map19589.9RGD
Cytogenetic Map19q12UniSTS
D19Got40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,436,199 - 42,436,413 (+)MAPPERmRatBN7.2
Rnor_6.01946,765,429 - 46,765,642NCBIRnor6.0
Rnor_5.01957,586,216 - 57,586,429UniSTSRnor5.0
RGSC_v3.41944,520,350 - 44,520,564RGDRGSC3.4
RGSC_v3.41944,520,351 - 44,520,564UniSTSRGSC3.4
RGSC_v3.11944,525,231 - 44,525,445RGD
Celera1941,744,618 - 41,744,831UniSTS
RH 3.4 Map19562.2UniSTS
RH 3.4 Map19562.2RGD
RH 2.0 Map19590.2RGD
Cytogenetic Map19q12UniSTS
D19Got45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,617,586 - 42,617,871 (+)MAPPERmRatBN7.2
Rnor_6.01946,948,749 - 46,949,033NCBIRnor6.0
Rnor_5.01957,767,125 - 57,767,409UniSTSRnor5.0
RGSC_v3.41944,703,632 - 44,703,917RGDRGSC3.4
RGSC_v3.41944,703,633 - 44,703,917UniSTSRGSC3.4
RGSC_v3.11944,708,514 - 44,708,798RGD
Celera1941,926,096 - 41,926,380UniSTS
RH 3.4 Map19571.7UniSTS
RH 3.4 Map19571.7RGD
RH 2.0 Map19597.5RGD
Cytogenetic Map19q12UniSTS
D19Got47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,632,153 - 42,632,285 (+)MAPPERmRatBN7.2
Rnor_6.01946,963,387 - 46,963,520NCBIRnor6.0
Rnor_5.01957,780,964 - 57,781,097UniSTSRnor5.0
RGSC_v3.41944,717,891 - 44,718,022RGDRGSC3.4
RGSC_v3.41944,717,892 - 44,718,023UniSTSRGSC3.4
RGSC_v3.11944,722,772 - 44,722,903RGD
Celera1941,940,439 - 41,940,570UniSTS
RH 3.4 Map19574.7UniSTS
RH 3.4 Map19574.7RGD
RH 2.0 Map19602.9RGD
Cytogenetic Map19q12UniSTS
D19Got37  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,355,765 - 43,356,080 (+)MAPPERmRatBN7.2
Rnor_6.01947,690,741 - 47,691,055NCBIRnor6.0
Rnor_5.01958,498,502 - 58,498,816UniSTSRnor5.0
RGSC_v3.41945,487,437 - 45,487,752RGDRGSC3.4
RGSC_v3.41945,487,438 - 45,487,752UniSTSRGSC3.4
RGSC_v3.11945,492,319 - 45,492,633RGD
Celera1942,661,321 - 42,661,635UniSTS
RH 3.4 Map19584.6UniSTS
RH 3.4 Map19584.6RGD
RH 2.0 Map19607.4RGD
Cytogenetic Map19q12UniSTS
D19Got39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,848,111 - 42,848,407 (+)MAPPERmRatBN7.2
Rnor_6.01947,179,548 - 47,179,841NCBIRnor6.0
Rnor_5.01957,994,650 - 57,994,943UniSTSRnor5.0
RGSC_v3.41944,950,644 - 44,950,938RGDRGSC3.4
RGSC_v3.41944,950,645 - 44,950,938UniSTSRGSC3.4
RGSC_v3.11944,955,526 - 44,955,819RGD
Celera1942,155,028 - 42,155,321UniSTS
RH 3.4 Map19576.0UniSTS
RH 3.4 Map19576.0RGD
RH 2.0 Map19609.0RGD
Cytogenetic Map19q12UniSTS
D19Got60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,355,825 - 43,356,068 (+)MAPPERmRatBN7.2
Rnor_6.01947,690,801 - 47,691,043NCBIRnor6.0
Rnor_5.01958,498,562 - 58,498,804UniSTSRnor5.0
RGSC_v3.41945,487,497 - 45,487,740RGDRGSC3.4
RGSC_v3.41945,487,498 - 45,487,740UniSTSRGSC3.4
RGSC_v3.11945,492,379 - 45,492,621RGD
Celera1942,661,381 - 42,661,623UniSTS
RH 3.4 Map19576.1UniSTS
RH 3.4 Map19576.1RGD
RH 2.0 Map19617.0RGD
Cytogenetic Map19q12UniSTS
D19Got59  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,278,835 - 43,279,001 (+)MAPPERmRatBN7.2
Rnor_6.01947,614,262 - 47,614,427NCBIRnor6.0
Rnor_5.01958,423,036 - 58,423,201UniSTSRnor5.0
RGSC_v3.41945,401,305 - 45,401,568RGDRGSC3.4
RGSC_v3.41945,401,306 - 45,401,471UniSTSRGSC3.4
RGSC_v3.11945,406,187 - 45,406,352RGD
Celera1942,585,291 - 42,585,456UniSTS
RH 3.4 Map19585.5RGD
RH 3.4 Map19585.5UniSTS
Cytogenetic Map19q12UniSTS
AW530821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,509,009 - 42,509,169 (+)MAPPERmRatBN7.2
Rnor_6.01946,840,249 - 46,840,408NCBIRnor6.0
Rnor_5.01957,658,839 - 57,658,998UniSTSRnor5.0
RGSC_v3.41944,594,143 - 44,594,302UniSTSRGSC3.4
Celera1941,817,406 - 41,817,565UniSTS
RH 3.4 Map19565.5UniSTS
Cytogenetic Map19q12UniSTS
BQ195504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,647,971 - 42,648,175 (+)MAPPERmRatBN7.2
Rnor_6.01946,978,951 - 46,979,154NCBIRnor6.0
Rnor_5.01957,798,005 - 57,798,208UniSTSRnor5.0
RGSC_v3.41944,733,588 - 44,733,791UniSTSRGSC3.4
Celera1941,955,752 - 41,955,955UniSTS
RH 3.4 Map19576.0UniSTS
Cytogenetic Map19q12UniSTS
AU049580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,484,856 - 42,485,148 (+)MAPPERmRatBN7.2
Rnor_6.01946,815,078 - 46,815,369NCBIRnor6.0
Rnor_5.01957,634,525 - 57,634,816UniSTSRnor5.0
RGSC_v3.41944,568,874 - 44,569,165UniSTSRGSC3.4
Celera1941,793,188 - 41,793,479UniSTS
Cytogenetic Map19q12UniSTS
RH132785  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,359,990 - 43,360,170 (+)MAPPERmRatBN7.2
Rnor_6.01947,694,964 - 47,695,143NCBIRnor6.0
Rnor_5.01958,502,725 - 58,502,904UniSTSRnor5.0
RGSC_v3.41945,491,663 - 45,491,842UniSTSRGSC3.4
Celera1942,665,546 - 42,665,725UniSTS
RH 3.4 Map19585.0UniSTS
Cytogenetic Map19q12UniSTS
RH142718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,297,447 - 43,297,556 (+)MAPPERmRatBN7.2
Rnor_6.01947,632,475 - 47,632,583NCBIRnor6.0
Rnor_5.01958,440,758 - 58,440,866UniSTSRnor5.0
RGSC_v3.41945,428,460 - 45,428,568UniSTSRGSC3.4
Celera1942,603,540 - 42,603,648UniSTS
RH 3.4 Map19575.8UniSTS
Cytogenetic Map19q12UniSTS
BE101992  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,356,992 - 43,357,180 (+)MAPPERmRatBN7.2
Rnor_6.01947,691,968 - 47,692,155NCBIRnor6.0
Rnor_5.01958,499,729 - 58,499,916UniSTSRnor5.0
RGSC_v3.41945,488,665 - 45,488,852UniSTSRGSC3.4
Celera1942,662,548 - 42,662,735UniSTS
RH 3.4 Map19575.8UniSTS
Cytogenetic Map19q12UniSTS
BE120591  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,590,454 - 42,590,626 (+)MAPPERmRatBN7.2
Rnor_6.01946,921,617 - 46,921,788NCBIRnor6.0
Rnor_5.01957,740,207 - 57,740,378UniSTSRnor5.0
RGSC_v3.41944,675,630 - 44,675,801UniSTSRGSC3.4
Celera1941,898,863 - 41,899,034UniSTS
RH 3.4 Map19565.5UniSTS
Cytogenetic Map19q12UniSTS
RH135382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,029,290 - 43,029,487 (+)MAPPERmRatBN7.2
Rnor_6.01947,364,015 - 47,364,211NCBIRnor6.0
Rnor_5.01958,177,978 - 58,178,174UniSTSRnor5.0
RGSC_v3.41945,137,778 - 45,137,974UniSTSRGSC3.4
Celera1942,336,874 - 42,337,070UniSTS
RH 3.4 Map19576.5UniSTS
Cytogenetic Map19q12UniSTS
RH141830  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,935,630 - 42,935,813 (+)MAPPERmRatBN7.2
Rnor_6.01947,266,047 - 47,266,229NCBIRnor6.0
Rnor_5.01958,081,149 - 58,081,331UniSTSRnor5.0
RGSC_v3.41945,038,090 - 45,038,272UniSTSRGSC3.4
Celera1942,242,538 - 42,242,720UniSTS
RH 3.4 Map19574.3UniSTS
Cytogenetic Map19q12UniSTS
AI548764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,727,096 - 42,727,289 (+)MAPPERmRatBN7.2
Rnor_6.01947,057,967 - 47,058,159NCBIRnor6.0
Rnor_5.01957,874,462 - 57,874,654UniSTSRnor5.0
RGSC_v3.41944,829,468 - 44,829,660UniSTSRGSC3.4
Celera1942,034,531 - 42,034,723UniSTS
RH 3.4 Map19579.9UniSTS
Cytogenetic Map19q12UniSTS
BE119764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,355,103 - 43,355,312 (+)MAPPERmRatBN7.2
Rnor_6.01947,690,079 - 47,690,287NCBIRnor6.0
Rnor_5.01958,497,840 - 58,498,048UniSTSRnor5.0
RGSC_v3.41945,486,776 - 45,486,984UniSTSRGSC3.4
Celera1942,660,659 - 42,660,867UniSTS
RH 3.4 Map19575.9UniSTS
Cytogenetic Map19q12UniSTS
BG373585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,446,599 - 42,446,714 (+)MAPPERmRatBN7.2
Rnor_6.01946,775,829 - 46,775,943NCBIRnor6.0
Rnor_5.01957,596,616 - 57,596,730UniSTSRnor5.0
RGSC_v3.41944,530,751 - 44,530,865UniSTSRGSC3.4
Celera1941,755,018 - 41,755,132UniSTS
RH 3.4 Map19565.0UniSTS
Cytogenetic Map19q12UniSTS
BE101986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,177,806 - 43,177,969 (+)MAPPERmRatBN7.2
Rnor_6.01947,515,159 - 47,515,321NCBIRnor6.0
Rnor_5.01958,324,609 - 58,324,771UniSTSRnor5.0
RGSC_v3.41945,299,310 - 45,299,472UniSTSRGSC3.4
Celera1942,485,702 - 42,485,864UniSTS
RH 3.4 Map19584.6UniSTS
Cytogenetic Map19q12UniSTS


Genetic Models
This gene Wwox is modified in the following models/strains:


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000058779   ⟹   ENSRNOP00000055573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1942,432,152 - 42,442,255 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100096   ⟹   ENSRNOP00000083662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1942,432,245 - 42,730,850 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106285   ⟹   ENSRNOP00000082048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1942,432,152 - 42,727,478 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110208   ⟹   ENSRNOP00000091460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1942,432,152 - 43,359,391 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111033   ⟹   ENSRNOP00000078346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1942,432,152 - 42,939,650 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115464   ⟹   ENSRNOP00000082697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1942,432,269 - 42,725,009 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120225   ⟹   ENSRNOP00000095515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1942,432,152 - 42,466,003 (+)Ensembl
RefSeq Acc Id: NM_001106188   ⟹   NP_001099658
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,341,384 - 59,636,474 (+)NCBI
mRatBN7.21942,432,272 - 42,727,380 (+)NCBI
Rnor_6.01946,761,469 - 47,058,348 (+)NCBI
Rnor_5.01957,582,172 - 58,503,008 (+)NCBI
RGSC_v3.41944,516,391 - 44,829,849 (+)RGD
Celera1941,740,658 - 42,034,912 (+)RGD
Sequence:
RefSeq Acc Id: NM_001415106   ⟹   NP_001402035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,341,384 - 60,269,323 (+)NCBI
mRatBN7.21942,432,272 - 43,360,274 (+)NCBI
RefSeq Acc Id: XM_006255670   ⟹   XP_006255732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,338,402 - 59,869,466 (+)NCBI
mRatBN7.21942,432,243 - 42,944,187 (+)NCBI
Rnor_6.01946,761,366 - 47,270,854 (+)NCBI
Rnor_5.01957,582,172 - 58,503,008 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255671   ⟹   XP_006255733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,338,402 - 59,972,100 (+)NCBI
mRatBN7.21942,432,243 - 43,029,600 (+)NCBI
Rnor_6.01946,761,367 - 47,364,324 (+)NCBI
Rnor_5.01957,582,172 - 58,503,008 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772491   ⟹   XP_008770713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,338,402 - 59,706,645 (+)NCBI
mRatBN7.21942,432,243 - 42,730,421 (+)NCBI
Rnor_6.01946,761,353 - 47,060,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097634   ⟹   XP_038953562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,338,402 - 59,805,566 (+)NCBI
mRatBN7.21942,432,243 - 42,815,259 (+)NCBI
RefSeq Acc Id: XM_039097635   ⟹   XP_038953563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,338,402 - 60,269,323 (+)NCBI
mRatBN7.21942,432,141 - 43,360,278 (+)NCBI
RefSeq Acc Id: XM_039097637   ⟹   XP_038953565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,338,402 - 59,412,765 (+)NCBI
mRatBN7.21942,432,243 - 42,502,625 (+)NCBI
RefSeq Acc Id: XM_063277944   ⟹   XP_063134014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81959,338,402 - 60,269,323 (+)NCBI
RefSeq Acc Id: NP_001099658   ⟸   NM_001106188
- Peptide Label: isoform 2
- UniProtKB: A0A8I5ZV74 (UniProtKB/TrEMBL),   A6IZE7 (UniProtKB/TrEMBL),   A0A8I5ZV28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255733   ⟸   XM_006255671
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZV28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255732   ⟸   XM_006255670
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GB09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770713   ⟸   XM_008772491
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLQ3 (UniProtKB/TrEMBL),   A0A8I6GB09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038953563   ⟸   XM_039097635
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953562   ⟸   XM_039097634
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZV28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953565   ⟸   XM_039097637
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000082697   ⟸   ENSRNOT00000115464
RefSeq Acc Id: ENSRNOP00000078346   ⟸   ENSRNOT00000111033
RefSeq Acc Id: ENSRNOP00000095515   ⟸   ENSRNOT00000120225
RefSeq Acc Id: ENSRNOP00000091460   ⟸   ENSRNOT00000110208
RefSeq Acc Id: ENSRNOP00000055573   ⟸   ENSRNOT00000058779
RefSeq Acc Id: ENSRNOP00000083662   ⟸   ENSRNOT00000100096
RefSeq Acc Id: ENSRNOP00000082048   ⟸   ENSRNOT00000106285
RefSeq Acc Id: NP_001402035   ⟸   NM_001415106
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AEI3 (UniProtKB/TrEMBL),   A0A8I5ZV28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134014   ⟸   XM_063277944
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV28 (UniProtKB/TrEMBL),   A0A8I6AEI3 (UniProtKB/TrEMBL)
Protein Domains
WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG54-F1-model_v2 AlphaFold D3ZG54 1-143 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309927 AgrOrtholog
BioCyc Gene G2FUF-5596 BioCyc
Ensembl Genes ENSRNOG00000012030 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058779.5 UniProtKB/TrEMBL
  ENSRNOT00000100096.1 UniProtKB/TrEMBL
  ENSRNOT00000106285 ENTREZGENE
  ENSRNOT00000106285.1 UniProtKB/TrEMBL
  ENSRNOT00000110208 ENTREZGENE
  ENSRNOT00000110208.1 UniProtKB/TrEMBL
  ENSRNOT00000111033.1 UniProtKB/TrEMBL
  ENSRNOT00000115464.1 UniProtKB/TrEMBL
  ENSRNOT00000120225.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  SDR_fam UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WWOX_SDR_c-like UniProtKB/TrEMBL
KEGG Report rno:292041 UniProtKB/TrEMBL
NCBI Gene 292041 ENTREZGENE
PANTHER RETINOL DEHYDROGENASE UniProtKB/TrEMBL
  WW DOMAIN-CONTAINING OXIDOREDUCTASE UniProtKB/TrEMBL
  WW DOMAIN-CONTAINING OXIDOREDUCTASE UniProtKB/TrEMBL
  YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Wwox PhenoGen
PRINTS GDHRDH UniProtKB/TrEMBL
PROSITE WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012030 RatGTEx
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF51045 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8I5ZLQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B2V8_RAT UniProtKB/TrEMBL
  A0A8I6GB09 ENTREZGENE, UniProtKB/TrEMBL
  A6IZE7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG54_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Wwox  WW domain-containing oxidoreductase   Wwox_predicted  WW domain-containing oxidoreductase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Wwox_predicted  WW domain-containing oxidoreductase (predicted)      Symbol and Name status set to approved 70820 APPROVED