Bdh2 (3-hydroxybutyrate dehydrogenase 2)

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Gene: Bdh2 (3-hydroxybutyrate dehydrogenase 2) Rattus norvegicus

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Symbol:

Bdh2

Name:

3-hydroxybutyrate dehydrogenase 2

RGD ID:

1309898

Description:

Predicted to enable 3-hydroxybutyrate dehydrogenase activity; NAD binding activity; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including fatty acid beta-oxidation; heme metabolic process; and siderophore biosynthetic process. Predicted to act upstream of with a positive effect on intracellular sequestering of iron ion. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2); PARTICIPATES IN butanoate metabolic pathway; ketone bodies metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

(R)-beta-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase type 2; 3-hydroxybutyrate dehydrogenase, type 2; 4-oxo-L-proline reductase; dehydrogenase/reductase (SDR family) member 6; dehydrogenase/reductase SDR family member 6; Dhrs6; LOC295458; oxidoreductase UCPA; R-beta-hydroxybutyrate dehydrogenase; short chain dehydrogenase/reductase family 15C member 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	226,376,346 - 226,397,010 (+)	NCBI		GRCr8
mRatBN7.2	2	223,702,410 - 223,723,076 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	223,702,412 - 223,723,072 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	231,428,579 - 231,449,290 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	229,328,317 - 229,349,029 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	224,193,101 - 224,213,813 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	240,461,505 - 240,482,149 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	240,461,505 - 240,482,145 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	258,981,008 - 259,001,652 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	232,765,049 - 232,785,694 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	232,751,789 - 232,772,438 (+)	NCBI
Celera	2	215,916,820 - 215,937,360 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

beta-mannosidosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

butanal (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (EXP,ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

ferric oxide (ISO)

gentamycin (EXP)

glutathione (EXP)

hydrogen peroxide (ISO)

hydroquinone (ISO)

indole-3-methanol (EXP)

indometacin (EXP,ISO)

ivermectin (ISO)

lead diacetate (ISO)

melatonin (EXP,ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP,ISO)

NAD zwitterion (ISO)

NAD(+) (ISO)

nickel atom (ISO)

ochratoxin A (ISO)

oxaliplatin (ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorobutanesulfonic acid (ISO)

perfluorodecanoic acid (ISO)

perfluorododecanoic acid (ISO)

perfluoroheptanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanesulfonamide (ISO)

perfluorooctanoic acid (ISO)

perfluoroundecanoic acid (ISO)

phenobarbital (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (EXP,ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (EXP,ISO)

Triptolide (ISO)

triptonide (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

epithelial cell differentiation (IEA,ISO)

fatty acid beta-oxidation (IEA,ISO)

heme metabolic process (ISS)

intracellular sequestering of iron ion (ISO,ISS)

siderophore biosynthetic process (IBA,ISO,ISS)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

mitochondrion (ISO)

Molecular Function

3-hydroxybutyrate dehydrogenase activity (IBA,IEA,ISO)

4-oxoproline reductase activity (IEA)

NAD binding (IEA,ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

butanoate metabolic pathway (IEA)

ketone bodies metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16380372	PMID:19056867	PMID:20550936	PMID:21492153	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Bdh2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	226,376,346 - 226,397,010 (+)	NCBI		GRCr8
mRatBN7.2	2	223,702,410 - 223,723,076 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	223,702,412 - 223,723,072 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	231,428,579 - 231,449,290 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	229,328,317 - 229,349,029 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	224,193,101 - 224,213,813 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	240,461,505 - 240,482,149 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	240,461,505 - 240,482,145 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	258,981,008 - 259,001,652 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	232,765,049 - 232,785,694 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	232,751,789 - 232,772,438 (+)	NCBI
Celera	2	215,916,820 - 215,937,360 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

BDH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	103,077,592 - 103,099,834 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	103,077,592 - 103,099,870 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	103,998,749 - 104,020,991 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	104,218,231 - 104,240,473 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	101,295,921 - 101,318,163 (-)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI
HuRef	4	99,732,546 - 99,754,789 (-)	NCBI		HuRef
CHM1_1	4	103,975,255 - 103,997,497 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	106,389,483 - 106,411,725 (-)	NCBI		T2T-CHM13v2.0

Bdh2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	134,986,982 - 135,010,187 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	134,986,982 - 135,010,187 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	135,281,221 - 135,304,426 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	135,281,221 - 135,304,426 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	134,944,185 - 134,967,390 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	135,218,676 - 135,241,813 (+)	NCBI		MGSCv36	mm8
Celera	3	141,694,433 - 141,718,218 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	62.55	NCBI

Bdh2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	5,518,245 - 5,538,669 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	5,518,403 - 5,534,325 (+)	NCBI	ChiLan1.0	ChiLan1.0

BDH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	101,159,619 - 101,181,970 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	101,446,029 - 101,468,384 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	95,533,173 - 95,556,000 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	106,157,222 - 106,179,402 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	106,157,229 - 106,179,402 (-)	Ensembl	panpan1.1		panPan2

BDH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	24,420,946 - 24,442,384 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	24,420,951 - 24,442,384 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	17,581,653 - 17,602,872 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	24,640,839 - 24,662,068 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	24,639,425 - 24,662,011 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	24,657,860 - 24,679,047 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	24,400,980 - 24,422,392 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	15,440,292 - 15,461,512 (+)	NCBI		UU_Cfam_GSD_1.0

Bdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	16,934,971 - 16,961,073 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936520	278,435 - 304,770 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936520	278,467 - 304,525 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BDH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	117,969,998 - 117,995,215 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	117,969,913 - 117,995,219 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	126,942,580 - 126,966,446 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BDH2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	51,185,303 - 51,206,300 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	51,183,107 - 51,206,261 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	29,696,953 - 29,718,299 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bdh2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	4,991,714 - 5,006,783 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624830	4,991,689 - 5,006,911 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bdh2
176 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	126
Count of miRNA genes:	97
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000019507
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1359019	Hrtrt19	Heart rate QTL 19	2.9		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	219753301	226277316	Rat

Markers in Region

AI013944

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	223,715,445 - 223,715,568 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	240,474,519 - 240,474,641	NCBI	Rnor6.0
Rnor_5.0	2	258,994,022 - 258,994,144	UniSTS	Rnor5.0
RGSC_v3.4	2	232,778,069 - 232,778,191	UniSTS	RGSC3.4
Celera	2	215,929,735 - 215,929,857	UniSTS
RH 3.4 Map	2	1561.2	UniSTS
Cytogenetic Map	2	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010063596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC095848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019507 ⟹ ENSRNOP00000019507

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	223,702,412 - 223,723,072 (+)	Ensembl
Rnor_6.0 Ensembl	2	240,461,505 - 240,482,145 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095079 ⟹ ENSRNOP00000088377

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	223,702,412 - 223,720,275 (+)	Ensembl

RefSeq Acc Id:

NM_001106473 ⟹ NP_001099943

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,376,356 - 226,397,006 (+)	NCBI
mRatBN7.2	2	223,702,412 - 223,723,072 (+)	NCBI
Rnor_6.0	2	240,461,505 - 240,482,145 (+)	NCBI
Rnor_5.0	2	258,981,008 - 259,001,652 (+)	NCBI
RGSC_v3.4	2	232,765,049 - 232,785,694 (+)	RGD
Celera	2	215,916,820 - 215,937,360 (+)	RGD

Sequence:

show sequence

GCCGGAATTAGCAAACCACAGAGAACGGACCTGAACTCCACCTCCCAGCATGCATTAATCAGCA
TGTGACTTCTCCTGCACAAAGATCCGAAGTCTGTCTTCTGAAGGAATCTGGAGGACTGTGTGGA
CTCGCTCTTCTAAAATCTACCACCTGCAAATTGATTTCCTACAACTTGAGCCATTAAAGGTGCA
TGTTTTTGGATTGCACTGCAGGATCCACCATGGGCCGCCTGGAAGGGAAAGTCATCGTCCTGAC
AGCTGCCGCTCAAGGGATCGGCCGGGCTTCTGCTTTAGCTTTCGCAAGAGAAGGAGCCAAAGTC
ATAGCCACAGATATCAACGAGGCCAAACTCCAGGAGCTGGAAAATTACCCAGGTATTCAAACTC
GAGTCCTTGATGTCACAAAGAAGAGACAAATTGATCAGTTCGCCTCAGAAATTGAGAAGATTGA
TGTTCTCTTTAACGTTGCTGGTTTTGTCCACCACGGAACCATCCTGGATTGCGAGGAAAAAGAC
TGGGACTTCTCCATGAATCTCAACGTCCGCAGCATGTACCTGATGATCAAGGCATTCCTGCCCA
AAATGCTTGCTCAGAAATCTGGCAACATTATCAACATGTCTTCCGTGGCCTCCAGCATCAAAGG
GGTGGAGAACAGATGTGTGTACAGTGCAACCAAGGCAGCTGTGATCGGCCTCACCAAGTCCGTG
GCTGCAGACTTCATCCAGCAGGGCATCAGATGCAACTGTGTGTGCCCAGGAACGGTTGACACCC
CATCTCTGCAAGAAAGAATACAAGCCAGAGATGATCCCAAAGAGGCACTGAAAGCTTTCCTAAA
CAGACAGAAGACCGGAAGGTTTGCATCTGCAGAAGAGGTCGCCCTGCTCTGCGTATACTTGGCC
TCAGATGAGTCAGCCTATGTGACTGGCACCCCTGTCGTCATCGATGGCGGTTGGAGTCTGTGAG
TGCATGGATCCCTGCTGGAAGACAGGCCCTCCCTAGCCACAGAGAAAAGCAAACTGGCCGGGTG
AGCATCTCTCCTGGGTGACACTCATGAAAACAAGCCCTGTAAGGGTCGTTCCCAAGAGCGACTC
GTTAATAGTCTCTCGTCTCTTCTGAAACCATGGTAAATAAATCAAATAAAATGTATTGATTTTT
TGGC

hide sequence

RefSeq Acc Id:

XM_006233322 ⟹ XP_006233384

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,376,352 - 226,397,010 (+)	NCBI
mRatBN7.2	2	223,702,410 - 223,723,076 (+)	NCBI
Rnor_6.0	2	240,461,517 - 240,482,149 (+)	NCBI
Rnor_5.0	2	258,981,008 - 259,001,652 (+)	NCBI

Sequence:

show sequence

AAACCACAGAGAACGGACCTGAACTCCACCTCCCAGCATGCATTAATCAGCATGTGACTTCTCC
TGCACAAAGATCCGAAGTCTGTCTTCTGAAGGAATCTGGAGGACTGTGTGGACTCGCTCTTCTA
AAGATCCACCATGGGCCGCCTGGAAGGGAAAGTCATCGTCCTGACAGCTGCCGCTCAAGGGATC
GGCCGGGCTTCTGCTTTAGCTTTCGCAAGAGAAGGAGCCAAAGTCATAGCCACAGATATCAACG
AGGCCAAACTCCAGGAGCTGGAAAATTACCCAGGTATTCAAACTCGAGTCCTTGATGTCACAAA
GAAGAGACAAATTGATCAGTTCGCCTCAGAAATTGAGAAGATTGATGTTCTCTTTAACGTTGCT
GGTTTTGTCCACCACGGAACCATCCTGGATTGCGAGGAAAAAGACTGGGACTTCTCCATGAATC
TCAACGTCCGCAGCATGTACCTGATGATCAAGGCATTCCTGCCCAAAATGCTTGCTCAGAAATC
TGGCAACATTATCAACATGTCTTCCGTGGCCTCCAGCATCAAAGGGGTGGAGAACAGATGTGTG
TACAGTGCAACCAAGGCAGCTGTGATCGGCCTCACCAAGTCCGTGGCTGCAGACTTCATCCAGC
AGGGCATCAGATGCAACTGTGTGTGCCCAGGAACGGTTGACACCCCATCTCTGCAAGAAAGAAT
ACAAGCCAGAGATGATCCCAAAGAGGCACTGAAAGCTTTCCTAAACAGACAGAAGACCGGAAGG
TTTGCATCTGCAGAAGAGGTCGCCCTGCTCTGCGTATACTTGGCCTCAGATGAGTCAGCCTATG
TGACTGGCACCCCTGTCGTCATCGATGGCGGTTGGAGTCTGTGAGTGCATGGATCCCTGCTGGA
AGACAGGCCCTCCCTAGCCACAGAGAAAAGCAAACTGGCCGGGTGAGCATCTCTCCTGGGTGAC
ACTCATGAAAACAAGCCCTGTAAGGGTCGTTCCCAAGAGCGACTCGTTAATAGTCTCTCGTCTC
TTCTGAAACCATGGTAAATAAATCAAATAAAATGTATTGATTTTTTGGCAAAA

hide sequence

RefSeq Acc Id:

XR_010063596

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,376,346 - 226,396,812 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099943	(Get FASTA)	NCBI Sequence Viewer
	XP_006233384	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D4A1J4	(Get FASTA)	NCBI Sequence Viewer
	EDL82248	(Get FASTA)	NCBI Sequence Viewer
	EDL82249	(Get FASTA)	NCBI Sequence Viewer
	EDL82250	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019507.4
	ENSRNOP00000088377.1

RefSeq Acc Id:

NP_001099943 ⟸ NM_001106473

- UniProtKB:

A0A0A0MXX5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFLDCTAGSTMGRLEGKVIVLTAAAQGIGRASALAFAREGAKVIATDINEAKLQELENYPGIQT
RVLDVTKKRQIDQFASEIEKIDVLFNVAGFVHHGTILDCEEKDWDFSMNLNVRSMYLMIKAFLP
KMLAQKSGNIINMSSVASSIKGVENRCVYSATKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDT
PSLQERIQARDDPKEALKAFLNRQKTGRFASAEEVALLCVYLASDESAYVTGTPVVIDGGWSL

hide sequence

RefSeq Acc Id:	XP_006233384 ⟸ XM_006233322
- Peptide Label:	isoform X1
- UniProtKB:	D4A1J4 (UniProtKB/Swiss-Prot), A6HVW3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGRLEGKVIVLTAAAQGIGRASALAFAREGAKVIATDINEAKLQELENYPGIQTRVLDVTKKRQ IDQFASEIEKIDVLFNVAGFVHHGTILDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNI INMSSVASSIKGVENRCVYSATKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQAR DDPKEALKAFLNRQKTGRFASAEEVALLCVYLASDESAYVTGTPVVIDGGWSL hide sequence

Ensembl Acc Id:

ENSRNOP00000019507 ⟸ ENSRNOT00000019507

Ensembl Acc Id:

ENSRNOP00000088377 ⟸ ENSRNOT00000095079

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A1J4-F1-model_v2	AlphaFold	D4A1J4	1-245	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691767

Promoter ID:

EPDNEW_R2292

Type:

initiation region

Name:

Bdh2_1

Description:

3-hydroxybutyrate dehydrogenase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	240,461,561 - 240,461,621	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309898	AgrOrtholog
BioCyc Gene	G2FUF-51143	BioCyc
BioCyc Pathway	PWY66-367 [ketogenesis]	BioCyc
	PWY66-368 [ketolysis]	BioCyc
BioCyc Pathway Image	PWY66-367	BioCyc
	PWY66-368	BioCyc
Ensembl Genes	ENSRNOG00000014490	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019507.6	UniProtKB/TrEMBL
	ENSRNOT00000095079.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDR_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDR_superfamily_enzyme	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:295458	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	295458	ENTREZGENE
PANTHER	3-HYDROXYBUTYRATE DEHYDROGENASE TYPE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DIHYDROANTICAPSIN 7-DEHYDROGENASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	adh_short_C2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Bdh2	PhenoGen
PRINTS	GDHRDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014490	RatGTEx
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0A0MXX5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A7Z5_RAT	UniProtKB/TrEMBL
	A6HVW3	ENTREZGENE, UniProtKB/TrEMBL
	BDH2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-01-03	Bdh2	3-hydroxybutyrate dehydrogenase 2	Bdh2	3-hydroxybutyrate dehydrogenase, type 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Bdh2	3-hydroxybutyrate dehydrogenase, type 2	Bdh2_predicted	3-hydroxybutyrate dehydrogenase, type 2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Bdh2_predicted	3-hydroxybutyrate dehydrogenase, type 2 (predicted)	Dhrs6_predicted	dehydrogenase/reductase (SDR family) member 6 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Dhrs6_predicted	dehydrogenase/reductase (SDR family) member 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

BioCyc Pathways