Macc1 (MET transcriptional regulator MACC1) - Rat Genome Database

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Gene: Macc1 (MET transcriptional regulator MACC1) Rattus norvegicus
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Symbol: Macc1
Name: MET transcriptional regulator MACC1
RGD ID: 1309838
Description: Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human MACC1 (MET transcriptional regulator MACC1); INTERACTS WITH bisphenol A; trichloroethene; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 7a5; LOC314539; MACC1, MET transcriptional regulator; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; putative binding protein 7a5; RGD1309838; similar to putative binding protein 7a5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86146,495,544 - 146,574,254 (+)NCBIGRCr8
mRatBN7.26140,352,690 - 140,430,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6140,352,755 - 140,430,255 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6143,861,345 - 143,879,849 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06140,478,811 - 140,497,315 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06141,034,353 - 141,066,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06147,315,232 - 147,392,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6147,315,328 - 147,394,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06156,224,923 - 156,301,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46146,988,261 - 147,006,788 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16146,994,439 - 147,012,778 (+)NCBI
Celera6138,056,152 - 138,074,679 (+)NCBICelera
Cytogenetic Map6q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IEA,ISO)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Long Intergenic Non-Coding RNA LINC00885 Promotes Tumorigenesis of Cervical Cancer by Upregulating MACC1 Expression Through Serving as a Competitive Endogenous RNA for microRNA-432-5p. Chen H, etal., Cancer Manag Res. 2021 Feb 12;13:1435-1447. doi: 10.2147/CMAR.S291778. eCollection 2021.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer. Xia J, etal., Cancer Lett. 2016 Oct 10;381(1):31-40. doi: 10.1016/j.canlet.2016.07.014. Epub 2016 Jul 16.
Additional References at PubMed
PMID:19098908   PMID:35014688  


Genomics

Comparative Map Data
Macc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86146,495,544 - 146,574,254 (+)NCBIGRCr8
mRatBN7.26140,352,690 - 140,430,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6140,352,755 - 140,430,255 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6143,861,345 - 143,879,849 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06140,478,811 - 140,497,315 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06141,034,353 - 141,066,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06147,315,232 - 147,392,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6147,315,328 - 147,394,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06156,224,923 - 156,301,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46146,988,261 - 147,006,788 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16146,994,439 - 147,012,778 (+)NCBI
Celera6138,056,152 - 138,074,679 (+)NCBICelera
Cytogenetic Map6q33NCBI
MACC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38720,134,655 - 20,217,384 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl720,134,655 - 20,217,404 (-)EnsemblGRCh38hg38GRCh38
GRCh37720,174,278 - 20,257,007 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36720,140,803 - 20,223,538 (-)NCBINCBI36Build 36hg18NCBI36
Celera720,158,544 - 20,241,270 (-)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef720,063,730 - 20,146,446 (-)NCBIHuRef
CHM1_1720,174,953 - 20,257,727 (-)NCBICHM1_1
T2T-CHM13v2.0720,268,945 - 20,351,674 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2720,225,621 - 20,308,353 (-)NCBI
Macc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912119,354,133 - 119,430,669 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12119,278,005 - 119,433,722 (+)EnsemblGRCm39 Ensembl
GRCm3812119,390,398 - 119,466,934 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12119,314,270 - 119,469,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712120,681,883 - 120,705,407 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612119,887,512 - 119,911,036 (+)NCBIMGSCv36mm8
MGSCv3612113,667,793 - 113,691,320 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1263.48NCBI
Macc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541022,811,786 - 22,894,572 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541022,777,518 - 22,894,561 (-)NCBIChiLan1.0ChiLan1.0
MACC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2625,002,900 - 25,030,546 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1773,327,625 - 73,355,282 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0720,826,105 - 20,904,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1720,144,960 - 20,223,069 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl720,144,960 - 20,170,423 (-)Ensemblpanpan1.1panPan2
MACC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11434,189,983 - 34,271,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1434,075,463 - 34,251,330 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1433,726,368 - 33,808,391 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01434,109,745 - 34,191,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1434,027,931 - 34,171,114 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11434,228,356 - 34,310,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01433,929,027 - 34,011,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01434,239,939 - 34,321,976 (-)NCBIUU_Cfam_GSD_1.0
Macc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511878,490,344 - 78,650,949 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365466,167,616 - 6,232,771 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365466,169,789 - 6,188,403 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl989,102,621 - 89,210,312 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1989,130,971 - 89,342,181 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2998,276,072 - 98,382,754 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12138,015,409 - 38,091,907 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604266,480,784 - 66,503,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Macc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473910,435,761 - 10,467,543 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473910,387,745 - 10,467,384 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Macc1
412 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:31
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000056654
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 19 54 56 55 24 25 24 6 149 63 34 45 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000056654   ⟹   ENSRNOP00000053492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6140,352,755 - 140,430,255 (+)Ensembl
Rnor_6.0 Ensembl6147,315,328 - 147,394,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098438   ⟹   ENSRNOP00000085467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6140,389,249 - 140,430,255 (+)Ensembl
RefSeq Acc Id: NM_001191775   ⟹   NP_001178704
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86146,554,712 - 146,573,239 (+)NCBI
mRatBN7.26140,411,726 - 140,430,255 (+)NCBI
Rnor_6.06147,374,003 - 147,392,530 (+)NCBI
Rnor_5.06156,224,923 - 156,301,994 (+)NCBI
Celera6138,056,152 - 138,074,679 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240694   ⟹   XP_006240756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86146,495,544 - 146,574,254 (+)NCBI
mRatBN7.26140,352,690 - 140,430,255 (+)NCBI
Rnor_6.06147,315,232 - 147,392,530 (+)NCBI
Rnor_5.06156,224,923 - 156,301,994 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178704 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240756 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89095 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053492.3
  ENSRNOP00000085467.1
RefSeq Acc Id: NP_001178704   ⟸   NM_001191775
- UniProtKB: F1LXW4 (UniProtKB/TrEMBL),   A0A8I6A082 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240756   ⟸   XM_006240694
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000053492   ⟸   ENSRNOT00000056654
Ensembl Acc Id: ENSRNOP00000085467   ⟸   ENSRNOT00000098438
Protein Domains
SH3   ZU5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LXW4-F1-model_v2 AlphaFold F1LXW4 1-850 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309838 AgrOrtholog
BioCyc Gene G2FUF-35450 BioCyc
Ensembl Genes ENSRNOG00000037436 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056654.5 UniProtKB/TrEMBL
  ENSRNOT00000098438.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.30 UniProtKB/TrEMBL
InterPro SH3_domain UniProtKB/TrEMBL
  ZU5_dom UniProtKB/TrEMBL
KEGG Report rno:314539 UniProtKB/TrEMBL
NCBI Gene 314539 ENTREZGENE
PANTHER METASTASIS-ASSOCIATED IN COLON CANCER PROTEIN 1 UniProtKB/TrEMBL
  SH3 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
PhenoGen Macc1 PhenoGen
PROSITE SH3 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037436 RatGTEx
UniProt A0A8I6A082 ENTREZGENE, UniProtKB/TrEMBL
  F1LXW4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-24 Macc1  MET transcriptional regulator MACC1  Macc1  MACC1, MET transcriptional regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-29 Macc1  MACC1, MET transcriptional regulator  Macc1  metastasis associated in colon cancer 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Macc1  metastasis associated in colon cancer 1  7a5  putative binding protein 7a5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-18 7a5  putative binding protein 7a5  RGD1309838_predicted  similar to putative binding protein 7a5 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1309838_predicted  similar to putative binding protein 7a5 (predicted)  LOC314539_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314539_predicted  similar to putative binding protein 7a5 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL