Ca1 (carbonic anhydrase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ca1 (carbonic anhydrase 1) Rattus norvegicus
Analyze
Symbol: Ca1 (Ensembl: Car1)
Name: carbonic anhydrase 1
RGD ID: 1309780
Description: Predicted to enable arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Involved in response to fructose. Predicted to be active in cytoplasm. Biomarker of colitis. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and viral hepatitis. Orthologous to human CA1 (carbonic anhydrase 1); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CA-I; Car1; Carbonate dehydratase I; carbonic anhydrase I; cyanamide hydratase CA1; LOC310218; LOC679649; similar to betaine-homocysteine methyltransferase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,550,681 - 88,593,454 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,495,475 - 88,593,454 (+)EnsemblGRCr8
mRatBN7.2286,829,436 - 86,872,209 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,861,897 - 86,872,208 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,154,953 - 93,195,719 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,275,953 - 91,316,725 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,332,778 - 86,373,541 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,185,204 - 88,227,486 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,217,188 - 88,227,479 (+)Ensemblrn6Rnor6.0
Rnor_5.02107,958,483 - 108,000,765 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,166,412 - 88,210,693 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,427,032 - 82,469,698 (+)NCBICelera
RGSC_v3.1288,143,727 - 88,155,654 (+)NCBI
Cytogenetic Map2q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
1H-1,2,4-triazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butylphenol  (ISO)
2,6-Dimethylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetazolamide  (ISO)
aflatoxin B1  (ISO)
anthocyanin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
candesartan  (ISO)
carbon nanotube  (ISO)
carbonates  (ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chloric acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethoxzolamide  (ISO)
Evodiamine  (ISO)
ferroheme b  (EXP)
flavonoids  (ISO)
gentamycin  (EXP)
guaiacol  (ISO)
heme b  (EXP)
hydrazinecarbothioamide  (ISO)
hydrogencarbonate  (ISO)
indometacin  (ISO)
irbesartan  (ISO)
lead(0)  (ISO)
malvidin 3-O-beta-D-glucoside  (ISO)
malvin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
Methazolamide  (ISO)
methylamines  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-phenylthiourea  (ISO)
nitric acid  (ISO)
nitrofen  (EXP)
orphenadrine  (EXP)
oryzalin  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pelargonidin 3-O-beta-D-glucoside  (ISO)
pelargonidin 3-O-beta-D-glucoside chloride  (ISO)
perchlorate  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propofol  (ISO)
pyrimidines  (ISO)
rac-lactic acid  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
senecionine  (ISO)
silychristin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulfamic acid  (ISO)
sulfates  (ISO)
synephrine  (ISO)
tetrachloromethane  (EXP,ISO)
thiazolidines  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiourea  (ISO)
topiramate  (ISO)
topotecan  (EXP)
trans-chalcone  (ISO)
triazoles  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
tungstate  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
voriconazole  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Low-avidity antibodies to carbonic anhydrase-I and -II in autoimmune chronic pancreatitis. Bartolomé MJ, etal., ScientificWorldJournal. 2002 Jun 11;2:1560-8. doi: 10.1100/tsw.2002.811.
2. Proteomic surveillance of putative new autoantigens in thyroid orbitopathy. Cheng KC, etal., Br J Ophthalmol. 2015 Nov;99(11):1571-6. doi: 10.1136/bjophthalmol-2015-306634. Epub 2015 Jun 1.
3. High fructose feeding enhances erythrocyte carbonic anhydrase 1 mRNA levels in rat. Gambhir KK, etal., Ann N Y Acad Sci. 1997 Sep 20;827:163-9. doi: 10.1111/j.1749-6632.1997.tb51831.x.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Urine Proteome Changes in a TNBS-Induced Colitis Rat Model. Qin W, etal., Proteomics Clin Appl. 2019 Sep;13(5):e1800100. doi: 10.1002/prca.201800100. Epub 2019 May 28.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2114290   PMID:7758465   PMID:12477932   PMID:14760703   PMID:15489334   PMID:22206666   PMID:23376485   PMID:23533145   PMID:24670789  


Genomics

Comparative Map Data
Ca1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8288,550,681 - 88,593,454 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl288,495,475 - 88,593,454 (+)EnsemblGRCr8
mRatBN7.2286,829,436 - 86,872,209 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,861,897 - 86,872,208 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx293,154,953 - 93,195,719 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,275,953 - 91,316,725 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,332,778 - 86,373,541 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,185,204 - 88,227,486 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,217,188 - 88,227,479 (+)Ensemblrn6Rnor6.0
Rnor_5.02107,958,483 - 108,000,765 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4288,166,412 - 88,210,693 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera282,427,032 - 82,469,698 (+)NCBICelera
RGSC_v3.1288,143,727 - 88,155,654 (+)NCBI
Cytogenetic Map2q23NCBI
CA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38885,327,608 - 85,378,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl885,327,608 - 85,379,014 (-)Ensemblhg38GRCh38
GRCh37886,239,837 - 86,290,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,427,709 - 86,477,594 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34886,427,708 - 86,477,594NCBI
Celera882,245,509 - 82,295,378 (-)NCBICelera
Cytogenetic Map8q21.2NCBI
HuRef881,734,656 - 81,784,498 (-)NCBIHuRef
CHM1_1886,292,190 - 86,342,023 (-)NCBICHM1_1
T2T-CHM13v2.0885,766,342 - 85,816,813 (-)NCBIT2T-CHM13v2.0
Car1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,831,274 - 14,873,425 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,831,276 - 14,873,428 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38314,766,214 - 14,808,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,766,216 - 14,808,368 (-)Ensemblmm10GRCm38
MGSCv37314,766,214 - 14,808,365 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36314,742,975 - 14,767,557 (-)NCBIMGSCv36mm8
Celera314,771,712 - 14,813,913 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.18NCBI
Ca1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,270,619 - 3,305,756 (-)Ensembl
ChiLan1.0NW_0049554173,270,619 - 3,313,261 (-)NCBIChiLan1.0ChiLan1.0
CA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27101,062,861 - 101,095,648 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1876,698,568 - 76,728,323 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0881,854,390 - 81,905,728 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1883,464,680 - 83,515,359 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl883,463,434 - 83,526,899 (-)EnsemblpanPan2panpan1.1
CA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,858,644 - 31,868,135 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,858,636 - 31,868,158 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2932,144,441 - 32,154,240 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02932,007,771 - 32,017,260 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2932,007,763 - 32,029,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12932,058,957 - 32,068,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02932,080,387 - 32,089,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02932,466,958 - 32,476,446 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ca1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,504,905 - 47,545,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936544246,797 - 257,650 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936544246,797 - 257,798 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,302,406 - 51,353,126 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1451,343,548 - 51,353,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,358,354 - 56,367,895 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,699,114 - 80,729,932 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl880,699,651 - 80,712,858 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603960,349,417 - 60,401,053 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247446,314,872 - 6,333,003 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247446,244,872 - 6,324,722 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ca1
289 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000014267
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH129986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,871,927 - 86,872,111 (+)MAPPERmRatBN7.2
Rnor_6.0288,227,205 - 88,227,388NCBIRnor6.0
Rnor_5.02108,000,484 - 108,000,667UniSTSRnor5.0
RGSC_v3.4288,210,412 - 88,210,595UniSTSRGSC3.4
Celera282,469,417 - 82,469,600UniSTS
RH 3.4 Map2533.6UniSTS
Cytogenetic Map2q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
16 12 49 114 86 89 58 82 58 5 294 161 11 88 51 52 31

Sequence


Ensembl Acc Id: ENSRNOT00000014267   ⟹   ENSRNOP00000014267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl288,495,475 - 88,593,454 (+)Ensembl
mRatBN7.2 Ensembl286,861,897 - 86,872,208 (+)Ensembl
Rnor_6.0 Ensembl288,217,188 - 88,227,479 (+)Ensembl
RefSeq Acc Id: NM_001107660   ⟹   NP_001101130
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,550,681 - 88,593,454 (+)NCBI
mRatBN7.2286,829,436 - 86,872,209 (+)NCBI
Rnor_6.0288,185,204 - 88,227,486 (+)NCBI
Rnor_5.02107,958,483 - 108,000,765 (+)NCBI
RGSC_v3.4288,166,412 - 88,210,693 (+)RGD
Celera282,427,032 - 82,469,698 (+)RGD
Sequence:
RefSeq Acc Id: XM_008760842   ⟹   XP_008759064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8288,581,975 - 88,593,453 (+)NCBI
mRatBN7.2286,860,786 - 86,872,208 (+)NCBI
Rnor_6.0288,216,063 - 88,227,485 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101130 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759064 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58889 (Get FASTA)   NCBI Sequence Viewer  
  B0BNN3 (Get FASTA)   NCBI Sequence Viewer  
  EDM00961 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014267
  ENSRNOP00000014267.4
RefSeq Acc Id: NP_001101130   ⟸   NM_001107660
- UniProtKB: B0BNN3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008759064   ⟸   XM_008760842
- Peptide Label: isoform X1
- UniProtKB: B0BNN3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014267   ⟸   ENSRNOT00000014267
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNN3-F1-model_v2 AlphaFold B0BNN3 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691223
Promoter ID:EPDNEW_R1746
Type:single initiation site
Name:Car1_1
Description:carbonic anhydrase I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0288,217,176 - 88,217,236EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309780 AgrOrtholog
BioCyc Gene G2FUF-53807 BioCyc
Ensembl Genes ENSRNOG00000010698 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014267 ENTREZGENE
  ENSRNOT00000014267.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8373855 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot
  CA_dom_sf UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
KEGG Report rno:310218 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188619 IMAGE-MGC_LOAD
NCBI Gene 310218 ENTREZGENE
PANTHER CARBONIC ANHYDRASE 1 UniProtKB/Swiss-Prot
  PTHR18952 UniProtKB/Swiss-Prot
Pfam Carb_anhydrase UniProtKB/Swiss-Prot
PhenoGen Ca1 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010698 RatGTEx
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot
UniProt B0BNN3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-28 Ca1  carbonic anhydrase 1  Car1  carbonic anhydrase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-08-21 Car1  carbonic anhydrase 1  Car1  carbonic anhydrase I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Car1  carbonic anhydrase I  LOC679649  similar to betaine-homocysteine methyltransferase 2  Data merged from RGD:1585940 737654 PROVISIONAL
2014-08-04 Car1  carbonic anhydrase I  Ca1  carbonic anhydrase I  Symbol changed 629549 APPROVED
2013-02-21 Ca1  carbonic anhydrase I  Car1  carbonic anhydrase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Car1  carbonic anhydrase 1   Car1_predicted  carbonic anhydrase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC679649  similar to betaine-homocysteine methyltransferase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Car1_predicted  carbonic anhydrase 1 (predicted)  Ca1_predicted  carbonic anhydrase I (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ca1_predicted  carbonic anhydrase I (predicted)      Symbol and Name status set to approved 70820 APPROVED