Ahnak2 (AHNAK nucleoprotein 2) - Rat Genome Database

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Gene: Ahnak2 (AHNAK nucleoprotein 2) Rattus norvegicus
Analyze
Symbol: Ahnak2
Name: AHNAK nucleoprotein 2
RGD ID: 1309696
Description: Predicted to be located in nucleus. Orthologous to human AHNAK2 (AHNAK nucleoprotein 2); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC314478; RGD1309696; similar to KIAA2019 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,648,867 - 137,697,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,652,537 - 137,675,546 (-)EnsemblGRCr8
mRatBN7.26131,830,668 - 131,876,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,831,454 - 131,854,463 (-)EnsemblmRatBN7.2
Rnor_6.06137,335,273 - 137,380,219 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06146,341,110 - 146,383,305 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,757,297 - 137,802,756 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,377,311 - 129,415,591 (-)NCBICelera
RGSC_v3.16137,763,483 - 137,808,943 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buserelin  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ferric oxide  (ISO)
FR900359  (ISO)
furfural  (ISO)
glyphosate  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dichloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Self-regulated alternative splicing at the AHNAK locus. de Morree A, etal., FASEB J. 2012 Jan;26(1):93-103. doi: 10.1096/fj.11-187971. Epub 2011 Sep 22.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15007166   PMID:20833135   PMID:21873635  


Genomics

Comparative Map Data
Ahnak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,648,867 - 137,697,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,652,537 - 137,675,546 (-)EnsemblGRCr8
mRatBN7.26131,830,668 - 131,876,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,831,454 - 131,854,463 (-)EnsemblmRatBN7.2
Rnor_6.06137,335,273 - 137,380,219 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06146,341,110 - 146,383,305 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,757,297 - 137,802,756 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,377,311 - 129,415,591 (-)NCBICelera
RGSC_v3.16137,763,483 - 137,808,943 (-)NCBI
Cytogenetic Map6q32NCBI
AHNAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,937,253 - 104,978,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,937,244 - 104,978,374 (-)Ensemblhg38GRCh38
GRCh3714105,403,590 - 105,444,711 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,474,636 - 104,515,739 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1485,457,805 - 85,498,909 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,597,412 - 85,638,515 (-)NCBIHuRef
CHM1_114105,341,352 - 105,382,455 (-)NCBICHM1_1
T2T-CHM13v2.01499,183,727 - 99,222,852 (-)NCBIT2T-CHM13v2.0
Ahnak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,738,631 - 112,766,278 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,738,628 - 112,766,277 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812112,772,197 - 112,802,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,772,194 - 112,802,657 (-)Ensemblmm10GRCm38
MGSCv3712114,010,404 - 114,013,975 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612114,010,405 - 114,013,851 (-)NCBIMGSCv36mm8
Celera12113,987,981 - 113,991,552 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Ahnak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555383,305,664 - 3,315,094 (-)NCBIChiLan1.0ChiLan1.0
AHNAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,121,879 - 106,163,732 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,338,381 - 105,380,178 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,587,016 - 85,627,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,372,577 - 105,391,480 (-)NCBIPanPan1.1PanPan1.1panPan2
AHNAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,423,322 - 72,446,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,923,976 - 71,958,982 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0872,693,877 - 72,731,271 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1872,376,730 - 72,411,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,420,230 - 72,456,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,819,643 - 72,837,121 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ahnak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,662,756 - 1,683,122 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936621486,855 - 512,079 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHNAK2
(Sus scrofa - pig)		 No map positions available.
AHNAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,861,459 - 82,872,671 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605370,288,030 - 70,329,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ahnak2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17130,361,508 - 130,400,169 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ahnak2
361 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000039631
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 48 47 116 75 11 47 34 32 16 16

Sequence


RefSeq Acc Id: XM_039113411   ⟹   XP_038969339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,697,580 (-)NCBI
mRatBN7.26131,830,668 - 131,876,308 (-)NCBI
RefSeq Acc Id: XM_039113412   ⟹   XP_038969340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,689,974 (-)NCBI
mRatBN7.26131,830,668 - 131,868,893 (-)NCBI
RefSeq Acc Id: XM_039113413   ⟹   XP_038969341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,692,083 (-)NCBI
mRatBN7.26131,830,668 - 131,870,997 (-)NCBI
RefSeq Acc Id: XM_063262710   ⟹   XP_063118780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,697,488 (-)NCBI
RefSeq Acc Id: XM_063262711   ⟹   XP_063118781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,697,488 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038969339 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969340 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969341 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118780 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118781 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088772.1
RefSeq Acc Id: XP_038969339   ⟸   XM_039113411
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969341   ⟸   XM_039113413
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969340   ⟸   XM_039113412
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118781   ⟸   XM_063262711
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063118780   ⟸   XM_063262710
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309696 AgrOrtholog
BioCyc Gene G2FUF-35775 BioCyc
Ensembl Genes ENSRNOG00000065195 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108552.2 UniProtKB/TrEMBL
InterPro Myelin_sheath_structural UniProtKB/TrEMBL
NCBI Gene 314478 ENTREZGENE
PANTHER PERIAXIN/AHNAK UniProtKB/TrEMBL
  PROTEIN AHNAK2 UniProtKB/TrEMBL
PhenoGen Ahnak2 PhenoGen
RatGTEx ENSRNOG00000065195 RatGTEx
UniProt A0A8I6AAE1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Ahnak2  AHNAK nucleoprotein 2  RGD1309696  similar to KIAA2019 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309696  similar to KIAA2019 protein   RGD1309696_predicted  similar to KIAA2019 protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309696_predicted  similar to KIAA2019 protein (predicted)  LOC314478_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314478_predicted  similar to KIAA2019 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL