Ahnak2 (AHNAK nucleoprotein 2) - Rat Genome Database

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Gene: Ahnak2 (AHNAK nucleoprotein 2) Rattus norvegicus
Analyze
Symbol: Ahnak2
Name: AHNAK nucleoprotein 2
RGD ID: 1309696
Description: Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; cytosol; and myofibril. Orthologous to human AHNAK2 (AHNAK nucleoprotein 2); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC314478; RGD1309696; similar to KIAA2019 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,648,867 - 137,697,580 (-)NCBIGRCr8
mRatBN7.26131,830,668 - 131,876,311 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.06137,335,273 - 137,380,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06146,341,110 - 146,383,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,757,297 - 137,802,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,763,483 - 137,808,943 (-)NCBI
Celera6129,377,311 - 129,415,591 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buserelin  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ferric oxide  (ISO)
FR900359  (ISO)
glyphosate  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
manganese(II) chloride  (EXP)
mercury dichloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Self-regulated alternative splicing at the AHNAK locus. de Morree A, etal., FASEB J. 2012 Jan;26(1):93-103. doi: 10.1096/fj.11-187971. Epub 2011 Sep 22.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15007166   PMID:20833135   PMID:21873635  


Genomics

Comparative Map Data
Ahnak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,648,867 - 137,697,580 (-)NCBIGRCr8
mRatBN7.26131,830,668 - 131,876,311 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.06137,335,273 - 137,380,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06146,341,110 - 146,383,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,757,297 - 137,802,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,763,483 - 137,808,943 (-)NCBI
Celera6129,377,311 - 129,415,591 (-)NCBICelera
Cytogenetic Map6q32NCBI
AHNAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,937,253 - 104,978,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,937,244 - 104,978,374 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,403,590 - 105,444,711 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,474,636 - 104,515,739 (-)NCBINCBI36Build 36hg18NCBI36
Celera1485,457,805 - 85,498,909 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,597,412 - 85,638,515 (-)NCBIHuRef
CHM1_114105,341,352 - 105,382,455 (-)NCBICHM1_1
T2T-CHM13v2.01499,183,727 - 99,222,852 (-)NCBIT2T-CHM13v2.0
Ahnak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,738,631 - 112,766,278 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,738,628 - 112,766,277 (-)EnsemblGRCm39 Ensembl
GRCm3812112,772,197 - 112,802,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,772,194 - 112,802,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,010,404 - 114,013,975 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612114,010,405 - 114,013,851 (-)NCBIMGSCv36mm8
Celera12113,987,981 - 113,991,552 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Ahnak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555383,305,664 - 3,315,094 (-)NCBIChiLan1.0ChiLan1.0
AHNAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,121,879 - 106,163,732 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,338,381 - 105,380,178 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,587,016 - 85,627,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,372,577 - 105,391,480 (-)NCBIpanpan1.1PanPan1.1panPan2
AHNAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,423,322 - 72,446,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,923,976 - 71,958,982 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,693,877 - 72,731,271 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1872,376,730 - 72,411,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,420,230 - 72,456,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,819,643 - 72,837,121 (-)NCBIUU_Cfam_GSD_1.0
Ahnak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,662,756 - 1,683,122 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936621486,855 - 512,079 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHNAK2
(Sus scrofa - pig)		 No map positions available.
AHNAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,861,459 - 82,872,671 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605370,288,030 - 70,329,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ahnak2
553 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000039631
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_039113411   ⟹   XP_038969339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,697,580 (-)NCBI
mRatBN7.26131,830,668 - 131,876,308 (-)NCBI
RefSeq Acc Id: XM_039113412   ⟹   XP_038969340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,689,974 (-)NCBI
mRatBN7.26131,830,668 - 131,868,893 (-)NCBI
RefSeq Acc Id: XM_039113413   ⟹   XP_038969341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,692,083 (-)NCBI
mRatBN7.26131,830,668 - 131,870,997 (-)NCBI
RefSeq Acc Id: XM_063262710   ⟹   XP_063118780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,697,488 (-)NCBI
RefSeq Acc Id: XM_063262711   ⟹   XP_063118781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,648,867 - 137,697,488 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038969339 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969340 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969341 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118780 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118781 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088772.1
RefSeq Acc Id: XP_038969339   ⟸   XM_039113411
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969341   ⟸   XM_039113413
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969340   ⟸   XM_039113412
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118781   ⟸   XM_063262711
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063118780   ⟸   XM_063262710
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AAE1 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309696 AgrOrtholog
BioCyc Gene G2FUF-35775 BioCyc
Ensembl Genes ENSRNOG00000065195 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108552.1 UniProtKB/TrEMBL
InterPro Myelin_sheath_structural UniProtKB/TrEMBL
NCBI Gene 314478 ENTREZGENE
PANTHER PERIAXIN/AHNAK UniProtKB/TrEMBL
  PROTEIN AHNAK2 UniProtKB/TrEMBL
PhenoGen Ahnak2 PhenoGen
RatGTEx ENSRNOG00000065195 RatGTEx
UniProt A0A8I6AAE1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Ahnak2  AHNAK nucleoprotein 2  RGD1309696  similar to KIAA2019 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309696  similar to KIAA2019 protein   RGD1309696_predicted  similar to KIAA2019 protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309696_predicted  similar to KIAA2019 protein (predicted)  LOC314478_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314478_predicted  similar to KIAA2019 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL