Klhl30 (kelch-like family member 30) - Rat Genome Database

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Gene: Klhl30 (kelch-like family member 30) Rattus norvegicus
Analyze
Symbol: Klhl30
Name: kelch-like family member 30
RGD ID: 1309644
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL30 (kelch like family member 30); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kelch-like 30; kelch-like 30 (Drosophila); kelch-like protein 30; LOC316624; RGD1309644; similar to Hypothetical protein KIAA0469
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,389,982 - 99,400,295 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,390,014 - 99,400,295 (+)EnsemblGRCr8
mRatBN7.2991,942,475 - 91,952,756 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,942,504 - 91,952,730 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,369,239 - 100,379,520 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,504,995 - 105,515,278 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,868,592 - 103,878,877 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,490,583 - 98,500,880 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,490,608 - 98,500,867 (+)Ensemblrn6Rnor6.0
Rnor_5.0998,167,151 - 98,177,317 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,580,293 - 90,588,134 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,483,479 - 89,493,780 (+)NCBICelera
RGSC_v3.1990,781,311 - 90,792,168 (+)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Klhl30
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,389,982 - 99,400,295 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,390,014 - 99,400,295 (+)EnsemblGRCr8
mRatBN7.2991,942,475 - 91,952,756 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,942,504 - 91,952,730 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9100,369,239 - 100,379,520 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,504,995 - 105,515,278 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,868,592 - 103,878,877 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,490,583 - 98,500,880 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,490,608 - 98,500,867 (+)Ensemblrn6Rnor6.0
Rnor_5.0998,167,151 - 98,177,317 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,580,293 - 90,588,134 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,483,479 - 89,493,780 (+)NCBICelera
RGSC_v3.1990,781,311 - 90,792,168 (+)NCBI
Cytogenetic Map9q36NCBI
KLHL30
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,138,668 - 238,152,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,138,668 - 238,152,947 (+)Ensemblhg38GRCh38
GRCh372239,047,309 - 239,061,588 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,714,156 - 238,726,286 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2232,759,906 - 232,774,089 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,838,490 - 230,852,667 (+)NCBIHuRef
CHM1_12239,052,469 - 239,066,653 (+)NCBICHM1_1
T2T-CHM13v2.02238,628,419 - 238,642,688 (+)NCBIT2T-CHM13v2.0
Klhl30
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,278,795 - 91,290,126 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,278,738 - 91,290,138 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38191,351,073 - 91,362,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,351,016 - 91,362,416 (+)Ensemblmm10GRCm38
MGSCv37193,247,650 - 93,258,981 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36193,181,479 - 93,192,810 (+)NCBIMGSCv36mm8
Celera194,288,207 - 94,299,554 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.09NCBI
Klhl30
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,418,324 - 2,428,062 (-)Ensembl
ChiLan1.0NW_0049555422,418,399 - 2,427,571 (-)NCBIChiLan1.0ChiLan1.0
KLHL30
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,770,218 - 140,786,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,787,147 - 140,801,575 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,370,477 - 125,386,866 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,220,949 - 244,234,879 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B244,220,949 - 244,234,879 (+)EnsemblpanPan2panpan1.1
KLHL30
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,638,889 - 48,650,050 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,640,753 - 48,648,830 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2549,134,407 - 49,146,021 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02549,024,541 - 49,036,145 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,025,018 - 49,035,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,899,709 - 48,911,318 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,688,321 - 48,699,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,920,320 - 48,931,941 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klhl30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,591,813 - 190,602,225 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525337,308 - 347,906 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936525337,473 - 347,860 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL30
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,709,322 - 137,721,800 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115137,709,315 - 137,721,806 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,121,459 - 152,132,837 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL30
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,157,815 - 124,174,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,161,796 - 124,175,409 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604075,243,014 - 75,258,472 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl30
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,302,135 - 3,310,696 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248473,302,124 - 3,310,701 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl30
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:124
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000027232
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH141808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2991,952,367 - 91,952,581 (+)MAPPERmRatBN7.2
Rnor_6.0998,500,495 - 98,500,708NCBIRnor6.0
Rnor_5.0998,177,044 - 98,177,257UniSTSRnor5.0
RGSC_v3.4990,587,837 - 90,588,050UniSTSRGSC3.4
Celera989,493,392 - 89,493,605UniSTS
RH 3.4 Map9785.39UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 78 77 46 54 46 6 304 154 11 142 80 90 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027232   ⟹   ENSRNOP00000027232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl999,390,014 - 99,400,295 (+)Ensembl
mRatBN7.2 Ensembl991,942,504 - 91,952,730 (+)Ensembl
Rnor_6.0 Ensembl998,490,608 - 98,500,867 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129927   ⟹   ENSRNOP00000100623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl999,390,014 - 99,400,295 (+)Ensembl
RefSeq Acc Id: NM_001399332   ⟹   NP_001386261
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,390,014 - 99,400,295 (+)NCBI
mRatBN7.2991,942,475 - 91,952,756 (+)NCBI
RefSeq Acc Id: XM_039084734   ⟹   XP_038940662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,391,717 - 99,400,295 (+)NCBI
mRatBN7.2991,944,176 - 91,952,756 (+)NCBI
RefSeq Acc Id: XM_063267317   ⟹   XP_063123387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,389,982 - 99,398,058 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386261 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940662 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123387 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92029 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027232
  ENSRNOP00000027232.4
Ensembl Acc Id: ENSRNOP00000027232   ⟸   ENSRNOT00000027232
RefSeq Acc Id: XP_038940662   ⟸   XM_039084734
- Peptide Label: isoform X1
- UniProtKB: D3ZHA2 (UniProtKB/TrEMBL),   A6JQQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386261   ⟸   NM_001399332
- UniProtKB: D3ZHA2 (UniProtKB/TrEMBL),   A6JQQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123387   ⟸   XM_063267317
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100623   ⟸   ENSRNOT00000129927
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHA2-F1-model_v2 AlphaFold D3ZHA2 1-581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696863
Promoter ID:EPDNEW_R7382
Type:initiation region
Name:Klhl30_1
Description:kelch-like family member 30
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,490,632 - 98,490,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309644 AgrOrtholog
BioCyc Gene G2FUF-26719 BioCyc
Ensembl Genes ENSRNOG00000020105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027232 ENTREZGENE
  ENSRNOT00000027232.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Kelch-like_gigaxonin UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL30 UniProtKB/TrEMBL
NCBI Gene 316624 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  PTHR24412:SF398 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Klhl30 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020105 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A6JQQ8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHA2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Klhl30  kelch-like family member 30  Klhl30  kelch-like 30 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Klhl30  kelch-like 30 (Drosophila)  RGD1309644_predicted  similar to Hypothetical protein KIAA0469 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1309644_predicted  similar to Hypothetical protein KIAA0469 (predicted)  LOC316624_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC316624_predicted  similar to Hypothetical protein KIAA0469 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL