Actbl2 (actin, beta-like 2) - Rat Genome Database

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Gene: Actbl2 (actin, beta-like 2) Rattus norvegicus
Analyze
Symbol: Actbl2
Name: actin, beta-like 2
RGD ID: 1309504
Description: Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in several cellular components, including actin filament; axon; and glutamatergic synapse. Orthologous to human ACTBL2 (actin beta like 2); INTERACTS WITH aconitine; bisphenol A; (-)-epigallocatechin 3-gallate (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-actin-like protein 2; LOC294732; RGD1309504; similar to cytoplasmic beta-actin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2242,858,020 - 42,860,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl242,858,020 - 42,860,767 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx249,977,431 - 49,980,178 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0248,035,889 - 48,038,636 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0242,887,407 - 42,890,154 (+)NCBIRnor_WKY
Rnor_6.0242,829,413 - 42,832,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl242,829,413 - 42,832,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0261,878,230 - 61,880,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4242,585,717 - 42,588,464 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1242,506,171 - 42,507,348 (+)NCBI
Celera238,649,115 - 38,651,862 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19056867   PMID:22664934   PMID:24413018   PMID:24625528  


Genomics

Comparative Map Data
Actbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2242,858,020 - 42,860,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl242,858,020 - 42,860,767 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx249,977,431 - 49,980,178 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0248,035,889 - 48,038,636 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0242,887,407 - 42,890,154 (+)NCBIRnor_WKY
Rnor_6.0242,829,413 - 42,832,160 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl242,829,413 - 42,832,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0261,878,230 - 61,880,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4242,585,717 - 42,588,464 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1242,506,171 - 42,507,348 (+)NCBI
Celera238,649,115 - 38,651,862 (+)NCBICelera
Cytogenetic Map2q14NCBI
ACTBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38557,480,018 - 57,482,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl557,480,018 - 57,482,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37556,775,845 - 56,778,638 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36556,811,600 - 56,814,393 (-)NCBINCBI36Build 36hg18NCBI36
Celera553,730,699 - 53,733,492 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef553,748,325 - 53,751,118 (-)NCBIHuRef
CHM1_1556,778,917 - 56,781,710 (-)NCBICHM1_1
T2T-CHM13v2.0558,308,736 - 58,311,529 (-)NCBIT2T-CHM13v2.0
Actbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913111,391,547 - 111,394,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13111,391,547 - 111,394,283 (+)EnsemblGRCm39 Ensembl
GRCm3813111,255,013 - 111,257,749 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13111,255,013 - 111,257,749 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713112,045,221 - 112,047,957 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613112,375,891 - 112,378,627 (+)NCBIMGSCv36mm8
Celera13115,574,358 - 115,577,094 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
Actbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544610,508,647 - 10,509,777 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544610,508,647 - 10,509,777 (+)NCBIChiLan1.0ChiLan1.0
ACTBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1558,159,900 - 58,162,687 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl558,159,996 - 58,161,126 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0556,526,042 - 56,528,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACTBL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1244,514,024 - 44,516,013 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl244,514,783 - 44,515,913 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha241,582,216 - 41,583,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0244,997,565 - 44,998,695 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl244,997,565 - 44,998,695 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1242,072,130 - 42,073,260 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,876,556 - 42,877,686 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,696,528 - 43,697,658 (-)NCBIUU_Cfam_GSD_1.0
Actbl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213201,588,190 - 201,589,526 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648010,524,713 - 10,526,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1636,470,503 - 36,471,739 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11636,469,062 - 36,471,776 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21638,870,299 - 38,871,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1453,702,645 - 53,710,029 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660492,610,195 - 2,612,962 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247591,787,161 - 1,788,634 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actbl2
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:763
Count of miRNA genes:299
Interacting mature miRNAs:384
Transcripts:ENSRNOT00000065528
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23237377043665178Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium
Low 8 2
Below cutoff 7 1 1 10 7 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065528   ⟹   ENSRNOP00000059847
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl242,858,020 - 42,860,767 (+)Ensembl
Rnor_6.0 Ensembl242,829,413 - 42,832,160 (+)Ensembl
RefSeq Acc Id: NM_001106409   ⟹   NP_001099879
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2242,858,020 - 42,860,767 (+)NCBI
Rnor_6.0242,829,413 - 42,832,160 (+)NCBI
Rnor_5.0261,878,230 - 61,880,977 (+)NCBI
RGSC_v3.4242,585,717 - 42,588,464 (+)RGD
Celera238,649,115 - 38,651,862 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099879 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10336 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099879   ⟸   NM_001106409
- UniProtKB: D3ZRN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059847   ⟸   ENSRNOT00000065528

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRN3-F1-model_v2 AlphaFold D3ZRN3 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309504 AgrOrtholog
BioCyc Gene G2FUF-54425 BioCyc
Ensembl Genes ENSRNOG00000043292 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059847 ENTREZGENE
  ENSRNOP00000059847.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065528 ENTREZGENE
  ENSRNOT00000065528.2 UniProtKB/TrEMBL
InterPro Actin-like UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  Actin_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
KEGG Report rno:294732 UniProtKB/TrEMBL
NCBI Gene 294732 ENTREZGENE
PANTHER Actin_like UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PhenoGen Actbl2 PhenoGen
PRINTS ACTIN UniProtKB/TrEMBL
PROSITE ACTINS_1 UniProtKB/TrEMBL
  ACTINS_2 UniProtKB/TrEMBL
  ACTINS_ACT_LIKE UniProtKB/TrEMBL
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt D3ZRN3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 Actbl2  actin, beta-like 2  RGD1309504  similar to cytoplasmic beta-actin   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309504  similar to cytoplasmic beta-actin   RGD1309504_predicted  similar to cytoplasmic beta-actin (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309504_predicted  similar to cytoplasmic beta-actin (predicted)  LOC294732_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC294732_predicted  similar to cytoplasmic beta-actin (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL