Med31 (mediator complex subunit 31) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Med31 (mediator complex subunit 31) Rattus norvegicus
Analyze
Symbol: Med31
Name: mediator complex subunit 31
RGD ID: 1309457
Description: Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED31 (mediator complex subunit 31); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC287475; mediator of RNA polymerase II transcription subunit 31; mediator of RNA polymerase II transcription, subunit 31 homolog; mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) ; RGD1309457; similar to CGI-125 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eae23
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81057,335,507 - 57,338,889 (-)NCBIGRCr8
mRatBN7.21056,836,944 - 56,840,326 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1056,836,944 - 56,840,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1061,499,924 - 61,503,307 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01060,988,409 - 60,991,792 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01056,487,487 - 56,490,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01058,780,987 - 58,784,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1058,780,597 - 58,784,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01058,521,398 - 58,524,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,104,233 - 59,107,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11059,117,860 - 59,121,235 (-)NCBI
Celera1055,966,875 - 55,970,257 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, etal., Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. Sato S, etal., J Biol Chem. 2003 Apr 25;278(17):15123-7. Epub 2003 Feb 12.
Additional References at PubMed
PMID:20347762   PMID:20508642  


Genomics

Comparative Map Data
Med31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81057,335,507 - 57,338,889 (-)NCBIGRCr8
mRatBN7.21056,836,944 - 56,840,326 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1056,836,944 - 56,840,326 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1061,499,924 - 61,503,307 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01060,988,409 - 60,991,792 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01056,487,487 - 56,490,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01058,780,987 - 58,784,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1058,780,597 - 58,784,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01058,521,398 - 58,524,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,104,233 - 59,107,615 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11059,117,860 - 59,121,235 (-)NCBI
Celera1055,966,875 - 55,970,257 (-)NCBICelera
Cytogenetic Map10q24NCBI
MED31
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,643,311 - 6,651,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,643,311 - 6,651,634 (-)EnsemblGRCh38hg38GRCh38
GRCh37176,546,631 - 6,554,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,487,357 - 6,495,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 34176,487,788 - 6,495,650NCBI
Celera176,567,689 - 6,576,019 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,441,917 - 6,450,238 (-)NCBIHuRef
CHM1_1176,556,928 - 6,565,240 (-)NCBICHM1_1
T2T-CHM13v2.0176,543,942 - 6,552,234 (-)NCBIT2T-CHM13v2.0
Med31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,102,550 - 72,106,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,102,550 - 72,106,418 (-)EnsemblGRCm39 Ensembl
GRCm381172,211,724 - 72,215,592 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,211,724 - 72,215,592 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,025,226 - 72,029,094 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,027,919 - 72,031,787 (-)NCBIMGSCv36mm8
Celera1179,738,234 - 79,742,078 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.93NCBI
Med31
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546712,147,277 - 12,155,066 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546712,147,277 - 12,155,066 (-)NCBIChiLan1.0ChiLan1.0
MED31
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,244,412 - 14,256,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,210,583 - 16,217,867 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0176,681,675 - 6,689,115 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,669,582 - 6,676,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,669,582 - 6,676,882 (-)Ensemblpanpan1.1panPan2
MED31
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1530,693,844 - 30,700,824 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl530,700,188 - 30,700,580 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha530,826,228 - 30,833,199 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0530,795,346 - 30,802,318 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl530,795,424 - 30,802,316 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1530,761,347 - 30,768,295 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0530,720,189 - 30,727,161 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0530,893,358 - 30,900,363 (+)NCBIUU_Cfam_GSD_1.0
Med31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560254,548,817 - 54,555,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366771,345,456 - 1,351,176 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366771,345,448 - 1,352,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED31
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,728,871 - 50,736,074 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,728,681 - 50,734,469 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,727,955 - 52,732,692 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED31
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,019,668 - 6,027,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605915,413,649 - 15,421,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med31
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247867,388,698 - 7,395,169 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247867,388,621 - 7,395,177 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Med31
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:124
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000019919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH137420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21056,837,040 - 56,837,246 (+)MAPPERmRatBN7.2
Rnor_6.01058,781,084 - 58,781,289NCBIRnor6.0
Rnor_5.01058,521,495 - 58,521,700UniSTSRnor5.0
RGSC_v3.41059,104,330 - 59,104,535UniSTSRGSC3.4
Celera1055,966,972 - 55,967,177UniSTS
Cytogenetic Map10q24UniSTS
G73120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21056,838,914 - 56,839,336 (+)MAPPERmRatBN7.2
Rnor_6.01058,782,958 - 58,783,379NCBIRnor6.0
Rnor_5.01058,523,369 - 58,523,790UniSTSRnor5.0
RGSC_v3.41059,106,204 - 59,106,625UniSTSRGSC3.4
Celera1055,968,846 - 55,969,267UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019919   ⟹   ENSRNOP00000019919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1056,836,944 - 56,840,326 (-)Ensembl
Rnor_6.0 Ensembl1058,780,597 - 58,784,374 (-)Ensembl
RefSeq Acc Id: NM_001135813   ⟹   NP_001129285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81057,335,507 - 57,338,889 (-)NCBI
mRatBN7.21056,836,944 - 56,840,326 (-)NCBI
Rnor_6.01058,780,987 - 58,784,369 (-)NCBI
Rnor_5.01058,521,398 - 58,524,780 (-)NCBI
RGSC_v3.41059,104,233 - 59,107,615 (-)RGD
Celera1055,966,875 - 55,970,257 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001129285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05096 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019919.5
RefSeq Acc Id: NP_001129285   ⟸   NM_001135813
- UniProtKB: D4A7J4 (UniProtKB/TrEMBL),   A6HGE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019919   ⟸   ENSRNOT00000019919

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7J4-F1-model_v2 AlphaFold D4A7J4 1-131 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697385
Promoter ID:EPDNEW_R7909
Type:initiation region
Name:Med31_1
Description:mediator complex subunit 31
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01058,784,366 - 58,784,426EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309457 AgrOrtholog
BioCyc Gene G2FUF-24374 BioCyc
Ensembl Genes ENSRNOG00000014618 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019919.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1340 UniProtKB/TrEMBL
InterPro Med31_sf UniProtKB/TrEMBL
  Mediator_Med31 UniProtKB/TrEMBL
KEGG Report rno:287475 UniProtKB/TrEMBL
NCBI Gene 287475 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 UniProtKB/TrEMBL
  SOH1 UniProtKB/TrEMBL
Pfam SOH1 UniProtKB/TrEMBL
PhenoGen Med31 PhenoGen
RatGTEx ENSRNOG00000014618 RatGTEx
UniProt A6HGE1 ENTREZGENE, UniProtKB/TrEMBL
  D4A7J4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-11 Med31  mediator complex subunit 31  Med31  mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Med31  mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)   Med31_predicted  mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Med31_predicted  mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) (predicted)  RGD1309457_predicted  similar to CGI-125 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1309457_predicted  similar to CGI-125 protein (predicted)  LOC287475_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287475_predicted  similar to CGI-125 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL