Dsc2 (desmocollin 2) - Rat Genome Database

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Gene: Dsc2 (desmocollin 2) Rattus norvegicus
Analyze
Symbol: Dsc2
Name: desmocollin 2
RGD ID: 1309426
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of p38MAPK cascade and regulation of heart contraction. Predicted to act upstream of or within cellular response to starvation. Predicted to be located in several cellular components, including adherens junction; endoplasmic reticulum; and intercalated disc. Predicted to be active in desmosome. Biomarker of acute myocardial infarction and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 11. Orthologous to human DSC2 (desmocollin 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: desmocollin-2; LOC291760; MGC124744
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,725,466 - 11,757,591 (-)NCBIGRCr8
mRatBN7.21811,450,392 - 11,482,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,450,390 - 11,482,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1811,644,945 - 11,677,017 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01812,432,593 - 12,464,666 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01811,704,248 - 11,736,312 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01811,826,705 - 11,858,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1811,826,706 - 11,858,754 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01811,625,847 - 11,658,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41811,902,185 - 11,933,989 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11811,930,689 - 11,960,686 (-)NCBI
Celera1811,467,743 - 11,499,764 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetazolamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (ISO)
cycloastragenol  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
folic acid  (ISO)
folpet  (ISO)
furfural  (ISO)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reduced expression of adherens and gap junction proteins can have a fundamental role in the development of heart failure following cardiac hypertrophy in rats. dos Santos DO, etal., Exp Mol Pathol. 2016 Feb;100(1):167-76. doi: 10.1016/j.yexmp.2015.12.009. Epub 2015 Dec 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. MicroRNA-130a Regulation of Desmocollin 2 in a Novel Model of Arrhythmogenic Cardiomyopathy. Mazurek SR, etal., Microrna. 2017;6(2):143-150. doi: 10.2174/2211536605666161109111031.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model. Moncayo-Arlandi J, etal., Hum Mol Genet. 2016 Sep 1;25(17):3676-3688. doi: 10.1093/hmg/ddw213. Epub 2016 Jul 12.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Desmosomal cadherins are decreased in explanted arrhythmogenic right ventricular dysplasia/cardiomyopathy patient hearts. Vite A, etal., PLoS One. 2013 Sep 23;8(9):e75082. doi: 10.1371/journal.pone.0075082. eCollection 2013.
14. Phenotypic analysis of arrhythmogenic cardiomyopathy in the Hutterite population: role of electrocardiogram in identifying high-risk desmocollin-2 carriers. Wong JA, etal., J Am Heart Assoc. 2014 Dec 11;3(6):e001407. doi: 10.1161/JAHA.114.001407.
Additional References at PubMed
PMID:9864371   PMID:12477932   PMID:15775979   PMID:19056867   PMID:19199708   PMID:21062920   PMID:21220045   PMID:23260145   PMID:23533145   PMID:23863954  


Genomics

Comparative Map Data
Dsc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81811,725,466 - 11,757,591 (-)NCBIGRCr8
mRatBN7.21811,450,392 - 11,482,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,450,390 - 11,482,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1811,644,945 - 11,677,017 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01812,432,593 - 12,464,666 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01811,704,248 - 11,736,312 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01811,826,705 - 11,858,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1811,826,706 - 11,858,754 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01811,625,847 - 11,658,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41811,902,185 - 11,933,989 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11811,930,689 - 11,960,686 (-)NCBI
Celera1811,467,743 - 11,499,764 (-)NCBICelera
Cytogenetic Map18p12NCBI
DSC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381831,058,840 - 31,102,421 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1831,058,545 - 31,102,600 (-)EnsemblGRCh38hg38GRCh38
GRCh371828,638,806 - 28,682,384 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361826,900,004 - 26,936,375 (-)NCBINCBI36Build 36hg18NCBI36
Build 341826,900,004 - 26,936,375NCBI
Celera1825,454,102 - 25,490,553 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1825,501,800 - 25,538,229 (-)NCBIHuRef
CHM1_11828,572,977 - 28,609,424 (-)NCBICHM1_1
T2T-CHM13v2.01831,249,110 - 31,292,671 (-)NCBIT2T-CHM13v2.0
Dsc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,163,690 - 20,192,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1820,163,690 - 20,192,611 (-)EnsemblGRCm39 Ensembl
GRCm381820,030,633 - 20,059,554 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,030,633 - 20,059,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv371820,189,299 - 20,218,006 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361820,173,808 - 20,202,515 (-)NCBIMGSCv36mm8
Celera1820,533,041 - 20,561,739 (-)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.14NCBI
Dsc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540218,464,989 - 18,489,475 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540218,465,631 - 18,496,948 (-)NCBIChiLan1.0ChiLan1.0
DSC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21748,471,325 - 48,507,896 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11834,163,920 - 34,200,470 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01824,296,505 - 24,332,997 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11827,894,596 - 27,930,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1827,894,603 - 27,930,843 (-)Ensemblpanpan1.1panPan2
DSC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1758,369,316 - 58,402,028 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl758,322,959 - 58,457,978 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,806,074 - 57,839,274 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0758,354,241 - 58,387,465 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl758,308,188 - 58,387,461 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1758,030,429 - 58,063,623 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0758,055,098 - 58,088,278 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0758,345,978 - 58,379,188 (+)NCBIUU_Cfam_GSD_1.0
Dsc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494454,055,760 - 54,089,453 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366822,057,190 - 2,164,429 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366822,057,331 - 2,091,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,596,870 - 49,637,587 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,599,940 - 49,639,526 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605024,246,069 - 24,283,869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247701,748,276 - 1,781,117 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247701,748,561 - 1,778,566 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dsc2
380 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:129
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000061417
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18679125112205285Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18679125112205285Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18679125112205285Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18679125112205285Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18679125112205285Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat

Markers in Region
AA851963  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,450,529 - 11,450,619 (+)MAPPERmRatBN7.2
Rnor_6.01811,826,843 - 11,826,932NCBIRnor6.0
Rnor_5.01811,625,985 - 11,626,074UniSTSRnor5.0
RGSC_v3.41811,902,323 - 11,902,412UniSTSRGSC3.4
Celera1811,467,881 - 11,467,970UniSTS
RH 3.4 Map18113.3UniSTS
Cytogenetic Map18p12UniSTS
L33779  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,452,029 - 11,452,140 (+)MAPPERmRatBN7.2
Rnor_6.01811,828,343 - 11,828,453NCBIRnor6.0
Rnor_5.01811,627,485 - 11,627,595UniSTSRnor5.0
RGSC_v3.41811,903,823 - 11,903,933UniSTSRGSC3.4
Celera1811,469,381 - 11,469,491UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000061417   ⟹   ENSRNOP00000058135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1811,450,393 - 11,482,392 (-)Ensembl
Rnor_6.0 Ensembl1811,826,706 - 11,858,744 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082891   ⟹   ENSRNOP00000072649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1811,450,390 - 11,482,392 (-)Ensembl
Rnor_6.0 Ensembl1811,826,714 - 11,858,754 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098761   ⟹   ENSRNOP00000080525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1811,450,390 - 11,482,392 (-)Ensembl
RefSeq Acc Id: NM_001033688   ⟹   NP_001028860
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81811,725,466 - 11,757,466 (-)NCBI
mRatBN7.21811,450,392 - 11,482,392 (-)NCBI
Rnor_6.01811,826,705 - 11,858,744 (-)NCBI
Rnor_5.01811,625,847 - 11,658,036 (-)NCBI
RGSC_v3.41811,902,185 - 11,933,989 (-)RGD
Celera1811,467,743 - 11,499,764 (-)RGD
Sequence:
RefSeq Acc Id: XM_008771935   ⟹   XP_008770157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81811,727,102 - 11,757,591 (-)NCBI
mRatBN7.21811,452,025 - 11,482,476 (-)NCBI
Rnor_6.01811,828,387 - 11,858,801 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028860 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770157 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01865 (Get FASTA)   NCBI Sequence Viewer  
  EDL76085 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058135
  ENSRNOP00000058135.5
  ENSRNOP00000072649
  ENSRNOP00000072649.2
  ENSRNOP00000080525.1
RefSeq Acc Id: NP_001028860   ⟸   NM_001033688
- Peptide Label: precursor
- UniProtKB: D3ZJR7 (UniProtKB/TrEMBL),   Q3T1K6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770157   ⟸   XM_008771935
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K3I3 (UniProtKB/TrEMBL),   A6J2F3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072649   ⟸   ENSRNOT00000082891
Ensembl Acc Id: ENSRNOP00000058135   ⟸   ENSRNOT00000061417
Ensembl Acc Id: ENSRNOP00000080525   ⟸   ENSRNOT00000098761
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJR7-F1-model_v2 AlphaFold D3ZJR7 1-902 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700651
Promoter ID:EPDNEW_R11175
Type:multiple initiation site
Name:Dsc2_1
Description:desmocollin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01811,858,541 - 11,858,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309426 AgrOrtholog
BioCyc Gene G2FUF-8239 BioCyc
Ensembl Genes ENSRNOG00000039969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061417 ENTREZGENE
  ENSRNOT00000061417.5 UniProtKB/TrEMBL
  ENSRNOT00000082891 ENTREZGENE
  ENSRNOT00000082891.2 UniProtKB/TrEMBL
  ENSRNOT00000098761.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7939139 IMAGE-MGC_LOAD
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-domain_protein UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/TrEMBL
  Cadherin_pro UniProtKB/TrEMBL
  Catenin_binding_dom UniProtKB/TrEMBL
  Desmo_cadherin UniProtKB/TrEMBL
KEGG Report rno:291760 UniProtKB/TrEMBL
MGC_CLONE MGC:124744 IMAGE-MGC_LOAD
NCBI Gene 291760 ENTREZGENE
PANTHER DESMOCOLLIN-2 UniProtKB/TrEMBL
  DESMOGLEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
  Cadherin_pro UniProtKB/TrEMBL
PhenoGen Dsc2 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
  DESMOCADHERN UniProtKB/TrEMBL
  DESMOCOLLIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039969 RatGTEx
SMART Cadherin_pro UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt A0A0G2K3I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT88_RAT UniProtKB/TrEMBL
  A6J2F3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJR7 ENTREZGENE, UniProtKB/TrEMBL
  Q3T1K6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dsc2  desmocollin 2  Dsc2_predicted  desmocollin 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dsc2_predicted  desmocollin 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED