Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1)

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Gene: Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Rattus norvegicus

Analyze

Symbol:

Appl1

Name:

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

RGD ID:

1309388

Description:

Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular biosynthetic process; and regulation of endocytosis. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha; LOC290537; RGD1309388; similar to DIP13 alpha

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	2,118,503 - 2,166,741 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	2,121,255 - 2,166,692 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	2,125,142 - 2,173,305 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	3,270,829 - 3,318,993 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	2,131,417 - 2,179,844 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	2,560,103 - 2,602,035 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	2,563,520 - 2,602,103 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	2,534,851 - 2,581,754 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	2,180,613 - 2,227,905 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	2,179,191 - 2,228,173 (-)	NCBI
Celera	16	2,089,133 - 2,134,528 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

maturity-onset diabetes of the young type 14 (ISO)

Pyruvate Dehydrogenase E1-Beta Deficiency (ISO)

septooptic dysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2-butoxyethanol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

bafilomycin A1 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

chloroquine (ISO)

cisplatin (ISO)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

geraniol (ISO)

haloperidol (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

lipopolysaccharide (ISO)

metformin (EXP)

methyl methanesulfonate (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodimethylamine (EXP)

paracetamol (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

poly(I:C) (ISO)

resiquimod (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

torcetrapib (ISO)

trametinib (ISO)

uranium atom (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adiponectin-activated signaling pathway (ISO)

cellular response to hepatocyte growth factor stimulus (ISO)

insulin receptor signaling pathway (IBA,ISO)

maintenance of synapse structure (ISO)

negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis (ISO)

positive regulation of cytokine production involved in inflammatory response (ISO)

positive regulation of glucose import (ISO)

positive regulation of macropinocytosis (ISO)

positive regulation of melanin biosynthetic process (ISO)

protein import into nucleus (ISO)

regulation of fibroblast migration (ISO)

regulation of G1/S transition of mitotic cell cycle (ISO)

regulation of glucose import (ISO)

regulation of innate immune response (ISO)

regulation of protein localization to plasma membrane (ISO)

regulation of toll-like receptor 4 signaling pathway (ISO)

signaling (IBA)

transforming growth factor beta receptor signaling pathway (ISO)

Cellular Component

cytoplasm (ISO)

cytoplasmic vesicle (ISO)

cytosol (ISO)

early endosome (ISO)

early endosome membrane (IEA)

early phagosome (ISO)

endosome (ISO)

endosome membrane (IBA,ISO)

glutamatergic synapse (ISO)

intracellular vesicle (ISO)

macropinosome (ISO)

membrane (ISO)

nucleus (ISO)

plasma membrane (ISO)

postsynapse (IDA)

presynapse (IDA)

ruffle (ISO)

vesicle membrane (ISO)

Molecular Function

beta-tubulin binding (ISO)

identical protein binding (ISO)

phosphatidylinositol binding (ISO)

phosphatidylserine binding (ISO)

protein binding (IPI,ISO)

protein homodimerization activity (ISO)

protein kinase B binding (IBA,ISO)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

colorectal cancer pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons.	Majumdar D, etal., Mol Cell Neurosci. 2011 Mar;46(3):633-44. doi: 10.1016/j.mcn.2011.01.003. Epub 2011 Jan 12.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation.	Saito T, etal., J Biol Chem. 2007 Nov 2;282(44):32280-7. Epub 2007 Sep 11.

Additional References at PubMed

PMID:15016378	PMID:17502098	PMID:17581628	PMID:18034774	PMID:18570454	PMID:19056867	PMID:19416712	PMID:19433865	PMID:19661063	PMID:21291857	PMID:21543456	PMID:21552570
PMID:21645192	PMID:21849472	PMID:23478100	PMID:23497197	PMID:24255018	PMID:24879834	PMID:25099270	PMID:25108566	PMID:25328665	PMID:25416956	PMID:25568335	PMID:26073777
PMID:26445298	PMID:26583432	PMID:27219021	PMID:27257087	PMID:29406784	PMID:31515488	PMID:34304702	PMID:34919285

Genomics

Comparative Map Data

Appl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	2,118,503 - 2,166,741 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	2,121,255 - 2,166,692 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	2,125,142 - 2,173,305 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	3,270,829 - 3,318,993 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	2,131,417 - 2,179,844 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	2,560,103 - 2,602,035 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	2,563,520 - 2,602,103 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	2,534,851 - 2,581,754 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	2,180,613 - 2,227,905 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	2,179,191 - 2,228,173 (-)	NCBI
Celera	16	2,089,133 - 2,134,528 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

APPL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	57,227,729 - 57,273,471 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	57,227,726 - 57,278,105 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	57,261,757 - 57,307,499 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	57,236,805 - 57,282,539 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	57,227,340 - 57,273,073 (+)	NCBI		Celera
Cytogenetic Map	3	p14.3	NCBI
HuRef	3	57,310,967 - 57,356,664 (+)	NCBI		HuRef
CHM1_1	3	57,211,913 - 57,257,646 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	57,267,997 - 57,313,740 (+)	NCBI		T2T-CHM13v2.0

Appl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	26,640,943 - 26,692,567 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	26,640,945 - 26,693,189 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	26,918,986 - 26,970,611 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	26,918,988 - 26,971,232 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	27,732,174 - 27,783,737 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	25,745,872 - 25,797,435 (-)	NCBI		MGSCv36	mm8
Celera	14	23,158,676 - 23,210,368 (-)	NCBI		Celera
Cytogenetic Map	14	A3	NCBI
cM Map	14	16.09	NCBI

Appl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	6,986,759 - 7,018,938 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	6,986,977 - 7,018,938 (+)	NCBI	ChiLan1.0	ChiLan1.0

APPL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	57,201,137 - 57,246,504 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	57,161,299 - 57,206,672 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	58,370,424 - 58,415,258 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	58,370,430 - 58,415,258 (+)	Ensembl	panpan1.1		panPan2

APPL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	33,123,577 - 33,166,831 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	33,130,723 - 33,166,792 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	33,051,161 - 33,094,218 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	33,395,990 - 33,439,031 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	33,402,695 - 33,439,040 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	32,845,010 - 32,887,864 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	33,203,498 - 33,246,471 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	33,374,797 - 33,418,067 (-)	NCBI		UU_Cfam_GSD_1.0

Appl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	174,441,878 - 174,476,919 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	7,579,780 - 7,611,923 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936473	7,580,495 - 7,647,471 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APPL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	39,089,077 - 39,129,781 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	39,089,157 - 39,124,969 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

APPL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	18,546,694 - 18,591,239 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	18,546,751 - 18,589,552 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	148,278,109 - 148,324,433 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Appl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624822	33,880 - 74,308 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624822	31,175 - 74,252 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Appl1
141 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	110
Count of miRNA genes:	83
Interacting mature miRNAs:	96
Transcripts:	ENSRNOT00000018413
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2325838	Bp347	Blood pressure QTL 347		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	1	3080679	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	9639137	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	380245	2995463	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
12903278	Am16	Aortic mass QTL 16		0.019	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	16	832380	2995225	Rat
12903279	Cm115	Cardiac mass QTL 115		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	16	832380	2995225	Rat
12903281	Cm116	Cardiac mass QTL 116		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	16	832380	2995225	Rat
12903952	Cm117	Cardiac mass QTL 117		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	16	832380	2995225	Rat
12903954	Bw186	Body weight QTL 186		0.011	body mass (VT:0001259)	body weight (CMO:0000012)	16	832380	2995225	Rat
2301404	Bp321	Blood pressure QTL 321		0.05	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	832380	2995225	Rat
12903955	Kidm69	Kidney mass QTL 69		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	832380	4227609	Rat

Markers in Region

RH129512

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	2,118,669 - 2,118,856 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	2,560,270 - 2,560,456	NCBI	Rnor6.0
Rnor_5.0	16	2,535,018 - 2,535,204	UniSTS	Rnor5.0
RGSC_v3.4	16	2,179,359 - 2,179,545	UniSTS	RGSC3.4
Celera	16	2,086,549 - 2,086,735	UniSTS
RH 3.4 Map	16	16.3	UniSTS
Cytogenetic Map	16	p16	UniSTS

RH139821

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	2,121,529 - 2,121,738 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	2,563,130 - 2,563,338	NCBI	Rnor6.0
Rnor_5.0	16	2,537,878 - 2,538,086	UniSTS	Rnor5.0
RGSC_v3.4	16	2,182,219 - 2,182,427	UniSTS	RGSC3.4
Celera	16	2,089,409 - 2,089,617	UniSTS
RH 3.4 Map	16	1.6	UniSTS
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	40	25	9	19	9	8	10	74	34	38	11	8
Low		3	32	32		32		1		1	3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017605020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	FQ226179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000018413 ⟹ ENSRNOP00000018413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	2,121,255 - 2,166,692 (-)	Ensembl
Rnor_6.0 Ensembl	16	2,563,520 - 2,602,103 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094750 ⟹ ENSRNOP00000084269

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	2,121,255 - 2,155,942 (-)	Ensembl

RefSeq Acc Id:

NM_001399084 ⟹ NP_001386013

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	2,118,503 - 2,166,667 (-)	NCBI

RefSeq Acc Id:

XM_039095136 ⟹ XP_038951064

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	2,118,503 - 2,166,741 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386013	(Get FASTA)	NCBI Sequence Viewer
	XP_038951064	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000018413 ⟸ ENSRNOT00000018413

RefSeq Acc Id:	XP_038951064 ⟸ XM_039095136
- Peptide Label:	isoform X1
- UniProtKB:	A6KMK1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000084269 ⟸ ENSRNOT00000094750

RefSeq Acc Id:	NP_001386013 ⟸ NM_001399084
- UniProtKB:	D3ZWA8 (UniProtKB/TrEMBL), A6KMK1 (UniProtKB/TrEMBL)

Protein Domains

PH PID

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZWA8-F1-model_v2	AlphaFold	D3ZWA8	1-671	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309388	AgrOrtholog
BioCyc Gene	G2FUF-12247	BioCyc
Ensembl Genes	ENSRNOG00000013574	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000018413	ENTREZGENE
	ENSRNOP00000018413.7	UniProtKB/TrEMBL
	ENSRNOP00000084269.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018413	ENTREZGENE
	ENSRNOT00000018413.7	UniProtKB/TrEMBL
	ENSRNOT00000094750.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.60	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
InterPro	AH/BAR-dom	UniProtKB/TrEMBL
	APPL1_BAR	UniProtKB/TrEMBL
	BAR_dom	UniProtKB/TrEMBL
	DP13A/B	UniProtKB/TrEMBL
	PH_DP13A/B	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	PTB_APPL	UniProtKB/TrEMBL
	PTyr_interaction_dom	UniProtKB/TrEMBL
NCBI Gene	290537	ENTREZGENE
PANTHER	ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2	UniProtKB/TrEMBL
	DCC-INTERACTING PROTEIN 13-ALPHA	UniProtKB/TrEMBL
Pfam	BAR_3	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	PID	UniProtKB/TrEMBL
PhenoGen	Appl1	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PID	UniProtKB/TrEMBL
SMART	PTB	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF103657	UniProtKB/TrEMBL
UniProt	A0A8I5ZXF9_RAT	UniProtKB/TrEMBL
	A6KMK1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZWA8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-22	Appl1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Appl1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1309388	similar to DIP13 alpha	RGD1309388_predicted	similar to DIP13 alpha (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1309388_predicted	similar to DIP13 alpha (predicted)	LOC290537_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC290537_predicted	similar to DIP13 alpha (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)