Lrp5 (LDL receptor related protein 5) - Rat Genome Database

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Gene: Lrp5 (LDL receptor related protein 5) Rattus norvegicus
Symbol: Lrp5
Name: LDL receptor related protein 5
RGD ID: 1309329
Description: Predicted to enable Wnt receptor activity; Wnt-protein binding activity; and coreceptor activity. Involved in response to peptide hormone and retina vasculature morphogenesis in camera-type eye. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study autosomal dominant polycystic kidney disease and polycystic liver disease. Biomarker of osteonecrosis; osteoporosis; and tendinitis. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to several human genes including LRP5 (LDL receptor related protein 5); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: LOC293649; low density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 5; MGC188568
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lrp5em1Vari   Lrp5em2Vari   Lrp5em3Vari  
Genetic Models: SD-Lrp5em3Vari SD-Lrp5em1Vari SD-Lrp5em2Vari SD-Lrp5em3Vari/Rrrc SD-Lrp5em2Vari/Rrrc SD-Lrp5em1Vari/Rrrc
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81210,243,499 - 210,346,886 (-)NCBIGRCr8
mRatBN7.21200,814,247 - 200,917,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,814,250 - 200,917,581 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,187,284 - 209,290,934 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,276,237 - 216,379,561 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,950,420 - 209,053,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
chromium(3+) trichloride  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
dioscin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
flavonoids  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
inulin  (ISO)
lovastatin  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (EXP)
methyltestosterone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
niclosamide  (EXP)
nimesulide  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
amino acid transport  (ISO)
anatomical structure regression  (ISO)
anterior/posterior pattern specification  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
blood vessel morphogenesis  (ISO)
bone development  (ISO)
bone marrow development  (ISO)
bone morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell migration involved in gastrulation  (ISO)
cell-cell adhesion  (ISO)
cell-cell signaling involved in mammary gland development  (ISO)
cholesterol homeostasis  (ISO)
cholesterol metabolic process  (ISO)
embryonic digit morphogenesis  (ISO)
endocytosis  (IEA)
establishment of blood-brain barrier  (ISO)
establishment of blood-retinal barrier  (ISO)
extracellular matrix-cell signaling  (ISO)
gastrulation with mouth forming second  (ISO)
gene expression  (ISO)
glucose catabolic process  (ISO)
limb morphogenesis  (ISO)
mammary gland duct morphogenesis  (ISO)
mesodermal cell migration  (ISO)
negative regulation of osteoblast differentiation  (ISO)
nervous system development  (IBA)
Norrin signaling pathway  (ISO)
osteoblast development  (ISO)
osteoblast proliferation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
response to peptide hormone  (IEP)
retina morphogenesis in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (IMP,ISO)
retinal blood vessel morphogenesis  (ISO)
somatic stem cell population maintenance  (ISO)
vasculature development  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. Caira FC, etal., J Am Coll Cardiol. 2006 Apr 18;47(8):1707-12. Epub 2006 Mar 20.
2. A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene. Cheung WM, etal., Bone. 2006 Sep;39(3):470-6. Epub 2006 May 6.
3. LRP5 variants may contribute to ADPKD. Cnossen WR, etal., Eur J Hum Genet. 2016 Feb;24(2):237-42. doi: 10.1038/ejhg.2015.86. Epub 2015 Apr 29.
4. Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis. Cnossen WR, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5343-8. doi: 10.1073/pnas.1309438111. Epub 2014 Mar 24.
5. LRP5-linked osteoporosis-pseudoglioma syndrome mimicking isolated microphthalmia. Ergun SG, etal., Eur J Med Genet. 2017 Mar;60(3):200-204. doi: 10.1016/j.ejmg.2017.01.007. Epub 2017 Jan 19.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Gong Y, etal., Cell. 2001 Nov 16;107(4):513-23.
9. Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta. Jacobsen CM, etal., J Bone Miner Res. 2014 Oct;29(10):2297-306. doi: 10.1002/jbmr.2198.
10. Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPAR¿ expression and activating Wnt signaling pathway. Jiang Y, etal., Exp Biol Med (Maywood). 2014 Mar;239(3):347-55. doi: 10.1177/1535370213519215. Epub 2014 Feb 7.
11. Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. Jiao X, etal., Am J Hum Genet. 2004 Nov;75(5):878-84. Epub 2004 Sep 2.
12. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
13. Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. Korvala J, etal., BMC Med Genet. 2012 Apr 10;13:26. doi: 10.1186/1471-2350-13-26.
14. Effects of parathyroid hormone on Wnt signaling pathway in bone. Kulkarni NH, etal., J Cell Biochem. 2005 Aug 15;95(6):1178-90.
15. Effects of zuogui pill (see text) on Wnt singal transduction in rats with glucocorticoid-induced osteoporosis. Liu MJ, etal., J Tradit Chin Med. 2011 Jun;31(2):98-102.
16. Expression of Wnt pathway mediators in metaplasic tissue in animal model and clinical samples of tendinopathy. Lui PP, etal., Rheumatology (Oxford). 2013 Sep;52(9):1609-18. doi: 10.1093/rheumatology/ket214. Epub 2013 Jun 17.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia. Niziolek PJ, etal., PLoS One. 2015 Nov 10;10(11):e0140775. doi: 10.1371/journal.pone.0140775. eCollection 2015.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Spoelgen R, etal., Neuroscience. 2008 Nov 8.
27. Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling. Sun L, etal., J Spinal Cord Med. 2013 Nov;36(6):616-22. doi: 10.1179/2045772312Y.0000000020. Epub 2013 Feb 20.
28. Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature. Ubels JL, etal., CRISPR J. 2020 Aug;3(4):284-298. doi: 10.1089/crispr.2020.0009.
29. Q89R polymorphism in the LDL receptor-related protein 5 gene is associated with spinal osteoarthritis in postmenopausal Japanese women. Urano T, etal., Spine (Phila Pa 1976). 2007 Jan 1;32(1):25-9.
30. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Wang Z, etal., Mol Cell Biol. 2005 Jun;25(12):5022-30.
31. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
32. Effects of pulsed electromagnetic fields on bone mass and Wnt/beta-catenin signaling pathway in ovariectomized rats. Zhou J, etal., Arch Med Res. 2012 May;43(4):274-82. doi: 10.1016/j.arcmed.2012.06.002. Epub 2012 Jun 13.
Additional References at PubMed
PMID:9790987   PMID:11029007   PMID:11336703   PMID:11956231   PMID:12121999   PMID:12477932   PMID:12509515   PMID:12817748   PMID:12857724   PMID:14651853   PMID:15024691   PMID:15035989  
PMID:15142971   PMID:15143170   PMID:15207752   PMID:15537447   PMID:15908424   PMID:16163358   PMID:16790443   PMID:16805831   PMID:16973609   PMID:17147489   PMID:17229572   PMID:17627087  
PMID:17680723   PMID:17700537   PMID:17955262   PMID:18044981   PMID:18089564   PMID:18263894   PMID:18350154   PMID:18721193   PMID:18762581   PMID:18957220   PMID:19041748   PMID:19107203  
PMID:19503830   PMID:19672307   PMID:19673927   PMID:19837032   PMID:20042609   PMID:20146170   PMID:20630166   PMID:23481549   PMID:26891291   PMID:27031698   PMID:34205318   PMID:35139333  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81210,243,499 - 210,346,886 (-)NCBIGRCr8
mRatBN7.21200,814,247 - 200,917,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,814,250 - 200,917,581 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,187,284 - 209,290,934 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,276,237 - 216,379,561 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,950,420 - 209,053,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381168,298,412 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,312,591 - 68,449,275 (+)EnsemblGRCh38hg38GRCh38
GRCh371168,080,059 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,570 - 68,100,925 (+)NCBICHM1_1
T2T-CHM13v2.01168,302,748 - 68,454,184 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39193,634,825 - 3,736,574 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,634,828 - 3,736,564 (-)EnsemblGRCm39 Ensembl
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBIMGSCv36mm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.33NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2969,265,553 - 69,403,200 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,308,771 - 70,446,940 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,048,981 - 48,156,123 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,355,437 - 50,463,484 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,355,578 - 50,464,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,575,315 - 49,682,550 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,149,276 - 49,256,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01849,942,316 - 50,049,714 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049475,303,946 - 5,374,226 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,746,406 - 1,814,321 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl24,533,614 - 4,653,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.116,090,048 - 6,224,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038103,373,623 - 103,436,978 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476718,438,274 - 18,551,338 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Lrp5
598 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:47
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1199773958202166723Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,814,315 - 200,814,429 (+)MAPPERmRatBN7.2
Rnor_6.01218,816,902 - 218,817,015NCBIRnor6.0
Rnor_5.01225,689,422 - 225,689,535UniSTSRnor5.0
RGSC_v3.41206,102,819 - 206,102,932UniSTSRGSC3.4
Celera1198,369,888 - 198,370,001UniSTS
Cytogenetic Map1q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21200,823,966 - 200,824,064 (+)MAPPERmRatBN7.2
Rnor_6.01218,826,551 - 218,826,648NCBIRnor6.0
Rnor_5.01225,699,071 - 225,699,168UniSTSRnor5.0
RGSC_v3.41206,112,468 - 206,112,565UniSTSRGSC3.4
Celera1198,379,537 - 198,379,634UniSTS
Cytogenetic Map1q42UniSTS

Genetic Models
This gene Lrp5 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 49 39 13 39 1 3 32 35 34 11 1
Low 8 2 6 2 7 8 42 7 7
Below cutoff


RefSeq Acc Id: ENSRNOT00000022213   ⟹   ENSRNOP00000022213
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1200,814,250 - 200,917,581 (-)Ensembl
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094146   ⟹   ENSRNOP00000080742
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1200,814,250 - 200,890,449 (-)Ensembl
RefSeq Acc Id: NM_001106321   ⟹   NP_001099791
Rat AssemblyChrPosition (strand)Source
GRCr81210,243,499 - 210,346,822 (-)NCBI
mRatBN7.21200,814,247 - 200,917,581 (-)NCBI
Rnor_6.01218,816,833 - 218,920,094 (-)NCBI
Rnor_5.01225,689,353 - 225,793,075 (-)NCBI
RGSC_v3.41206,102,750 - 206,206,350 (-)RGD
Celera1198,369,819 - 198,473,093 (-)RGD
RefSeq Acc Id: XM_063286724   ⟹   XP_063142794
Rat AssemblyChrPosition (strand)Source
GRCr81210,243,501 - 210,346,886 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099791 (Get FASTA)   NCBI Sequence Viewer  
  XP_063142794 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66786 (Get FASTA)   NCBI Sequence Viewer  
  EDM12295 (Get FASTA)   NCBI Sequence Viewer  
  EDM12296 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022213
RefSeq Acc Id: NP_001099791   ⟸   NM_001106321
- Peptide Label: precursor
- UniProtKB: B2RYI1 (UniProtKB/TrEMBL),   A0A8I6G721 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022213   ⟸   ENSRNOT00000022213
RefSeq Acc Id: ENSRNOP00000080742   ⟸   ENSRNOT00000094146
RefSeq Acc Id: XP_063142794   ⟸   XM_063286724
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G721 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAD0-F1-model_v2 AlphaFold F1MAD0 1-1600 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690599
Promoter ID:EPDNEW_R1123
Type:initiation region
Description:LDL receptor related protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01218,920,133 - 218,920,193EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309329 AgrOrtholog
BioCyc Gene G2FUF-56806 BioCyc
Ensembl Genes ENSRNOG00000015911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022213 ENTREZGENE
  ENSRNOT00000022213.8 UniProtKB/TrEMBL
  ENSRNOT00000094146.1 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  Low_density_Lipo_rcpt-rel_p5/6 UniProtKB/TrEMBL
KEGG Report rno:293649 UniProtKB/TrEMBL
Pfam FXa_inhibition UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PhenoGen Lrp5 PhenoGen
PIRSF LDL_recpt-rel_p5/6 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015911 RatGTEx
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  LDL_rcpt_classA_cys-rich UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp5  LDL receptor related protein 5  Lrp5  low density lipoprotein receptor-related protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lrp5  low density lipoprotein receptor-related protein 5   Lrp5_predicted  low density lipoprotein receptor-related protein 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lrp5_predicted  low density lipoprotein receptor-related protein 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED