Ccl12 (C-C motif chemokine ligand 12) - Rat Genome Database

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Gene: Ccl12 (C-C motif chemokine ligand 12) Rattus norvegicus
Analyze
Symbol: Ccl12
Name: C-C motif chemokine ligand 12
RGD ID: 1309255
Description: Predicted to enable CCR2 chemokine receptor binding activity and chemokine activity. Involved in negative regulation of leukocyte proliferation and positive regulation of leukocyte migration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to several human genes including CCL2 (C-C motif chemokine ligand 2); PARTICIPATES IN Chagas disease pathway; chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chemokine (C-C motif) ligand 12; LOC287562; MCP-5; monocyte chemotactic protein 5
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,567,876 - 67,569,426 (+)NCBIGRCr8
mRatBN7.21067,070,230 - 67,071,780 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,070,230 - 67,071,780 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,691,474 - 71,693,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,196,825 - 71,198,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,657,944 - 66,659,494 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,476,866 - 69,478,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,476,775 - 69,478,462 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,111,876 - 69,113,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,321,036 - 70,322,586NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1066,017,637 - 66,019,187 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
alpha-Zearalanol  (EXP)
amphibole asbestos  (EXP)
antirheumatic drug  (ISO)
asperentin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dichlorine  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
fragrance  (ISO)
genistein  (ISO)
hexanal  (EXP)
indometacin  (ISO)
lead diacetate  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
MK 571  (ISO)
mycotoxin  (ISO)
naphthalene  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prednisone  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
zaragozic acid A  (EXP,ISO)
zileuton  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
2. MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. Bektas-Kayhan K, etal., Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
3. CCR2-64I gene polymorphism increase susceptibility to oral cancer. Chen MK, etal., Oral Oncol. 2011 Jul;47(7):577-82. doi: 10.1016/j.oraloncology.2011.04.008. Epub 2011 May 12.
4. MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
5. Preserving prostaglandin E2 level prevents rejection of implanted allogeneic mesenchymal stem cells and restores postinfarction ventricular function. Dhingra S, etal., Circulation. 2013 Sep 10;128(11 Suppl 1):S69-78. doi: 10.1161/CIRCULATIONAHA.112.000324.
6. Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma. Fang JZ, etal., PLoS One. 2015 Nov 16;10(11):e0143042. doi: 10.1371/journal.pone.0143042. eCollection 2015.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
9. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. McTigue DM, etal., J Neurosci Res. 1998 Aug 1;53(3):368-76.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. Ockinger J, etal., Genes Immun. 2010 Mar;11(2):142-54. Epub 2009 Oct 29.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
18. Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases. Silva TA, etal., Oral Microbiol Immunol. 2005 Oct;20(5):310-6.
19. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. Venza I, etal., J Periodontol. 2010 Jan;81(1):99-108. doi: 10.1902/jop.2009.090358.
20. Chemokine gene polymorphisms in idiopathic anterior uveitis. Yeo TK, etal., Cytokine. 2006 Jul;35(1-2):29-35. Epub 2006 Sep 6.
21. Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
Additional References at PubMed
PMID:8996246   PMID:10072545   PMID:12949249   PMID:18334747   PMID:24913911  


Genomics

Comparative Map Data
Ccl12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,567,876 - 67,569,426 (+)NCBIGRCr8
mRatBN7.21067,070,230 - 67,071,780 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,070,230 - 67,071,780 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,691,474 - 71,693,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,196,825 - 71,198,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,657,944 - 66,659,494 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,476,866 - 69,478,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,476,775 - 69,478,462 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,111,876 - 69,113,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,321,036 - 70,322,586NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1066,017,637 - 66,019,187 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,356,480 - 34,358,610 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,356,480 - 34,358,610 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,683,499 - 32,685,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,707,584 - 29,709,742 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,707,583 - 29,709,741NCBI
Celera1729,593,701 - 29,595,859 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,869,568 - 28,871,726 (+)NCBIHuRef
CHM1_11732,747,735 - 32,749,893 (+)NCBICHM1_1
T2T-CHM13v2.01735,303,463 - 35,305,593 (+)NCBIT2T-CHM13v2.0
Ccl12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,992,671 - 81,994,225 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,992,671 - 81,994,226 (+)EnsemblGRCm39 Ensembl
GRCm381182,101,845 - 82,103,399 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,101,845 - 82,103,400 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,915,347 - 81,916,901 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,918,073 - 81,919,486 (+)NCBIMGSCv36mm8
Celera1186,814,429 - 86,815,983 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.9NCBI
CCL13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,110,619 - 30,120,918 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11731,991,689 - 32,002,241 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,430,633 - 22,432,893 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,724,145 - 22,726,306 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,723,888 - 22,726,381 (-)Ensemblpanpan1.1panPan2
CCL13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,938,944 - 38,940,231 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,938,135 - 38,940,231 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,162,012 - 38,163,300 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,752,155 - 39,753,443 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,728,462 - 39,769,550 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1938,539,350 - 38,540,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,818,831 - 38,820,119 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,907,308 - 38,908,596 (-)NCBIUU_Cfam_GSD_1.0
CCL13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,864,260 - 27,867,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,865,318 - 27,867,415 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,152,140 - 2,154,842 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:23
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000031626
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944767750281Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944767750281Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)106631944767750281Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944768164786Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944768164786Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944768164786Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944768164786Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944767750281Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944767750281Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 33 20 12 18 12 1 1 2 29 27 11 1
Below cutoff 2 4 33 26 1 26 4 4 43 5 8 4

Sequence


RefSeq Acc Id: ENSRNOT00000031626   ⟹   ENSRNOP00000038407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,070,230 - 67,071,780 (+)Ensembl
Rnor_6.0 Ensembl1069,476,775 - 69,478,462 (+)Ensembl
RefSeq Acc Id: NM_001105822   ⟹   NP_001099292
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81067,567,876 - 67,569,426 (+)NCBI
mRatBN7.21067,070,230 - 67,071,780 (+)NCBI
Rnor_6.01069,476,866 - 69,478,416 (+)NCBI
Rnor_5.01069,111,876 - 69,113,426 (+)NCBI
RGSC_v3.41070,321,036 - 70,322,586 (+)RGD
Celera1066,017,637 - 66,019,187 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099292 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05440 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038407.4
RefSeq Acc Id: NP_001099292   ⟸   NM_001105822
- Peptide Label: precursor
- UniProtKB: D4ABS1 (UniProtKB/TrEMBL),   A6HHD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038407   ⟸   ENSRNOT00000031626
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABS1-F1-model_v2 AlphaFold D4ABS1 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697510
Promoter ID:EPDNEW_R8035
Type:single initiation site
Name:Ccl12_1
Description:chemokine (C-C motif) ligand 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01069,476,856 - 69,476,916EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309255 AgrOrtholog
BioCyc Gene G2FUF-23932 BioCyc
Ensembl Genes ENSRNOG00000029768 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031626.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro CC_chemkine_sml_CS UniProtKB/TrEMBL
  Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_IL8 UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report rno:287562 UniProtKB/TrEMBL
NCBI Gene 287562 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 2 UniProtKB/TrEMBL
  PTHR12015 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PhenoGen Ccl12 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029768 RatGTEx
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP Chemokine_IL8 UniProtKB/TrEMBL
UniProt A6HHD5 ENTREZGENE, UniProtKB/TrEMBL
  D4ABS1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-04 Ccl12  C-C motif chemokine ligand 12  Ccl12  chemokine (C-C motif) ligand 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ccl12  chemokine (C-C motif) ligand 12   Ccl12_predicted  chemokine (C-C motif) ligand 12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ccl12_predicted  chemokine (C-C motif) ligand 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED