Mlh3 (mutL homolog 3) - Rat Genome Database

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Gene: Mlh3 (mutL homolog 3) Rattus norvegicus
Analyze
Symbol: Mlh3
Name: mutL homolog 3
RGD ID: 1309227
Description: Predicted to enable ATP hydrolysis activity; centromeric DNA binding activity; and chromatin binding activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within DNA damage response; meiotic nuclear division; and protein localization. Predicted to be located in male germ cell nucleus and nuclear lumen. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3); PARTICIPATES IN mismatch repair pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA mismatch repair protein Mlh3; LOC314320; mutL homolog 3 (E. coli)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,612,535 - 110,649,408 (-)NCBIGRCr8
mRatBN7.26104,881,483 - 104,917,686 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,881,483 - 104,917,728 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,051,106 - 105,087,218 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,349,977 - 105,386,089 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,719,639 - 104,755,751 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,059,386 - 109,095,876 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,059,341 - 109,095,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,461,410 - 116,497,654 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,280,910 - 109,318,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,285,219 - 109,322,303 (-)NCBI
Celera6102,704,430 - 102,740,558 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. A role for MLH3 in hereditary nonpolyposis colorectal cancer. Wu Y, etal., Nat Genet. 2001 Oct;29(2):137-8.
12. The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were linked to the risk of colorectal cancer in a case-control study. Zhang Q, etal., Cancer Med. 2018 Apr;7(4):1264-1274. doi: 10.1002/cam4.1319. Epub 2018 Mar 8.
Additional References at PubMed
PMID:12091911   PMID:15467367   PMID:16204034   PMID:16260499   PMID:17696610   PMID:22164254   PMID:24891606  


Genomics

Comparative Map Data
Mlh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,612,535 - 110,649,408 (-)NCBIGRCr8
mRatBN7.26104,881,483 - 104,917,686 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,881,483 - 104,917,728 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,051,106 - 105,087,218 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,349,977 - 105,386,089 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,719,639 - 104,755,751 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,059,386 - 109,095,876 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,059,341 - 109,095,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,461,410 - 116,497,654 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,280,910 - 109,318,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,285,219 - 109,322,303 (-)NCBI
Celera6102,704,430 - 102,740,558 (-)NCBICelera
Cytogenetic Map6q31NCBI
MLH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,013,775 - 75,051,467 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,013,769 - 75,051,532 (-)EnsemblGRCh38hg38GRCh38
GRCh371475,480,478 - 75,518,170 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,550,220 - 74,587,988 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,553,052 - 74,587,886NCBI
Celera1455,518,160 - 55,555,906 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,648,309 - 55,686,423 (-)NCBIHuRef
CHM1_11475,419,018 - 75,456,769 (-)NCBICHM1_1
T2T-CHM13v2.01469,222,838 - 69,260,934 (-)NCBIT2T-CHM13v2.0
Mlh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,281,240 - 85,317,421 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,281,294 - 85,317,373 (-)EnsemblGRCm39 Ensembl
GRCm381285,234,466 - 85,270,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,234,520 - 85,270,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,575,470 - 86,611,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,123,567 - 86,159,702 (-)NCBIMGSCv36mm8
Celera1286,692,170 - 86,728,214 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.61NCBI
Mlh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523518,565 - 546,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955523515,409 - 547,257 (+)NCBIChiLan1.0ChiLan1.0
MLH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,099,113 - 76,133,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,315,617 - 75,351,233 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,568,033 - 55,603,672 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,413,023 - 74,447,543 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,413,319 - 74,445,749 (-)Ensemblpanpan1.1panPan2
MLH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,123,263 - 48,153,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,124,105 - 48,154,102 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,806,221 - 47,838,110 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,349,721 - 48,381,613 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,351,734 - 48,381,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,020,522 - 48,052,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,042,010 - 48,073,886 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,440,485 - 48,472,367 (-)NCBIUU_Cfam_GSD_1.0
Mlh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,873,503 - 27,906,386 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,164,918 - 4,195,517 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,164,322 - 4,195,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,231,468 - 52,266,179 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605340,458,381 - 40,497,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mlh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,642,946 - 26,674,315 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,642,800 - 26,677,187 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mlh3
64 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:97
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000033493
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
RH127516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,881,731 - 104,881,916 (+)MAPPERmRatBN7.2
Rnor_6.06109,059,635 - 109,059,819NCBIRnor6.0
Rnor_5.06116,497,221 - 116,497,405UniSTSRnor5.0
RGSC_v3.46109,281,159 - 109,281,343UniSTSRGSC3.4
Celera6102,704,679 - 102,704,863UniSTS
RH 3.4 Map6758.3UniSTS
Cytogenetic Map6q31UniSTS
RH129328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26104,919,271 - 104,919,456 (+)MAPPERmRatBN7.2
Rnor_6.06109,097,175 - 109,097,359NCBIRnor6.0
Rnor_5.06116,459,687 - 116,459,871UniSTSRnor5.0
RGSC_v3.46109,320,553 - 109,320,737UniSTSRGSC3.4
Celera6102,742,218 - 102,742,402UniSTS
RH 3.4 Map6742.39UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000033493   ⟹   ENSRNOP00000038334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,881,483 - 104,917,612 (-)Ensembl
Rnor_6.0 Ensembl6109,059,341 - 109,095,557 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102201   ⟹   ENSRNOP00000090967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,881,483 - 104,917,728 (-)Ensembl
RefSeq Acc Id: NM_001108043   ⟹   NP_001101513
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,612,535 - 110,648,663 (-)NCBI
mRatBN7.26104,881,483 - 104,917,612 (-)NCBI
Rnor_6.06109,059,386 - 109,095,515 (-)NCBI
Rnor_5.06116,461,410 - 116,497,654 (+)NCBI
RGSC_v3.46109,280,910 - 109,318,893 (-)RGD
Celera6102,704,430 - 102,740,558 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240311   ⟹   XP_006240373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,612,583 - 110,649,408 (-)NCBI
mRatBN7.26104,881,531 - 104,917,686 (-)NCBI
Rnor_6.06109,059,434 - 109,095,876 (-)NCBI
Rnor_5.06116,461,410 - 116,497,654 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240312   ⟹   XP_006240374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,612,583 - 110,649,408 (-)NCBI
mRatBN7.26104,881,531 - 104,917,686 (-)NCBI
Rnor_6.06109,059,434 - 109,095,872 (-)NCBI
Rnor_5.06116,461,410 - 116,497,654 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240313   ⟹   XP_006240375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,627,674 - 110,649,408 (-)NCBI
mRatBN7.26104,896,624 - 104,917,686 (-)NCBI
Rnor_6.06109,075,116 - 109,095,870 (-)NCBI
Rnor_5.06116,461,410 - 116,497,654 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240314   ⟹   XP_006240376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,631,602 - 110,649,408 (-)NCBI
mRatBN7.26104,900,475 - 104,917,686 (-)NCBI
Rnor_6.06109,078,854 - 109,095,870 (-)NCBI
Rnor_5.06116,461,410 - 116,497,654 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063261941   ⟹   XP_063118011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,627,575 - 110,649,408 (-)NCBI
RefSeq Acc Id: NP_001101513   ⟸   NM_001108043
- UniProtKB: D4ADG4 (UniProtKB/TrEMBL),   A6JE18 (UniProtKB/TrEMBL),   A6JE19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240375   ⟸   XM_006240313
- Peptide Label: isoform X3
- UniProtKB: A6JE19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240376   ⟸   XM_006240314
- Peptide Label: isoform X5
- UniProtKB: A6JE19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240373   ⟸   XM_006240311
- Peptide Label: isoform X1
- UniProtKB: A6JE19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240374   ⟸   XM_006240312
- Peptide Label: isoform X2
- UniProtKB: A0A8I6APJ9 (UniProtKB/TrEMBL),   A6JE19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038334   ⟸   ENSRNOT00000033493
Ensembl Acc Id: ENSRNOP00000090967   ⟸   ENSRNOT00000102201
RefSeq Acc Id: XP_063118011   ⟸   XM_063261941
- Peptide Label: isoform X4
Protein Domains
DNA mismatch repair protein S5   MutL C-terminal dimerisation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADG4-F1-model_v2 AlphaFold D4ADG4 1-1442 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694738
Promoter ID:EPDNEW_R5263
Type:initiation region
Name:Mlh3_1
Description:mutL homolog 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06109,095,513 - 109,095,573EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309227 AgrOrtholog
BioCyc Gene G2FUF-36791 BioCyc
Ensembl Genes ENSRNOG00000006699 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033493.4 UniProtKB/TrEMBL
  ENSRNOT00000102201.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.100 UniProtKB/TrEMBL
  3.30.1540.20 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_C UniProtKB/TrEMBL
  DNA_mismatch_repair_CS UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  MutL/Mlh/Pms UniProtKB/TrEMBL
  MutL/Mlh/PMS UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
  MutL_C_dimsub UniProtKB/TrEMBL
  MutL_C_regsub UniProtKB/TrEMBL
  MutL_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
KEGG Report rno:314320 UniProtKB/TrEMBL
NCBI Gene 314320 ENTREZGENE
PANTHER PTHR10073 UniProtKB/TrEMBL
  PTHR10073:SF47 UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
PhenoGen Mlh3 PhenoGen
PROSITE DNA_MISMATCH_REPAIR_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006699 RatGTEx
SMART DNA_mis_repair UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
Superfamily-SCOP ATP_bd_ATPase UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  SSF118116 UniProtKB/TrEMBL
UniProt A0A8I6APJ9 ENTREZGENE, UniProtKB/TrEMBL
  A6JE18 ENTREZGENE, UniProtKB/TrEMBL
  A6JE19 ENTREZGENE, UniProtKB/TrEMBL
  D4ADG4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-19 Mlh3  mutL homolog 3  Mlh3  mutL homolog 3 (E. coli)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mlh3  mutL homolog 3 (E. coli)   Mlh3_predicted  mutL homolog 3 (E. coli) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mlh3_predicted  mutL homolog 3 (E. coli) (predicted)      Symbol and Name status set to approved 70820 APPROVED