Slc7a12 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 12) - Rat Genome Database

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Gene: Slc7a12 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 12) Rattus norvegicus
Analyze
Symbol: Slc7a12
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
RGD ID: 1309208
Description: Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in cytoplasm and plasma membrane; INTERACTS WITH acrylamide; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC294881
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2287,079,724 - 87,146,875 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl287,079,749 - 87,146,875 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx293,409,295 - 93,476,443 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0291,530,310 - 91,597,461 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0286,587,120 - 86,654,267 (-)NCBIRnor_WKY
Rnor_6.0288,559,677 - 88,660,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,559,702 - 88,660,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02108,364,359 - 108,366,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02108,332,499 - 108,333,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02108,432,230 - 108,432,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,429,238 - 88,496,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1288,374,210 - 88,441,855 (-)NCBI
Celera282,670,076 - 82,737,132 (-)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11591708   PMID:12477932   PMID:15632090  


Genomics

Comparative Map Data
Slc7a12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2287,079,724 - 87,146,875 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl287,079,749 - 87,146,875 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx293,409,295 - 93,476,443 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0291,530,310 - 91,597,461 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0286,587,120 - 86,654,267 (-)NCBIRnor_WKY
Rnor_6.0288,559,677 - 88,660,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,559,702 - 88,660,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02108,364,359 - 108,366,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02108,332,499 - 108,333,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02108,432,230 - 108,432,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,429,238 - 88,496,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1288,374,210 - 88,441,855 (-)NCBI
Celera282,670,076 - 82,737,132 (-)NCBICelera
Cytogenetic Map2q23NCBI
Slc7a12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,545,757 - 14,570,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,545,757 - 14,570,890 (+)EnsemblGRCm39 Ensembl
GRCm38314,480,697 - 14,505,819 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,480,697 - 14,505,830 (+)EnsemblGRCm38mm10GRCm38
MGSCv37314,480,697 - 14,505,819 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36314,455,795 - 14,482,563 (+)NCBIMGSCv36mm8
Celera314,489,110 - 14,514,234 (+)NCBICelera
Cytogenetic Map3A1NCBI

Variants

.
Variants in Slc7a12
1562 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:103
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000051741
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)27478666494359546Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 13
Low 6 1 3 1 6 6 3
Below cutoff 1 8 17 6 15 6 8 8 4 8 6 9 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051741   ⟹   ENSRNOP00000050128
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl287,079,749 - 87,146,875 (-)Ensembl
Rnor_6.0 Ensembl288,559,702 - 88,660,449 (-)Ensembl
RefSeq Acc Id: NM_001011948   ⟹   NP_001011948
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2287,079,724 - 87,146,875 (-)NCBI
Rnor_6.0288,559,677 - 88,660,449 (-)NCBI
Rnor_5.02108,332,499 - 108,333,025 (-)NCBI
Rnor_5.02108,364,359 - 108,366,610 (-)NCBI
Rnor_5.02108,432,230 - 108,432,980 (-)NCBI
RGSC_v3.4288,429,238 - 88,496,893 (-)RGD
Celera282,670,076 - 82,737,132 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011948 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78940 (Get FASTA)   NCBI Sequence Viewer  
  AAH79349 (Get FASTA)   NCBI Sequence Viewer  
  EDM00969 (Get FASTA)   NCBI Sequence Viewer  
  EDM00970 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001011948   ⟸   NM_001011948
- UniProtKB: Q6AYR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050128   ⟸   ENSRNOT00000051741

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYR7-F1-model_v2 AlphaFold Q6AYR7 1-472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691228
Promoter ID:EPDNEW_R1751
Type:multiple initiation site
Name:Slc7a12_1
Description:solute carrier family 7 (cationic amino acid transporter, y+system), member 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0288,660,463 - 88,660,523EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309208 AgrOrtholog
BioCyc Gene G2FUF-53801 BioCyc
Ensembl Genes ENSRNOG00000033830 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050128 ENTREZGENE
  ENSRNOP00000050128.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051741 ENTREZGENE
  ENSRNOT00000051741.5 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109204 IMAGE-MGC_LOAD
InterPro AA/rel_permease1 UniProtKB/TrEMBL
KEGG Report rno:294881 UniProtKB/TrEMBL
MGC_CLONE MGC:93774 IMAGE-MGC_LOAD
NCBI Gene 294881 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  ASC-TYPE AMINO ACID TRANSPORTER 2 UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PhenoGen Slc7a12 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
UniProt Q6AYR7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Slc7a12  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12  Slc7a12_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Slc7a12_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED