Zfp622 (zinc finger protein 622) - Rat Genome Database

Name: Zfp622
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Zfp622 (zinc finger protein 622) Rattus norvegicus

Analyze

Symbol:

Zfp622

Name:

zinc finger protein 622

RGD ID:

1309146

Description:

Predicted to enable preribosome binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Orthologous to human ZNF622 (zinc finger protein 622); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cytoplasmic 60S subunit biogenesis factor ZNF622; liver regeneration-related protein LRRG121; LOC103690028; LOC294846; MGC108936; Znf622

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZNF622 (zinc finger protein 622)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Zfp622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Znf622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZNF622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZNF622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Znf622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZNF622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZNF622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Znf622 (zinc finger protein 622)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ZNF622 (zinc finger protein 622)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Zfp622 (zinc finger protein 622)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	znf622 (zinc finger protein 622)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C16A3.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6769	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	REH1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	REI1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	76,479,605 - 76,494,405 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	76,335,609 - 76,493,898 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	83,600,813 - 83,614,642 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	81,722,535 - 81,736,364 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	76,727,805 - 76,741,608 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	78,407,312 - 78,421,152 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	78,407,414 - 78,421,024 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	78,103,387 - 78,276,927 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	97,978,551 - 97,992,642 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	77,571,866 - 77,585,706 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	77,500,100 - 77,513,940 (+)	NCBI
Celera	2	72,188,230 - 72,202,089 (+)	NCBI		Celera
Cytogenetic Map	2	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

choline (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clofibric acid (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (EXP)

cyclosporin A (ISO)

disulfiram (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

hydralazine (ISO)

L-methionine (ISO)

Licochalcone B (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intrinsic apoptotic signaling pathway in response to oxidative stress (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of JNK cascade (ISO)

positive regulation of kinase activity (ISO)

positive regulation of MAPK cascade (ISO)

reticulophagy (IEA)

ribosomal large subunit biogenesis (IBA,ISO,ISS)

ribosome biogenesis (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

endoplasmic reticulum membrane (IEA)

Golgi apparatus (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (IEA)

preribosome, large subunit precursor (IBA)

Molecular Function

nucleic acid binding (IEA)

preribosome binding (ISO,ISS)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein.	Seong HA, etal., J Biol Chem 2003 Mar 14;278(11):9655-62.

Additional References at PubMed

PMID:12477932	PMID:21771788	PMID:22658674

Genomics

Comparative Map Data

Zfp622
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	76,479,605 - 76,494,405 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	76,335,609 - 76,493,898 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	83,600,813 - 83,614,642 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	81,722,535 - 81,736,364 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	76,727,805 - 76,741,608 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	78,407,312 - 78,421,152 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	78,407,414 - 78,421,024 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	78,103,387 - 78,276,927 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	97,978,551 - 97,992,642 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	77,571,866 - 77,585,706 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	77,500,100 - 77,513,940 (+)	NCBI
Celera	2	72,188,230 - 72,202,089 (+)	NCBI		Celera
Cytogenetic Map	2	q22	NCBI

ZNF622
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	16,451,519 - 16,465,800 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	16,451,519 - 16,465,800 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	16,451,628 - 16,465,909 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	16,504,628 - 16,518,894 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	16,504,628 - 16,518,894	NCBI
Celera	5	16,475,243 - 16,489,513 (-)	NCBI		Celera
Cytogenetic Map	5	p15.1	NCBI
HuRef	5	16,423,532 - 16,437,805 (-)	NCBI		HuRef
CHM1_1	5	16,451,589 - 16,465,842 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	16,390,866 - 16,405,145 (-)	NCBI		T2T-CHM13v2.0

Zfp622
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	25,984,452 - 25,998,568 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	25,984,452 - 25,998,567 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	25,984,366 - 25,998,482 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	25,984,366 - 25,998,481 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	25,914,121 - 25,928,237 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	25,929,091 - 25,943,207 (+)	NCBI		MGSCv36	mm8
Celera	15	26,755,941 - 26,770,057 (+)	NCBI		Celera
Cytogenetic Map	15	B1	NCBI
cM Map	15	9.71	NCBI

Znf622
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	5,553,610 - 5,568,646 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955426	5,554,655 - 5,569,067 (-)	NCBI	ChiLan1.0	ChiLan1.0

ZNF622
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	16,591,135 - 16,605,842 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	16,591,135 - 16,605,842 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	16,753,135 - 16,767,378 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ZNF622
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	86,929,947 - 86,943,711 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	86,826,892 - 86,951,542 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	86,447,527 - 86,461,291 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	87,567,057 - 87,580,819 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	87,442,238 - 87,587,920 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	87,089,290 - 87,103,023 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	87,326,254 - 87,340,001 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	88,183,313 - 88,197,085 (+)	NCBI		UU_Cfam_GSD_1.0

Znf622
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	210,156,464 - 210,171,924 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	19,091,502 - 19,108,990 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936480	19,092,959 - 19,108,418 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNF622
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	5,699,744 - 5,714,516 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	5,699,740 - 5,714,824 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	6,144,037 - 6,159,117 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZNF622
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	16,131,215 - 16,145,763 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	16,127,777 - 16,145,777 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666064	12,333,090 - 12,348,421 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Znf622
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	13,358,276 - 13,374,239 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624751	13,361,474 - 13,374,398 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zfp622
74 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	25
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000066879
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	26917817	81754745	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	81754745	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	35023117	80023117	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	35134841	88029593	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	40067944	102785628	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	43171017	83575226	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	57605612	76539510	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	59324377	103795077	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	59324377	103795077	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	59324719	102755241	Rat
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	59846005	104846005	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	64366971	109366971	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
7411551	Bw131	Body weight QTL 131	29.6	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	67942638	112942638	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	74786664	94359546	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	74786664	94359546	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat

Markers in Region

RH134526

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	9	38,639,969 - 38,640,187	UniSTS	Rnor5.0
Rnor_5.0	2	97,991,384 - 97,992,496	UniSTS	Rnor5.0
RGSC_v3.4	9	31,985,216 - 31,985,434	UniSTS	RGSC3.4
RGSC_v3.4	2	77,584,448 - 77,585,560	UniSTS	RGSC3.4
Celera	9	33,273,459 - 33,273,677	UniSTS
Celera	2	72,200,831 - 72,201,943	UniSTS
RH 3.4 Map	9	355.89	UniSTS
Cytogenetic Map	2	q22	UniSTS
Cytogenetic Map	9	q21	UniSTS

AU016070

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	2	98,108,193 - 98,108,286	NCBI	Rnor5.0
Rnor_5.0	9	38,640,166 - 38,640,259	NCBI	Rnor5.0
RGSC_v3.4	9	31,985,144 - 31,985,236	UniSTS	RGSC3.4
RGSC_v3.4	2	77,585,540 - 77,585,632	UniSTS	RGSC3.4
Celera	9	33,273,387 - 33,273,479	UniSTS
Celera	2	72,201,923 - 72,202,015	UniSTS
Cytogenetic Map	9	q21	UniSTS
Cytogenetic Map	2	q22	UniSTS

REN91033

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	9	38,639,945 - 38,640,201	UniSTS	Rnor5.0
Rnor_5.0	2	97,991,360 - 97,992,510	UniSTS	Rnor5.0
RGSC_v3.4	9	31,985,202 - 31,985,458	UniSTS	RGSC3.4
RGSC_v3.4	2	77,584,424 - 77,585,574	UniSTS	RGSC3.4
Celera	9	33,273,445 - 33,273,701	UniSTS
Celera	2	72,200,807 - 72,201,957	UniSTS
Cytogenetic Map	9	q21	UniSTS
Cytogenetic Map	2	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	33	3	3	1	3	8	10	46	23	11	8	8
Low		10	54	38	18	38		1	28	12	30	3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005500257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000063951 ⟹ ENSRNOP00000062258

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	76,335,609 - 76,474,796 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079455 ⟹ ENSRNOP00000069183

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	76,441,501 - 76,474,802 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000084541 ⟹ ENSRNOP00000075424

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	76,463,167 - 76,493,898 (+)	Ensembl
Rnor_6.0 Ensembl	2	78,407,414 - 78,415,604 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087109 ⟹ ENSRNOP00000068737

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	78,407,414 - 78,421,024 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089551 ⟹ ENSRNOP00000073087

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	76,468,405 - 76,488,847 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089805 ⟹ ENSRNOP00000075409

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	76,443,711 - 76,474,802 (+)	Ensembl

RefSeq Acc Id:

NM_001009652 ⟹ NP_001009652

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	76,480,551 - 76,494,393 (+)	NCBI
Rnor_6.0	2	78,407,312 - 78,421,152 (+)	NCBI
Rnor_5.0	2	97,978,551 - 97,992,642 (+)	NCBI
RGSC_v3.4	2	77,571,866 - 77,585,706 (+)	RGD
Celera	2	72,188,230 - 72,202,089 (+)	RGD

Sequence:

show sequence

CGTACCTACAGGCGAAGGAGTGTTTTGGGAGCTTGTGAGACTAGAAGACTGATCAAGACTAGAA
GGTTCTCGGCTAGGTCGTCTCTTCCTTCCGGCCCGACAATGGCGACGTACACCTGCATCACCTG
CCGGGTGGCGTTCCGCGATGCGGAGATGCAGCGGGCTCACTACAAGACCGACTGGCACCGCTAC
AACCTGCGGCGCAAGGTGGCTAATATGGCCCCGGTGACCGCCGAAGGCTTCCAGGAGCGGGTGC
GAGCGCAGCGGGCGGTGGCGGAGGAGGAGAGCAAGGGCACGGCCACCTACTGCACCGTGTGCAG
CAAGAAGTTCGCCACGTTCAACGCCTACGAGAACCACCTTAAGTCCCGGCGGCACGTGGAGCTG
GAGAAGAAGGCGGTGCAGGCCGTGAGCCGCCAAGTGGAGATGATGAACGAGAAGAACTTGGAGA
AGGGACTGGGCGTGGACAGTGTGAACAAGGATGCCATGAACGCCGCCATCCAGCAGGCCATCAA
GGCCCAGCCTTCCACGTCTCCCAAGAAAGCGCCCTTCATGCCCACGGACGAATCCAGGAGGGTG
GCGGGCGCGGTCCGACGGGGCACCCCGGAGCGAGACCCGACGGAGAAGCCGCCCCGGCTCCAGT
GGTTCGAACAGCAGGCGAAGAAGCTGGCGAAGCAGCAGTGGGAGGAGAGTGAGGAGGAGGGAGA
GGAAGACGACGAAGATTGGGAAGATATTGATTCCGATGATGGATTGGAATGTGAGAACCCTGGA
GTGGAGGAAGAGGATGCAGAAGATGCAGAGGCTGAGGAGAGCCCACCCCTAGGTGCCATCCCAA
TAACAGACTGCTTATTTTGTTCCCATCATTCAAGCTCCCTTGTGAAGAATGTGGCTCATATGAC
TAAAGTCCACAGCTTTTTTATTCCTGATATAGAGTATCTTTCAGATTTGAAAGGATTAATTAAA
TATTTGGGAGAGAAAGTTGGTGTTGGCAAAATCTGCTTGTGGTGCAATGAGAAAGGGAAGTCCT
TCTATTCCACAGAAGCTGTGCAGGCACACATGAATGACAAAAGCCACTGTAAGCTCTTTACAGA
TGGTGATGCTGCGCTGGAGTTTGCAGACTTCTATGATTTTAGGAGTAGCTACCCAGATTACAAG
GAGGGGCAGGATCCTGCTGAGATTGAAGACTTGTCCTCAGAAAAGATCTTGGAATGTGATGATG
AAACCATGGAGCTGATACTCCCCTCTGGTGCCAGGGTGGGTCATCGCTCCTTGATGAGATACTA
CAAACAACGATTCGGCTTGCCAAGAGCTGTGACAGTTGCTAGAAATCAAAAGGCTGTGGGCAGG
GTCCTCCAGCAGTACCGAGCCCTGGGGTGGACGGGCAGCACAGGAGCAGCTCTCATGCGTGAAC
GGGACATGCAGTATGTACAGAGGATGAAGTCGAAATGGATGCTGAAGACCGGGATGAAGAACAA
TGCCACCAAGCAGATGCACTTTAGGGCCCAAGTGAGATTCTGAGAGGCTGAGGCTGAGAGATGT
ATCTCTGGCTGCATTCCCTCCTTGTCTGAGGACCAGTGAAGCCAGATTGCCGAATGGTTCTTTT
GCTGCTACTTCATTTGTTCTGATTTAATAAAGTCAAGATCATAAAAAAAAAAAAAAAAAAAAAA
AAAAAA

hide sequence

RefSeq Acc Id:

XR_005500257

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	76,479,605 - 76,494,405 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009652	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88214	(Get FASTA)	NCBI Sequence Viewer
	EDL82619	(Get FASTA)	NCBI Sequence Viewer
	EDL82620	(Get FASTA)	NCBI Sequence Viewer
	Q7TM96	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001009652 ⟸ NM_001009652

- UniProtKB:

Q5M855 (UniProtKB/TrEMBL), F1LQ57 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATYTCITCRVAFRDAEMQRAHYKTDWHRYNLRRKVANMAPVTAEGFQERVRAQRAVAEEESKG
TATYCTVCSKKFATFNAYENHLKSRRHVELEKKAVQAVSRQVEMMNEKNLEKGLGVDSVNKDAM
NAAIQQAIKAQPSTSPKKAPFMPTDESRRVAGAVRRGTPERDPTEKPPRLQWFEQQAKKLAKQQ
WEESEEEGEEDDEDWEDIDSDDGLECENPGVEEEDAEDAEAEESPPLGAIPITDCLFCSHHSSS
LVKNVAHMTKVHSFFIPDIEYLSDLKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMND
KSHCKLFTDGDAALEFADFYDFRSSYPDYKEGQDPAEIEDLSSEKILECDDETMELILPSGARV
GHRSLMRYYKQRFGLPRAVTVARNQKAVGRVLQQYRALGWTGSTGAALMRERDMQYVQRMKSKW
MLKTGMKNNATKQMHFRAQVRF

hide sequence

RefSeq Acc Id:

ENSRNOP00000075424 ⟸ ENSRNOT00000084541

RefSeq Acc Id:

ENSRNOP00000068737 ⟸ ENSRNOT00000087109

RefSeq Acc Id:

ENSRNOP00000069183 ⟸ ENSRNOT00000079455

RefSeq Acc Id:

ENSRNOP00000073087 ⟸ ENSRNOT00000089551

RefSeq Acc Id:

ENSRNOP00000075409 ⟸ ENSRNOT00000089805

RefSeq Acc Id:

ENSRNOP00000062258 ⟸ ENSRNOT00000063951

Protein Domains

C2H2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TM96-F1-model_v2	AlphaFold	Q7TM96	1-386	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309146	AgrOrtholog
BioCyc Gene	G2FUF-53937	BioCyc
Ensembl Genes	ENSRNOG00000010589	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000059443	Ensembl
Ensembl Protein	ENSRNOP00000073087.2	UniProtKB/TrEMBL
	ENSRNOP00000075409.2	UniProtKB/TrEMBL
	ENSRNOP00000075424	ENTREZGENE
	ENSRNOP00000075424.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000084541	ENTREZGENE
	ENSRNOT00000084541.2	UniProtKB/TrEMBL
	ENSRNOT00000089551.2	UniProtKB/TrEMBL
	ENSRNOT00000089805.2	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7383802	IMAGE-MGC_LOAD
InterPro	Matrin/U1-like-C_Znf_C2H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RETREG1/3	UniProtKB/TrEMBL
	ZN622/Rei1/Reh1_Znf-C2H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf622/Rei1/Reh1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_jaz	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:294846	UniProtKB/TrEMBL
MGC_CLONE	MGC:108936	IMAGE-MGC_LOAD
NCBI Gene	294846	ENTREZGENE
PANTHER	PTHR13182	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR28659	UniProtKB/TrEMBL
	PTHR28659:SF3	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 622	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	zf-C2H2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-C2H2_jaz	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Zfp622	PhenoGen
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZnF_U1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K4L3_RAT	UniProtKB/TrEMBL
	A0A0G2KAI5_RAT	UniProtKB/TrEMBL
	A0A8L2URM4_RAT	UniProtKB/TrEMBL
	F1LQ57	ENTREZGENE
	Q5M855	ENTREZGENE, UniProtKB/TrEMBL
	Q7TM96	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	F1LQ57	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Zfp622	zinc finger protein 622	LOC103690028	zinc finger protein 622	Data Merged	737654	PROVISIONAL
2014-08-25	LOC103690028	zinc finger protein 622			Symbol and Name status set to provisional	70820	PROVISIONAL
2011-07-19	Zfp622	zinc finger protein 622	Znf622	zinc finger protein 622	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Znf622	zinc finger protein 622	Zfp622	zinc finger protein 622	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Zfp622	zinc finger protein 622	Znf622_predicted	zinc finger protein 622 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Znf622_predicted	zinc finger protein 622 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar