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Gene: C1r (complement C1r) Rattus norvegicus

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Symbol:

C1r

Name:

complement C1r

RGD ID:

1309091

Description:

Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within several processes, including complement activation; killing of cells of another organism; and opsonization. Predicted to be located in extracellular region. Predicted to be part of complement component C1 complex. Predicted to be active in blood microparticle and symbiont cell surface. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 1. Orthologous to human C1R (complement C1r); PARTICIPATES IN coagulation cascade pathway; complement system pathway; phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

complement C1r subcomponent; complement component 1, r subcomponent; LOC312705

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	C1R (complement C1r)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	C1rb (complement component 1, r subcomponent B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	C1r (complement C1r)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	C1R (complement C1r)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C1R (complement C1r)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	C1r (complement C1r)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C1R (complement C1r)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103218858 (complement C1r subcomponent)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	C1r (complement C1r)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	C1r (complement C1r)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HHIP (hedgehog interacting protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	C1R (complement C1r)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	C1ra (complement component 1, r subcomponent A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	C1rb (complement component 1, r subcomponent B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c1r (complement component 1, r subcomponent)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c1r	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c1r	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	c1rl	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	159,099,013 - 159,109,770 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	159,098,918 - 159,109,714 (+)	Ensembl				GRCr8
mRatBN7.2	4	157,412,718 - 157,423,483 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	157,412,692 - 157,423,484 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	163,635,374 - 163,646,172 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	159,418,283 - 159,429,081 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	158,064,480 - 158,075,420 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	157,126,060 - 157,136,825 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	157,125,998 - 157,136,829 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	224,144,564 - 224,155,329 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	160,712,582 - 160,729,362 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	146,152,622 - 146,163,370 (+)	NCBI		Celera
RGSC_v3.1	4	160,957,464 - 160,974,090 (+)	NCBI
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ehlers-Danlos syndrome (ISO)

Ehlers-Danlos syndrome periodontal type 1 (ISO)

Ehlers-Danlos syndrome periodontal type 2 (ISO)

endometriosis (ISO)

Insulin Resistance (ISO)

Paratuberculosis (ISO)

vascular dementia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

aripiprazole (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

bucladesine (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) chloride (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

dimethylarsinic acid (EXP)

dioxygen (EXP)

disulfiram (ISO)

diuron (EXP)

doxorubicin (EXP,ISO)

endosulfan (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

indinavir (ISO)

indometacin (ISO)

isotretinoin (ISO)

L-methionine (ISO)

lamivudine (ISO)

lead(0) (ISO)

medroxyprogesterone acetate (ISO)

methidathion (ISO)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

nefazodone (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

nicotine (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (EXP,ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propanal (ISO)

saquinavir (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sotorasib (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

tetrachloromethane (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trametinib (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

vancomycin (ISO)

zidovudine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

complement activation (IEA)

complement activation, classical pathway (IEA,ISO)

immune system process (IEA)

innate immune response (IEA)

proteolysis (IEA)

zymogen activation (IBA,ISO)

Cellular Component

blood microparticle (IBA)

cell surface (IEA)

complement component C1 complex (ISO)

extracellular region (IEA)

extracellular space (IBA,IEA,ISO)

symbiont cell surface (ISO)

Molecular Function

calcium ion binding (IEA,ISO)

hydrolase activity (IEA)

identical protein binding (ISO)

metal ion binding (IEA)

molecular sequestering activity (ISO)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IBA,IEA,ISO)

serine-type peptidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (IEA)

complement system pathway (IEA)

phagocytosis pathway (IEA)

Staphylococcus aureus infection pathway (IEA)

systemic lupus erythematosus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Alterations of the Classic Pathway of Complement in Adipose Tissue of Obesity and Insulin Resistance.	Zhang J, etal., Am J Physiol Endocrinol Metab. 2007 Jan 23;.

Additional References at PubMed

PMID:11823416	PMID:12477932	PMID:20178990	PMID:20970424	PMID:22516433	PMID:23533145	PMID:31749804

Genomics

Comparative Map Data

C1r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	159,099,013 - 159,109,770 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	159,098,918 - 159,109,714 (+)	Ensembl				GRCr8
mRatBN7.2	4	157,412,718 - 157,423,483 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	157,412,692 - 157,423,484 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	163,635,374 - 163,646,172 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	159,418,283 - 159,429,081 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	158,064,480 - 158,075,420 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	157,126,060 - 157,136,825 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	157,125,998 - 157,136,829 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	224,144,564 - 224,155,329 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	160,712,582 - 160,729,362 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	146,152,622 - 146,163,370 (+)	NCBI		Celera
RGSC_v3.1	4	160,957,464 - 160,974,090 (+)	NCBI
Cytogenetic Map	4	q42	NCBI

C1R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	7,080,219 - 7,092,445 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	7,080,213 - 7,092,540 (-)	Ensembl			hg38	GRCh38
GRCh37	12	7,187,523 - 7,245,041 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	7,132,347 - 7,136,184 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 36	12	7,057,768 - 7,058,863 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	7,132,345 - 7,136,184	NCBI
Celera	12	8,810,415 - 8,821,122 (-)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	7,051,362 - 7,057,949 (-)	NCBI		HuRef
HuRef	12	7,047,821 - 7,049,720 (-)	NCBI		HuRef
CHM1_1	12	7,186,493 - 7,188,392 (-)	NCBI		CHM1_1
CHM1_1	12	7,240,180 - 7,244,018 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	7,093,689 - 7,105,531 (-)	NCBI		T2T-CHM13v2.0

C1rb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	124,547,389 - 124,558,003 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	124,547,253 - 124,558,130 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	124,570,430 - 124,581,044 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	124,570,294 - 124,581,171 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	124,520,448 - 124,531,062 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	124,535,681 - 124,546,793 (+)	NCBI		MGSCv36	mm8
Celera	6	126,253,012 - 126,262,880 (+)	NCBI		Celera
Cytogenetic Map	6	F2	NCBI
cM Map	6	59.17	NCBI

C1r
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	4,652,308 - 4,660,304 (-)	Ensembl
ChiLan1.0	NW_004955413	4,652,156 - 4,660,897 (-)	NCBI	ChiLan1.0	ChiLan1.0

C1R
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	12,646,068 - 12,658,919 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	12,642,630 - 12,654,475 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,211,162 - 7,222,673 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	7,126,723 - 7,137,895 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	7,126,723 - 7,137,895 (-)	Ensembl			panPan2	panpan1.1

C1R
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	37,951,137 - 37,960,687 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	37,950,246 - 37,960,557 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	8,656,115 - 8,665,621 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	38,303,593 - 38,313,135 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	38,303,136 - 38,333,701 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	38,178,473 - 38,188,007 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	38,219,555 - 38,229,110 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	8,134,262 - 8,143,646 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

C1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	102,041,423 - 102,052,228 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936709	708,968 - 720,478 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936709	709,001 - 719,758 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C1R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	63,643,374 - 63,655,143 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	63,644,097 - 63,655,149 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103218858
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	7,115,964 - 7,134,612 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	7,125,367 - 7,134,758 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666063	1,078,052 - 1,089,520 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C1r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	3,676,252 - 3,684,406 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624860	3,675,926 - 3,684,598 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

C1r
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	23,264,839 - 23,275,780 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in C1r
130 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	81
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000056051
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	149763204	169799698	Rat
61446	Coreg2	Compensatory renal growth QTL 2	3.5		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	4	150095743	159267220	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	127263297	172263297	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	134199006	168870974	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	148834094	168870974	Rat

Markers in Region

RH128516

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	159,109,189 - 159,109,393 (+)	Marker Load Pipeline
mRatBN7.2	4	157,422,894 - 157,423,098 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	157,136,237 - 157,136,440	NCBI	Rnor6.0
Rnor_5.0	4	224,154,741 - 224,154,944	UniSTS	Rnor5.0
RGSC_v3.4	4	160,728,774 - 160,728,977	UniSTS	RGSC3.4
Celera	4	146,162,782 - 146,162,985	UniSTS
RH 3.4 Map	4	1005.8	UniSTS
Cytogenetic Map	4	q42	UniSTS

RH142322

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	157,422,678 - 157,422,876 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	157,136,021 - 157,136,218	NCBI	Rnor6.0
Rnor_5.0	4	224,154,525 - 224,154,722	UniSTS	Rnor5.0
RGSC_v3.4	4	160,728,558 - 160,728,755	UniSTS	RGSC3.4
Celera	4	146,162,566 - 146,162,763	UniSTS
RH 3.4 Map	4	1005.6	UniSTS
Cytogenetic Map	4	q42	UniSTS

RH140263

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	157,423,226 - 157,423,406 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	157,136,569 - 157,136,748	NCBI	Rnor6.0
Rnor_5.0	4	224,155,073 - 224,155,252	UniSTS	Rnor5.0
RGSC_v3.4	4	160,729,106 - 160,729,285	UniSTS	RGSC3.4
Celera	4	146,163,114 - 146,163,293	UniSTS
RH 3.4 Map	4	1003.9	UniSTS
Cytogenetic Map	4	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	89	59	6	353	189	11	142	81	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000056051 ⟹ ENSRNOP00000052903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	157,413,405 - 157,423,484 (+)	Ensembl
Rnor_6.0 Ensembl	4	157,126,935 - 157,136,303 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078349 ⟹ ENSRNOP00000069123

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	159,098,918 - 159,109,714 (+)	Ensembl
mRatBN7.2 Ensembl	4	157,412,692 - 157,423,483 (+)	Ensembl
Rnor_6.0 Ensembl	4	157,125,998 - 157,136,829 (+)	Ensembl

RefSeq Acc Id:

NM_001134555 ⟹ NP_001128027

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	159,099,013 - 159,109,770 (+)	NCBI
mRatBN7.2	4	157,412,718 - 157,423,483 (+)	NCBI
Rnor_6.0	4	157,126,060 - 157,136,825 (+)	NCBI
Rnor_5.0	4	224,144,564 - 224,155,329 (+)	NCBI
RGSC_v3.4	4	160,712,582 - 160,729,362 (+)	RGD
Celera	4	146,152,622 - 146,163,370 (+)	RGD

Sequence:

show sequence

CCCACTCCCTCCTTCAACTTACAGTGCCTGAAGACTCTTGCAGGAGAGCTGAGGACCCAAAACA
AACTGGCCTTGAGACATGCGTCTCATCCCCCTCCTCCTGGTGACCCTGTTCTGTGGGGTGGAGG
GCTCCATCTACCTCCCTCAGAAGCTCTATGGAGAGGTGACCTCCCCTCTGTATCCCAAGCCTTA
CCCCAGTGACTTGGAGACGACCACCGTGATCACTGTCCCCACGGGGTACAGGGTGAAGCTGGTC
TTCTGGCAGTTTGATGTGGAGCCTTCTGAAGGCTGTTTCTATGACTACGTCAAGATTTCTGCTG
ATAAGAAAACTCTGGGGAGGTTCTGTGGGCAGCAGGATTCTCCTCAGGGCAACCCCCCAGGAAG
GAAGGAATTCATGTCCCAAGGAAACAAGATGCTGCTGACCTTTCACACAGACTTCTCCAACGAG
GAGAATGGGACCATCATGTTCTACAAGGGCTTCCTGGCCTACTACCAGGCTGTGGACCTTGATG
AATGTACGTCCCAGCCCAACTCAGTGGAGGAGGGTTTGCAGCCCCGATGCCAACACCTGTGCCA
CAACTATGTTGGAGGTTACTTCTGTTCCTGCCGTCCTGGCTACGAGCTTCAGAAAGACAGGCAA
TCCTGCCAGGCCGAGTGCAGCAGTGGGCTCTACACGGAGCCCTCGGGCTACATCTCCAGCCTCG
AGTACCCGAAGCCCTATCCACCCGATCTGCGCTGTAACTACAGCATCCGGGTAGAGAGGGGCCT
CACTGTGCACCTCAAGTTCCTGGATCCTTTTGAAATTGATGACCACCAGCAAGTACACTGCCCC
TATGACCAGCTCCAGATCTACGCTAATGGGAAGAACTTGGGTGAATTCTGTGGAACGCAAAGGC
CTCCAGACCTTGACACCAGCAGCAACGCCGTGGATCTGCTGTTCTTCACGGATGAGTCCGGGGA
CAGCCGAGGCTGGAAGCTTCGCTACACCACTGAAATCATCAAGTGCCCCCAACCCAAGGCCCTG
GATGAGTTCACCATCATCCAGGATCCACAGCCTCAGTACCAGTTCCGGGATTACTTCATTGTCA
CCTGCAAACAAGGCTACCAGCTCATGGAGGGAAGTCAGGCGCTGCTCTCCTTCACGGCTGTTTG
CCAGCATGATGGCACGTGGCACCGTGCCATGCCCAGGTGCAAGATCAAGGACTGTGGACAGCCC
CGCAGCCTGTCTAATGGGGACTTCCGCTACCTCACCACAAGAGGCGTGAACACCTATGAAGCCA
GGATCCAGTATTACTGCCATGACCCATATTACAAGATGATGACCAGAGCTGGCAGCAGCGAGTC
CGTACGAGGGATATATACCTGCACACCCCAAGGCATTTGGAAGAACGAAGAGGAAGGAGAGAAA
ATGCCCCGGTGTCTGCCAGTATGTGGGAAGCCTGTCAACCCCGTGACACAGAAGCAGCGCATCA
TCGGAGGGCAGAAAGCCAATCCGGGCAACTTCCCCTGGCAGGCATTCACCAATATCCACGGGCG
AGGGGGCGGGGCCCTGCTTGGAGACCGCTGGATCCTCACGGCAGCCCACACCATCTACCCCAAG
GAACACAACAAAGAAAACAACGTCAACGTCAGTAAAGATGTTTTCCTGGGCCACACAAACGTGG
AAGAGATCAAAAAACTGGGACATCACCCTGTCCGTCGGGTCATCATACACCCAGACTACCGCCA
AGATGAGCCTAACAATTTTGAAGGAGACATTGCCCTACTGGAGCTGGAAAACAGTGTCACACTG
GGTCCCAACCTCCTCCCCATCTGTCTCCCAGACAATGAGACCTTCTATGACAAAGACCTTATGG
GTTATGTCAGCGGCTTCGGGATAACAGAAGATAAAATAGCTTTTAATCTCAGGTTTGTCCGTCT
GCCCATAGCCGATCGAGAGGCATGCCAGAGGTGGCTCCGGACGAAAAACAGTAATGATGTATTT
TCTCAAAATATGTTCTGTTCTGGGGACCCAACTCTCAAGCATGACGCCTGCCAGGGGGACAGTG
GGGGTGTTTTTGCAGTCAGGGACCGCAGTCGTGATATCTGGGTGGCTACAGGCATCGTATCCTG
GGGCATTGGGTGTGGTGAGGGATACGGCTTTTACACCAAGTTACTGAATTATGTTGACTGGATC
AAGAAAGAGATTGGAGATGAAAACTGAAGCCAGCATTCACTGGGTTAGAATCCAGTGTGTAGTA
TATTAAAAAAAAAAAGTATCTAACCAATTTTTGATAAGCACTACGTTTCTCATATTAAAATCAC
GGAGGCAGACAGTGTATAGAATAAATTCTCTTTTCTATAATCTCATCAGCATTCTGGCGTCTTG
TTTTCAACATAGTTTGACTATGTGGCCCAGGCTGCCCTAGAATATACAGTCCTCCTGCTTGAGG
CTCAGGGTTAGAGCTAACAATGTTAGGTTGGAGGATTGCTTCCCAGCTAAGAGTGTGGACTGTC
GGCTAGGCAGTGCTGGCACAGGCCTTTAATCCCAGCACTCTGGAAGCTGAGAGGTAGGTGGGTG
GGTCTCAGTGAGTTCGAGGCCAGCCTGTTCTATAGAGTGAGTTCCAGAACAGCCAGAAGTACAC
GGAAAAAACATGTCCTGAAAAACAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAA
ATAAATAAATAAATAAATATAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001128027	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98803	(Get FASTA)	NCBI Sequence Viewer
	AAI68673	(Get FASTA)	NCBI Sequence Viewer
	EDM01954	(Get FASTA)	NCBI Sequence Viewer
	EDM01955	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069123
	ENSRNOP00000069123.1

RefSeq Acc Id:	NP_001128027 ⟸ NM_001134555
- Peptide Label:	precursor
- UniProtKB:	B5DEH7 (UniProtKB/TrEMBL), D4A1T6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLIPLLLVTLFCGVEGSIYLPQKLYGEVTSPLYPKPYPSDLETTTVITVPTGYRVKLVFWQFD VEPSEGCFYDYVKISADKKTLGRFCGQQDSPQGNPPGRKEFMSQGNKMLLTFHTDFSNEENGTI MFYKGFLAYYQAVDLDECTSQPNSVEEGLQPRCQHLCHNYVGGYFCSCRPGYELQKDRQSCQAE CSSGLYTEPSGYISSLEYPKPYPPDLRCNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPYDQLQ IYANGKNLGEFCGTQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKALDEFTI IQDPQPQYQFRDYFIVTCKQGYQLMEGSQALLSFTAVCQHDGTWHRAMPRCKIKDCGQPRSLSN GDFRYLTTRGVNTYEARIQYYCHDPYYKMMTRAGSSESVRGIYTCTPQGIWKNEEEGEKMPRCL PVCGKPVNPVTQKQRIIGGQKANPGNFPWQAFTNIHGRGGGALLGDRWILTAAHTIYPKEHNKE NNVNVSKDVFLGHTNVEEIKKLGHHPVRRVIIHPDYRQDEPNNFEGDIALLELENSVTLGPNLL PICLPDNETFYDKDLMGYVSGFGITEDKIAFNLRFVRLPIADREACQRWLRTKNSNDVFSQNMF CSGDPTLKHDACQGDSGGVFAVRDRSRDIWVATGIVSWGIGCGEGYGFYTKLLNYVDWIKKEIG DEN hide sequence

Ensembl Acc Id:

ENSRNOP00000069123 ⟸ ENSRNOT00000078349

Ensembl Acc Id:

ENSRNOP00000052903 ⟸ ENSRNOT00000056051

Protein Domains

CUB Peptidase S1 Sushi

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DEH7-F1-model_v2	AlphaFold	B5DEH7	1-707	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693383

Promoter ID:

EPDNEW_R3906

Type:

initiation region

Name:

C1r_1

Description:

complement C1r

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	157,126,063 - 157,126,123	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309091	AgrOrtholog
BioCyc Gene	G2FUF-43093	BioCyc
Ensembl Genes	ENSRNOG00000011796	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078349	ENTREZGENE
	ENSRNOT00000078349.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	2.60.120.290	UniProtKB/TrEMBL
	Complement Module, domain 1	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7376270	IMAGE-MGC_LOAD
InterPro	CUB_dom	UniProtKB/TrEMBL
	EG-like_dom	UniProtKB/TrEMBL
	EGF-like_Ca-bd	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Pept_S1A_C1r/C1S/mannan-bd	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Ser/Cys_Pept_Trypsin-like	UniProtKB/TrEMBL
	sperma_CUB_dom	UniProtKB/TrEMBL
	Sushi/SCR/CCP_sf	UniProtKB/TrEMBL
	Sushi_SCR_CCP	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	rno:312705	UniProtKB/TrEMBL
MGC_CLONE	MGC:112846	IMAGE-MGC_LOAD
NCBI Gene	312705	ENTREZGENE
PANTHER	COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED	UniProtKB/TrEMBL
	PTHR24255:SF25	UniProtKB/TrEMBL
Pfam	CUB	UniProtKB/TrEMBL
	FXa_inhibition	UniProtKB/TrEMBL
	Sushi	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	C1r	PhenoGen
PIRSF	C1r_C1s_MASP	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	CUB	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	SUSHI	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011796	RatGTEx
SMART	CCP	UniProtKB/TrEMBL
	CUB	UniProtKB/TrEMBL
	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	Complement_control_module	UniProtKB/TrEMBL
	CUB	UniProtKB/TrEMBL
	EGF/Laminin	UniProtKB/TrEMBL
	Pept_Ser_Cys	UniProtKB/TrEMBL
UniProt	B5DEH7	ENTREZGENE, UniProtKB/TrEMBL
	D4A1T6	ENTREZGENE
	Q4G030_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-18	C1r	complement C1r	C1r	complement C1r subcomponent	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-15	C1r	complement C1r subcomponent	C1r	complement component 1, r subcomponent	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	C1r	complement component 1, r subcomponent	C1r_predicted	complement component 1, r subcomponent (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	C1r_predicted	complement component 1, r subcomponent (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)