Dennd2b (DENN domain containing 2B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dennd2b (DENN domain containing 2B) Rattus norvegicus
Analyze
Symbol: Dennd2b
Name: DENN domain containing 2B
RGD ID: 1308995
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade. Orthologous to human DENND2B (DENN domain containing 2B); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DENN domain-containing protein 2B; LOC102554209; LOC308944; St5; suppression of tumorigenicity 5; suppression of tumorigenicity 5 protein; uncharacterized LOC102554209
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81172,978,895 - 173,129,623 (-)NCBIGRCr8
mRatBN7.21163,544,075 - 163,734,736 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1163,544,074 - 163,694,680 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,882,574 - 172,033,829 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,068,621 - 179,219,875 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,751,246 - 171,902,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,137,120 - 174,290,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,137,120 - 174,289,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01181,125,790 - 181,275,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,119,711 - 167,284,482 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,230,639 - 167,278,304 (-)NCBI
Celera1161,445,725 - 161,593,908 (-)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
N,N-diethyl-m-toluamide  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9632734   PMID:20937701  


Genomics

Comparative Map Data
Dennd2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81172,978,895 - 173,129,623 (-)NCBIGRCr8
mRatBN7.21163,544,075 - 163,734,736 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1163,544,074 - 163,694,680 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,882,574 - 172,033,829 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,068,621 - 179,219,875 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,751,246 - 171,902,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,137,120 - 174,290,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,137,120 - 174,289,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01181,125,790 - 181,275,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,119,711 - 167,284,482 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,230,639 - 167,278,304 (-)NCBI
Celera1161,445,725 - 161,593,908 (-)NCBICelera
Cytogenetic Map1q33NCBI
DENND2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38118,693,352 - 8,910,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl118,693,351 - 8,910,951 (-)EnsemblGRCh38hg38GRCh38
GRCh37118,714,899 - 8,932,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36118,671,475 - 8,889,074 (-)NCBINCBI36Build 36hg18NCBI36
Build 34118,671,475 - 8,788,800NCBI
Celera118,832,533 - 9,052,256 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef118,382,896 - 8,602,816 (-)NCBIHuRef
CHM1_1118,713,829 - 8,931,377 (-)NCBICHM1_1
T2T-CHM13v2.0118,775,106 - 8,995,121 (-)NCBIT2T-CHM13v2.0
Dennd2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397109,123,118 - 109,302,828 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7109,123,118 - 109,302,812 (-)EnsemblGRCm39 Ensembl
GRCm387109,523,911 - 109,703,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7109,523,911 - 109,703,605 (-)EnsemblGRCm38mm10GRCm38
MGSCv377116,667,425 - 116,760,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367109,315,088 - 109,408,324 (-)NCBIMGSCv36mm8
Celera7109,497,846 - 109,591,326 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.27NCBI
Dennd2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541424,470,795 - 24,560,203 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541424,470,795 - 24,632,507 (-)NCBIChiLan1.0ChiLan1.0
DENND2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2911,124,223 - 11,302,309 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,082,896 - 11,260,742 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,817,897 - 9,039,913 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1118,560,468 - 8,781,601 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl118,560,468 - 8,617,257 (-)Ensemblpanpan1.1panPan2
DENND2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12132,109,193 - 32,272,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2132,109,905 - 32,255,007 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2131,677,762 - 31,840,558 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02132,982,787 - 33,081,926 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2132,982,793 - 33,128,916 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12132,251,987 - 32,317,831 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02132,418,133 - 32,581,087 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02132,711,675 - 32,875,219 (-)NCBIUU_Cfam_GSD_1.0
Dennd2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494753,152,777 - 53,306,196 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365289,239,305 - 9,341,351 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365289,187,147 - 9,340,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9665,282 - 703,382 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19653,814 - 703,383 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29630,168 - 772,200 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DENND2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,988,014 - 56,105,432 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl156,049,006 - 56,106,922 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038153,617,798 - 153,794,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624766842,702 - 940,280 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624766842,700 - 1,025,854 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dennd2b
943 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:493
Count of miRNA genes:253
Interacting mature miRNAs:293
Transcripts:ENSRNOT00000064902
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat

Markers in Region
MARC_7533-7534:996687916:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21163,545,788 - 163,546,387 (+)MAPPERmRatBN7.2
Rnor_6.01174,138,834 - 174,139,432NCBIRnor6.0
Rnor_5.01181,127,504 - 181,128,102UniSTSRnor5.0
RGSC_v3.41167,121,425 - 167,122,023UniSTSRGSC3.4
Celera1161,447,439 - 161,448,037UniSTS
Cytogenetic Map1q33UniSTS
RH125122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21163,560,160 - 163,560,317 (+)MAPPERmRatBN7.2
Rnor_6.01174,153,206 - 174,153,362NCBIRnor6.0
Rnor_5.01181,141,876 - 181,142,032UniSTSRnor5.0
RGSC_v3.41167,135,797 - 167,135,953UniSTSRGSC3.4
Celera1161,461,811 - 161,461,967UniSTS
Cytogenetic Map1q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 48 37 14 37 1 1 74 29 38 11 1
Low 9 4 5 4 7 10 6 3 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001395094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000064902   ⟹   ENSRNOP00000061141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,075 - 163,694,390 (-)Ensembl
Rnor_6.0 Ensembl1174,137,120 - 174,289,647 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099927   ⟹   ENSRNOP00000089151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,075 - 163,592,751 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100159   ⟹   ENSRNOP00000094375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,075 - 163,694,680 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100789   ⟹   ENSRNOP00000078383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,075 - 163,694,680 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101472   ⟹   ENSRNOP00000084498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,079 - 163,694,680 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113598   ⟹   ENSRNOP00000095419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,079 - 163,592,751 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114792   ⟹   ENSRNOP00000093299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,075 - 163,592,010 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114796   ⟹   ENSRNOP00000085739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,075 - 163,581,992 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116719   ⟹   ENSRNOP00000093154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1163,544,074 - 163,659,349 (-)Ensembl
RefSeq Acc Id: NM_001395094   ⟹   NP_001382023
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,895 - 173,129,484 (-)NCBI
mRatBN7.21163,544,075 - 163,694,680 (-)NCBI
RefSeq Acc Id: XM_039078194   ⟹   XP_038934122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,073,282 (-)NCBI
mRatBN7.21163,544,075 - 163,639,014 (-)NCBI
RefSeq Acc Id: XM_039078198   ⟹   XP_038934126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,580 (-)NCBI
mRatBN7.21163,544,075 - 163,694,765 (-)NCBI
RefSeq Acc Id: XM_039078199   ⟹   XP_038934127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,090,336 (-)NCBI
mRatBN7.21163,544,075 - 163,670,557 (-)NCBI
RefSeq Acc Id: XM_039078202   ⟹   XP_038934130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,335 (-)NCBI
mRatBN7.21163,544,075 - 163,694,535 (-)NCBI
RefSeq Acc Id: XM_039078204   ⟹   XP_038934132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,335 (-)NCBI
mRatBN7.21163,544,075 - 163,694,535 (-)NCBI
RefSeq Acc Id: XM_039078205   ⟹   XP_038934133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,335 (-)NCBI
mRatBN7.21163,544,075 - 163,694,215 (-)NCBI
RefSeq Acc Id: XM_039078206   ⟹   XP_038934134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,094,345 (-)NCBI
mRatBN7.21163,544,075 - 163,659,544 (-)NCBI
RefSeq Acc Id: XM_039078207   ⟹   XP_038934135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,073,933 (-)NCBI
mRatBN7.21163,544,075 - 163,639,117 (-)NCBI
RefSeq Acc Id: XM_039078208   ⟹   XP_038934136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,062,071 (-)NCBI
mRatBN7.21163,544,075 - 163,627,249 (-)NCBI
RefSeq Acc Id: XM_039078209   ⟹   XP_038934137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,026,857 (-)NCBI
mRatBN7.21163,544,075 - 163,581,992 (-)NCBI
RefSeq Acc Id: XM_039078211   ⟹   XP_038934139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,982,162 - 173,129,623 (-)NCBI
mRatBN7.21163,547,338 - 163,592,035 (-)NCBI
RefSeq Acc Id: XM_039078212   ⟹   XP_038934140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,991,176 - 173,062,081 (-)NCBI
mRatBN7.21163,558,222 - 163,592,035 (-)NCBI
RefSeq Acc Id: XM_063263081   ⟹   XP_063119151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,623 (-)NCBI
RefSeq Acc Id: XM_063263096   ⟹   XP_063119166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,623 (-)NCBI
RefSeq Acc Id: XM_063263099   ⟹   XP_063119169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,469 (-)NCBI
RefSeq Acc Id: XM_063263101   ⟹   XP_063119171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,978,901 - 173,129,479 (-)NCBI
RefSeq Acc Id: XM_063263111   ⟹   XP_063119181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81172,991,176 - 173,129,623 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382023 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934122 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934126 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934127 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934130 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934132 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934133 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934134 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934135 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934136 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934137 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934139 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934140 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119151 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119166 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119169 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119171 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119181 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM17903 (Get FASTA)   NCBI Sequence Viewer  
  EDM17904 (Get FASTA)   NCBI Sequence Viewer  
  EDM17905 (Get FASTA)   NCBI Sequence Viewer  
  EDM17906 (Get FASTA)   NCBI Sequence Viewer  
  EDM17907 (Get FASTA)   NCBI Sequence Viewer  
  EDM17908 (Get FASTA)   NCBI Sequence Viewer  
  EDM17909 (Get FASTA)   NCBI Sequence Viewer  
  EDM17910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061141
  ENSRNOP00000061141.1
  ENSRNOP00000078383.1
  ENSRNOP00000084498.1
  ENSRNOP00000085739
  ENSRNOP00000085739.1
  ENSRNOP00000089151
  ENSRNOP00000089151.1
  ENSRNOP00000093154.1
  ENSRNOP00000093299.1
  ENSRNOP00000094375.1
  ENSRNOP00000095419.1
RefSeq Acc Id: ENSRNOP00000061141   ⟸   ENSRNOT00000064902
RefSeq Acc Id: XP_038934126   ⟸   XM_039078198
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934130   ⟸   XM_039078202
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934132   ⟸   XM_039078204
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934133   ⟸   XM_039078205
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934127   ⟸   XM_039078199
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934134   ⟸   XM_039078206
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934135   ⟸   XM_039078207
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934122   ⟸   XM_039078194
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934136   ⟸   XM_039078208
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934137   ⟸   XM_039078209
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A484 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934139   ⟸   XM_039078211
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AIH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934140   ⟸   XM_039078212
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000085739   ⟸   ENSRNOT00000114796
RefSeq Acc Id: ENSRNOP00000093154   ⟸   ENSRNOT00000116719
RefSeq Acc Id: ENSRNOP00000089151   ⟸   ENSRNOT00000099927
RefSeq Acc Id: ENSRNOP00000084498   ⟸   ENSRNOT00000101472
RefSeq Acc Id: ENSRNOP00000093299   ⟸   ENSRNOT00000114792
RefSeq Acc Id: ENSRNOP00000094375   ⟸   ENSRNOT00000100159
RefSeq Acc Id: ENSRNOP00000078383   ⟸   ENSRNOT00000100789
RefSeq Acc Id: ENSRNOP00000095419   ⟸   ENSRNOT00000113598
RefSeq Acc Id: NP_001382023   ⟸   NM_001395094
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119166   ⟸   XM_063263096
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119151   ⟸   XM_063263081
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119171   ⟸   XM_063263101
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZM26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119169   ⟸   XM_063263099
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZM26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119181   ⟸   XM_063263111
- Peptide Label: isoform X8
Protein Domains
uDENN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9H6-F1-model_v2 AlphaFold D4A9H6 1-1100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690302
Promoter ID:EPDNEW_R827
Type:initiation region
Name:St5_1
Description:suppression of tumorigenicity 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01174,289,637 - 174,289,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308995 AgrOrtholog
BioCyc Gene G2FUF-57864 BioCyc
Ensembl Genes ENSRNOG00000013934 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064902.3 UniProtKB/TrEMBL
  ENSRNOT00000099927 ENTREZGENE
  ENSRNOT00000099927.1 UniProtKB/TrEMBL
  ENSRNOT00000100159.1 UniProtKB/TrEMBL
  ENSRNOT00000100789.1 UniProtKB/TrEMBL
  ENSRNOT00000101472.1 UniProtKB/TrEMBL
  ENSRNOT00000113598.1 UniProtKB/TrEMBL
  ENSRNOT00000114792.1 UniProtKB/TrEMBL
  ENSRNOT00000114796.1 UniProtKB/TrEMBL
  ENSRNOT00000116719.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.200 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
InterPro dDENN_dom UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  DENN_dom UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
KEGG Report rno:308944 UniProtKB/TrEMBL
NCBI Gene 308944 ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  DENN DOMAIN-CONTAINING PROTEIN 2B UniProtKB/TrEMBL
Pfam dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
PhenoGen Dennd2b PhenoGen
PROSITE DENN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013934 RatGTEx
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
UniProt A0A8I5ZM26 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A1G4_RAT UniProtKB/TrEMBL
  A0A8I6A484 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH99_RAT UniProtKB/TrEMBL
  A0A8I6AIH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANG7_RAT UniProtKB/TrEMBL
  A0A8I6GL52_RAT UniProtKB/TrEMBL
  D4A9H6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Dennd2b  DENN domain containing 2B  St5  suppression of tumorigenicity 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 St5  suppression of tumorigenicity 5  LOC102554209  uncharacterized LOC102554209  Data merged from RGD:7685325 737654 PROVISIONAL
2013-12-18 LOC102554209  uncharacterized LOC102554209      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 St5  suppression of tumorigenicity 5   St5_predicted  suppression of tumorigenicity 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 St5_predicted  suppression of tumorigenicity 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED