Trim41 (tripartite motif-containing 41)

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Gene: Trim41 (tripartite motif-containing 41) Rattus norvegicus

Analyze

Symbol:

Trim41

Name:

tripartite motif-containing 41

RGD ID:

1308885

Description:

Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in nucleolus. Predicted to be active in nuclear body. Orthologous to human TRIM41 (tripartite motif containing 41); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase TRIM41; LOC303088; MGC188087; tripartite motif protein 41

RGD Orthologs

Alliance Genes

More Info

more info ...

Candidate Gene For:

Pia26

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	33,175,213 - 33,186,472 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	33,175,213 - 33,186,694 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	37,855,399 - 37,866,483 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	6,393,822 - 6,404,906 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	32,849,037 - 32,860,121 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	34,155,515 - 34,166,599 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	34,155,515 - 34,166,599 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	33,939,418 - 33,950,502 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	34,072,993 - 34,084,077 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	34,074,090 - 34,085,114 (-)	NCBI
Celera	10	32,561,371 - 32,572,455 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

choline (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibenzo[a,l]pyrene (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

folic acid (ISO)

L-methionine (ISO)

methimazole (EXP)

nitrofen (EXP)

paracetamol (ISO)

phenobarbital (ISO)

silicon dioxide (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tetrachloromethane (ISO)

triadimefon (EXP)

triptonide (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cellular response to lipopolysaccharide (ISO)

cellular response to muramyl dipeptide (ISO)

defense response to virus (ISO)

positive regulation of type I interferon-mediated signaling pathway (ISO)

protein monoubiquitination (ISO)

protein ubiquitination (IBA)

Cellular Component

nuclear body (IBA,ISO)

nucleolus (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:17893151	PMID:22493164	PMID:25416956	PMID:27812135

Genomics

Comparative Map Data

Trim41
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	33,175,213 - 33,186,472 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	33,175,213 - 33,186,694 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	37,855,399 - 37,866,483 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	6,393,822 - 6,404,906 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	32,849,037 - 32,860,121 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	34,155,515 - 34,166,599 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	34,155,515 - 34,166,599 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	33,939,418 - 33,950,502 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	34,072,993 - 34,084,077 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	34,074,090 - 34,085,114 (-)	NCBI
Celera	10	32,561,371 - 32,572,455 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

TRIM41
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	181,223,281 - 181,235,808 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	181,222,499 - 181,235,808 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	180,650,281 - 180,662,808 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	180,582,912 - 180,595,414 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	180,582,911 - 180,595,414	NCBI
Celera	5	176,278,161 - 176,290,662 (+)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	175,377,371 - 175,389,753 (+)	NCBI		HuRef
CHM1_1	5	180,081,205 - 180,095,212 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	181,783,233 - 181,795,759 (+)	NCBI		T2T-CHM13v2.0

Trim41
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	48,697,230 - 48,709,026 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	48,697,231 - 48,708,180 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	48,806,403 - 48,818,199 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	48,806,404 - 48,817,353 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	48,619,906 - 48,630,893 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	48,649,825 - 48,661,138 (-)	NCBI		MGSCv36	mm8
Celera	11	53,388,643 - 53,399,510 (-)	NCBI		Celera
Cytogenetic Map	11	B1.2	NCBI
cM Map	11	28.78	NCBI

Trim41
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955530	84,683 - 95,835 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955530	84,683 - 95,835 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRIM41
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	174,410,842 - 174,423,488 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	176,449,281 - 176,461,840 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	183,699,842 - 183,711,523 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	183,699,842 - 183,711,522 (+)	Ensembl	panpan1.1		panPan2

TRIM41
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	414,725 - 426,074 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	415,764 - 425,656 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	475,313 - 484,740 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	378,817 - 388,245 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	378,601 - 388,243 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	350,987 - 360,414 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	438,568 - 447,995 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	599,986 - 609,412 (+)	NCBI		UU_Cfam_GSD_1.0

Trim41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	117,858,244 - 117,870,767 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936826	734,493 - 747,047 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936826	734,306 - 747,047 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIM41
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	57,285,406 - 57,295,771 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	57,285,401 - 57,295,771 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TRIM41
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	82,786,967 - 82,798,993 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	82,787,021 - 82,798,588 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	14,246,823 - 14,259,923 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trim41
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624958	188,133 - 198,242 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624958	187,174 - 198,971 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trim41
29 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	122
Count of miRNA genes:	99
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000003246
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum total immunoglobulin E level (CMO:0001542)	10	22918268	36400810	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2298480	Eau7	Experimental allergic uveoretinitis QTL 7		0.0049	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	27957626	34490668	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat

Markers in Region

RH130854

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	33,175,306 - 33,175,503 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	34,155,609 - 34,155,805	NCBI	Rnor6.0
Rnor_5.0	10	33,939,512 - 33,939,708	UniSTS	Rnor5.0
RGSC_v3.4	10	34,073,087 - 34,073,283	UniSTS	RGSC3.4
Celera	10	32,561,465 - 32,561,661	UniSTS
RH 3.4 Map	10	347.1	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	33	42	33	18	33		1	73	30	41	11
Low		10	15	8	1	8	8	10	1	5			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW434688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP492647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB615599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB714434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB784926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY315972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000003246 ⟹ ENSRNOP00000003246

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	33,175,213 - 33,186,298 (-)	Ensembl
Rnor_6.0 Ensembl	10	34,155,515 - 34,166,599 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103107 ⟹ ENSRNOP00000091440

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	33,175,213 - 33,186,694 (-)	Ensembl

RefSeq Acc Id:

NM_001134737 ⟹ NP_001128209

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	33,175,213 - 33,186,298 (-)	NCBI
Rnor_6.0	10	34,155,515 - 34,166,599 (-)	NCBI
Rnor_5.0	10	33,939,418 - 33,950,502 (-)	NCBI
RGSC_v3.4	10	34,072,993 - 34,084,077 (-)	RGD
Celera	10	32,561,371 - 32,572,455 (-)	RGD

Sequence:

show sequence

GTCCTGGGAGTCCCTTCTGCAGTCGTCCGTGCCTGGTCGGTAGGATGGCGCTAGGCCGCTGCGA
TTGTAGCACGGAGAACAGGGCGCTGCTCAACGTCCTCGCTACCCTCCGCCGTCTGTCCCCGCTG
GCAGGGCATGGGGGCTTCTTCCGCTCTGTACGCGTTCTTCGCGGCCAGTCATCACCGAGATGTG
GGCCTCCGCCGTCCTAGCCCTCCCGTCCTGTTCCCGCGTGTCAGCTAGAGCGTCTCCTCCTCGT
TTCCTGTCGCTCCGGGGCTGGGCGTGGGAGAAGGGGGCGTAACACACCCTCGAAGGGAACTCGT
GAGTTCAGGTCGTGTGGAGACGCCGGAAGCGTTGGGAGGGAGGCCGGAAGCTGGGGGGCGGGGC
CAGGAAGTGAGGAGGGGCGGGGGTTTATGAGGAGGCCAGGGGAGCGTTGGGGCAGATTTGCACT
CAGGTCCACCTGAGGTACTTGTCGGTGGTACTCACCTCTGTCCCCTCCCTTCTGTGAGACAAGG
TTGTCGTCTCGGGGTAGGGGACTGTGTGTGGAGGGGCGGGCTGGTCGGAGGACATTCCTTTGCC
TCGCCGCAGGCAAGGTGTGGAGAGGCTGGGCTTGGGGTGGGGACGGGTCTTCTGGGCTTCAGAG
ACGGGAGACCCCCCCGCCCCACCCCCCCGCTCCCCCCACCGCACTTCTACACTGGCTGACTGGA
CACTAAGATGGCTGCCGTTGCCATGACACCCAACCCTGTGCAGACCCTTCAGGAGGAGGCGGTG
TGCGCCATCTGCCTCGATTACTTCACGGACCCCGTGTCCATCGGCTGCGGGCACAACTTCTGCC
GAGTGTGTGTAACCCAGTTGTGGGGCGGGGAGGATGAAGAAGACAGAGATGAGTTGGATCGGGA
GGAGGAGGAGGAGGTCGGAGAGGAGGAAGAAGTGGAGGCTGTCGGGGCAGGCGGGGGTTGGGAC
ACCCCTATGCGCGATGAAGATTATGAGGGTGACATGGAGGAGGAGGCCGAGGAGGAAGAGGAAG
GTGTGTTCTGGAGTAGTGGTATAGGCGGGTCTAACTGGGACAACATGGACTATGTGTGGGAGGA
GGAGGAGGAGGAGGAAGAACTGGACTATTACTTGGGGGATGTGGAGGACCTGAGGGTGGAAGAT
GAGGATGAGGAGGAGGAAGTCCTGGAGGAAGACGAGGAAGAGGAGCTGGACCCGATCACCCAAC
TGCCACCACCTCCAGCCCCTCGGAGGTGCTTCACTTGTCCCCAGTGTCGAAAAAGTTTTCCTCG
GCGGAGCTTCCGCCCCAACCTGCAGTTGGCCAACATGGTCCAGGTGATTCGGCAGATGCATCCA
ACCCCTGGTCGAGGGAGTCGTGTGAATGAACAAGGCATCTGTCCCAGACACCAAGAAGCCCTGA
AGCTGTTCTGTGAGGTGGATGAAGAAGCCATCTGTGTGGTGTGCCGCGAATCCAGGAGCCACAA
ACAGCATAGTGTGGTGCCATTGGAGGAGGTAGTGCAGGAGTACAAGGCCAAGCTACAAGGGCAT
GTGGAACCACTTAGGAAGCATCTAGAGGCTGTGCAGAAGATGAAGGCCAAGGAGGAGAGGCGGG
TGACAGAGCTGAAGAGCCAGATGAAGTCAGAGCTGGCAGCTGTGGCCTCAGAGTTTGGACGGTT
AACACGGTTTCTGGCTGAAGAGCAGGCAGGACTAGAACGGCGCCTCCGGGAGATGCATGAAGCT
CAGTTAGGACGTGCAGGAGCAGCAGCCAACCGCCTTGAAGAGCAGGCTGTCCAGCTAAGCCGCC
TGCTTGCTGAAGCCCAAGAGCGGAGCCAACAGGGGGGCCTGCGGCTATTGCAAGACATCAAGGA
GACTTTCAATAGGTGTGAAGAGATACAGTTGCAGCCCCCAGAGATTTGGTCCCCTGACCCATGC
CAACCCCATAGCCACGACTTTCTGACAGACGCCATCGTGAGGAAAATGAGCCGGATGTTCTGTC
AGGCTGCAAGAGTGGACCTGACACTGGACCCAGACACAGCTCACCCGGCTCTGCTGCTGTCCCC
TGATCGCCGTGGAGTCCGCTTGGCAGAACGTCGGCAGGAGGTTCCTGAACATTCCAAGCGCTTT
TCAGCAGACTGCTGTGTACTAGGGGCCCAGGGCTTCCGCTCGGGCCGGCACTACTGGGAGGTAG
AGGTGGGTGGGCGGCGGGGCTGGGCAGTGGGTGCTGCCCGTGAATCAACCCATCATAAAGAAAA
AGTGGGCTCTGGGGGGTCCTCTGTTAGCAGTGGGGATGCCAGCTCCTCACGCCATCACCATCGC
CGCCGCCGGCTCCATCTGCCTCAGCAGCTCCTGCTTCAGCGGGAAGTGTGGTGCGTGGGCACCC
ACGGCAAACGATACCAGGCGCAGAGCTCAACAGAGCAGACACTGCTGAGCCCATGTGAGAAACC
ACGGCGTTTCGGCGTGTACCTGGACTATGAGGCTGGGCGCCTGGGCTTCTACAACGCAGATACC
TTAGCTCATGTACACACCTTCTCAGCTGCCTTTCTTGGCGAGCGTGTTTTTCCTTTCTTCCGGG
TACTTTCCAAGGGTACCCGCATCAAGCTCTGCCCTTGATCAGCCTGCCACCCGCAGGGGCCCCT
CTGGTCACCACTGGGGGGGCGGGTGGTGGTGGATGGTTGCCCACTGTTTGGGAGCCCAGACTCC
TCCCACTGTTTGAGTTGCTTCCTGCTCCCTCTTGTACACAGGCTACTTCTCCCTCTAGGAGCCC
AAAAAAAAAAAAAAAAAAAAAACAAAACCCCTCCAGCTCAGCCTTTTCTTACCCTTGTCTGACA
GGTCTGCATGGGTCCCAGTAATGAACAGCTGCCTGATATGACCTTCCCTCCCTGTCTACCTAGC
TTGGTCCAGCTCTGGGTCCCACATGTTGGAGTATGGAGTGTGTGGAGATTATTTAATGCAACCT
TTTCCACCCCTACTCAACCCGTCATTTCTGAGGCTGGAGGGTTTGGGCAAAACACTCCCATGTT
TTGGTGCAGACCAGCTAAGTTTTAGAGGCTCTGTGGGAAGTCAGACTGGGCAAAAGGGTAGTGC
TGTGTAAAGTCTACTTTTCTTGGGGAAGTAGGAATTCTTAAGCTTTCCTTCCACCCCCAATTTC
TACCTCCATAGACTGGCCAGAATTTAGCTTCAGTGAGATCTGGAATGGTCAGCATGACATCTCT
ACCATTACCCAATAAATTATTTTCTCTGTGCATCTTAGTTTTTTTCGTTAGGTAGGAGCCCAAG
TCTTCACTGCCAGGCTCTCTTCCCTTTTCAGTGAGGTTTCTGGCCTCTCCATGCCTTTTAGTTA
CATGTGGTTAGCCCTGTTAGGGGAGCTCGGGACAGGGGTCTGGATCCTTGGGAGACTGTTGGGT
ATAATCTATTTTTCTAGTAACCCCTTGCCTTCTGACACAGCAACAGCTTTTGTCCTCTGCTTTG
GTGGCTGAGGTCAGTCCATGTTCTTGGGGAGGGAAAGTGGGTTGTATTGCAAAAAATAAAAAAA
GTGTTTATTTGCTTCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039085918 ⟹ XP_038941846

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	33,175,213 - 33,186,472 (-)	NCBI

RefSeq Acc Id:

XM_039085919 ⟹ XP_038941847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	33,177,164 - 33,186,472 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128209	(Get FASTA)	NCBI Sequence Viewer
	XP_038941846	(Get FASTA)	NCBI Sequence Viewer
	XP_038941847	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68206	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001128209 ⟸ NM_001134737

- UniProtKB:

B4F7B4 (UniProtKB/TrEMBL), F1LMK2 (UniProtKB/TrEMBL), A0A8I6AF80 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEE
EEVGEEEEVEAVGAGGGWDTPMRDEDYEGDMEEEAEEEEEGVFWSSGIGGSNWDNMDYVWEEEE
EEEELDYYLGDVEDLRVEDEDEEEEVLEEDEEEELDPITQLPPPPAPRRCFTCPQCRKSFPRRS
FRPNLQLANMVQVIRQMHPTPGRGSRVNEQGICPRHQEALKLFCEVDEEAICVVCRESRSHKQH
SVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTR
FLAEEQAGLERRLREMHEAQLGRAGAAANRLEEQAVQLSRLLAEAQERSQQGGLRLLQDIKETF
NRCEEIQLQPPEIWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALLLSPDR
RGVRLAERRQEVPEHSKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVG
SGGSSVSSGDASSSRHHHRRRRLHLPQQLLLQREVWCVGTHGKRYQAQSSTEQTLLSPCEKPRR
FGVYLDYEAGRLGFYNADTLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP

hide sequence

RefSeq Acc Id:

ENSRNOP00000003246 ⟸ ENSRNOT00000003246

RefSeq Acc Id:	XP_038941846 ⟸ XM_039085918
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AF80 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038941847 ⟸ XM_039085919
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000091440 ⟸ ENSRNOT00000103107

Protein Domains

B box-type B30.2/SPRY RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LMK2-F1-model_v2	AlphaFold	F1LMK2	1-628	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308885	AgrOrtholog
BioCyc Gene	G2FUF-25338	BioCyc
Ensembl Genes	ENSRNOG00000002388	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000003246.5	UniProtKB/TrEMBL
	ENSRNOP00000091440	ENTREZGENE
	ENSRNOP00000091440.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003246.5	UniProtKB/TrEMBL
	ENSRNOT00000103107	ENTREZGENE
	ENSRNOT00000103107.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.920	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	B30.2/SPRY	UniProtKB/TrEMBL
	B30.2/SPRY_sf	UniProtKB/TrEMBL
	Butyrophylin	UniProtKB/TrEMBL
	ConA-like_dom	UniProtKB/TrEMBL
	PRY	UniProtKB/TrEMBL
	SPRY_rcpt	UniProtKB/TrEMBL
	TRIM41_SPRY_PRY	UniProtKB/TrEMBL
	Znf_B-box	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	rno:303088	UniProtKB/TrEMBL
NCBI Gene	303088	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/TrEMBL
	E3 UBIQUITIN-PROTEIN LIGASE TRIM41	UniProtKB/TrEMBL
Pfam	PRY	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
	zf-B_box	UniProtKB/TrEMBL
	zf-C3HC4_4	UniProtKB/TrEMBL
PhenoGen	Trim41	PhenoGen
PRINTS	BUTYPHLNCDUF	UniProtKB/TrEMBL
PROSITE	B302_SPRY	UniProtKB/TrEMBL
	ZF_BBOX	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	BBOX	UniProtKB/TrEMBL
	PRY	UniProtKB/TrEMBL
	RING	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/TrEMBL
	ConA_like_lec_gl	UniProtKB/TrEMBL
	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A8I6AF80	ENTREZGENE, UniProtKB/TrEMBL
	B4F7B4	ENTREZGENE, UniProtKB/TrEMBL
	F1LMK2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Trim41	tripartite motif-containing 41	Trim41_predicted	tripartite motif protein 41 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Trim41_predicted	tripartite motif protein 41 (predicted)		tripartite motif-containing 41 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Trim41_predicted	tripartite motif-containing 41 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar