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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Apmap | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of APMAP mRNA] | CTD | PMID:31150632 | Apmap | Rat | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of APMAP mRNA | CTD | PMID:25380136 | Apmap | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of APMAP protein | CTD | PMID:32145629 | Apmap | Rat | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | Metribolone results in increased expression of APMAP protein | CTD | PMID:17152098 | Apmap | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of APMAP protein | CTD | PMID:31675489 | Apmap | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of APMAP mRNA | CTD | PMID:20106945 | Apmap | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of APMAP mRNA | CTD | PMID:32109520 | Apmap | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of APMAP mRNA | CTD | PMID:21215274 | Apmap | Rat | 2,4,6-tribromophenol | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | 2,4,6-tribromophenol results in decreased expression of APMAP mRNA | CTD | PMID:31675489 | Apmap | Rat | 2,6-dimethoxyphenol | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in increased expression of and affects the more ... | CTD | PMID:38598786 | Apmap | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of APMAP protein | CTD | PMID:31675489 | Apmap | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Apmap | Rat | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of APMAP mRNA | CTD | PMID:25380136 | Apmap | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Apmap (Mus musculus) | 6480464 | bisphenol S results in decreased expression of APMAP mRNA | CTD | PMID:39298647 | Apmap | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | bisphenol S results in increased expression of APMAP protein | CTD | PMID:34186270 | Apmap | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Apmap (Mus musculus) | 6480464 | Fenretinide results in decreased expression of APMAP mRNA | CTD | PMID:28973697 | Apmap | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of APMAP mRNA | CTD | PMID:31881176 | Apmap | Rat | actinomycin D | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of APMAP protein | CTD | PMID:38460933 | Apmap | Rat | aflatoxin B1 | decreases methylation | ISO | APMAP (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of APMAP gene | CTD | PMID:27153756 | Apmap | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of APMAP mRNA | CTD | PMID:35163327 | Apmap | Rat | benzo[a]pyrene | increases methylation | ISO | APMAP (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of APMAP promoter | CTD | PMID:27901495 | Apmap | Rat | benzo[e]pyrene | increases methylation | ISO | APMAP (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of APMAP exon | CTD | PMID:30157460 | Apmap | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of APMAP mRNA | CTD | PMID:26496021 | Apmap | Rat | bisphenol A | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of APMAP protein | CTD | PMID:31675489|PMID:34186270 | Apmap | Rat | bisphenol A | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | bisphenol A results in increased expression of APMAP protein | CTD | PMID:33376534|PMID:37567409 | Apmap | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of APMAP mRNA; bisphenol A results in increased expression more ... | CTD | PMID:30816183|PMID:32145629|PMID:32528016|PMID:34947998 | Apmap | Rat | bisphenol A | affects expression | ISO | APMAP (Homo sapiens) | 6480464 | bisphenol A affects the expression of APMAP mRNA | CTD | PMID:30903817 | Apmap | Rat | bisphenol A | increases methylation | ISO | Apmap (Mus musculus) | 6480464 | bisphenol A results in increased methylation of APMAP promoter | CTD | PMID:27312807 | Apmap | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of APMAP mRNA | CTD | PMID:25181051 | Apmap | Rat | bisphenol A | increases expression | ISO | Apmap (Mus musculus) | 6480464 | bisphenol A results in increased expression of APMAP mRNA | CTD | PMID:26063408 | Apmap | Rat | bisphenol AF | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of APMAP protein | CTD | PMID:34186270 | Apmap | Rat | Bisphenol B | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | bisphenol B results in increased expression of APMAP protein | CTD | PMID:34186270 | Apmap | Rat | bisphenol F | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Apmap | Rat | bisphenol F | increases expression | ISO | Apmap (Mus musculus) | 6480464 | bisphenol F results in increased expression of APMAP mRNA | CTD | PMID:38685157 | Apmap | Rat | bisphenol F | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | bisphenol F results in increased expression of APMAP protein | CTD | PMID:34186270 | Apmap | Rat | cadmium atom | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APMAP more ... | CTD | PMID:35301059 | Apmap | Rat | cadmium atom | multiple interactions | ISO | Apmap (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APMAP more ... | CTD | PMID:37325564 | Apmap | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of APMAP mRNA | CTD | PMID:33453195 | Apmap | Rat | cadmium dichloride | multiple interactions | ISO | Apmap (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APMAP more ... | CTD | PMID:37325564 | Apmap | Rat | cadmium dichloride | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APMAP more ... | CTD | PMID:35301059 | Apmap | Rat | cadmium dichloride | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of APMAP mRNA | CTD | PMID:38568856 | Apmap | Rat | carbon nanotube | increases expression | ISO | Apmap (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of APMAP mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25620056 | Apmap | Rat | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of APMAP protein | CTD | PMID:22023808 | Apmap | Rat | clofibrate | increases expression | ISO | Apmap (Mus musculus) | 6480464 | Clofibrate results in increased expression of APMAP mRNA | CTD | PMID:23811191 | Apmap | Rat | clofibric acid | affects expression | EXP | | 6480464 | Clofibric Acid affects the expression of APMAP mRNA | CTD | PMID:17602206 | Apmap | Rat | cyclosporin A | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of APMAP mRNA | CTD | PMID:25562108 | Apmap | Rat | dexamethasone | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Apmap | Rat | disodium selenite | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of APMAP mRNA | CTD | PMID:18175754 | Apmap | Rat | doxorubicin | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of APMAP mRNA | CTD | PMID:29803840 | Apmap | Rat | fenthion | decreases expression | ISO | Apmap (Mus musculus) | 6480464 | Fenthion results in decreased expression of APMAP mRNA | CTD | PMID:34813904 | Apmap | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of APMAP mRNA | CTD | PMID:34044035 | Apmap | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of APMAP mRNA | CTD | PMID:24793618 | Apmap | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of APMAP gene | CTD | PMID:22079235 | Apmap | Rat | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of APMAP mRNA | CTD | PMID:24136188 | Apmap | Rat | indometacin | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | Apmap | Rat | iodide salt | decreases expression | EXP | | 6480464 | Iodides deficiency results in decreased expression of APMAP protein | CTD | PMID:26795019 | Apmap | Rat | ivermectin | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of APMAP protein | CTD | PMID:32959892 | Apmap | Rat | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of APMAP mRNA | CTD | PMID:20080153 | Apmap | Rat | methapyrilene | increases methylation | ISO | APMAP (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of APMAP exon | CTD | PMID:30157460 | Apmap | Rat | methidathion | decreases expression | ISO | Apmap (Mus musculus) | 6480464 | methidathion results in decreased expression of APMAP mRNA | CTD | PMID:34813904 | Apmap | Rat | monosodium L-glutamate | multiple interactions | ISO | Apmap (Mus musculus) | 6480464 | [Trans Fatty Acids co-treated with Sodium Glutamate] results in increased expression of APMAP mRNA | CTD | PMID:22078008 | Apmap | Rat | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of APMAP mRNA | CTD | PMID:24136188 | Apmap | Rat | nickel sulfate | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of APMAP mRNA | CTD | PMID:22714537 | Apmap | Rat | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of APMAP mRNA | CTD | PMID:24136188 | Apmap | Rat | Nutlin-3 | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of APMAP protein | CTD | PMID:38460933 | Apmap | Rat | O-methyleugenol | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of APMAP mRNA | CTD | PMID:32234424 | Apmap | Rat | okadaic acid | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of APMAP mRNA | CTD | PMID:38832940 | Apmap | Rat | paracetamol | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of APMAP mRNA | CTD | PMID:22230336 | Apmap | Rat | paracetamol | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of APMAP mRNA | CTD | PMID:29067470 | Apmap | Rat | perfluorohexanesulfonic acid | increases expression | ISO | Apmap (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of APMAP mRNA | CTD | PMID:37995155 | Apmap | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of APMAP mRNA | CTD | PMID:35163327 | Apmap | Rat | SB 431542 | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of APMAP protein | CTD | PMID:25670856 | Apmap | Rat | SB 431542 | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of APMAP more ... | CTD | PMID:37664457 | Apmap | Rat | simvastatin | decreases expression | EXP | | 6480464 | Simvastatin results in decreased expression of APMAP protein | CTD | PMID:20217863 | Apmap | Rat | sodium arsenite | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of APMAP mRNA | CTD | PMID:22714537 | Apmap | Rat | sodium chloride | multiple interactions | ISO | APMAP (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in increased expression of and affects the more ... | CTD | PMID:38598786 | Apmap | Rat | temozolomide | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | Temozolomide results in increased expression of APMAP mRNA | CTD | PMID:31758290 | Apmap | Rat | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of APMAP mRNA | CTD | PMID:26496021 | Apmap | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of APMAP mRNA] | CTD | PMID:31150632 | Apmap | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of APMAP mRNA | CTD | PMID:31150632 | Apmap | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of APMAP mRNA | CTD | PMID:23411599|PMID:34492290 | Apmap | Rat | thiram | decreases expression | ISO | APMAP (Homo sapiens) | 6480464 | Thiram results in decreased expression of APMAP mRNA | CTD | PMID:38568856 | Apmap | Rat | tolcapone | affects binding | EXP | | 6480464 | tolcapone binds to APMAP protein | CTD | PMID:19783845 | Apmap | Rat | triphenyl phosphate | affects expression | ISO | APMAP (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of APMAP mRNA | CTD | PMID:37042841 | Apmap | Rat | triptonide | increases expression | ISO | Apmap (Mus musculus) | 6480464 | triptonide results in increased expression of APMAP mRNA | CTD | PMID:33045310 | Apmap | Rat | tungsten | increases expression | ISO | Apmap (Mus musculus) | 6480464 | Tungsten results in increased expression of APMAP mRNA | CTD | PMID:30912803 | Apmap | Rat | valdecoxib | decreases expression | EXP | | 6480464 | valdecoxib results in decreased expression of APMAP mRNA | CTD | PMID:24136188 | Apmap | Rat | valproic acid | increases expression | ISO | APMAP (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of APMAP mRNA | CTD | PMID:23179753 | Apmap | Rat | valproic acid | affects expression | ISO | APMAP (Homo sapiens) | 6480464 | Valproic Acid affects the expression of APMAP mRNA | CTD | PMID:25979313 | |