Fus (Fus RNA binding protein) - Rat Genome Database

Name: Fus
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fus (Fus RNA binding protein) Rattus norvegicus

Analyze

Symbol:

Fus

Name:

Fus RNA binding protein

RGD ID:

1308864

Description:

Enables ionotropic glutamate receptor binding activity; myosin V binding activity; and nuclear receptor binding activity. Involved in cellular response to calcium ion. Located in dendritic spine head; perikaryon; and perinuclear region of cytoplasm. Part of polysome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

16) in malignant liposarcoma); 16) malignant liposarcoma; fused in sarcoma; fusion (involved in t(12; fusion (involved in t(12,16) in malignant liposarcoma); fusion (involved in t(12,16) in malignant liposarcoma) (human); fusion, derived from t(12; fusion, derived from t(12,16) malignant liposarcoma; fusion, derived from t(12,16) malignant liposarcoma (human); fusion, derived from t(12;16) malignant liposarcoma; LOC317385; RNA-binding protein FUS

RGD Orthologs

Human

Mouse

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FUS (FUS RNA binding protein)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Fus (fused in sarcoma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FUS (FUS RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FUS (FUS RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fus (FUS RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FUS (FUS RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FUS (FUS RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fus (FUS RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FUS (FUS RNA binding protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fus (fused in sarcoma)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fus (FUS RNA binding protein)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	caz	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fust-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Fus^em1Ionsz

Genetic Models:

SD-Fus^em1Ionsz

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	182,576,479 - 182,590,417 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	182,576,545 - 182,590,414 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,927,082 - 190,940,953 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	198,113,173 - 198,127,044 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	190,783,656 - 190,797,528 (+)	NCBI	Rnor_WKY
Rnor_6.0	1	199,412,805 - 199,426,705 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	199,412,834 - 199,426,702 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	206,435,510 - 206,449,423 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	187,250,871 - 187,264,742 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	187,400,751 - 187,414,620 (+)	NCBI
Celera	1	180,227,600 - 180,241,475 (+)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

amyotrophic lateral sclerosis type 1 (ISO)

amyotrophic lateral sclerosis type 6 (ISO)

branched-chain keto acid dehydrogenase kinase deficiency (ISO)

dystonia (ISO)

essential tremor 4 (ISO)

frontotemporal dementia (ISO)

Frontotemporal Lobar Degeneration (ISO)

genetic disease (ISO)

Juvenile Amyotrophic Lateral Sclerosis (ISO)

liposarcoma (ISO)

myxoid liposarcoma (ISO)

neurodegenerative disease (ISO)

sarcoma (ISO)

spinal muscular atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(Z)-3-butylidenephthalide (ISO)

1,2-dimethylhydrazine (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17alpha-ethynylestradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

4-vinylcyclohexene dioxide (ISO)

7,12-dimethyltetraphene (EXP,ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

buspirone (EXP)

buta-1,3-diene (ISO)

Butylparaben (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

cerium trichloride (ISO)

chlordecone (ISO)

chloroprene (ISO)

chlorpyrifos (EXP)

choline (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

coumarin (ISO)

curcumin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

entinostat (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

Ethylenethiourea (EXP)

ferric oxide (ISO)

folic acid (ISO)

formaldehyde (ISO)

glafenine (EXP)

isoprenaline (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

methotrexate (ISO)

methoxychlor (ISO)

methylparaben (ISO)

naphthalene (ISO)

nefazodone (EXP)

nickel sulfate (ISO)

nonanoic acid (ISO)

ozone (EXP,ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rotenone (EXP)

SB 431542 (ISO)

selenic acid (ISO)

selenium atom (ISO)

selenomethionine (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

succimer (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid fibril formation (ISO)

cellular response to calcium ion (IDA)

DNA-templated transcription (IEA)

gene expression (ISO)

mRNA stabilization (ISO)

positive regulation of DNA-templated transcription (IEA)

positive regulation of double-strand break repair via homologous recombination (ISO)

protein homooligomerization (ISO)

regulation of DNA-templated transcription (ISO)

regulation of RNA splicing (ISO)

regulation of transcription by RNA polymerase II (ISO)

RNA splicing (ISO)

Cellular Component

cytoplasm (IDA)

cytoplasm (ISO)

dendrite (IDA)

dendritic spine (IDA)

dendritic spine head (IDA)

intracellular non-membrane-bounded organelle (ISO)

neuronal cell body (IDA)

nucleoplasm (ISO)

nucleus (IBA,ISO)

nucleus (ISO)

perikaryon (IDA)

perinuclear region of cytoplasm (IDA)

polysome (IDA)

Molecular Function

chromatin binding (ISO)

identical protein binding (ISO)

ionotropic glutamate receptor binding (IPI)

metal ion binding (IEA)

molecular condensate scaffold activity (ISO)

mRNA 3'-UTR binding (ISO)

myosin V binding (IPI)

nuclear estrogen receptor binding (IDA)

nuclear retinoid X receptor binding (IPI)

nuclear thyroid hormone receptor binding (IDA)

protein binding (ISO)

RNA binding (IBA,ISO)

transcription coactivator activity (ISO)

transcription coregulator activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads.	Belly A, etal., Neurosci Lett. 2005 May 13;379(3):152-7. Epub 2005 Jan 25.
2.	Transportin1: a marker of FTLD-FUS.	Brelstaff J, etal., Acta Neuropathol. 2011 Nov;122(5):591-600. Epub 2011 Aug 17.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.	Huang C, etal., PLoS Genet. 2011 Mar;7(3):e1002011. doi: 10.1371/journal.pgen.1002011. Epub 2011 Mar 3.
6.	Specificity of fusion genes in adipocytic tumors.	Kubo T, etal., Anticancer Res. 2010 Feb;30(2):661-4.
7.	Low-grade fibromyxoid sarcoma of the small intestine: report of 4 cases with molecular cytogenetic confirmation.	Laurini JA, etal., Am J Surg Pathol. 2011 Jul;35(7):1069-73.
8.	Low-grade fibromyxoid sarcoma of the perineum with heterotopic ossification: case report and review of the literature.	Lee AF, etal., Hum Pathol. 2011 Nov;42(11):1770-5. Epub 2011 Jun 11.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors.	Powers CA, etal., Mol Endocrinol. 1998 Jan;12(1):4-18.
12.	GOA pipeline	RGD automated data pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Comprehensive gene review and curation	RGD comprehensive gene curation
16.	Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration.	Rohrer JD, etal., Brain. 2011 Sep;134(Pt 9):2565-81.
17.	TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5.	Selamat W, etal., Neurosci Lett. 2009 Jan 30;450(2):163-6. doi: 10.1016/j.neulet.2008.12.014. Epub 2008 Dec 16.
18.	FUS mutations in sporadic amyotrophic lateral sclerosis: Clinical and genetic analysis.	Sproviero W, etal., Neurobiol Aging. 2011 Nov 3.
19.	Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.	Vance C, etal., Science. 2009 Feb 27;323(5918):1208-11. doi: 10.1126/science.1165942.

Additional References at PubMed

PMID:10567410	PMID:12477932	PMID:12950080	PMID:16365397	PMID:18509338	PMID:20616880	PMID:21909421	PMID:22658674	PMID:22681889	PMID:22710833	PMID:23975937	PMID:25453086
PMID:26124092	PMID:27378374	PMID:27731383	PMID:29610493	PMID:30273830	PMID:31220774	PMID:34193962	PMID:35659652

Genomics

Comparative Map Data

Fus
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	182,576,479 - 182,590,417 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	182,576,545 - 182,590,414 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,927,082 - 190,940,953 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	198,113,173 - 198,127,044 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	190,783,656 - 190,797,528 (+)	NCBI	Rnor_WKY
Rnor_6.0	1	199,412,805 - 199,426,705 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	199,412,834 - 199,426,702 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	206,435,510 - 206,449,423 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	187,250,871 - 187,264,742 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	187,400,751 - 187,414,620 (+)	NCBI
Celera	1	180,227,600 - 180,241,475 (+)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

FUS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	31,180,110 - 31,194,871 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	31,180,138 - 31,191,605 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	31,191,431 - 31,206,192 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	31,098,954 - 31,110,601 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	31,098,953 - 31,110,598	NCBI
Celera	16	29,091,832 - 29,106,593 (-)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	28,753,052 - 28,767,812 (+)	NCBI		HuRef
CHM1_1	16	32,509,148 - 32,523,909 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	31,567,541 - 31,582,292 (+)	NCBI		T2T-CHM13v2.0

Fus
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	127,565,276 - 127,581,204 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	127,566,629 - 127,584,873 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,966,789 - 127,982,032 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,967,457 - 127,985,701 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	135,110,993 - 135,125,546 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	127,758,702 - 127,773,179 (+)	NCBI		MGSCv36	mm8
Celera	7	127,802,588 - 127,817,000 (+)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI

FUS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	31,551,035 - 31,562,494 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	31,551,135 - 31,562,327 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	16	23,775,389 - 23,786,881 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

FUS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	17,059,904 - 17,071,227 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	17,060,061 - 17,071,178 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	18,635,210 - 18,646,537 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	17,190,782 - 17,202,115 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	17,190,642 - 17,202,069 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	16,990,989 - 17,002,315 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	16,910,098 - 16,921,413 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	17,222,097 - 17,233,413 (-)	NCBI		UU_Cfam_GSD_1.0

Fus
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	125,431,822 - 125,442,925 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	13,529,803 - 13,540,764 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936501	13,529,732 - 13,541,102 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FUS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	17,314,332 - 17,326,637 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	17,314,936 - 17,326,663 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	17,545,614 - 17,557,346 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FUS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,870,456 - 27,881,563 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	27,870,330 - 27,882,145 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	1,582,582 - 1,594,493 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fus
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624782	14,211,294 - 14,223,698 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fus
27 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	168
Count of miRNA genes:	133
Interacting mature miRNAs:	145
Transcripts:	ENSRNOT00000031891
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642722	214537671	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383635	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
2312558	Glom17	Glomerulus QTL 17	3.9	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	166532971	191278129	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169112897	197261052	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	169112897	197261052	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	174133260	196383635	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
2325725	Eae31	Experimental allergic encephalomyelitis QTL 31			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	178810256	188377506	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
61378	Bp43	Blood pressure QTL 43	22.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	181746937	196383635	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat

Markers in Region

RH130052

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	182,590,207 - 182,590,401 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	199,426,496 - 199,426,689	NCBI	Rnor6.0
Rnor_5.0	1	206,449,214 - 206,449,407	UniSTS	Rnor5.0
RGSC_v3.4	1	187,264,533 - 187,264,726	UniSTS	RGSC3.4
Celera	1	180,241,266 - 180,241,459	UniSTS
Cytogenetic Map	1	q36	UniSTS

RH137118

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	182,587,365 - 182,587,559 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	199,423,654 - 199,423,847	NCBI	Rnor6.0
Rnor_5.0	1	206,446,372 - 206,446,565	UniSTS	Rnor5.0
RGSC_v3.4	1	187,261,691 - 187,261,884	UniSTS	RGSC3.4
Celera	1	180,238,424 - 180,238,617	UniSTS
Cytogenetic Map	1	q36	UniSTS

Genetic Models

This gene Fus is modified in the following models/strains

SD-Fus^em1Ionsz

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	48	33	19	33	1	4	74	34	41	11	1
Low		8	9	8		8	7	7		1			7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000031891 ⟹ ENSRNOP00000033029

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	182,576,545 - 182,590,414 (+)	Ensembl
Rnor_6.0 Ensembl	1	199,412,834 - 199,426,702 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098752 ⟹ ENSRNOP00000094078

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	182,576,545 - 182,590,414 (+)	Ensembl

RefSeq Acc Id:

NM_001012137 ⟹ NP_001012137

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	182,576,545 - 182,590,417 (+)	NCBI
Rnor_6.0	1	199,412,834 - 199,426,705 (+)	NCBI
Rnor_5.0	1	206,435,510 - 206,449,423 (+)	NCBI
RGSC_v3.4	1	187,250,871 - 187,264,742 (+)	RGD
Celera	1	180,227,600 - 180,241,475 (+)	RGD

Sequence:

show sequence

CGCGGCGTCCCTTCGCAGTCGTCTGGAATCCTGTTGCTTGGCGGCCTGTGCGCGCGTGCGCGGA
CATGGCTTCAAACGACTATACCCAACAAGCAACTCAAAGCTATGGGGCCTATCCTACCCAGCCT
GGGCAGGGCTATTCCCAACAGAGCAATCAGCCCTATGGCCAGCAGAGTTACAGTGGTTATGGCC
AATCAGCTGACACTTCAGGATACGGCCAGAGCAGCTATGGTTCTTCTTATGGACAGACCCAAAA
CACAGGCTATGGAACTCAGTCAGCACCCCAGGGATATGGTTCCACTGGTGGCTATGGCAGCAGC
CAAAGTTCCCAGTCTTCTTATGGGCAGCAGTCCTCCTACCCCGGTTATGGCCAACAGCCAGCTC
CTAGTAGCACCTCAGGAAGTTATGGTGGAAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAG
TGGAGGCTATGGTCAACAGTCTGGCTATGGTGGACAGCAACAAAGCTACGGACAGCAACAAAGC
TCCTATAACCCACCTCAGGGTTATGGACAACAGAACCAGTACAACAGCAGCAGTGGAGGTGGTG
GAGGGGGTGGTGGAGGCAACTATGGCCAAGATCAGTCCTCTATGAGTGGCGGCGGCGGTGGTGG
TGGTTATGGCAATCAGGACCAGAGTGGTGGCGGCGGTGGTGGCTACGGGGGAGGCCAGCAGGAT
CGTGGGGGCCGTGGCAGGGGCGGTGGAGGTGGTTACAACCGAAGCAGTGGTGGCTATGAACCCA
GAGGCCGTGGAGGTGGCCGAGGAGGCAGAGGCGGCATGGGCGGAAGTGACCGTGGTGGCTTCAA
TAAATTTGGTGGTCCTCGGGATCAAGGATCTCGTCATGATTCTGAACAGGATAATTCAGACAAT
AATACCATCTTCGTGCAAGGCCTAGGCGAGAATGTTACAATTGAATCTGTGGCGGATTACTTCA
AGCAGATTGGAATTATTAAGACAAACAAGAAAACTGGACAGCCTATGATTAATTTGTATACAGA
CAGAGAAACTGGCAAGTTGAAGGGTGAGGCAACAGTCTCATTTGATGACCCACCTTCTGCTAAA
GCTGCAATCGACTGGTTTGATGGAAAAGAATTCTCTGGGAATCCTATTAAAGTTTCATTTGCTA
CCCGGCGTGCTGACTTCAACCGGGGTGGTGGAAATGGTCGTGGAGGCCGAGGGCGAGGAGGACC
CATGGGCCGTGGAGGCTATGGAGGAGGTGGCAGCGGTGGTGGTGGCCGGGGAGGATTTCCCAGT
GGAGGTGGTGGAGGTGGAGGACAGCAACGAGCTGGGGACTGGAAGTGTCCTAATCCTACATGTG
AGAACATGAACTTCTCTTGGAGAAGTGAATGCAACCAGTGTAAGGCACCTAAGCCAGATGGCCC
AGGAGGGGGACCAGGAGGCTCTCATATGGGGGGAAACTACGGAGATGATCGGCGTGGCAGAGGA
GGATATGATCGGGGCGGCTACCGGGGCCGAGGAGGGGACCGAGGGGGCTTCAGAGGGGGCCGGG
GTGGTGGGGACAGAGGTGGTTTTGGCCCTGGCAAGATGGACTCCAGGGGTGAGCACAGACAGGA
TCGCAGGGAGAGGCCATATTAGCCTGACTCCTGAAGTTCTGGAACAGCTCTTCCTGTACCCAGT
GTTACCCTTGTTATTTTGTAAACTTACAATTCAGGATTGCTCATGGATATTTTTTGGGGGGGTG
GGCAACGGTATGTGTGTGTGTGTGAGTGTGTCAGACTACCGTAATTGTAACCATATCTCTGGTT
CCCATTAAAAACCATTTTAGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006230290 ⟹ XP_006230352

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	182,576,479 - 182,590,417 (+)	NCBI
Rnor_6.0	1	199,412,805 - 199,426,705 (+)	NCBI
Rnor_5.0	1	206,435,510 - 206,449,423 (+)	NCBI

Sequence:

show sequence

GGGCGCGGGAGGCGGGGCTGCTCAGTCCTCGCGGCGTCCCTTCGCAGTCGTCTGGAATCCTGTT
GCTTGGCGGCCTGTGCGCGCGTGCGCGGACATGGCTTCAAACGACTATACCCAACAAGCAACTC
AAAGCTATGGGGCCTATCCTACCCAGCCTGGGCAGGGCTATTCCCAACAGAGCAATCAGCCCTA
TGGCCAGCAGAGTTACAGTGGTTATGGCCAATCAGCTGACACTTCAGGATACGGCCAGAGCAGC
TATGGTTCTTCTTATGGACAGACCCAAAACAGCTATGGAACTCAGTCAGCACCCCAGGGATATG
GTTCCACTGGTGGCTATGGCAGCAGCCAAAGTTCCCAGTCTTCTTATGGGCAGCAGTCCTCCTA
CCCCGGTTATGGCCAACAGCCAGCTCCTAGTAGCACCTCAGGAAGTTATGGTGGAAGTTCTCAG
AGCAGCAGCTATGGGCAGCCCCAGAGTGGAGGCTATGGTCAACAGTCTGGCTATGGTGGACAGC
AACAAAGCTACGGACAGCAACAAAGCTCCTATAACCCACCTCAGGGTTATGGACAACAGAACCA
GTACAACAGCAGCAGTGGAGGTGGTGGAGGGGGTGGTGGAGGCAACTATGGCCAAGATCAGTCC
TCTATGAGTGGCGGCGGCGGTGGTGGTGGTTATGGCAATCAGGACCAGAGTGGTGGCGGCGGTG
GTGGCTACGGGGGAGGCCAGCAGGATCGTGGGGGCCGTGGCAGGGGCGGTGGAGGTGGTTACAA
CCGAAGCAGTGGTGGCTATGAACCCAGAGGCCGTGGAGGTGGCCGAGGAGGCAGAGGCGGCATG
GGCGGAAGTGACCGTGGTGGCTTCAATAAATTTGGTGGTCCTCGGGATCAAGGATCTCGTCATG
ATTCTGAACAGGATAATTCAGACAATAATACCATCTTCGTGCAAGGCCTAGGCGAGAATGTTAC
AATTGAATCTGTGGCGGATTACTTCAAGCAGATTGGAATTATTAAGACAAACAAGAAAACTGGA
CAGCCTATGATTAATTTGTATACAGACAGAGAAACTGGCAAGTTGAAGGGTGAGGCAACAGTCT
CATTTGATGACCCACCTTCTGCTAAAGCTGCAATCGACTGGTTTGATGGAAAAGAATTCTCTGG
GAATCCTATTAAAGTTTCATTTGCTACCCGGCGTGCTGACTTCAACCGGGGTGGTGGAAATGGT
CGTGGAGGCCGAGGGCGAGGAGGACCCATGGGCCGTGGAGGCTATGGAGGAGGTGGCAGCGGTG
GTGGTGGCCGGGGAGGATTTCCCAGTGGAGGTGGTGGAGGTGGAGGACAGCAACGAGCTGGGGA
CTGGAAGTGTCCTAATCCTACATGTGAGAACATGAACTTCTCTTGGAGAAGTGAATGCAACCAG
TGTAAGGCACCTAAGCCAGATGGCCCAGGAGGGGGACCAGGAGGCTCTCATATGGGGGGAAACT
ACGGAGATGATCGGCGTGGCAGAGGAGGATATGATCGGGGCGGCTACCGGGGCCGAGGAGGGGA
CCGAGGGGGCTTCAGAGGGGGCCGGGGTGGTGGGGACAGAGGTGGTTTTGGCCCTGGCAAGATG
GACTCCAGGGGTGAGCACAGACAGGATCGCAGGGAGAGGCCATATTAGCCTGACTCCTGAAGTT
CTGGAACAGCTCTTCCTGTACCCAGTGTTACCCTTGTTATTTTGTAAACTTACAATTCAGGATT
GCTCATGGATATTTTTTGGGGGGGTGGGCAACGGTATGTGTGTGTGTGTGAGTGTGTCAGACTA
CCGTAATTGTAACCATATCTCTGGTTCCCATTAAAAACCATTTTAGTTAAA

hide sequence

RefSeq Acc Id:

XM_039080885 ⟹ XP_038936813

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	182,576,535 - 182,590,417 (+)	NCBI

RefSeq Acc Id:

XM_039080890 ⟹ XP_038936818

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	182,576,553 - 182,590,417 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012137	(Get FASTA)	NCBI Sequence Viewer
	XP_006230352	(Get FASTA)	NCBI Sequence Viewer
	XP_038936813	(Get FASTA)	NCBI Sequence Viewer
	XP_038936818	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87153	(Get FASTA)	NCBI Sequence Viewer
	EDM17204	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012137 ⟸ NM_001012137

- UniProtKB:

Q5PQK2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASNDYTQQATQSYGAYPTQPGQGYSQQSNQPYGQQSYSGYGQSADTSGYGQSSYGSSYGQTQN
TGYGTQSAPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGGSSQSSSYGQPQS
GGYGQQSGYGGQQQSYGQQQSSYNPPQGYGQQNQYNSSSGGGGGGGGGNYGQDQSSMSGGGGGG
GYGNQDQSGGGGGGYGGGQQDRGGRGRGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTD
RETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGP
MGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRSECNQCKAPKPDGP
GGGPGGSHMGGNYGDDRRGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQD
RRERPY

hide sequence

RefSeq Acc Id:

XP_006230352 ⟸ XM_006230290

- Peptide Label:

isoform X1

- Sequence:

show sequence

MASNDYTQQATQSYGAYPTQPGQGYSQQSNQPYGQQSYSGYGQSADTSGYGQSSYGSSYGQTQN
SYGTQSAPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGGSSQSSSYGQPQSG
GYGQQSGYGGQQQSYGQQQSSYNPPQGYGQQNQYNSSSGGGGGGGGGNYGQDQSSMSGGGGGGG
YGNQDQSGGGGGGYGGGQQDRGGRGRGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNK
FGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDR
ETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRSECNQCKAPKPDGPG
GGPGGSHMGGNYGDDRRGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDR
RERPY

hide sequence

RefSeq Acc Id:

ENSRNOP00000033029 ⟸ ENSRNOT00000031891

RefSeq Acc Id:	XP_038936813 ⟸ XM_039080885
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038936818 ⟸ XM_039080890
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000094078 ⟸ ENSRNOT00000098752

Protein Domains

RanBP2-type RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PQK2-F1-model_v2	AlphaFold	Q5PQK2	1-518	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690448

Promoter ID:

EPDNEW_R973

Type:

single initiation site

Name:

Fus_1

Description:

FUS RNA binding protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	199,412,828 - 199,412,888	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308864	AgrOrtholog
BioCyc Gene	G2FUF-57326	BioCyc
Ensembl Genes	ENSRNOG00000023360	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000033029	ENTREZGENE
	ENSRNOP00000033029.4	UniProtKB/TrEMBL
	ENSRNOP00000094078.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000031891	ENTREZGENE
	ENSRNOT00000031891.5	UniProtKB/TrEMBL
	ENSRNOT00000098752.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
	Zinc finger, RanBP2-type	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7132489	IMAGE-MGC_LOAD
InterPro	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RRM_RNP1	UniProtKB/TrEMBL
	TET_fam	UniProtKB/TrEMBL
	Znf_RanBP2	UniProtKB/TrEMBL
	Znf_RanBP2_sf	UniProtKB/TrEMBL
KEGG Report	rno:317385	UniProtKB/TrEMBL
MGC_CLONE	MGC:95219	IMAGE-MGC_LOAD
NCBI Gene	317385	ENTREZGENE
PANTHER	PTHR23238	UniProtKB/TrEMBL
	PTHR23238:SF5	UniProtKB/TrEMBL
Pfam	RRM_1	UniProtKB/TrEMBL
	zf-RanBP	UniProtKB/TrEMBL
PhenoGen	Fus	PhenoGen
PROSITE	RRM	UniProtKB/TrEMBL
	ZF_RANBP2_1	UniProtKB/TrEMBL
	ZF_RANBP2_2	UniProtKB/TrEMBL
SMART	RRM	UniProtKB/TrEMBL
	ZnF_RBZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
	SSF90209	UniProtKB/TrEMBL
UniProt	A0A8I6AN32_RAT	UniProtKB/TrEMBL
	Q5PQK2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-05-06	Fus	Fus RNA binding protein	Fus	FUS RNA binding protein	Name changed	629549	APPROVED
2014-05-21	Fus	fused in sarcoma RNA binding protein	Fus	fused in sarcoma	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-01-17	Fus	fused in sarcoma	Fus	fusion (involved in t(12;16) in malignant liposarcoma) (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-10-22	Fus	fusion (involved in t(12;16) in malignant liposarcoma) (human)	Fus	fusion, derived from t(12;16) malignant liposarcoma (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Fus	fusion, derived from t(12;16) malignant liposarcoma (human)		fusion (involved in t(12;16) in malignant liposarcoma)	Name updated	1299863	APPROVED
2005-12-06	Fus	fusion (involved in t(12;16) in malignant liposarcoma)	Fus_predicted	fusion (involved in t(12;16) in malignant liposarcoma) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Fus_predicted	fusion (involved in t(12;16) in malignant liposarcoma) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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