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Gene: Grhpr (glyoxylate and hydroxypyruvate reductase) Rattus norvegicus

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Symbol:

Grhpr

Name:

glyoxylate and hydroxypyruvate reductase

RGD ID:

1308851

Description:

Enables adenyl nucleotide binding activity; carboxylic acid binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in dicarboxylic acid metabolic process. Predicted to be located in mitochondrion. Predicted to be part of catalytic complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

glyoxylate reductase/hydroxypyruvate reductase; glyoxylate reductase/hydroxypyruvate reductase (predicted); Grhpr_predicted; LOC298085; LOC680021; similar to glyoxylate reductase/hydroxypyruvate reductase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GRHPR (glyoxylate and hydroxypyruvate reductase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Grhpr (glyoxylate reductase/hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Grhpr (glyoxylate and hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GRHPR (glyoxylate and hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GRHPR (glyoxylate and hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Grhpr (glyoxylate and hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GRHPR (glyoxylate and hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GRHPR (glyoxylate and hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Grhpr (glyoxylate and hydroxypyruvate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	OR51B4 (olfactory receptor family 51 subfamily B member 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GRHPR (glyoxylate and hydroxypyruvate reductase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Grhpr (glyoxylate reductase/hydroxypyruvate reductase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grhpra (glyoxylate reductase/hydroxypyruvate reductase a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1236	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GOR1	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31673	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31674	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	grhpr.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	grhpr.2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	grhpr.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	grhpr.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	64,029,856 - 64,039,287 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	64,022,368 - 64,039,276 (+)	Ensembl				GRCr8
mRatBN7.2	5	59,234,179 - 59,243,614 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	59,234,192 - 59,243,603 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	61,208,299 - 61,217,720 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	63,027,813 - 63,037,236 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	62,997,054 - 63,006,475 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	60,528,981 - 60,538,410 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	60,528,997 - 60,538,375 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	65,037,813 - 65,047,242 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	61,536,652 - 61,545,982 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	57,802,736 - 57,812,175 (+)	NCBI		Celera
RGSC_v3.1	5	61,502,910 - 61,546,124 (+)	NCBI
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

COVID-19 (ISO)

distal arthrogryposis type 1A (ISO)

familial hypocalciuric hypercalcemia (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

nephrocalcinosis (ISO)

paraplegia (ISO)

primary ciliary dyskinesia (ISO)

primary hyperoxaluria (ISO)

primary hyperoxaluria type 2 (ISO,ISS)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

clobetasol (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (ISO)

diuron (EXP)

epoxiconazole (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

indometacin (EXP)

isoniazide (ISO)

ivermectin (ISO)

lead(0) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

methidathion (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosomorpholine (EXP)

nitrofen (EXP)

Nutlin-3 (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pirinixic acid (ISO)

SB 431542 (ISO)

sodium arsenite (EXP,ISO)

sulfadimethoxine (EXP)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (EXP)

triphenyl phosphate (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dicarboxylic acid metabolic process (IDA)

glyoxylate metabolic process (IEA,ISO)

Cellular Component

catalytic complex (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IBA)

mitochondrion (ISO)

Molecular Function

carboxylic acid binding (IPI)

glyoxylate reductase (NADPH) activity (IBA,IDA,IEA,ISO)

hydroxypyruvate reductase (NADH) activity (IBA,IDA,IEA,ISO)

hydroxypyruvate reductase [NAD(P)H] activity (IDA,IEA,ISO)

NAD binding (IDA,IEA)

NADP binding (IDA)

NADPH binding (IEA,ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Leigh disease pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.	Cramer SD, etal., Hum Mol Genet. 1999 Oct;8(11):2063-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Coenzyme specificity of mammalian liver D-glycerate dehydrogenase.	Van Schaftingen E, etal., Eur J Biochem. 1989 Dec 8;186(1-2):355-9.

Additional References at PubMed

PMID:10524214	PMID:12477932	PMID:16756993	PMID:17510093	PMID:19056867	PMID:20458337	PMID:23376485	PMID:23533145	PMID:34800366

Genomics

Comparative Map Data

Grhpr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	64,029,856 - 64,039,287 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	64,022,368 - 64,039,276 (+)	Ensembl				GRCr8
mRatBN7.2	5	59,234,179 - 59,243,614 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	59,234,192 - 59,243,603 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	61,208,299 - 61,217,720 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	63,027,813 - 63,037,236 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	62,997,054 - 63,006,475 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	60,528,981 - 60,538,410 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	60,528,997 - 60,538,375 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	65,037,813 - 65,047,242 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	61,536,652 - 61,545,982 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	57,802,736 - 57,812,175 (+)	NCBI		Celera
RGSC_v3.1	5	61,502,910 - 61,546,124 (+)	NCBI
Cytogenetic Map	5	q22	NCBI

GRHPR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	37,422,435 - 37,439,494 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	37,422,666 - 37,436,990 (+)	Ensembl			hg38	GRCh38
GRCh37	9	37,422,693 - 37,436,987 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	37,412,707 - 37,426,986 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	37,412,706 - 37,426,986	NCBI
Celera	9	37,355,941 - 37,370,220 (+)	NCBI		Celera
Cytogenetic Map	9	p13.2	NCBI
HuRef	9	37,374,615 - 37,388,916 (+)	NCBI		HuRef
CHM1_1	9	37,424,404 - 37,438,680 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	37,446,127 - 37,461,475 (+)	NCBI		T2T-CHM13v2.0

Grhpr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	44,981,394 - 44,990,734 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	44,981,395 - 44,990,734 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	44,981,394 - 44,990,734 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	44,981,395 - 44,990,734 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	44,994,283 - 45,003,568 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	45,002,511 - 45,011,796 (+)	NCBI		MGSCv36	mm8
Celera	4	45,001,471 - 45,010,756 (+)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	23.65	NCBI

Grhpr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	29,032,600 - 29,044,257 (-)	Ensembl
ChiLan1.0	NW_004955419	29,032,591 - 29,044,046 (-)	NCBI	ChiLan1.0	ChiLan1.0

GRHPR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	87,155,354 - 87,169,687 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	87,161,295 - 87,175,622 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	37,267,918 - 37,282,253 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	38,192,149 - 38,206,478 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	38,192,149 - 38,206,478 (+)	Ensembl			panPan2	panpan1.1

GRHPR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	53,748,389 - 53,759,692 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	53,748,414 - 53,759,693 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	52,338,611 - 52,350,198 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	54,858,069 - 54,869,657 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	54,858,093 - 54,870,227 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	53,356,298 - 53,367,876 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	53,385,397 - 53,396,943 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	54,081,961 - 54,093,542 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Grhpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	168,661,215 - 168,671,975 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	5,208,492 - 5,219,970 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	5,208,793 - 5,219,555 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRHPR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	238,139,794 - 238,152,382 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	238,139,764 - 238,151,631 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	266,090,894 - 266,101,733 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRHPR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	43,157,323 - 43,171,546 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	43,156,840 - 43,171,532 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	40,225,479 - 40,239,697 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grhpr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624930	1,043,036 - 1,054,216 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624930	1,043,643 - 1,054,216 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Grhpr
27 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	31
Count of miRNA genes:	30
Interacting mature miRNAs:	30
Transcripts:	ENSRNOT00000051445
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	56546393	101546393	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	91	59	6	355	191	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001113754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC158680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000051445 ⟹ ENSRNOP00000046867

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	64,029,880 - 64,039,250 (+)	Ensembl
mRatBN7.2 Ensembl	5	59,234,192 - 59,243,603 (+)	Ensembl
Rnor_6.0 Ensembl	5	60,528,997 - 60,538,373 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092818 ⟹ ENSRNOP00000075967

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	60,529,093 - 60,535,129 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092966

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	60,536,197 - 60,538,375 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093034 ⟹ ENSRNOP00000075980

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	60,529,087 - 60,538,188 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093060

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	60,530,053 - 60,533,017 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132105 ⟹ ENSRNOP00000104635

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	64,022,368 - 64,039,276 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144148 ⟹ ENSRNOP00000100315

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	64,022,535 - 64,039,276 (+)	Ensembl

RefSeq Acc Id:

NM_001113754 ⟹ NP_001107226

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	64,029,856 - 64,039,287 (+)	NCBI
mRatBN7.2	5	59,234,179 - 59,243,614 (+)	NCBI
Rnor_6.0	5	60,528,981 - 60,538,410 (+)	NCBI
Rnor_5.0	5	65,037,813 - 65,047,242 (+)	NCBI
RGSC_v3.4	5	61,536,652 - 61,545,982 (+)	RGD
Celera	5	57,802,736 - 57,812,175 (+)	RGD

Sequence:

show sequence

CACACTTCCGTCGCCTTTTGCTAGGCTAGGTTGGTTAATGTTTGCAGCTGCGGGTCTTGTGAAA
CCCGCGCGACTCATGAAGGTGTTCGTCACTGGCCCTTTGCCGGCCCAGGGCAGGGCTGCGCTCG
CCCAGGCCACAGACTGTGAGGTAGAGCAGTGGAATTCGGATGATCCCATCCCCAGCAAGGATCT
GGAGCAAGGCGTGGCGGGGGCCTATGGCTTGCTCTGCCGCCTCAGTGACCGCGTGGACAAGAAA
CTTCTGGATGCTGCGGGAGCCAACCTCAGAGTCATCAGCACCCTGTCTGTGGGGGTTGACCACT
TGGCTTTAGATGAGATCAAGAAACGCGGGATCCGGGTGGGCTACACGCCAGGTGTCCTGACAGA
CGCCACGGCAGAACTTGCTGTCTCCCTCCTGCTCACCACCTGCCGCCGGTTGCCGGAAGCCATA
GAGGAAGTAAAGAACGGTGGCTGGAGCTCCTGGAGCCCCTTGTGGATGTGCGGTTATGGACTCT
CCGAGAGCACTGTTGGCATTGTGGGGCTGGGGCGCATAGGTCAGGCCATTGCTCGACGACTGAA
ACCATTTGGTGTCCAGAGATTTCTCTACACGGGGCGCCAGCCCAGGCCTCAGGAAGCAGCAGAG
TTTCAGGCAGAGTTTGTGCCTATTGCTCAGCTGGCTGCCGAGTCAGACTTCATTGTAGTGTCCT
GCTCCTTAACACCGGCTACCAGGGGGCTCTGCAACAAGGACTTCTTCCAGAAGATGAAGAACAC
TGCTGTCTTCATCAACATCAGCAGAGGAGATGTGGTAAACCAGGAAGACCTGTACCAGGCATTA
GCCAGTGGTCAGATTGCAGCAGCAGGACTGGATGTGACCACCCCAGAACCACTGCCTCCAAGCC
ACCCCCTGCTGACCCTCAAGAACTGCGTGATCCTGCCCCACATCGGCAGTGCCACCTACAAAAC
TCGCAACACCATGTCCTTGCTGGCGGCTAACAACTTGCTGGCTGGCCTAAGAGGGGAGCCAATG
CCCAGTGAACTCAAGCTGTAGCCAGATGGGCTTTCATGGACTGGAGACATCTCGCTGGACAAAC
CCAAGCTGAAGTCTGGACTGAGGCCAGAGCTTGGGGCATGCCCCCTCTGCTGTGTTCTCAGTGG
ACATGGGAACGGACAGATGGGCTTGCCATATACTTGCCAAAAGCCTGTAATTCTAACATTAAAC
AGTTTCTGACACGGTGTCTAGGTCTATGACTTGGGGCACTAACAAAAAGAG

hide sequence

RefSeq Acc Id:

XM_017593620 ⟹ XP_017449109

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	64,030,018 - 64,039,252 (+)	NCBI
mRatBN7.2	5	59,234,285 - 59,243,579 (+)	NCBI
Rnor_6.0	5	60,529,087 - 60,538,375 (+)	NCBI

Sequence:

show sequence

GCCCAGGGCAGGGCTGCGCTCGCCCAGGCCACAGAGTAAGCGCCCGCGTCGGCGTGGGGTCTGC
AGCTGAGCCCCTGGCACGCTGTCCAGTCCACCCAACCTCAGACACCCCTGCAGCCGCGCTGGGT
AGATCGTGAGTCTCCAGACACACGGCTGGGGCTTCCGGAGCTGTCCCAGGACTGGGGGCTACCT
TCCAAGAGCCGGGCGCCTGGCAGCTGTGAGGTAGAGCAGTGGAATTCGGATGATCCCATCCCCA
GCAAGGATCTGGAGCAAGGCGTGGCGGGGGCCTATGGCTTGCTCTGCCGCCTCAGTGACCGCGT
GGACAAGAAACTTCTGGATGCTGCGGGAGCCAACCTCAGAGTCATCAGCACCCTGTCTGTGGGG
GTTGACCACTTGGCTTTAGATGAGATCAAGAAACGCGGGATCCGGGTGGGCTACACGCCAGGTG
TCCTGACAGACGCCACGGCAGAACTTGCTGTCTCCCTCCTGCTCACCACCTGCCGCCGGTTGCC
GGAAGCCATAGAGGAAGTAAAGAACGGTGGCTGGAGCTCCTGGAGCCCCTTGTGGATGTGCGGT
TATGGACTCTCCGAGAGCACTGTTGGCATTGTGGGGCTGGGGCGCATAGGTCAGGCCATTGCTC
GACGACTGAAACCATTTGGTGTCCAGAGATTTCTCTACACGGGGCGCCAGCCCAGGCCTCAGGA
AGCAGCAGAGTTTCAGGCAGAGTTTGTGCCTATTGCTCAGCTGGCTGCCGAGTCAGACTTCATT
GTAGTGTCCTGCTCCTTAACACCGGCTACCAGGGGGCTCTGCAACAAGGACTTCTTCCAGAAGA
TGAAGAACACTGCTGTCTTCATCAACATCAGCAGAGGAGATGTGGTAAACCAGGAAGACCTGTA
CCAGGCATTAGCCAGTGGTCAGATTGCAGCAGCAGGACTGGATGTGACCACCCCAGAACCACTG
CCTCCAAGCCACCCCCTGCTGACCCTCAAGAACTGCGTGATCCTGCCCCACATCGGCAGTGCCA
CCTACAAAACTCGCAACACCATGTCCTTGCTGGCGGCTAACAACTTGCTGGCTGGCCTAAGAGG
GGAGCCAATGCCCAGTGAACTCAAGCTGTAGCCAGATGGGCTTTCATGGACTGGAGACATCTCG
CTGGACAAACCCAAGCTGAAGTCTGGACTGAGGCCAGAGCTTGGGGCATGCCCCCTCTGCTGTG
TTCTCAGTGGACATGGGAACGGACAGATGGGCTTGCCATATACTTGCCAAAAGCCTGTAATTCT
AACATTAAACAGTTTCTGACACGGTG

hide sequence

RefSeq Acc Id:

XM_017593621 ⟹ XP_017449110

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	64,029,884 - 64,039,252 (+)	NCBI
mRatBN7.2	5	59,234,229 - 59,243,579 (+)	NCBI
Rnor_6.0	5	60,529,008 - 60,538,375 (+)	NCBI

Sequence:

show sequence

AGGTTGGTTAATGTTTGCAGCTGCGGGTCTTGTGAAACCCGCGCGACTCATGAAGGTGTTCGTC
ACTGGCCCTTTGCCGGCCCAGGGCAGGGCTGCGCTCGCCCAGGCCACAGAGTAAGCGCCCGCGT
CGGCGTGGGGTCTGCAGCTGAGCCCCTGGCACGCTGTCCAGTCCACCCAACCTCAGACACCCCT
GCAGCCGCGCTGGGTAGATCCTGTGAGGTAGAGCAGTGGAATTCGGATGATCCCATCCCCAGCA
AGGATCTGGAGCAAGGCGTGGCGGGGGCCTATGGCTTGCTCTGCCGCCTCAGTGACCGCGTGGA
CAAGAAACTTCTGGATGCTGCGGGAGCCAACCTCAGAGTCATCAGCACCCTGTCTGTGGGGGTT
GACCACTTGGCTTTAGATGAGATCAAGAAACGCGGGATCCGGGTGGGCTACACGCCAGGTGTCC
TGACAGACGCCACGGCAGAACTTGCTGTCTCCCTCCTGCTCACCACCTGCCGCCGGTTGCCGGA
AGCCATAGAGGAAGTAAAGAACGGTGGCTGGAGCTCCTGGAGCCCCTTGTGGATGTGCGGTTAT
GGACTCTCCGAGAGCACTGTTGGCATTGTGGGGCTGGGGCGCATAGGTCAGGCCATTGCTCGAC
GACTGAAACCATTTGGTGTCCAGAGATTTCTCTACACGGGGCGCCAGCCCAGGCCTCAGGAAGC
AGCAGAGTTTCAGGCAGAGTTTGTGCCTATTGCTCAGCTGGCTGCCGAGTCAGACTTCATTGTA
GTGTCCTGCTCCTTAACACCGGCTACCAGGGGGCTCTGCAACAAGGACTTCTTCCAGAAGATGA
AGAACACTGCTGTCTTCATCAACATCAGCAGAGGAGATGTGGTAAACCAGGAAGACCTGTACCA
GGCATTAGCCAGTGGTCAGATTGCAGCAGCAGGACTGGATGTGACCACCCCAGAACCACTGCCT
CCAAGCCACCCCCTGCTGACCCTCAAGAACTGCGTGATCCTGCCCCACATCGGCAGTGCCACCT
ACAAAACTCGCAACACCATGTCCTTGCTGGCGGCTAACAACTTGCTGGCTGGCCTAAGAGGGGA
GCCAATGCCCAGTGAACTCAAGCTGTAGCCAGATGGGCTTTCATGGACTGGAGACATCTCGCTG
GACAAACCCAAGCTGAAGTCTGGACTGAGGCCAGAGCTTGGGGCATGCCCCCTCTGCTGTGTTC
TCAGTGGACATGGGAACGGACAGATGGGCTTGCCATATACTTGCCAAAAGCCTGTAATTCTAAC
ATTAAACAGTTTCTGACACGGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001107226	(Get FASTA)	NCBI Sequence Viewer
	XP_017449109	(Get FASTA)	NCBI Sequence Viewer
	XP_017449110	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58681	(Get FASTA)	NCBI Sequence Viewer
	EDL98798	(Get FASTA)	NCBI Sequence Viewer
	EDL98799	(Get FASTA)	NCBI Sequence Viewer
	EDL98800	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000046867
	ENSRNOP00000046867.5

RefSeq Acc Id:

NP_001107226 ⟸ NM_001113754

- UniProtKB:

A0A8J8XIM5 (UniProtKB/TrEMBL), B0BN46 (UniProtKB/TrEMBL), E9PSJ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFAAAGLVKPARLMKVFVTGPLPAQGRAALAQATDCEVEQWNSDDPIPSKDLEQGVAGAYGLLC
RLSDRVDKKLLDAAGANLRVISTLSVGVDHLALDEIKKRGIRVGYTPGVLTDATAELAVSLLLT
TCRRLPEAIEEVKNGGWSSWSPLWMCGYGLSESTVGIVGLGRIGQAIARRLKPFGVQRFLYTGR
QPRPQEAAEFQAEFVPIAQLAAESDFIVVSCSLTPATRGLCNKDFFQKMKNTAVFINISRGDVV
NQEDLYQALASGQIAAAGLDVTTPEPLPPSHPLLTLKNCVILPHIGSATYKTRNTMSLLAANNL
LAGLRGEPMPSELKL

hide sequence

RefSeq Acc Id:	XP_017449110 ⟸ XM_017593621
- Peptide Label:	isoform X1
- Sequence:	show sequence MCGYGLSESTVGIVGLGRIGQAIARRLKPFGVQRFLYTGRQPRPQEAAEFQAEFVPIAQLAAES DFIVVSCSLTPATRGLCNKDFFQKMKNTAVFINISRGDVVNQEDLYQALASGQIAAAGLDVTTP EPLPPSHPLLTLKNCVILPHIGSATYKTRNTMSLLAANNLLAGLRGEPMPSELKL hide sequence

RefSeq Acc Id:	XP_017449109 ⟸ XM_017593620
- Peptide Label:	isoform X1
- Sequence:	show sequence MCGYGLSESTVGIVGLGRIGQAIARRLKPFGVQRFLYTGRQPRPQEAAEFQAEFVPIAQLAAES DFIVVSCSLTPATRGLCNKDFFQKMKNTAVFINISRGDVVNQEDLYQALASGQIAAAGLDVTTP EPLPPSHPLLTLKNCVILPHIGSATYKTRNTMSLLAANNLLAGLRGEPMPSELKL hide sequence

Ensembl Acc Id:

ENSRNOP00000075967 ⟸ ENSRNOT00000092818

Ensembl Acc Id:

ENSRNOP00000046867 ⟸ ENSRNOT00000051445

Ensembl Acc Id:

ENSRNOP00000075980 ⟸ ENSRNOT00000093034

Ensembl Acc Id:

ENSRNOP00000100315 ⟸ ENSRNOT00000144148

Ensembl Acc Id:

ENSRNOP00000104635 ⟸ ENSRNOT00000132105

Protein Domains

D-isomer specific 2-hydroxyacid dehydrogenase D-isomer specific 2-hydroxyacid dehydrogenase NAD-

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B0BN46-F1-model_v2	AlphaFold	B0BN46	1-335	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693694

Promoter ID:

EPDNEW_R4219

Type:

initiation region

Name:

Grhpr_1

Description:

glyoxylate and hydroxypyruvate reductase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	60,528,984 - 60,529,044	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308851	AgrOrtholog
BioCyc Gene	G2FUF-41461	BioCyc
Ensembl Genes	ENSRNOG00000012794	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000051445	ENTREZGENE
	ENSRNOT00000051445.7	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8373346	IMAGE-MGC_LOAD
InterPro	D-isomer_2-hydroxyacid_DH	UniProtKB/TrEMBL
	D-isomer_2_OHA_DH_cat_dom	UniProtKB/TrEMBL
	D-isomer_2_OHA_DH_NAD-bd	UniProtKB/TrEMBL
	D-isomer_DH_CS	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:680021	UniProtKB/TrEMBL
MGC_CLONE	MGC:187689	IMAGE-MGC_LOAD
NCBI Gene	Grhpr	ENTREZGENE
PANTHER	2-HYDROXYACID DEHYDROGENASE-RELATED	UniProtKB/TrEMBL
	GLYOXYLATE REDUCTASE/HYDROXYPYRUVATE REDUCTASE	UniProtKB/TrEMBL
Pfam	2-Hacid_dh	UniProtKB/TrEMBL
	2-Hacid_dh_C	UniProtKB/TrEMBL
PhenoGen	Grhpr	PhenoGen
PROSITE	D_2_HYDROXYACID_DH_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012794	RatGTEx
Superfamily-SCOP	Formate/glycerate dehydrogenase catalytic domain-like	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8J8XIM5	ENTREZGENE, UniProtKB/TrEMBL
	B0BN46	ENTREZGENE, UniProtKB/TrEMBL
	E9PSJ6	ENTREZGENE
UniProt Secondary	E9PSJ6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-27	Grhpr	glyoxylate and hydroxypyruvate reductase	Grhpr	glyoxylate reductase/hydroxypyruvate reductase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Grhpr	glyoxylate reductase/hydroxypyruvate reductase	Grhpr_predicted	glyoxylate reductase/hydroxypyruvate reductase (predicted)	'predicted' is removed	2292626	APPROVED
2008-01-09	Grhpr_predicted	glyoxylate reductase/hydroxypyruvate reductase (predicted)	LOC683694	similar to glyoxylate reductase/hydroxypyruvate reductase	Data merged from RGD:1584459	1643240	APPROVED
2007-01-30	Grhpr_predicted	glyoxylate reductase/hydroxypyruvate reductase (predicted)	LOC680021	similar to glyoxylate reductase/hydroxypyruvate reductase	Data merged from RGD:1596866	737654	APPROVED
2006-11-20	LOC680021	similar to glyoxylate reductase/hydroxypyruvate reductase			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC683694	similar to glyoxylate reductase/hydroxypyruvate reductase			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Grhpr_predicted	glyoxylate reductase/hydroxypyruvate reductase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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