Tmeff2 (transmembrane protein with EGF-like and two follistatin-like domains 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tmeff2 (transmembrane protein with EGF-like and two follistatin-like domains 2) Rattus norvegicus
Analyze
Symbol: Tmeff2
Name: transmembrane protein with EGF-like and two follistatin-like domains 2
RGD ID: 1308839
Description: Predicted to be involved in cell differentiation. Predicted to act upstream of or within negative regulation of cell migration; negative regulation of cellular component organization; and wound healing, spreading of cells. Predicted to be located in membrane. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in prostate cancer and urinary bladder cancer. Orthologous to human TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363228; tomoregulin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8957,937,873 - 58,225,372 (-)NCBIGRCr8
GRCr8 Ensembl957,937,873 - 58,225,372 (-)EnsemblGRCr8 Ensembl
mRatBN7.2950,445,947 - 50,733,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl950,436,079 - 50,733,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,992,474 - 59,279,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0964,115,319 - 64,402,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0962,411,281 - 62,698,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0955,379,130 - 55,673,704 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl955,384,100 - 55,673,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0955,079,810 - 55,369,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4947,519,306 - 47,811,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera948,081,045 - 48,369,704 (-)NCBICelera
RGSC_v3.1947,522,306 - 47,812,884 (-)NCBI
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
carbon nanotube  (ISO)
chrysene  (ISO)
clotrimazole  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fragrance  (ISO)
furan  (EXP)
indometacin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (ISO)
paracetamol  (EXP)
parathion  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
Rutecarpine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer. Afar DE, etal., Mol Cancer Ther. 2004 Aug;3(8):921-32.
2. Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Chen Q, etal., Cancer Lett. 2006 Dec 8;244(2):274-88. Epub 2006 Feb 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. Suzuki M, etal., Br J Cancer. 2005 Oct 31;93(9):1029-37.
8. Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer. Suzuki M, etal., Cancer Lett. 2006 Oct 28;242(2):222-30. Epub 2006 Feb 3.
Additional References at PubMed
PMID:21814219   PMID:24632071   PMID:25931508  


Genomics

Comparative Map Data
Tmeff2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8957,937,873 - 58,225,372 (-)NCBIGRCr8
GRCr8 Ensembl957,937,873 - 58,225,372 (-)EnsemblGRCr8 Ensembl
mRatBN7.2950,445,947 - 50,733,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl950,436,079 - 50,733,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx958,992,474 - 59,279,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0964,115,319 - 64,402,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0962,411,281 - 62,698,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0955,379,130 - 55,673,704 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl955,384,100 - 55,673,829 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0955,079,810 - 55,369,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4947,519,306 - 47,811,472 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera948,081,045 - 48,369,704 (-)NCBICelera
RGSC_v3.1947,522,306 - 47,812,884 (-)NCBI
Cytogenetic Map9q22NCBI
TMEFF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382191,949,046 - 192,194,933 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2191,949,043 - 192,194,933 (-)EnsemblGRCh38hg38GRCh38
GRCh372192,813,772 - 193,059,659 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362192,522,988 - 192,767,889 (-)NCBINCBI36Build 36hg18NCBI36
Build 342192,640,254 - 192,885,150NCBI
Celera2186,409,789 - 186,655,054 (-)NCBICelera
Cytogenetic Map2q32.3NCBI
HuRef2184,672,895 - 184,920,068 (-)NCBIHuRef
CHM1_12192,820,711 - 193,065,780 (-)NCBICHM1_1
T2T-CHM13v2.02192,437,261 - 192,683,624 (-)NCBIT2T-CHM13v2.0
Tmeff2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39150,951,946 - 51,226,429 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl150,939,806 - 51,226,429 (+)EnsemblGRCm39 Ensembl
GRCm38150,900,683 - 51,187,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl150,900,647 - 51,187,270 (+)EnsemblGRCm38mm10GRCm38
MGSCv37150,984,367 - 51,244,114 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36150,872,068 - 51,131,815 (+)NCBIMGSCv36mm8
Celera151,227,901 - 51,485,691 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map125.95NCBI
Tmeff2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554037,121,834 - 7,354,908 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554037,122,019 - 7,353,769 (+)NCBIChiLan1.0ChiLan1.0
TMEFF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21394,623,048 - 94,863,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B94,638,032 - 94,878,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B79,242,825 - 79,489,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B197,157,426 - 197,397,439 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B197,158,689 - 197,396,254 (-)Ensemblpanpan1.1panPan2
TMEFF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1372,414,208 - 2,635,283 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl372,414,440 - 2,635,431 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha373,361,937 - 3,582,835 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0372,303,017 - 2,524,548 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl372,303,191 - 2,524,547 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1372,312,184 - 2,533,428 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0372,279,821 - 2,500,794 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0372,292,309 - 2,514,442 (-)NCBIUU_Cfam_GSD_1.0
Tmeff2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303150,461,820 - 150,724,361 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365066,114,108 - 6,355,200 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365066,113,521 - 6,375,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEFF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1596,594,970 - 96,855,743 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11596,594,901 - 96,856,848 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215108,167,977 - 108,396,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEFF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11077,491,041 - 77,735,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1077,490,095 - 77,735,849 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040121,733,118 - 121,975,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmeff2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248544,021,094 - 4,250,812 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248544,021,022 - 4,249,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmeff2
1677 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:179
Interacting mature miRNAs:223
Transcripts:ENSRNOT00000066231
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
D9Mco73  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2950,687,152 - 50,687,400 (+)MAPPERmRatBN7.2
Rnor_6.0955,627,251 - 55,627,498NCBIRnor6.0
Rnor_5.0955,322,961 - 55,323,208UniSTSRnor5.0
RGSC_v3.4947,764,110 - 47,764,357UniSTSRGSC3.4
Celera948,323,418 - 48,323,665UniSTS
Cytogenetic Map9q22UniSTS
BF415825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2950,570,231 - 50,570,373 (+)MAPPERmRatBN7.2
Rnor_6.0955,510,279 - 55,510,420NCBIRnor6.0
Rnor_5.0955,205,989 - 55,206,130UniSTSRnor5.0
RGSC_v3.4947,647,197 - 47,647,338UniSTSRGSC3.4
Celera948,206,626 - 48,206,767UniSTS
Cytogenetic Map9q22UniSTS
RH142566  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2950,663,949 - 50,664,123 (+)MAPPERmRatBN7.2
Rnor_6.0955,603,998 - 55,604,171NCBIRnor6.0
Rnor_5.0955,299,708 - 55,299,881UniSTSRnor5.0
RGSC_v3.4947,740,907 - 47,741,080UniSTSRGSC3.4
Celera948,300,211 - 48,300,384UniSTS
Cytogenetic Map9q22UniSTS
AU047406  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8958,184,438 - 58,184,602 (+)Marker Load Pipeline
mRatBN7.2950,692,531 - 50,692,695 (+)MAPPERmRatBN7.2
Rnor_6.0955,632,630 - 55,632,793NCBIRnor6.0
Rnor_5.0955,328,340 - 55,328,503UniSTSRnor5.0
RGSC_v3.4947,769,489 - 47,769,652UniSTSRGSC3.4
Celera948,328,797 - 48,328,966UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 74 73 42 23 42 6 196 95 11 93 42 60 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000066231   ⟹   ENSRNOP00000063711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl957,937,873 - 58,225,372 (-)Ensembl
mRatBN7.2 Ensembl950,445,550 - 50,733,475 (-)Ensembl
Rnor_6.0 Ensembl955,384,100 - 55,673,704 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081677   ⟹   ENSRNOP00000071191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl950,447,145 - 50,733,291 (-)Ensembl
Rnor_6.0 Ensembl955,385,695 - 55,673,829 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099269   ⟹   ENSRNOP00000087425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl958,173,565 - 58,225,372 (-)Ensembl
mRatBN7.2 Ensembl950,436,079 - 50,733,459 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118919   ⟹   ENSRNOP00000088921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl957,937,873 - 58,225,372 (-)Ensembl
mRatBN7.2 Ensembl950,446,146 - 50,733,465 (-)Ensembl
RefSeq Acc Id: NM_001394330   ⟹   NP_001381259
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8957,937,873 - 58,225,372 (-)NCBI
mRatBN7.2950,445,947 - 50,733,473 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001381259 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99080 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063711.1
  ENSRNOP00000071191.2
  ENSRNOP00000087425.1
  ENSRNOP00000088921
  ENSRNOP00000088921.1
Ensembl Acc Id: ENSRNOP00000071191   ⟸   ENSRNOT00000081677
Ensembl Acc Id: ENSRNOP00000063711   ⟸   ENSRNOT00000066231
Ensembl Acc Id: ENSRNOP00000087425   ⟸   ENSRNOT00000099269
Ensembl Acc Id: ENSRNOP00000088921   ⟸   ENSRNOT00000118919
RefSeq Acc Id: NP_001381259   ⟸   NM_001394330
- UniProtKB: A0A0G2JZU6 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZU6-F1-model_v2 AlphaFold A0A0G2JZU6 1-374 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696663
Promoter ID:EPDNEW_R7187
Type:single initiation site
Name:Tmeff2_1
Description:transmembrane protein with EGF-like and two follistatin-likedomains 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0955,673,685 - 55,673,745EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308839 AgrOrtholog
BioCyc Gene G2FUF-27590 BioCyc
Ensembl Genes ENSRNOG00000016623 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066231.3 UniProtKB/TrEMBL
  ENSRNOT00000081677.2 UniProtKB/TrEMBL
  ENSRNOT00000099269.1 UniProtKB/TrEMBL
  ENSRNOT00000118919 ENTREZGENE
  ENSRNOT00000118919.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  Prot_inh_Kazal UniProtKB/TrEMBL
NCBI Gene 363228 ENTREZGENE
PANTHER REGULATORY PROTEIN ZESTE UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN WITH EGF LIKE AND TWO FOLLISTATIN LIKE DOMAINS 2 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam Kazal_2 UniProtKB/TrEMBL
PhenoGen Tmeff2 PhenoGen
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016623 RatGTEx
SMART KAZAL UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF100895 UniProtKB/TrEMBL
UniProt A0A0G2JZU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5U1_RAT UniProtKB/TrEMBL
  A0A8I6GGQ4_RAT UniProtKB/TrEMBL
  D3ZRB9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tmeff2  transmembrane protein with EGF-like and two follistatin-like domains 2   Tmeff2_predicted  transmembrane protein with EGF-like and two follistatin-like domains 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tmeff2_predicted  transmembrane protein with EGF-like and two follistatin-like domains 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED