Numa1 (nuclear mitotic apparatus protein 1) - Rat Genome Database

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Gene: Numa1 (nuclear mitotic apparatus protein 1) Rattus norvegicus
Analyze
Symbol: Numa1
Name: nuclear mitotic apparatus protein 1
RGD ID: 1308777
Description: Enables microtubule binding activity. Involved in meiotic cell cycle. Located in several cellular components, including neuronal cell body; nuclear matrix; and spindle. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3'-diindolylmethane; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,709,893 - 165,784,848 (+)NCBIGRCr8
GRCr8 Ensembl1165,709,905 - 165,784,848 (+)EnsemblGRCr8 Ensembl
mRatBN7.21156,297,907 - 156,372,855 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,310,748 - 164,357,511 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,490,844 - 171,537,603 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,367,923 - 164,414,758 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,044,544 - 167,091,453 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,051,209 - 167,091,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,235,586 - 173,280,299 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,419,804 - 159,470,987 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1154,399,899 - 154,445,842 (+)NCBICelera
RGSC_v3.11159,498,820 - 159,550,004 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
lupeol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold. Barboro P, etal., Exp Cell Res. 2002 Oct 1;279(2):202-18.
2. The nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron. Ferhat L, etal., J Neurocytol. 1998 Dec;27(12):887-99.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. NuMA in rat testis--evidence for roles in proliferative activity and meiotic cell division. Taimen P, etal., Exp Cell Res. 2004 Aug 15;298(2):512-20.
Additional References at PubMed
PMID:1541636   PMID:7962183   PMID:10811826   PMID:11092755   PMID:11590136   PMID:11781568   PMID:11956313   PMID:12445386   PMID:12477932   PMID:14718566   PMID:16076287   PMID:17172455  
PMID:18331714   PMID:18570454   PMID:20109190   PMID:21816348   PMID:22074847   PMID:22082260   PMID:22327364   PMID:23027904   PMID:23783028   PMID:23870127   PMID:23921553   PMID:24371089  
PMID:24625528   PMID:24996901   PMID:25657325   PMID:26195665   PMID:26562023   PMID:26765568   PMID:26766442   PMID:27462074   PMID:31505169  


Genomics

Comparative Map Data
Numa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,709,893 - 165,784,848 (+)NCBIGRCr8
GRCr8 Ensembl1165,709,905 - 165,784,848 (+)EnsemblGRCr8 Ensembl
mRatBN7.21156,297,907 - 156,372,855 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,310,748 - 164,357,511 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,490,844 - 171,537,603 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,367,923 - 164,414,758 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,044,544 - 167,091,453 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,051,209 - 167,091,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,235,586 - 173,280,299 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,419,804 - 159,470,987 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1154,399,899 - 154,445,842 (+)NCBICelera
RGSC_v3.11159,498,820 - 159,550,004 (+)NCBI
Cytogenetic Map1q32NCBI
NUMA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,002,864 - 72,080,542 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,002,864 - 72,080,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371171,713,910 - 71,791,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,391,559 - 71,469,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 341171,391,566 - 71,469,209NCBI
Celera1169,015,884 - 69,093,534 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,007,666 - 68,085,181 (-)NCBIHuRef
CHM1_11171,597,790 - 71,675,396 (-)NCBICHM1_1
T2T-CHM13v2.01171,929,780 - 72,007,446 (-)NCBIT2T-CHM13v2.0
Numa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,583,169 - 101,664,166 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,583,318 - 101,664,171 (+)EnsemblGRCm39 Ensembl
GRCm387101,933,977 - 102,014,959 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,934,111 - 102,014,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,118,357 - 109,163,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,843,664 - 101,888,780 (+)NCBIMGSCv36mm8
Celera7102,345,277 - 102,389,657 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.7NCBI
Numa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,252,191 - 19,327,504 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,252,191 - 19,327,504 (+)NCBIChiLan1.0ChiLan1.0
NUMA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2972,952,851 - 73,030,204 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11173,995,189 - 74,072,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,083,378 - 67,160,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11170,307,847 - 70,384,425 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,307,847 - 70,384,425 (-)Ensemblpanpan1.1panPan2
NUMA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,000,579 - 26,076,281 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,037,095 - 26,075,549 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,807,053 - 25,845,823 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,209,480 - 26,285,035 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,246,198 - 26,285,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,037,623 - 26,076,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,216,869 - 26,292,447 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,118,493 - 26,194,367 (+)NCBIUU_Cfam_GSD_1.0
Numa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,759,062 - 59,838,501 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,359,285 - 1,438,382 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,358,598 - 1,438,041 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUMA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,591,945 - 6,662,085 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,591,943 - 6,662,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,353,400 - 7,424,395 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUMA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,204,968 - 63,284,673 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,202,913 - 63,273,774 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604362,614,605 - 62,694,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Numa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,924,827 - 4,963,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248174,896,066 - 4,963,440 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Numa1
454 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:163
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000000474, ENSRNOT00000055249
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1165278545168003898Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Got153  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,323,989 - 156,324,231 (+)MAPPERmRatBN7.2
Rnor_6.01167,042,277 - 167,042,516NCBIRnor6.0
Rnor_5.01173,233,319 - 173,233,558UniSTSRnor5.0
RGSC_v3.41159,416,889 - 159,417,127RGDRGSC3.4
RGSC_v3.41159,416,888 - 159,417,127UniSTSRGSC3.4
Celera1154,397,632 - 154,397,871UniSTS
RGSC_v3.11159,495,906 - 159,496,144RGD
RH 3.4 Map11275.4RGD
RH 3.4 Map11275.4UniSTS
Cytogenetic Map1q32UniSTS
BF394104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,361,028 - 156,361,274 (+)MAPPERmRatBN7.2
Rnor_6.01167,079,626 - 167,079,872NCBIRnor6.0
Rnor_5.01173,268,507 - 173,268,718NCBIRnor5.0
RGSC_v3.41159,459,685 - 159,459,930UniSTSRGSC3.4
Celera1154,433,972 - 154,434,217UniSTS
RH 3.4 Map11274.39UniSTS
Cytogenetic Map1q32UniSTS
D1Bda33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,371,888 - 156,372,124 (+)MAPPERmRatBN7.2
Rnor_6.01167,090,487 - 167,090,722NCBIRnor6.0
Rnor_5.01173,279,333 - 173,279,568UniSTSRnor5.0
RGSC_v3.41159,470,655 - 159,470,890UniSTSRGSC3.4
Celera1154,444,876 - 154,445,111UniSTS
Cytogenetic Map1q32UniSTS
AW535302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,365,780 - 156,365,955 (+)MAPPERmRatBN7.2
Rnor_6.01167,084,379 - 167,084,553NCBIRnor6.0
Rnor_5.01173,273,225 - 173,273,399UniSTSRnor5.0
RGSC_v3.41159,464,547 - 159,464,721UniSTSRGSC3.4
Celera1154,438,768 - 154,438,942UniSTS
RH 3.4 Map11277.4UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 24 93 45 60 31 49 49

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC098753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000474   ⟹   ENSRNOP00000000474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,709,905 - 165,784,186 (+)Ensembl
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)Ensembl
Rnor_6.0 Ensembl1167,066,516 - 167,090,296 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000055249   ⟹   ENSRNOP00000052124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,752,309 - 165,783,084 (+)Ensembl
mRatBN7.2 Ensembl1156,340,316 - 156,372,855 (+)Ensembl
Rnor_6.0 Ensembl1167,051,209 - 167,091,453 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094333   ⟹   ENSRNOP00000094619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,738,252 - 165,784,848 (+)Ensembl
mRatBN7.2 Ensembl1156,326,259 - 156,372,855 (+)Ensembl
RefSeq Acc Id: NM_001100691   ⟹   NP_001094161
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,738,252 - 165,784,848 (+)NCBI
mRatBN7.21156,326,259 - 156,372,855 (+)NCBI
Rnor_6.01167,044,544 - 167,091,453 (+)NCBI
Rnor_5.01173,235,586 - 173,280,299 (+)NCBI
Celera1154,399,899 - 154,445,842 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039113343   ⟹   XP_038969271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,907 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113344   ⟹   XP_038969272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
mRatBN7.21156,326,982 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113345   ⟹   XP_038969273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
mRatBN7.21156,326,537 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113346   ⟹   XP_038969274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
mRatBN7.21156,326,099 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113349   ⟹   XP_038969277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,710,073 - 165,784,187 (+)NCBI
mRatBN7.21156,298,117 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113350   ⟹   XP_038969278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,909 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113354   ⟹   XP_038969282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,907 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_039113357   ⟹   XP_038969285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,924 - 165,784,187 (+)NCBI
mRatBN7.21156,297,909 - 156,372,194 (+)NCBI
RefSeq Acc Id: XM_063262821   ⟹   XP_063118891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,709,893 - 165,784,187 (+)NCBI
RefSeq Acc Id: XM_063262822   ⟹   XP_063118892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
RefSeq Acc Id: XM_063262823   ⟹   XP_063118893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,731,126 - 165,784,187 (+)NCBI
RefSeq Acc Id: NP_001094161   ⟸   NM_001100691
- UniProtKB: A0A8I6AMK5 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052124   ⟸   ENSRNOT00000055249
Ensembl Acc Id: ENSRNOP00000000474   ⟸   ENSRNOT00000000474
RefSeq Acc Id: XP_038969271   ⟸   XM_039113343
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969282   ⟸   XM_039113354
- Peptide Label: isoform X3
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969278   ⟸   XM_039113350
- Peptide Label: isoform X2
- UniProtKB: F1LW91 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969285   ⟸   XM_039113357
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMK5 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969277   ⟸   XM_039113349
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969274   ⟸   XM_039113346
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969273   ⟸   XM_039113345
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969272   ⟸   XM_039113344
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094619   ⟸   ENSRNOT00000094333
RefSeq Acc Id: XP_063118891   ⟸   XM_063262821
- Peptide Label: isoform X1
- UniProtKB: F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118892   ⟸   XM_063262822
- Peptide Label: isoform X2
- UniProtKB: F1LW91 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118893   ⟸   XM_063262823
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMK5 (UniProtKB/TrEMBL),   F7FF45 (UniProtKB/TrEMBL)
Protein Domains
Nuclear mitotic apparatus protein 1 N-terminal hook

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FF45-F1-model_v2 AlphaFold F7FF45 1-2091 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308777 AgrOrtholog
BioCyc Gene G2FUF-58267 BioCyc
Ensembl Genes ENSRNOG00000000417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000474 ENTREZGENE
  ENSRNOT00000000474.7 UniProtKB/TrEMBL
  ENSRNOT00000055249 ENTREZGENE
  ENSRNOT00000055249.3 UniProtKB/TrEMBL
  ENSRNOT00000094333 ENTREZGENE
  ENSRNOT00000094333.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370001 IMAGE-MGC_LOAD
InterPro MT-Golgi_org_protein UniProtKB/TrEMBL
  NuMA_LGNBD UniProtKB/TrEMBL
  NuMA_N_HOOK UniProtKB/TrEMBL
KEGG Report rno:308870 UniProtKB/TrEMBL
MGC_CLONE MGC:112774 IMAGE-MGC_LOAD
NCBI Gene 308870 ENTREZGENE
PANTHER NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED UniProtKB/TrEMBL
  PTHR18902:SF24 UniProtKB/TrEMBL
Pfam HOOK_N_NuMA UniProtKB/TrEMBL
PhenoGen Numa1 PhenoGen
RatGTEx ENSRNOG00000000417 RatGTEx
Superfamily-SCOP Hook domain UniProtKB/TrEMBL
UniProt A0A8I6AMK5 ENTREZGENE, UniProtKB/TrEMBL
  A6I6Z1_RAT UniProtKB/TrEMBL
  A6I6Z3_RAT UniProtKB/TrEMBL
  A6I6Z4_RAT UniProtKB/TrEMBL
  A6I6Z5_RAT UniProtKB/TrEMBL
  F1LW91 ENTREZGENE, UniProtKB/TrEMBL
  F7FF45 ENTREZGENE, UniProtKB/TrEMBL
  Q4G051_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Numa1  nuclear mitotic apparatus protein 1  Numa1_predicted  nuclear mitotic apparatus protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Numa1_predicted  nuclear mitotic apparatus protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED