Ddx23 (DEAD-box helicase 23) - Rat Genome Database

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Gene: Ddx23 (DEAD-box helicase 23) Rattus norvegicus
Analyze
Symbol: Ddx23
Name: DEAD-box helicase 23
RGD ID: 1308685
Description: Predicted to enable mRNA binding activity. Predicted to be involved in R-loop processing and mRNA splicing, via spliceosome. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and catalytic step 2 spliceosome. Orthologous to human DDX23 (DEAD-box helicase 23); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; LOC300208; probable ATP-dependent RNA helicase DDX23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,676,636 - 131,693,917 (-)NCBIGRCr8
mRatBN7.27129,797,620 - 129,814,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,797,614 - 129,814,949 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,604,960 - 131,622,123 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,830,506 - 133,847,669 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,743,008 - 133,760,171 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,325,453 - 140,342,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,325,431 - 140,342,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,828,726 - 114,846,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,394,834 - 137,412,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,471,818 - 137,488,539 (-)NCBI
Celera7126,287,854 - 126,305,095 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing. Chang TH, etal., Biochim Biophys Acta. 2013 Aug;1829(8):764-74. doi: 10.1016/j.bbagrm.2013.02.006. Epub 2013 Feb 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
Additional References at PubMed
PMID:9409622   PMID:9539711   PMID:11991638   PMID:12477932   PMID:19199708   PMID:22681889   PMID:28076779  


Genomics

Comparative Map Data
Ddx23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,676,636 - 131,693,917 (-)NCBIGRCr8
mRatBN7.27129,797,620 - 129,814,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,797,614 - 129,814,949 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,604,960 - 131,622,123 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,830,506 - 133,847,669 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,743,008 - 133,760,171 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,325,453 - 140,342,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,325,431 - 140,342,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,828,726 - 114,846,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,394,834 - 137,412,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,471,818 - 137,488,539 (-)NCBI
Celera7126,287,854 - 126,305,095 (-)NCBICelera
Cytogenetic Map7q36NCBI
DDX23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,829,756 - 48,852,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,829,756 - 48,852,842 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,223,539 - 49,245,946 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,509,806 - 47,532,224 (-)NCBINCBI36Build 36hg18NCBI36
Build 341247,509,806 - 47,532,224NCBI
Celera1248,019,665 - 48,042,067 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,256,781 - 46,278,800 (-)NCBIHuRef
CHM1_11249,189,355 - 49,211,761 (-)NCBICHM1_1
T2T-CHM13v2.01248,791,783 - 48,814,355 (-)NCBIT2T-CHM13v2.0
Ddx23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,543,012 - 98,560,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,543,015 - 98,560,775 (-)EnsemblGRCm39 Ensembl
GRCm381598,645,379 - 98,662,928 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,645,134 - 98,662,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,475,938 - 98,493,320 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,473,541 - 98,490,923 (-)NCBIMGSCv36mm8
Celera15100,794,107 - 100,811,425 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Ddx23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,685,954 - 7,695,765 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,685,954 - 7,698,880 (-)NCBIChiLan1.0ChiLan1.0
DDX23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,329,615 - 45,351,501 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,326,375 - 45,348,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,896,354 - 39,917,195 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,774,975 - 40,796,466 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,774,975 - 40,796,466 (+)Ensemblpanpan1.1panPan2
DDX23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,690,452 - 5,704,762 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,693,931 - 5,704,778 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,553,181 - 40,567,447 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,741,282 - 5,755,600 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,744,758 - 5,755,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,705,190 - 5,719,452 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,695,245 - 5,709,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02740,945,432 - 40,959,725 (-)NCBIUU_Cfam_GSD_1.0
Ddx23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,481,233 - 66,497,853 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,666,814 - 6,682,728 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,666,972 - 6,682,596 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,888,958 - 14,899,174 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,888,951 - 14,909,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,182,736 - 15,185,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DDX23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,071,884 - 45,092,287 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,071,611 - 45,092,646 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037201,054,301 - 201,075,103 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddx23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,320,065 - 3,334,559 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,320,218 - 3,334,198 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddx23
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:124
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000055529
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Rat3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,807,172 - 129,807,284 (+)MAPPERmRatBN7.2
Rnor_6.07140,335,001 - 140,335,112NCBIRnor6.0
Rnor_5.0X114,838,279 - 114,838,390UniSTSRnor5.0
RGSC_v3.47137,404,381 - 137,404,493RGDRGSC3.4
RGSC_v3.47137,404,382 - 137,404,493UniSTSRGSC3.4
RGSC_v3.17137,480,819 - 137,480,930RGD
Celera7126,297,402 - 126,297,513UniSTS
RH 3.4 Map71077.1RGD
RH 3.4 Map71077.1UniSTS
SHRSP x BN Map786.2299UniSTS
SHRSP x BN Map786.2299RGD
FHH x ACI Map771.32RGD
Cytogenetic Map7q36UniSTS
RH127810  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,797,915 - 129,798,102 (+)MAPPERmRatBN7.2
Rnor_6.07140,325,744 - 140,325,930NCBIRnor6.0
Rnor_5.0X114,829,022 - 114,829,208UniSTSRnor5.0
RGSC_v3.47137,395,125 - 137,395,311UniSTSRGSC3.4
Celera7126,288,145 - 126,288,331UniSTS
RH 3.4 Map71086.5UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000089612   ⟹   ENSRNOP00000072026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,797,614 - 129,814,949 (-)Ensembl
Rnor_6.0 Ensembl7140,325,431 - 140,342,727 (-)Ensembl
RefSeq Acc Id: NM_001106793   ⟹   NP_001100263
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,676,636 - 131,693,877 (-)NCBI
mRatBN7.27129,797,625 - 129,814,866 (-)NCBI
Rnor_6.07140,325,453 - 140,342,694 (-)NCBI
Rnor_5.0X114,828,726 - 114,846,002 (-)NCBI
RGSC_v3.47137,394,834 - 137,412,075 (-)RGD
Celera7126,287,854 - 126,305,095 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257343   ⟹   XP_006257405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,676,639 - 131,693,917 (-)NCBI
mRatBN7.27129,797,620 - 129,814,909 (-)NCBI
Rnor_6.07140,325,456 - 140,342,730 (-)NCBI
Rnor_5.0X114,828,726 - 114,846,002 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100263 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257405 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69082 (Get FASTA)   NCBI Sequence Viewer  
  EDL87045 (Get FASTA)   NCBI Sequence Viewer  
  EDL87046 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072026.2
RefSeq Acc Id: NP_001100263   ⟸   NM_001106793
- UniProtKB: G3V9M1 (UniProtKB/TrEMBL),   A6KC96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257405   ⟸   XM_006257343
- Peptide Label: isoform X1
- UniProtKB: G3V9M1 (UniProtKB/TrEMBL),   A6KC96 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072026   ⟸   ENSRNOT00000089612
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9M1-F1-model_v2 AlphaFold G3V9M1 1-819 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695628
Promoter ID:EPDNEW_R6153
Type:initiation region
Name:Ddx23_1
Description:DEAD-box helicase 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07140,342,717 - 140,342,777EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308685 AgrOrtholog
BioCyc Gene G2FUF-32123 BioCyc
Ensembl Genes ENSRNOG00000060154 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089612.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD-like_helicase UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAD/DEAH_N UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/TrEMBL
KEGG Report rno:300208 UniProtKB/TrEMBL
NCBI Gene 300208 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/TrEMBL
  RNA HELICASE UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
PhenoGen Ddx23 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060154 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A6KC96 ENTREZGENE, UniProtKB/TrEMBL
  B5DFJ3_RAT UniProtKB/TrEMBL
  G3V9M1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Ddx23  DEAD-box helicase 23  Ddx23  DEAD (Asp-Glu-Ala-Asp) box polypeptide 23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ddx23  DEAD (Asp-Glu-Ala-Asp) box polypeptide 23   Ddx23_predicted  DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ddx23_predicted  DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 (predicted)      Symbol and Name status set to approved 70820 APPROVED