Kcng4 (potassium voltage-gated channel modifier subfamily G member 4) - Rat Genome Database

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Gene: Kcng4 (potassium voltage-gated channel modifier subfamily G member 4) Rattus norvegicus
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Symbol: Kcng4
Name: potassium voltage-gated channel modifier subfamily G member 4
RGD ID: 1308553
Description: Predicted to enable potassium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG4 (potassium voltage-gated channel modifier subfamily G member 4); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307900; potassium channel, voltage gated modifier subfamily G, member 4; potassium voltage-gated channel subfamily G member 4; potassium voltage-gated channel, subfamily G, member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,585,252 - 64,598,025 (-)NCBIGRCr8
mRatBN7.21947,677,307 - 47,689,410 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,677,327 - 47,689,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,471,657 - 54,483,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,152,397 - 55,164,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,365,883 - 57,377,782 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,270,907 - 52,283,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,270,927 - 52,282,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,018,981 - 63,031,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,880,614 - 49,892,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,887,567 - 49,897,080 (-)NCBI
Celera1946,935,300 - 46,947,254 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19074135  


Genomics

Comparative Map Data
Kcng4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,585,252 - 64,598,025 (-)NCBIGRCr8
mRatBN7.21947,677,307 - 47,689,410 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,677,327 - 47,689,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,471,657 - 54,483,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,152,397 - 55,164,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,365,883 - 57,377,782 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,270,907 - 52,283,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,270,927 - 52,282,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,018,981 - 63,031,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,880,614 - 49,892,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,887,567 - 49,897,080 (-)NCBI
Celera1946,935,300 - 46,947,254 (-)NCBICelera
Cytogenetic Map19q12NCBI
KCNG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,218,657 - 84,240,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,218,657 - 84,240,012 (-)EnsemblGRCh38hg38GRCh38
GRCh371684,252,263 - 84,273,618 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,813,324 - 82,830,857 (-)NCBINCBI36Build 36hg18NCBI36
Build 341682,813,323 - 82,830,857NCBI
Celera1668,557,618 - 68,575,161 (-)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1670,008,536 - 70,027,162 (-)NCBIHuRef
CHM1_11685,666,125 - 85,684,742 (-)NCBICHM1_1
T2T-CHM13v2.01690,284,733 - 90,306,433 (-)NCBIT2T-CHM13v2.0
Kcng4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,350,593 - 120,362,497 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,350,593 - 120,362,419 (-)EnsemblGRCm39 Ensembl
GRCm388119,623,854 - 119,635,680 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,623,854 - 119,635,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv378122,147,754 - 122,159,580 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,509,831 - 122,521,657 (-)NCBIMGSCv36mm8
Celera8123,841,678 - 123,853,504 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map868.07NCBI
Kcng4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495556484,772 - 99,125 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495556484,772 - 99,125 (+)NCBIChiLan1.0ChiLan1.0
KCNG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,968,892 - 93,986,981 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,886,058 - 99,904,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,886,498 - 64,905,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,228,460 - 84,246,857 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,228,460 - 84,246,857 (-)Ensemblpanpan1.1panPan2
KCNG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,135,729 - 68,156,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,136,945 - 68,150,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha568,150,305 - 68,171,013 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,369,292 - 68,383,958 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,369,217 - 68,448,166 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,381,856 - 68,402,516 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,218,554 - 68,239,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,633,795 - 68,654,486 (+)NCBIUU_Cfam_GSD_1.0
Kcng4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,864,810 - 27,882,704 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,618,906 - 3,630,033 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366413,618,756 - 3,633,505 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,412,165 - 4,430,684 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,411,265 - 4,430,548 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.264,993,994 - 5,012,206 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,627,775 - 69,646,566 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl569,628,861 - 69,644,163 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660476,108,929 - 6,127,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcng4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,369,145 - 3,380,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,367,021 - 3,384,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcng4
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:151
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000021271
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
AI547739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,676,868 - 47,677,065 (+)MAPPERmRatBN7.2
Rnor_6.01952,270,469 - 52,270,665NCBIRnor6.0
Rnor_5.01963,018,543 - 63,018,739UniSTSRnor5.0
RGSC_v3.41949,880,176 - 49,880,372UniSTSRGSC3.4
Celera1946,934,862 - 46,935,058UniSTS
RH 3.4 Map19654.0UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 108 90 89 58 25 58 6 214 97 88 42 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000021271   ⟹   ENSRNOP00000021271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,677,327 - 47,689,268 (-)Ensembl
Rnor_6.0 Ensembl1952,270,927 - 52,282,877 (-)Ensembl
RefSeq Acc Id: NM_001107435   ⟹   NP_001100905
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,585,934 - 64,597,888 (-)NCBI
mRatBN7.21947,677,307 - 47,689,268 (-)NCBI
Rnor_6.01952,270,907 - 52,282,877 (-)NCBI
Rnor_5.01963,018,981 - 63,031,147 (-)NCBI
RGSC_v3.41949,880,614 - 49,892,567 (-)RGD
Celera1946,935,300 - 46,947,254 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255709   ⟹   XP_006255771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,585,252 - 64,598,022 (-)NCBI
mRatBN7.21947,678,635 - 47,689,407 (-)NCBI
Rnor_6.01952,271,130 - 52,283,317 (-)NCBI
Rnor_5.01963,018,981 - 63,031,147 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255710   ⟹   XP_006255772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,585,252 - 64,598,025 (-)NCBI
mRatBN7.21947,678,635 - 47,689,410 (-)NCBI
Rnor_6.01952,271,130 - 52,283,317 (-)NCBI
Rnor_5.01963,018,981 - 63,031,147 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255711   ⟹   XP_006255773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,585,252 - 64,598,022 (-)NCBI
mRatBN7.21947,678,635 - 47,689,407 (-)NCBI
Rnor_6.01952,271,130 - 52,283,317 (-)NCBI
Rnor_5.01963,018,981 - 63,031,147 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063278061   ⟹   XP_063134131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,585,252 - 64,598,025 (-)NCBI
RefSeq Acc Id: NP_001100905   ⟸   NM_001107435
- UniProtKB: A6IZK0 (UniProtKB/TrEMBL),   D4AD66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255773   ⟸   XM_006255711
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006255771   ⟸   XM_006255709
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006255772   ⟸   XM_006255710
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000021271   ⟸   ENSRNOT00000021271
RefSeq Acc Id: XP_063134131   ⟸   XM_063278061
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AD66-F1-model_v2 AlphaFold D4AD66 1-506 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308553 AgrOrtholog
BioCyc Gene G2FUF-5509 BioCyc
Ensembl Genes ENSRNOG00000015746 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021271.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BTB/POZ_fold UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv6 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv_tetra UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report rno:307900 UniProtKB/TrEMBL
NCBI Gene 307900 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 4 UniProtKB/TrEMBL
  PTHR11537 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  K_tetra UniProtKB/TrEMBL
PhenoGen Kcng4 PhenoGen
PRINTS KCHANNEL UniProtKB/TrEMBL
  KV6CHANNEL UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015746 RatGTEx
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A6IZK0 ENTREZGENE, UniProtKB/TrEMBL
  D4AD66 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcng4  potassium voltage-gated channel modifier subfamily G member 4  Kcng4  potassium channel, voltage gated modifier subfamily G, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcng4  potassium channel, voltage gated modifier subfamily G, member 4  Kcng4  potassium voltage-gated channel, subfamily G, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Kcng4  potassium voltage-gated channel, subfamily G, member 4   Kcng4_predicted  potassium voltage-gated channel, subfamily G, member 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kcng4_predicted  potassium voltage-gated channel, subfamily G, member 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED