Sirt1 (sirtuin 1) - Rat Genome Database

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Gene: Sirt1 (sirtuin 1) Rattus norvegicus
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Symbol: Sirt1
Name: sirtuin 1
RGD ID: 1308542
Description: Enables histone deacetylase activity, NAD-dependent and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in growth cone and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); cocaine dependence; impotence; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; p53 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Sir2; Sir2alpha; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,305,953 - 25,328,000 (+)NCBIGRCr8
mRatBN7.22025,307,225 - 25,329,273 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
autosomal dominant intellectual developmental disorder 70  (ISO)
Binge Drinking  (IEP)
brain infarction  (ISO)
Brain Injuries  (IEP)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (IEP)
Carotid Atherosclerosis  (ISO)
cocaine dependence  (IEP)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
endocrine system disease  (ISO)
epilepsy  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Fibrosis  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (IEP,IMP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hypertrophy  (ISO)
impotence  (IEP)
Insulin Resistance  (IDA,ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (IEP)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IEP)
Lung Injury  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (IDA,IEP,ISO)
middle cerebral artery infarction  (IMP,ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrogenic diabetes insipidus  (ISS)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (IEP,IMP,ISO)
osteoporosis  (IDA,IMP)
osteosarcoma  (ISO)
Paralysis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
retinal disease  (ISO)
senile cataract  (ISO)
steatotic liver disease  (ISO,ISS)
systemic scleroderma  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (IMP,ISO)
Ventricular Dysfunction, Left  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-acanthoic acid  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(S)-ropivacaine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylglutaric acid  (EXP)
3-nitropropanoic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetic acid  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
agomelatine  (EXP)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (EXP)
alpha-D-galactose  (EXP,ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
apocynin  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
bafilomycin A1  (EXP)
baicalein  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzophenanthridine  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
beta-lapachone  (ISO)
Betanin  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (EXP)
calcium oxalate  (ISO)
calycosin  (EXP)
camptothecin  (ISO)
capsaicin  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carteolol  (ISO)
catalpol  (ISO)
CAY10591  (ISO)
CDP-choline  (EXP)
CGS-21680  (ISO)
Chikusetsusaponin-V  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium(6+)  (EXP)
chrysin  (EXP)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
corynoline  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cudraflavone B  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproheptadine  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dihydrogen  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diprotium  (ISO)
disulfiram  (ISO)
dizocilpine  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
enzyme inhibitor  (ISO)
ergosterol  (EXP)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
everolimus  (ISO)
excitatory amino acid agonist  (EXP)
fenbendazole  (ISO)
fenitrothion  (EXP)
fenofibrate  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
fisetin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formononetin  (EXP)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
galactose  (EXP,ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
Garcinol  (ISO)
Genipin  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycyrrhizinic acid  (EXP)
glyoxylic acid  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP,ISO)
imidacloprid  (ISO)
inositol  (EXP)
ionomycin  (EXP)
iprodione  (EXP)
iron atom  (ISO)
iron dextran  (EXP)
iron(0)  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isonicotinamide  (ISO)
isoquinoline-1,5-diol  (ISO)
kainic acid  (EXP,ISO)
ketoconazole  (EXP)
KT 5720  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
Licarin A  (ISO)
lidocaine  (EXP,ISO)
linagliptin  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
Magnolol  (EXP)
malonaldehyde  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methotrexate  (EXP)
methylglyoxal  (EXP)
metiram  (ISO)
mifepristone  (EXP)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
monooxygen  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
naringin  (EXP,ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrites  (EXP)
nitroprusside  (ISO)
nitroxoline  (ISO)
NMN zwitterion  (EXP,ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
octreotide  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
organoselenium compound  (EXP)
oxaloacetic acid  (ISO)
oxidopamine  (ISO)
P(1),P(5)-bis(5'-adenosyl) pentaphosphate  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
polymyxin B2  (ISO)
potassium atom  (EXP)
potassium dichromate  (EXP)
prasugrel hydrochloride  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Primycin  (ISO)
propionic acid  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrethrins  (EXP)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
ramipril  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-nitroso-L-cysteine  (ISO)
salicylic acid  (EXP)
Salidroside  (ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP,ISO)
splitomicin  (EXP,ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
suramin  (ISO)
T-2 toxin  (EXP)
taurine  (ISO)
temozolomide  (ISO)
tert-butanol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (ISO)
trans-piceid  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (EXP)
Vinpocetine  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
apoptotic process  (IEA)
behavioral response to starvation  (IEA,ISO)
cardiac muscle cell apoptotic process  (IMP)
cell differentiation  (IEA)
cellular response to amyloid-beta  (IEP,IMP)
cellular response to antibiotic  (IEP)
cellular response to curcumin  (IEP)
cellular response to glucose starvation  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,IEP,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to ionizing radiation  (IEA,ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to resveratrol  (IMP)
cellular response to rotenone  (IEP)
cellular response to starvation  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to vitamin B3  (IEP)
cholesterol homeostasis  (IEA,ISO)
chromatin organization  (IEA,ISO)
circadian regulation of gene expression  (IEA,ISO)
circadian rhythm  (IEA,ISO)
DNA damage response  (IEA,ISO)
DNA repair-dependent chromatin remodeling  (IEA,ISO)
DNA synthesis involved in DNA repair  (IEA,ISO)
energy homeostasis  (IEA,IMP,ISO)
fatty acid homeostasis  (IEA,ISO)
heterochromatin formation  (IBA,IEA,ISO)
intracellular glucose homeostasis  (IEA,ISO)
intracellular triglyceride homeostasis  (IEA,ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
leptin-mediated signaling pathway  (IEA,ISO)
macrophage differentiation  (IEA,ISO)
maintenance of nucleus location  (IEA,ISO)
mitochondrion organization  (ISO)
muscle organ development  (IEA)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of attachment of mitotic spindle microtubules to kinetochore  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of cellular response to testosterone stimulus  (IEA,ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of DNA binding  (IMP)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IBA,IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of fibroblast apoptotic process  (IMP)
negative regulation of gene expression  (IEA,ISO)
negative regulation of growth hormone secretion  (IMP)
negative regulation of hippo signaling  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,IMP,ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of prostaglandin biosynthetic process  (IEA,ISO)
negative regulation of protein acetylation  (IMP,ISO)
negative regulation of protein localization to nucleus  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of signal transduction by p53 class mediator  (IEA,ISO)
negative regulation of TOR signaling  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of triglyceride biosynthetic process  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IMP)
neuron apoptotic process  (IMP)
ovulation from ovarian follicle  (IEA,ISO)
peptidyl-lysine acetylation  (ISO)
positive regulation of adaptive immune response  (IEA,ISO)
positive regulation of adipose tissue development  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cAMP-dependent protein kinase activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cellular senescence  (IEA,ISO)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of DNA repair  (IEA,ISO)
positive regulation of double-strand break repair  (IEA,ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (IEA,IMP,ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (IMP)
positive regulation of insulin receptor signaling pathway  (IEA,ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of macrophage apoptotic process  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein deacetylation  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle cell proliferation  (IMP)
positive regulation of smooth muscle cell differentiation  (IEA,ISO)
positive regulation of thyroid-stimulating hormone secretion  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein deacetylation  (IDA,ISO)
protein depropionylation  (ISO,ISS)
protein destabilization  (IEA,ISO)
protein ubiquitination  (IEA,ISO)
pyrimidine dimer repair by nucleotide-excision repair  (IEA,ISO)
rDNA heterochromatin formation  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of bile acid biosynthetic process  (IEA,ISO)
regulation of brown fat cell differentiation  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of centrosome duplication  (IEA,ISO,ISS)
regulation of endodeoxyribonuclease activity  (ISO)
regulation of glucose metabolic process  (IEA,ISO)
regulation of lipid storage  (IEA,ISO)
regulation of mitotic cell cycle  (IEA,ISO)
regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
regulation of smooth muscle cell apoptotic process  (IEA,ISO)
regulation of transcription by glucose  (IEA,ISO)
response to cocaine  (IEP)
response to ethanol  (IDA)
response to fluoride  (IEP)
response to hydrogen peroxide  (IEA,ISO)
response to insulin  (IEA,ISO)
response to kainic acid  (IEP)
response to leptin  (IEA,ISO)
response to mycotoxin  (IEP)
response to nutrient levels  (IEP)
response to oxidative stress  (IEA,ISO)
response to resveratrol  (IEP)
rhythmic process  (IEA)
single strand break repair  (IEA,ISO)
spermatogenesis  (IEA,ISO)
stress-induced premature senescence  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
triglyceride mobilization  (IEA,ISO)
UV-damage excision repair  (IEA,ISO)
vasodilation  (IMP)
white fat cell differentiation  (IEA,ISO)

Cellular Component
axon  (IDA)
chromatin  (IEA,ISO)
chromatin silencing complex  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
eNoSc complex  (IEA,ISO)
ESC/E(Z) complex  (IEA,ISO)
euchromatin  (IEA,ISO)
fibrillar center  (IEA,ISO)
growth cone  (IDA)
heterochromatin  (IEA,ISO)
mitochondrion  (IEA,ISO)
nuclear envelope  (IEA,ISO)
nuclear inner membrane  (IBA,IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
PML body  (IEA,ISO)
protein-containing complex  (IEA,ISO)
rDNA heterochromatin  (IBA,IEA,ISO)

Molecular Function
bHLH transcription factor binding  (IEA,ISO)
caspase binding  (ISO)
deacetylase activity  (IEA,ISO)
DNA-binding transcription factor binding  (IEA,ISO)
enzyme activator activity  (IEA,ISO)
enzyme binding  (IEA,IPI,ISO)
histone binding  (IEA,ISO)
histone deacetylase activity  (IEA,ISO)
histone deacetylase activity, NAD-dependent  (IBA,IDA,IEA,ISO)
histone H3K deacetylase activity  (IEA,ISO)
histone H3K14 deacetylase activity, NAD-dependent  (IEA,ISO)
histone H3K9 deacetylase activity, NAD-dependent  (IEA,ISO)
histone H4K12 deacetylase activity, hydrolytic mechanism  (IEA,ISO)
histone H4K16 deacetylase activity, NAD-dependent  (IEA,ISO)
HLH domain binding  (IEA,ISO)
identical protein binding  (IEA,ISO)
keratin filament binding  (IEA,ISO)
metal ion binding  (IEA)
mitogen-activated protein kinase binding  (IEA,ISO)
NAD+ binding  (IBA,IEA)
NAD-dependent histone decrotonylase activity  (IEA,ISO,ISS)
NAD-dependent protein decrotonylase activity  (IEA)
NAD-dependent protein lysine deacetylase activity  (IEA,ISO)
NAD-dependent protein lysine delactylase activity  (IEA,ISO)
NAD-dependent protein-lysine depropionylase activity  (IEA,ISO,ISS)
nuclear receptor binding  (IEA,ISO)
p53 binding  (IBA,IEA,ISO)
promoter-specific chromatin binding  (IEA,ISO)
protein binding  (ISO)
protein domain specific binding  (IEA,ISO)
protein kinase B binding  (IDA)
protein lysine deacetylase activity  (IEA,ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IEA,ISO)
transcription coactivator activity  (IEA,ISO)
transcription corepressor activity  (IBA,IEA,ISO)
transcription regulator inhibitor activity  (IEA,ISO)
transferase activity  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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67. SIRT1 inhibits TNF-alpha-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Wang W, etal., Apoptosis. 2013 Jun;18(6):689-701. doi: 10.1007/s10495-013-0833-7.
68. Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. Wu A, etal., J Neurotrauma. 2007 Oct;24(10):1587-95.
69. Novel Role of Resveratrol: Suppression of HMGB1 Nucleocytoplasmic Translocation by the Up-Regulation of SIRT1 in Sepsis-Induced Liver Injury. Xu W, etal., Shock. 2014 Jul 4.
70. Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury. Yan H, etal., Crit Care Med. 2014 May;42(5):e373-81. doi: 10.1097/CCM.0000000000000246.
71. Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis. Yang J, etal., Arch Med Res. 2011 Jul;42(5):354-60. doi: 10.1016/j.arcmed.2011.07.005. Epub 2011 Jul 31.
72. The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats. Yar AS, etal., Genet Mol Res. 2011 Nov 29;10(4):2962-75. doi: 10.4238/2011.November.29.7.
73. Resveratrol ameliorates experimental autoimmune myocarditis. Yoshida Y, etal., Circ J. 2007 Mar;71(3):397-404.
74. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Yoshizaki T, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28. doi: 10.1152/ajpendo.00417.2009. Epub 2009 Dec 8.
75. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging. Zarzuelo MJ, etal., Biochem Pharmacol. 2013 May 1;85(9):1288-96. doi: 10.1016/j.bcp.2013.02.015. Epub 2013 Feb 17.
76. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. Zhang J, etal., Age (Dordr). 2013 Jun;35(3):807-20. doi: 10.1007/s11357-012-9412-z. Epub 2012 May 4.
77. Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. Zhang L, etal., Eur J Pharmacol. 2014 Dec 5;744:203-10. doi: 10.1016/j.ejphar.2014.09.037. Epub 2014 Sep 30.
78. miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease. Zhang QS, etal., J Biosci. 2017 Sep;42(3):397-404.
79. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Zheng T and Lu Y, Curr Eye Res. 2011 May;36(5):449-55. doi: 10.3109/02713683.2011.559301.
Additional References at PubMed
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PMID:23292098   PMID:23296834   PMID:23299244   PMID:23313858   PMID:23337935   PMID:23359486   PMID:23382074   PMID:23566837   PMID:23734259   PMID:23744058   PMID:23806367   PMID:23880291  
PMID:23891692   PMID:23951196   PMID:23960241   PMID:23973301   PMID:23973402   PMID:23994215   PMID:24043310   PMID:24048733   PMID:24052229   PMID:24058702   PMID:24089055   PMID:24096033  
PMID:24113524   PMID:24239092   PMID:24356887   PMID:24421392   PMID:24435709   PMID:24472096   PMID:24482345   PMID:24535021   PMID:24570140   PMID:24722566   PMID:24747689   PMID:24824780  
PMID:24908092   PMID:24913149   PMID:24918615   PMID:25052362   PMID:25192797   PMID:25193706   PMID:25217442   PMID:25242624   PMID:25245521   PMID:25333348   PMID:25375034   PMID:25389371  
PMID:25440363   PMID:25448608   PMID:25455260   PMID:25461268   PMID:25501750   PMID:25526086   PMID:25544867   PMID:25614777   PMID:25684941   PMID:25703252   PMID:25766524   PMID:25782776  
PMID:25843933   PMID:25849131   PMID:25863291   PMID:25965594   PMID:25966629   PMID:26086862   PMID:26185373   PMID:26203862   PMID:26252661   PMID:26261574   PMID:26273643   PMID:26329673  
PMID:26339397   PMID:26379395   PMID:26384348   PMID:26489513   PMID:26522222   PMID:26720481   PMID:26755731   PMID:26767982   PMID:26845416   PMID:26872534   PMID:26891083   PMID:26968221  
PMID:27035562   PMID:27076782   PMID:27133433   PMID:27174562   PMID:27212443   PMID:27270300   PMID:27294899   PMID:27339462   PMID:27357961   PMID:27363270   PMID:27387128   PMID:27526155  
PMID:27547294   PMID:27573670   PMID:27581932   PMID:27600292   PMID:27631411   PMID:27735947   PMID:27749604   PMID:27878231   PMID:27916733   PMID:27980322   PMID:27989594   PMID:27993241  
PMID:28003866   PMID:28017962   PMID:28025657   PMID:28108221   PMID:28116292   PMID:28197553   PMID:28361889   PMID:28395272   PMID:28419207   PMID:28429887   PMID:28455824   PMID:28482939  
PMID:28579512   PMID:28599575   PMID:28708259   PMID:28817690   PMID:28827681   PMID:28847722   PMID:28937253   PMID:28948423   PMID:28973641   PMID:28974454   PMID:29081884   PMID:29104731  
PMID:29115394   PMID:29115493   PMID:29199862   PMID:29220696   PMID:29288528   PMID:29307666   PMID:29369849   PMID:29435095   PMID:29446047   PMID:29452170   PMID:29480757   PMID:29486220  
PMID:29576121   PMID:29614311   PMID:29653943   PMID:29771428   PMID:29849897   PMID:29863652   PMID:29913437   PMID:30026585   PMID:30129147   PMID:30132522   PMID:30193097   PMID:30305620  
PMID:30345866   PMID:30365940   PMID:30504847   PMID:30528733   PMID:30578379   PMID:30582744   PMID:30616245   PMID:30649099   PMID:30661205   PMID:30717220   PMID:30776367   PMID:30778838  
PMID:30816451   PMID:30849417   PMID:30854676   PMID:30967498   PMID:30968966   PMID:31041919   PMID:31202897   PMID:31264206   PMID:31340436   PMID:31373965   PMID:31526389   PMID:31527356  
PMID:31652118   PMID:31688999   PMID:31778153   PMID:31781938   PMID:31877121   PMID:32000560   PMID:32005763   PMID:32007785   PMID:32026477   PMID:32196615   PMID:32219698   PMID:32303670  
PMID:32319664   PMID:32357375   PMID:32420373   PMID:32434515   PMID:32437714   PMID:32446297   PMID:32461588   PMID:32615849   PMID:32620714   PMID:32633335   PMID:32712090   PMID:32747445  
PMID:32749162   PMID:32819170   PMID:32826847   PMID:32865007   PMID:32894639   PMID:33064238   PMID:33064974   PMID:33095054   PMID:33155221   PMID:33155431   PMID:33185125   PMID:33206628  
PMID:33220291   PMID:33336750   PMID:33395186   PMID:33433144   PMID:33479807   PMID:33495841   PMID:33534060   PMID:33551999   PMID:33577060   PMID:33638320   PMID:33650806   PMID:33661552  
PMID:33725228   PMID:33737560   PMID:33772412   PMID:33779856   PMID:33821324   PMID:33931577   PMID:33978298   PMID:34029951   PMID:34080028   PMID:34146302   PMID:34175265   PMID:34245841  
PMID:34248837   PMID:34259031   PMID:34265417   PMID:34296298   PMID:34313929   PMID:34363387   PMID:34420010   PMID:34494279   PMID:34514556   PMID:34530105   PMID:34530866   PMID:34533647  
PMID:34592882   PMID:34609722   PMID:34624463   PMID:34647720   PMID:34666848   PMID:34676022   PMID:34725563   PMID:34730891   PMID:34817332   PMID:34881386   PMID:34899720   PMID:34989469  
PMID:35030965   PMID:35064582   PMID:35167998   PMID:35225027   PMID:35229761   PMID:35253650   PMID:35305383   PMID:35383535   PMID:35389569   PMID:35395161   PMID:35416184   PMID:35488974  
PMID:35594890   PMID:35665875   PMID:35688305   PMID:35882013   PMID:36047349   PMID:36155419   PMID:36159018   PMID:36224490   PMID:36226790   PMID:36429082   PMID:36584755   PMID:36728843  
PMID:36916335   PMID:37057212   PMID:37087770   PMID:37088752   PMID:37183461   PMID:37323056   PMID:37336147   PMID:37354359   PMID:37366125   PMID:37501791   PMID:37597099   PMID:37711250  
PMID:37774988   PMID:37820952   PMID:38063102   PMID:38071166   PMID:38134189   PMID:38141805   PMID:38146686   PMID:38183511   PMID:38261732   PMID:38267754   PMID:38277398   PMID:38281279  
PMID:38555046   PMID:38650126   PMID:38678672   PMID:38700532   PMID:38767771   PMID:38904464   PMID:39012929   PMID:39216234  


Genomics

Comparative Map Data
Sirt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,305,953 - 25,328,000 (+)NCBIGRCr8
mRatBN7.22025,307,225 - 25,329,273 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
SIRT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381067,884,656 - 67,918,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1067,884,656 - 67,918,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371069,644,414 - 69,678,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,314,433 - 69,348,149 (+)NCBINCBI36Build 36hg18NCBI36
Build 341069,314,432 - 69,348,147NCBI
Celera1062,919,307 - 62,953,016 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1063,643,871 - 63,677,731 (+)NCBIHuRef
CHM1_11069,926,404 - 69,960,153 (+)NCBICHM1_1
T2T-CHM13v2.01068,753,401 - 68,787,131 (+)NCBIT2T-CHM13v2.0
Sirt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391063,154,784 - 63,174,814 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1063,154,784 - 63,217,483 (-)EnsemblGRCm39 Ensembl
GRCm381063,319,005 - 63,339,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1063,319,005 - 63,381,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371062,781,753 - 62,801,783 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,714,418 - 62,734,374 (-)NCBIMGSCv36mm8
Celera1064,419,012 - 64,437,105 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.57NCBI
Sirt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,279,963 - 20,307,663 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,280,725 - 20,307,663 (+)NCBIChiLan1.0ChiLan1.0
SIRT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2880,046,153 - 80,080,740 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11080,053,299 - 80,086,063 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01064,368,878 - 64,401,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11066,681,983 - 66,714,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1066,681,598 - 66,715,069 (+)Ensemblpanpan1.1panPan2
SIRT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,188,616 - 19,220,031 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,188,675 - 19,218,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,317,273 - 19,349,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0419,454,692 - 19,486,553 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl419,454,710 - 19,546,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,337,295 - 19,369,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0419,559,257 - 19,591,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0419,901,939 - 19,934,337 (+)NCBIUU_Cfam_GSD_1.0
Sirt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,803,376 - 61,829,477 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652110,296,097 - 10,322,215 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493652110,296,097 - 10,316,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,091,167 - 71,123,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,091,167 - 71,126,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,182,651 - 77,184,716 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21477,053,991 - 77,079,850 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1963,463,059 - 63,497,893 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl963,462,389 - 63,497,867 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604824,231,602 - 24,266,452 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247542,304,634 - 2,330,946 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247542,304,476 - 2,332,705 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt1
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000000427, ENSRNOT00000057829
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH140601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,328,230 - 25,328,418 (-)MAPPERmRatBN7.2
Rnor_6.02026,832,814 - 26,833,001NCBIRnor6.0
Rnor_5.0208,140,697 - 8,140,884UniSTSRnor5.0
RGSC_v3.42025,667,457 - 25,667,644UniSTSRGSC3.4
Celera2026,626,314 - 26,626,501UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map20p11UniSTS
RH124528  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,327,437 - 25,327,686 (-)MAPPERmRatBN7.2
Rnor_6.02026,833,546 - 26,833,794NCBIRnor6.0
Rnor_5.0208,141,429 - 8,141,677UniSTSRnor5.0
RGSC_v3.42025,668,189 - 25,668,437UniSTSRGSC3.4
Celera2026,625,521 - 26,625,769UniSTS
Cytogenetic Map20p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000078739   ⟹   ENSRNOP00000070943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,306,917 - 25,327,667 (+)Ensembl
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095567   ⟹   ENSRNOP00000086140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111766   ⟹   ENSRNOP00000094805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,307,221 - 25,329,260 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119601   ⟹   ENSRNOP00000094468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,315,088 - 25,329,260 (+)Ensembl
RefSeq Acc Id: NM_001372090   ⟹   NP_001359019
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,313,816 - 25,327,987 (+)NCBI
mRatBN7.22025,315,088 - 25,329,260 (+)NCBI
RefSeq Acc Id: NM_001414959   ⟹   NP_001401888
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,305,953 - 25,328,000 (+)NCBI
mRatBN7.22025,307,225 - 25,329,273 (+)NCBI
RefSeq Acc Id: XM_063279169   ⟹   XP_063135239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,313,840 - 25,327,987 (+)NCBI
Ensembl Acc Id: ENSRNOP00000070943   ⟸   ENSRNOT00000078739
RefSeq Acc Id: NP_001359019   ⟸   NM_001372090
- Peptide Label: isoform 2
- UniProtKB: A0A8I6B0Z5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094468   ⟸   ENSRNOT00000119601
Ensembl Acc Id: ENSRNOP00000094805   ⟸   ENSRNOT00000111766
Ensembl Acc Id: ENSRNOP00000086140   ⟸   ENSRNOT00000095567
RefSeq Acc Id: NP_001401888   ⟸   NM_001414959
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AMW7 (UniProtKB/TrEMBL),   A0A8I6A306 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135239   ⟸   XM_063279169
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B0Z5 (UniProtKB/TrEMBL)
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ79-F1-model_v2 AlphaFold A0A0G2JZ79 1-555 view protein structure
AF-A0A182DWI7-F1-model_v2 AlphaFold A0A182DWI7 1-730 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308542 AgrOrtholog
BioCyc Gene G2FUF-3820 BioCyc
Ensembl Genes ENSRNOG00000051592 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000095567 ENTREZGENE
  ENSRNOT00000119601 ENTREZGENE
Gene3D-CATH 3.30.1600.10 UniProtKB/Swiss-Prot
  TPP-binding domain UniProtKB/Swiss-Prot
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot
  NAD-dep_sirtuin_deacylases UniProtKB/Swiss-Prot
  Sirtuin UniProtKB/Swiss-Prot
  Sirtuin_cat_small_dom_sf UniProtKB/Swiss-Prot
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot
NCBI Gene 309757 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1 UniProtKB/Swiss-Prot
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
Pfam SIR2 UniProtKB/Swiss-Prot
PhenoGen Sirt1 PhenoGen
PROSITE SIRTUIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051592 RatGTEx
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ79 ENTREZGENE
  A0A182DWI7_RAT UniProtKB/TrEMBL
  A0A8I6A306 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B0Z5 ENTREZGENE, UniProtKB/TrEMBL
  SIR1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt1  sirtuin 1  Sirt1  sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Sirt1  sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)  Sirt1  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sirt1  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)   Sirt1_predicted  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sirt1_predicted  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED