Sfxn1 (sideroflexin 1) - Rat Genome Database

Name: Sfxn1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Sfxn1 (sideroflexin 1) Rattus norvegicus

Analyze

Symbol:

Sfxn1

Name:

sideroflexin 1

RGD ID:

1308482

Description:

Predicted to enable D-serine transmembrane transporter activity; L-alanine transmembrane transporter activity; and L-serine transmembrane transporter activity. Predicted to be involved in neutral amino acid transport. Predicted to act upstream of or within erythrocyte differentiation and iron ion transport. Predicted to be located in mitochondrial inner membrane. Orthologous to human SFXN1 (sideroflexin 1); INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC364678; sideroflexin-1; SLC64A1; solute carrier family 64 member 1; TCC; tricarboxylate carrier protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SFXN1 (sideroflexin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sfxn1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sfxn1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SFXN1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SFXN1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sfxn1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SFXN1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SFXN1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sfxn1 (sideroflexin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SFXN3 (sideroflexin 3)	HGNC	OrthoDB
Homo sapiens (human):	ZFYVE28 (zinc finger FYVE-type containing 28)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SFXN1 (sideroflexin 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sfxn1 (sideroflexin 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sfxn1 (sideroflexin 1)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FSF1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Drosophila melanogaster (fruit fly):	Sfxn1-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sfxn-1.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sfxn1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	10,486,250 - 10,522,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	10,486,271 - 10,522,529 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	10,500,879 - 10,536,327 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	12,035,078 - 12,070,519 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	10,497,317 - 10,532,759 (-)	NCBI	Rnor_WKY
Rnor_6.0	17	11,046,588 - 11,082,219 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	11,045,761 - 11,082,047 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	13,157,817 - 13,193,253 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	16,601,066 - 16,636,502 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	16,601,065 - 16,636,502 (-)	NCBI
Celera	17	10,555,805 - 10,591,237 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Colorectal Neoplasms (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2,2-tetramine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP)

butanal (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cisplatin (EXP)

clofibrate (EXP,ISO)

clofibric acid (EXP)

clozapine (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (ISO)

curcumin (ISO)

cyclosporin A (ISO)

diethyl maleate (ISO)

doxorubicin (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glafenine (EXP)

glutathione (EXP)

indole-3-methanol (EXP)

ivermectin (ISO)

L-ethionine (EXP)

lamivudine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

omeprazole (EXP)

p-toluidine (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

Propiverine (EXP)

rifampicin (ISO)

sodium arsenite (ISO)

streptozocin (EXP)

tamoxifen (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

vinclozolin (EXP)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid transport (IEA)

erythrocyte differentiation (ISO)

iron ion transport (ISO)

L-alanine transport (ISO,ISS)

L-serine transport (ISO,ISS)

monoatomic ion transmembrane transport (IEA)

one-carbon metabolic process (ISO,ISS)

serine import into mitochondrion (IBA,ISO,ISS)

Cellular Component

mitochondrial inner membrane (ISO,ISS)

mitochondrial membrane (IEA)

mitochondrion (ISO)

Molecular Function

L-alanine transmembrane transporter activity (ISO,ISS)

L-serine transmembrane transporter activity (ISO,ISS)

monoatomic ion transmembrane transporter activity (IEA)

protein binding (ISO)

serine transmembrane transporter activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11274051	PMID:12477932	PMID:12865426	PMID:14651853	PMID:18614015	PMID:21700703	PMID:27488499	PMID:29476059	PMID:30442778

Genomics

Comparative Map Data

Sfxn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	10,486,250 - 10,522,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	10,486,271 - 10,522,529 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	10,500,879 - 10,536,327 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	17	12,035,078 - 12,070,519 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	17	10,497,317 - 10,532,759 (-)	NCBI	Rnor_WKY
Rnor_6.0	17	11,046,588 - 11,082,219 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	11,045,761 - 11,082,047 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	13,157,817 - 13,193,253 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	16,601,066 - 16,636,502 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	16,601,065 - 16,636,502 (-)	NCBI
Celera	17	10,555,805 - 10,591,237 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

SFXN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	175,478,560 - 175,529,742 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	175,477,062 - 175,529,742 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	174,905,563 - 174,956,745 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	174,838,189 - 174,888,218 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	174,838,188 - 174,888,218	NCBI
Celera	5	170,944,525 - 170,994,642 (+)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	170,004,689 - 170,054,733 (+)	NCBI		HuRef
CHM1_1	5	174,337,958 - 174,388,345 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	176,022,352 - 176,073,526 (+)	NCBI		T2T-CHM13v2.0

Sfxn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	54,225,675 - 54,262,365 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	54,225,888 - 54,262,361 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	54,071,656 - 54,108,346 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	54,071,869 - 54,108,342 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	54,167,214 - 54,203,715 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	54,081,490 - 54,117,966 (+)	NCBI		MGSCv36	mm8
Celera	13	55,144,580 - 55,182,917 (+)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	28.4	NCBI

Sfxn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	28,054,211 - 28,106,175 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	28,054,211 - 28,105,294 (+)	NCBI	ChiLan1.0	ChiLan1.0

SFXN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	168,748,446 - 168,798,866 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	170,825,507 - 170,876,741 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	177,726,518 - 177,776,344 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	177,738,961 - 177,775,212 (+)	Ensembl	panpan1.1		panPan2

SFXN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	37,485,360 - 37,517,743 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	37,487,438 - 37,512,289 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	37,431,872 - 37,472,432 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	37,851,035 - 37,891,568 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	37,851,044 - 37,891,597 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	37,675,678 - 37,716,181 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	37,863,646 - 37,904,164 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	38,373,604 - 38,414,131 (-)	NCBI		UU_Cfam_GSD_1.0

Sfxn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	92,004,958 - 92,032,126 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936609	729,589 - 754,774 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936609	727,621 - 754,806 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SFXN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	82,025,820 - 82,057,564 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	82,025,799 - 82,057,629 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	83,647,666 - 83,679,493 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SFXN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	77,625,740 - 77,675,935 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	77,625,775 - 77,674,907 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	912,795 - 964,512 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sfxn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	14,403,957 - 14,452,280 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	14,404,646 - 14,451,943 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sfxn1
153 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	481
Count of miRNA genes:	255
Interacting mature miRNAs:	302
Transcripts:	ENSRNOT00000024707
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22871563	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2115149	21881669	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	17	4299130	21293263	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	4299130	21293263	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7979968	16317111	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9201365	23653323	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9201365	23653323	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9201365	23653323	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat

Markers in Region

AA964229

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	10,487,198 - 10,487,332 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	11,046,725 - 11,046,858	NCBI	Rnor6.0
Rnor_5.0	17	13,157,954 - 13,158,087	UniSTS	Rnor5.0
RGSC_v3.4	17	16,601,203 - 16,601,336	UniSTS	RGSC3.4
Celera	17	10,555,942 - 10,556,075	UniSTS
RH 3.4 Map	17	110.5	UniSTS
Cytogenetic Map	17	p14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	56	41	18	41			74	35	34	3
Low		17	1		1		8	11			7	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000024707 ⟹ ENSRNOP00000024707

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	10,486,276 - 10,522,529 (-)	Ensembl
Rnor_6.0 Ensembl	17	11,045,761 - 11,082,047 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102311 ⟹ ENSRNOP00000091417

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	10,486,271 - 10,522,450 (-)	Ensembl

RefSeq Acc Id:

NM_001012213 ⟹ NP_001012213

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	10,487,062 - 10,522,501 (-)	NCBI
Rnor_6.0	17	11,046,588 - 11,082,024 (-)	NCBI
Rnor_5.0	17	13,157,817 - 13,193,253 (-)	NCBI
RGSC_v3.4	17	16,601,066 - 16,636,502 (-)	RGD
Celera	17	10,555,805 - 10,591,237 (-)	RGD

Sequence:

show sequence

GGAGGCGGCACGGAGCGGGACCGAGAGGCGCGGGTGGCGGCCGGGGAGGCGGATCTGGGACAAT
GTCTGGGGAAGTGCCACCCAACATTAACATCAAGGAGCCTCGATGGGACCAGAGCACGTTCATT
GGCCGAGCCAGTCACTTCTTCACGGTTACTGATCCCAGAAACATCCTTTTAACGAACGAACAGC
TAGAGAATGCGAGGAAAGTGGTACACGATTACAGGCAAGGAATCGTTCCTGCTGGCCTCACGGA
AAATGAGTTATGGAGAGCGAAGTACGCGTATGACTCGGCCTTCCATCCCGACACGGGTGAAAAG
ATGACTCTGATAGGAAGAATGTCGGCTCAGGTCCCGATGAACATGACCATCACGGGCTGCATGA
TGACCTTCTACCGGACCACACCGGCTGTGCTTTTCTGGCAGTGGATAAACCAGTCCTTCAATGC
CGTGGTCAACTACACCAATAGAAGTGGTGACGCTCCCCTCACTGTAAATGAGCTGGGAACGGCT
TATGTTTCTGCAACAACCGGCGCCGTGGCGACAGCCCTTGGACTCAATGCCCTAACCAAGCATG
TGTCGCCGCTGATAGGACGTTTTGTTCCCTTCGCTGCTGTAGCTGCTGCTAACTGCATTAACAT
CCCGCTGATGAGACAAAGGGAACTCAAGGTTGGTATTCCTGTCACTGATGAGAATGGCACACGC
TTGGGAGAATCGACCAACGCAGCAAAGCAAGCCATCACGCAGGTGGTCATCTCCAGGATCCTCA
TGGCGGCCCCTGGCATGGCCATCCCTCCGTTTATCATGAACACCTTGGAGAAGAAAGCCTTTTT
GAAGAGGTTCCCGTGGATGAGCGCACCAATTCAAGTCACACTGGTTGGCTTTTGTTTGGTGTTC
GCCACCCCCCTGTGCTGTGCTCTGTTTCCTCAGAAGAGTTCCATGTCTGTGACAAGCTTGGAGG
ATGAGTTGCAAGCCAGCATCCAAAAGAGTCATCCTGAATTACGGCGTGTGTACTTTAACAAGGG
CCTGTGAAGCCAAGATCAAGTGCTGGAGGCACCTCCTGCCATCTGTGAACCTCCTGAAGCCAAG
CAGTGAGGAAATACGTGTGCTGGGCACTCCCCGCTACAAAAGCCTCTGCAAAATCTGTGTTAGA
GTCAAGCTGCCTGTCAGGAACCTGACATTTGAATCGTGTTGTAATTTACAAAAAATACCCTTCT
GGTAGATTTTAATGATGCTGTTTTTTCCAAAGCCCCCACCTTGAGCTTTCAAAAGCTCTGGTGG
GCATAGCATATATGCTCCAGTTACACACTCAGCAAACACTGGTTATCAATCATTGGAAAGGTTA
CCAGCTCAACTATCACATTCTGTTTCTACTTCTCTCCCACTGGGGTCTCAGCAATGAATTGGGA
AAACACAAAAGGTCTAAGACAAAATATCCAAATTTAAATACTAAGGAAACTATATCTCCAGTTT
GGCAATGGACCAGTCCAAAGTAGAACCTCAATTAAAAAAATTGAGGTTCAGAGCATAAACACTC
CATACACCTTCCTGAAGTCAGCCATAGACCAGGGTAGGATGCCTTCCCTGCCATCCTGGATTCT
TCAACTCTTCAATGTGTTTAGTGTTCTTAAAATATTAATTGTACCTCACAGGTACTTTATAATC
ATGAATTTCCATCAAATACTTAACTGAAATGGTCTATTCAGTACCAGTACAATGTGACATTGAC
TGGGTGACCGGTTTTTCAGAAGTGAAACCATAGTCCCTATATGCCTTTTTCCCCCCATCCTTGT
AGAATTTCTTTGGCTTTCAGGAAGATATACAGAAACCACACAAACTAGTCCAGCAACTGTGCAC
ATTGTGCTGCGTTCCACCCTGTTTGAAGACCATGAAGTCTTGTGGCATGTCAACATTTCTATGG
TGATTTTTACATGTGACATATTGGGTGTAGCTGAGGTTGCTTTGGAAGTCTGTGGCTATTCCAC
GTCATAGACAAGCCACTTGTTATGCTGAGTGAAAAATCATTGTTAATTCAGATATTTGTACGTG
GAAAAAAACCCCACAAAAATAGAGACTATCTAGTTTCTGTAGATTCTTTTTCCCAATGTTTCCA
GATTGAATTTCCTCATAAAGAAAATATGGTGTGCCTTGTGAAAAAAAAAAAAAAAAAAAAAAAA
AA

hide sequence

RefSeq Acc Id:

XM_008771502 ⟹ XP_008769724

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	10,486,533 - 10,522,640 (-)	NCBI
Rnor_6.0	17	11,047,709 - 11,082,219 (-)	NCBI

Sequence:

show sequence

TTAGGCGTTCTCGGTGGGGTCAGAAGCAGAGACGCAGGCACAAGGGGCGTGCGCAGACTGCGGA
GTTCAGCAGCCAAAGCCGATCTGGGACAATGTCTGGGGAAGTGCCACCCAACATTAACATCAAG
GAGCCTCGATGGGACCAGAGCACGTTCATTGGCCGAGCCAGTCACTTCTTCACGGTTACTGATC
CCAGAAACATCCTTTTAACGAACGAACAGCTAGAGAATGCGAGGAAAGTGGTACACGATTACAG
GCAAGGAATCGTTCCTGCTGGCCTCACGGAAAATGAGTTATGGAGAGCGAAGTACGCGTATGAC
TCGGCCTTCCATCCCGACACGGGTGAAAAGATGACTCTGATAGGAAGAATGTCGGCTCAGGTCC
CGATGAACATGACCATCACGGGCTGCATGATGACCTTCTACCGGACCACACCGGCTGTGCTTTT
CTGGCAGTGGATAAACCAGTCCTTCAATGCCGTGGTCAACTACACCAATAGAAGTGGTGACGCT
CCCCTCACTGTAAATGAGCTGGGAACGGCTTATGTTTCTGCAACAACCGGCGCCGTGGCGACAG
CCCTTGGACTCAATGCCCTAACCAAGCATGTGTCGCCGCTGATAGGACGTTTTGTTCCCTTCGC
TGCTGTAGCTGCTGCTAACTGCATTAACATCCCGCTGATGAGACAAAGGGAACTCAAGGTTGGT
ATTCCTGTCACTGATGAGAATGGCACACGCTTGGGAGAATCGACCAACGCAGCAAAGCAAGCCA
TCACGCAGGTGGTCATCTCCAGGATCCTCATGGCGGCCCCTGGCATGGCCATCCCTCCGTTTAT
CATGAACACCTTGGAGAAGAAAGCCTTTTTGAAGAGGTTCCCGTGGATGAGCGCACCAATTCAA
GTCACACTGGTTGGCTTTTGTTTGGTGTTCGCCACCCCCCTGTGCTGTGCTCTGTTTCCTCAGA
AGAGTTCCATGTCTGTGACAAGCTTGGAGGATGAGTTGCAAGCCAGCATCCAAAAGAGTCATCC
TGAATTACGGCGTGTGTACTTTAACAAGGGCCTGTGA

hide sequence

RefSeq Acc Id:

XM_039095968 ⟹ XP_038951896

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	10,486,533 - 10,522,138 (-)	NCBI

RefSeq Acc Id:

XM_039095969 ⟹ XP_038951897

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	10,486,250 - 10,522,605 (-)	NCBI

RefSeq Acc Id:

XR_005495309

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	10,486,533 - 10,522,138 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012213	(Get FASTA)	NCBI Sequence Viewer
	XP_008769724	(Get FASTA)	NCBI Sequence Viewer
	XP_038951896	(Get FASTA)	NCBI Sequence Viewer
	XP_038951897	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78935	(Get FASTA)	NCBI Sequence Viewer
	EDL94064	(Get FASTA)	NCBI Sequence Viewer
	Q63965	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012213 ⟸ NM_001012213

- UniProtKB:

Q6AYS2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGEVPPNINIKEPRWDQSTFIGRASHFFTVTDPRNILLTNEQLENARKVVHDYRQGIVPAGLT
ENELWRAKYAYDSAFHPDTGEKMTLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFN
AVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCIN
IPLMRQRELKVGIPVTDENGTRLGESTNAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAF
LKRFPWMSAPIQVTLVGFCLVFATPLCCALFPQKSSMSVTSLEDELQASIQKSHPELRRVYFNK
GL

hide sequence

RefSeq Acc Id:	XP_008769724 ⟸ XM_008771502
- Peptide Label:	isoform X1
- UniProtKB:	Q6AYS2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSGEVPPNINIKEPRWDQSTFIGRASHFFTVTDPRNILLTNEQLENARKVVHDYRQGIVPAGLT ENELWRAKYAYDSAFHPDTGEKMTLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFN AVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCIN IPLMRQRELKVGIPVTDENGTRLGESTNAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAF LKRFPWMSAPIQVTLVGFCLVFATPLCCALFPQKSSMSVTSLEDELQASIQKSHPELRRVYFNK GL hide sequence

RefSeq Acc Id:

ENSRNOP00000024707 ⟸ ENSRNOT00000024707

RefSeq Acc Id:	XP_038951897 ⟸ XM_039095969
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038951896 ⟸ XM_039095968
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000091417 ⟸ ENSRNOT00000102311

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63965-F1-model_v2	AlphaFold	Q63965	1-322	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700328

Promoter ID:

EPDNEW_R10852

Type:

initiation region

Name:

Sfxn1_1

Description:

sideroflexin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	11,082,037 - 11,082,097	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308482	AgrOrtholog
BioCyc Gene	G2FUF-10157	BioCyc
Ensembl Genes	ENSRNOG00000018279	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000024707	ENTREZGENE
	ENSRNOP00000024707.4	UniProtKB/TrEMBL
	ENSRNOP00000091417.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024707	ENTREZGENE
	ENSRNOT00000024707.8	UniProtKB/TrEMBL
	ENSRNOT00000102311.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7108166	IMAGE-MGC_LOAD
InterPro	Mtc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:364678	UniProtKB/TrEMBL
MGC_CLONE	MGC:93747	IMAGE-MGC_LOAD
NCBI Gene	364678	ENTREZGENE
PANTHER	PTHR11153	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIDEROFLEXIN-1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Mtc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sfxn1	PhenoGen
TIGRFAMs	mtc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AC07_RAT	UniProtKB/TrEMBL
	Q63965	ENTREZGENE
	Q6AYS2	ENTREZGENE, UniProtKB/TrEMBL
	SFXN1_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Sfxn1	sideroflexin 1	Sfxn1_predicted	sideroflexin 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Sfxn1_predicted	sideroflexin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD