Srp19 (signal recognition particle 19)

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Gene: Srp19 (signal recognition particle 19) Rattus norvegicus

Analyze

Symbol:

Srp19

Name:

signal recognition particle 19

RGD ID:

1308437

Description:

Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be located in cytosol; nuclear body; and nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP19 (signal recognition particle 19); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC291685; signal recognition particle 19 kDa protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SRP19 (signal recognition particle 19)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Srp19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Srp19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SRP19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SRP19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Srp19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SRP19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SRP19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Srp19 (signal recognition particle 19)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SRP19 (signal recognition particle 19)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Srp19 (signal recognition particle 19)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	srp19 (signal recognition particle 19)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F37F2.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SEC65	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Srp19	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	srp19	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	25,931,734 - 25,937,974 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	25,931,589 - 25,938,017 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	26,059,149 - 26,065,389 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	26,822,051 - 26,828,303 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	26,156,956 - 26,163,208 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	27,114,822 - 27,121,062 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	27,114,822 - 27,121,059 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	26,828,291 - 26,834,644 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	26,800,249 - 26,806,489 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	26,826,836 - 26,833,178 (+)	NCBI
Celera	18	25,673,614 - 25,679,848 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

Shwachman-Diamond syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

enzyme inhibitor (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

glafenine (EXP)

irinotecan (ISO)

ivermectin (ISO)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

resveratrol (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

titanium dioxide (ISO)

Triptolide (EXP)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition (IBA)

Cellular Component

cytosol (ISO)

nuclear body (ISO)

nucleolus (ISO)

signal recognition particle (ISO)

signal recognition particle, endoplasmic reticulum targeting (IBA,ISO)

Molecular Function

7S RNA binding (IBA,ISO)

protein binding (ISO)

ribosome binding (ISO)

RNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10618370	PMID:12477932	PMID:17434535	PMID:18089836	PMID:22658674	PMID:27899666

Genomics

Comparative Map Data

Srp19
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	25,931,734 - 25,937,974 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	25,931,589 - 25,938,017 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	26,059,149 - 26,065,389 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	26,822,051 - 26,828,303 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	26,156,956 - 26,163,208 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	27,114,822 - 27,121,062 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	27,114,822 - 27,121,059 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	26,828,291 - 26,834,644 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	26,800,249 - 26,806,489 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	26,826,836 - 26,833,178 (+)	NCBI
Celera	18	25,673,614 - 25,679,848 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

SRP19
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	112,861,287 - 112,898,371 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	112,861,188 - 112,898,371 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	112,196,984 - 112,234,068 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	112,224,892 - 112,231,503 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	112,224,891 - 112,231,502	NCBI
Celera	5	108,142,564 - 108,149,171 (+)	NCBI		Celera
Cytogenetic Map	5	q22.2	NCBI
HuRef	5	107,375,987 - 107,408,525 (+)	NCBI		HuRef
CHM1_1	5	111,630,190 - 111,662,066 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	113,371,827 - 113,408,903 (+)	NCBI		T2T-CHM13v2.0

Srp19
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	34,464,185 - 34,469,652 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	34,463,900 - 34,469,652 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	34,331,121 - 34,336,599 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	34,330,847 - 34,336,599 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	34,490,799 - 34,496,253 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	34,455,984 - 34,461,399 (+)	NCBI		MGSCv36	mm8
Celera	18	34,782,673 - 34,788,127 (+)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI
cM Map	18	18.57	NCBI

Srp19
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955418	2,551,533 - 2,558,252 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRP19
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	106,271,295 - 106,301,821 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	108,221,482 - 108,251,955 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	114,024,636 - 114,031,845 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	114,024,636 - 114,031,845 (+)	Ensembl	panpan1.1		panPan2

SRP19
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	239,651 - 245,078 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	239,652 - 245,078 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	1,639,882 - 1,645,309 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	81,422 - 86,852 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	79,578 - 86,852 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	74,586 - 80,015 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	73,664 - 79,087 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	237,129 - 242,552 (-)	NCBI		UU_Cfam_GSD_1.0

Srp19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	154,580,657 - 154,587,218 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	7,024,143 - 7,031,692 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936531	7,024,358 - 7,031,139 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRP19
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	116,890,800 - 116,901,444 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	116,890,800 - 116,901,501 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	121,515,476 - 121,523,217 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRP19
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	16,151,409 - 16,180,132 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666034	62,275,384 - 62,304,500 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srp19
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	30,645,258 - 30,652,761 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	30,645,249 - 30,651,947 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Srp19
46 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	158
Count of miRNA genes:	120
Interacting mature miRNAs:	133
Transcripts:	ENSRNOT00000027418
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	11944273	26548295	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	11944273	26548295	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	11944273	26548295	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	11944273	26548295	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	11944273	26548295	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	11944273	26548295	Rat
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944273	26548295	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat

Markers in Region

RH137512

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	18	p12	UniSTS

RH140681

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	18	p12	UniSTS

AI228530

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	103,835,819 - 103,836,072 (+)	MAPPER	mRatBN7.2
mRatBN7.2	18	25,951,336 - 25,951,586 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	27,134,422 - 27,134,671	NCBI	Rnor6.0
Rnor_6.0	10	107,631,211 - 107,631,463	NCBI	Rnor6.0
Rnor_5.0	18	26,847,961 - 26,848,210	UniSTS	Rnor5.0
Rnor_5.0	10	107,265,698 - 107,265,950	UniSTS	Rnor5.0
RGSC_v3.4	10	108,608,479 - 108,608,731	UniSTS	RGSC3.4
RGSC_v3.4	18	26,819,849 - 26,820,098	UniSTS	RGSC3.4
Celera	18	25,692,430 - 25,692,679	UniSTS
Celera	10	102,395,754 - 102,396,006	UniSTS
RH 3.4 Map	18	346.4	UniSTS
Cytogenetic Map	10	q32.3	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH125924

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	18,768,732 - 18,768,964 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	20,402,545 - 20,402,776	NCBI	Rnor6.0
Rnor_5.0	14	20,308,989 - 20,309,220	UniSTS	Rnor5.0
RGSC_v3.4	14	20,306,142 - 20,306,373	UniSTS	RGSC3.4
Celera	14	18,127,790 - 18,128,021	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC167043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027418 ⟹ ENSRNOP00000027418

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	25,931,957 - 25,938,016 (+)	Ensembl
Rnor_6.0 Ensembl	18	27,114,822 - 27,121,059 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097724 ⟹ ENSRNOP00000091385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	25,931,631 - 25,938,015 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104312 ⟹ ENSRNOP00000084542

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	25,931,589 - 25,938,017 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108712 ⟹ ENSRNOP00000077002

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	25,931,631 - 25,938,015 (+)	Ensembl

RefSeq Acc Id:

NM_001106157 ⟹ NP_001099627

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	25,931,734 - 25,937,974 (+)	NCBI
Rnor_6.0	18	27,114,822 - 27,121,062 (+)	NCBI
Rnor_5.0	18	26,828,291 - 26,834,644 (+)	NCBI
RGSC_v3.4	18	26,800,249 - 26,806,489 (+)	RGD
Celera	18	25,673,614 - 25,679,848 (+)	RGD

Sequence:

show sequence

CCGGTGGAGATGGCATGCGCTGCCGCGCGGTCCCCGGCCGACCAGGACAGGTTTATTTGTATCT
ACCCCGCTTATTTAAATAATAAGAAGACCATAGCTGAGGGGAGGCGGATCCCCATTAATAAGGC
TGTAGAAAACCCCACGGCTACTGAGATTCAGGATGTATGTTCAGCAGTTGGACTGAATGCGTTT
CTGGAGAAAAACAAAATGTACTCCAGAGAATGGAATCGTGATGTTCAGTATAGAGGCAGAGTTC
GGGTACAGCTCAAACAGGAAGATGGCAGCCTCTGTCTTGTACAGTTCCCATCACGTAAGTCGGT
GATGCTGTACGTAGCAGAAATGATACCCAAGCTAAAAACAAGGACTCAGAAGTCAGGAGGTGCT
GACCCAAGTCTTCAGCAGGGAGAGGGGAGTAAGAAAGGGAAAGGAAAGAAGAAGAAATGATGTG
GCGTGAACATACAGTGTGCAGTTCTGCTGGGAGAGACGTGGCATCTTTGCGTGTGAGGGAACAG
CTTTTTGTTGTGTTGTTTAACTGAGCTGCGAACGTGTGTCTCCCATCTTCAACAGTTAACAATG
AAGTCAGTTTACATCACAAGTTTGCATCCAGCTTTTAGATGTAAAAAGAAAAATTGTGTGTGTG
GAAGAAAGAATATTTTTAACAGATAATGACTGTCCCATAAGTTACTTGAAATATCTATCTGTTT
GTCCTCCGTGTAAACATATTTCAGATATATATGTTTAATAAAGTTTGGAATACACAAAAAAAAA
AAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099627	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67043	(Get FASTA)	NCBI Sequence Viewer
	EDL76221	(Get FASTA)	NCBI Sequence Viewer
	EDL76222	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001099627 ⟸ NM_001106157
- UniProtKB:	B2RZ66 (UniProtKB/TrEMBL), A0A8I6AFH8 (UniProtKB/TrEMBL), F7F3N8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPINKAVENPTATEIQDVCSAVGLNAFLEK NKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYVAEMIPKLKTRTQKSGGADPS LQQGEGSKKGKGKKKK hide sequence

RefSeq Acc Id:

ENSRNOP00000027418 ⟸ ENSRNOT00000027418

RefSeq Acc Id:

ENSRNOP00000077002 ⟸ ENSRNOT00000108712

RefSeq Acc Id:

ENSRNOP00000084542 ⟸ ENSRNOT00000104312

RefSeq Acc Id:

ENSRNOP00000091385 ⟸ ENSRNOT00000097724

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RZ66-F1-model_v2	AlphaFold	B2RZ66	1-144	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308437	AgrOrtholog
BioCyc Gene	G2FUF-7961	BioCyc
Ensembl Genes	ENSRNOG00000020204	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000027418.6	UniProtKB/TrEMBL
	ENSRNOP00000077002.1	UniProtKB/TrEMBL
	ENSRNOP00000084542.1	UniProtKB/TrEMBL
	ENSRNOP00000091385	ENTREZGENE
	ENSRNOP00000091385.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027418.8	UniProtKB/TrEMBL
	ENSRNOT00000097724	ENTREZGENE
	ENSRNOT00000097724.1	UniProtKB/TrEMBL
	ENSRNOT00000104312.1	UniProtKB/TrEMBL
	ENSRNOT00000108712.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.56.30	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7319792	IMAGE-MGC_LOAD
InterPro	Signal_recog_particle_SRP19	UniProtKB/TrEMBL
	SRP19-like_sf	UniProtKB/TrEMBL
KEGG Report	rno:291685	UniProtKB/TrEMBL
MGC_CLONE	MGC:189310	IMAGE-MGC_LOAD
NCBI Gene	291685	ENTREZGENE
PANTHER	SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN	UniProtKB/TrEMBL
	SRP19	UniProtKB/TrEMBL
Pfam	SRP19	UniProtKB/TrEMBL
PhenoGen	Srp19	PhenoGen
Superfamily-SCOP	Signal_recog_particle_SRP19	UniProtKB/TrEMBL
UniProt	A0A8I5Y7C0_RAT	UniProtKB/TrEMBL
	A0A8I5ZXH6_RAT	UniProtKB/TrEMBL
	A0A8I6AFH8	ENTREZGENE, UniProtKB/TrEMBL
	B2RZ66	ENTREZGENE, UniProtKB/TrEMBL
	F7F3N8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Srp19	signal recognition particle 19	Srp19_predicted	signal recognition particle 19 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Srp19_predicted	signal recognition particle 19 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar