Dclk2 (doublecortin-like kinase 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dclk2 (doublecortin-like kinase 2) Rattus norvegicus
Analyze
Symbol: Dclk2
Name: doublecortin-like kinase 2
RGD ID: 1308384
Description: Predicted to enable microtubule binding activity and protein kinase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within hippocampus development; negative regulation of protein localization to nucleus; and pyramidal neuron development. Predicted to be located in cytoplasm and cytoskeleton. Orthologous to human DCLK2 (doublecortin like kinase 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: caMK-like CREB regulatory kinase 2; CL2; CLICK-II; CLICK2; Dck2; doublecortin kinase 2; doublecortin-like and CAM kinase-like 2; LOC310697; RGD1308384; serine/threonine-protein kinase DCLK2; similar to doublecortin-like kinase 2; similar to RIKEN cDNA 6330415M09
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82174,506,660 - 174,636,353 (-)NCBIGRCr8
mRatBN7.22172,202,733 - 172,338,411 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2172,208,706 - 172,338,250 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2179,354,803 - 179,483,823 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02177,377,163 - 177,506,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02171,976,590 - 172,106,387 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02186,116,624 - 186,245,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2186,116,624 - 186,245,771 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02205,515,413 - 205,644,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42178,793,765 - 178,923,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12178,743,870 - 178,873,706 (-)NCBI
Celera2166,170,116 - 166,297,500 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15611072   PMID:16684769   PMID:16869982   PMID:18075264   PMID:19342486   PMID:20236041   PMID:30053369  


Genomics

Comparative Map Data
Dclk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82174,506,660 - 174,636,353 (-)NCBIGRCr8
mRatBN7.22172,202,733 - 172,338,411 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2172,208,706 - 172,338,250 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2179,354,803 - 179,483,823 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02177,377,163 - 177,506,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02171,976,590 - 172,106,387 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02186,116,624 - 186,245,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2186,116,624 - 186,245,771 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02205,515,413 - 205,644,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42178,793,765 - 178,923,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12178,743,870 - 178,873,706 (-)NCBI
Celera2166,170,116 - 166,297,500 (-)NCBICelera
Cytogenetic Map2q34NCBI
DCLK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384150,078,445 - 150,257,438 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4150,078,445 - 150,257,438 (+)EnsemblGRCh38hg38GRCh38
GRCh374150,999,597 - 151,178,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364151,219,530 - 151,398,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 344151,357,745 - 151,536,188NCBI
Celera4148,317,796 - 148,498,175 (+)NCBICelera
Cytogenetic Map4q31.23-q31.3NCBI
HuRef4146,722,453 - 146,904,055 (+)NCBIHuRef
CHM1_14150,976,053 - 151,155,056 (+)NCBICHM1_1
T2T-CHM13v2.04153,399,764 - 153,581,437 (+)NCBIT2T-CHM13v2.0
Dclk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39386,693,457 - 86,828,292 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl386,693,458 - 86,828,159 (-)EnsemblGRCm39 Ensembl
GRCm38386,786,150 - 86,920,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl386,786,151 - 86,920,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv37386,590,073 - 86,724,803 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36386,872,080 - 87,006,779 (-)NCBIMGSCv36mm8
Celera386,797,139 - 86,946,298 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.88NCBI
Dclk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554714,903,077 - 5,044,788 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554714,903,077 - 5,044,426 (+)NCBIChiLan1.0ChiLan1.0
DCLK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23147,950,183 - 148,127,634 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14148,313,676 - 148,490,300 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04142,412,945 - 142,590,129 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14154,064,018 - 154,239,156 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4154,064,018 - 154,239,156 (+)Ensemblpanpan1.1panPan2
DCLK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11548,119,227 - 48,365,807 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1548,119,001 - 48,365,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1548,459,584 - 48,704,409 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01548,794,655 - 49,041,539 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1548,794,701 - 49,041,280 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11548,065,813 - 48,311,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01548,158,219 - 48,403,823 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01548,481,665 - 48,728,574 (+)NCBIUU_Cfam_GSD_1.0
Dclk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530142,105,216 - 42,259,110 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936689272,130 - 426,078 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936689272,136 - 428,145 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCLK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl878,681,415 - 78,854,848 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1878,680,241 - 78,854,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2883,617,774 - 83,722,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCLK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1796,526,698 - 96,706,958 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl796,527,073 - 96,707,347 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603776,274,270 - 76,455,164 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dclk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248581,637,986 - 1,788,172 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248581,638,145 - 1,809,605 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dclk2
701 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:207
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000022292, ENSRNOT00000057062, ENSRNOT00000066004
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
D17S1873  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,229,616 - 172,229,912 (+)MAPPERmRatBN7.2
mRatBN7.210105,596,188 - 105,597,792 (+)MAPPERmRatBN7.2
Rnor_6.02186,137,635 - 186,137,930NCBIRnor6.0
Rnor_6.010109,495,160 - 109,496,763NCBIRnor6.0
Rnor_5.010109,090,603 - 109,092,206UniSTSRnor5.0
Rnor_5.02205,536,197 - 205,536,492UniSTSRnor5.0
RGSC_v3.42178,814,871 - 178,815,166UniSTSRGSC3.4
Celera2166,191,112 - 166,191,407UniSTS
Cytogenetic Map2q34UniSTS
RH142675  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,208,714 - 172,208,814 (+)MAPPERmRatBN7.2
Rnor_6.02186,116,629 - 186,116,728NCBIRnor6.0
Rnor_5.02205,515,422 - 205,515,521UniSTSRnor5.0
RGSC_v3.42178,793,764 - 178,793,863UniSTSRGSC3.4
Celera2166,170,121 - 166,170,220UniSTS
RH 3.4 Map2651.2UniSTS
Cytogenetic Map2q34UniSTS
RH144449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,317,383 - 172,317,492 (+)MAPPERmRatBN7.2
Rnor_6.02186,225,079 - 186,225,187NCBIRnor6.0
Rnor_5.02205,623,242 - 205,623,350UniSTSRnor5.0
RGSC_v3.42178,903,262 - 178,903,370UniSTSRGSC3.4
Celera2166,276,634 - 166,276,742UniSTS
RH 3.4 Map21128.3UniSTS
Cytogenetic Map2q34UniSTS
BF398261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,208,889 - 172,209,026 (+)MAPPERmRatBN7.2
Rnor_6.02186,116,804 - 186,116,940NCBIRnor6.0
Rnor_5.02205,515,597 - 205,515,733UniSTSRnor5.0
RGSC_v3.42178,793,939 - 178,794,075UniSTSRGSC3.4
Celera2166,170,296 - 166,170,432UniSTS
RH 3.4 Map2649.3UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:234717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22172,265,270 - 172,265,470 (+)MAPPERmRatBN7.2
Rnor_6.02186,173,490 - 186,173,689NCBIRnor6.0
Rnor_5.02205,571,653 - 205,571,852UniSTSRnor5.0
RGSC_v3.42178,851,154 - 178,851,353UniSTSRGSC3.4
Celera2166,224,790 - 166,224,989UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 74 29 11
Low 3 43 49 37 19 37 8 10 35 12 8
Below cutoff 4 4 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001195832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_351806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY673997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY673998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY673999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY674000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM030581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000022292   ⟹   ENSRNOP00000022292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2172,213,909 - 172,338,250 (-)Ensembl
Rnor_6.0 Ensembl2186,119,729 - 186,245,361 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000057062   ⟹   ENSRNOP00000053894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2172,208,706 - 172,338,250 (-)Ensembl
Rnor_6.0 Ensembl2186,117,355 - 186,245,342 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000066004   ⟹   ENSRNOP00000062805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2172,208,710 - 172,338,250 (-)Ensembl
Rnor_6.0 Ensembl2186,116,630 - 186,245,771 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079954   ⟹   ENSRNOP00000075203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2172,208,710 - 172,338,250 (-)Ensembl
Rnor_6.0 Ensembl2186,116,630 - 186,245,771 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087088   ⟹   ENSRNOP00000070484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2186,143,811 - 186,232,292 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2186,116,624 - 186,117,257 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089339   ⟹   ENSRNOP00000074906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2186,117,778 - 186,245,163 (-)Ensembl
RefSeq Acc Id: NM_001009691   ⟹   NP_001009691
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,192 (-)NCBI
mRatBN7.22172,208,710 - 172,338,250 (-)NCBI
Rnor_6.02186,116,624 - 186,245,771 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
RGSC_v3.42178,793,765 - 178,923,600 (-)RGD
Celera2166,170,116 - 166,297,500 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001195832   ⟹   NP_001182761
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,192 (-)NCBI
mRatBN7.22172,208,710 - 172,338,250 (-)NCBI
Rnor_6.02186,116,624 - 186,245,771 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
Celera2166,170,116 - 166,297,500 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232680   ⟹   XP_006232742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,351 (-)NCBI
mRatBN7.22172,202,733 - 172,338,410 (-)NCBI
Rnor_6.02186,117,322 - 186,245,937 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232681   ⟹   XP_006232743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,351 (-)NCBI
mRatBN7.22172,202,733 - 172,338,410 (-)NCBI
Rnor_6.02186,117,322 - 186,245,937 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232682   ⟹   XP_006232744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,351 (-)NCBI
mRatBN7.22172,202,733 - 172,338,410 (-)NCBI
Rnor_6.02186,117,322 - 186,245,937 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232684   ⟹   XP_006232746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,352 (-)NCBI
mRatBN7.22172,209,810 - 172,338,411 (-)NCBI
Rnor_6.02186,117,870 - 186,245,937 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232685   ⟹   XP_006232747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,352 (-)NCBI
mRatBN7.22172,209,810 - 172,338,410 (-)NCBI
Rnor_6.02186,117,870 - 186,245,937 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281894   ⟹   XP_063137964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,352 (-)NCBI
RefSeq Acc Id: XM_063281895   ⟹   XP_063137965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,507,747 - 174,636,352 (-)NCBI
RefSeq Acc Id: XM_063281896   ⟹   XP_063137966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,353 (-)NCBI
RefSeq Acc Id: XM_063281897   ⟹   XP_063137967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,352 (-)NCBI
RefSeq Acc Id: XM_063281898   ⟹   XP_063137968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,352 (-)NCBI
RefSeq Acc Id: XM_063281899   ⟹   XP_063137969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,507,747 - 174,636,352 (-)NCBI
RefSeq Acc Id: XM_063281900   ⟹   XP_063137970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,506,660 - 174,636,352 (-)NCBI
RefSeq Acc Id: XM_063281901   ⟹   XP_063137971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,519,533 - 174,636,351 (-)NCBI
RefSeq Acc Id: XR_351806
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82174,507,763 - 174,636,352 (-)NCBI
mRatBN7.22172,209,817 - 172,338,411 (-)NCBI
Rnor_6.02186,117,878 - 186,245,937 (-)NCBI
Rnor_5.02205,515,413 - 205,644,091 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001009691   ⟸   NM_001009691
- Peptide Label: isoform b
- UniProtKB: Q5MPA8 (UniProtKB/Swiss-Prot),   Q5MPA7 (UniProtKB/Swiss-Prot),   Q5MPB0 (UniProtKB/Swiss-Prot),   Q5MPA9 (UniProtKB/Swiss-Prot),   A0A8L2RA10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001182761   ⟸   NM_001195832
- Peptide Label: isoform a
- UniProtKB: A0A8L2QVM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232744   ⟸   XM_006232682
- Peptide Label: isoform X3
- UniProtKB: A0A8L2RA10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232743   ⟸   XM_006232681
- Peptide Label: isoform X2
- UniProtKB: A0A8L2RA10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232742   ⟸   XM_006232680
- Peptide Label: isoform X1
- UniProtKB: A0A8L2RA10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232746   ⟸   XM_006232684
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QVM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232747   ⟸   XM_006232685
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QQT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053894   ⟸   ENSRNOT00000057062
RefSeq Acc Id: ENSRNOP00000074906   ⟸   ENSRNOT00000089339
RefSeq Acc Id: ENSRNOP00000075203   ⟸   ENSRNOT00000079954
RefSeq Acc Id: ENSRNOP00000070484   ⟸   ENSRNOT00000087088
RefSeq Acc Id: ENSRNOP00000062805   ⟸   ENSRNOT00000066004
RefSeq Acc Id: ENSRNOP00000022292   ⟸   ENSRNOT00000022292
RefSeq Acc Id: XP_063137966   ⟸   XM_063281896
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QVM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137968   ⟸   XM_063281898
- Peptide Label: isoform X10
- UniProtKB: A0A8L2QQT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137970   ⟸   XM_063281900
- Peptide Label: isoform X12
- UniProtKB: A0A8L2QVM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137964   ⟸   XM_063281894
- Peptide Label: isoform X4
- UniProtKB: A0A8L2RA10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137967   ⟸   XM_063281897
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QVM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137969   ⟸   XM_063281899
- Peptide Label: isoform X11
- UniProtKB: A0A8L2QVM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137965   ⟸   XM_063281895
- Peptide Label: isoform X7
- UniProtKB: A0A8L2QVM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137971   ⟸   XM_063281901
- Peptide Label: isoform X13
- UniProtKB: A0A8L2QQT4 (UniProtKB/TrEMBL)
Protein Domains
Doublecortin   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5MPA9-F1-model_v2 AlphaFold Q5MPA9 1-767 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308384 AgrOrtholog
BioCyc Gene G2FUF-52567 BioCyc
Ensembl Genes ENSRNOG00000016550 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055025208 UniProtKB/Swiss-Prot
  ENSRNOG00060031672 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022292.7 UniProtKB/TrEMBL
  ENSRNOT00000057062.6 UniProtKB/TrEMBL
  ENSRNOT00000066004.5 UniProtKB/TrEMBL
  ENSRNOT00000079954.2 UniProtKB/TrEMBL
  ENSRNOT00055043536 UniProtKB/Swiss-Prot
  ENSRNOT00060054927 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Doublecortin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Doublecortin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310698 UniProtKB/Swiss-Prot
NCBI Gene 310698 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE DCLK2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DCX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dclk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016550 RatGTEx
  ENSRNOG00055025208 RatGTEx
  ENSRNOG00060031672 RatGTEx
SMART DCX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF89837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QQT4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QVM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RA10 ENTREZGENE, UniProtKB/TrEMBL
  DCLK2_RAT UniProtKB/Swiss-Prot
  E9PSS1_RAT UniProtKB/TrEMBL
  Q5MPA7 ENTREZGENE
  Q5MPA8 ENTREZGENE
  Q5MPA9 ENTREZGENE
  Q5MPB0 ENTREZGENE
UniProt Secondary Q5MPA7 UniProtKB/Swiss-Prot
  Q5MPA8 UniProtKB/Swiss-Prot
  Q5MPB0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Dclk2  doublecortin-like kinase 2  Dclk2_predicted  similar to doublecortin-like kinase 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-03 Dclk3_predicted  similar to doublecortin-like kinase 2 (predicted)  Dclk2_predicted  similar to doublecortin and CaM kinase-like 2 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2007-04-03 Dclk2_predicted  similar to doublecortin and CaM kinase-like 2 (predicted)  RGD1308384_predicted  similar to RIKEN cDNA 6330415M09 (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1308384_predicted  similar to RIKEN cDNA 6330415M09 (predicted)  RGD1308384  similar to RIKEN cDNA 6330415M09  Symbol and Name status set to approved 1299863 APPROVED
2005-12-06 RGD1308384  similar to RIKEN cDNA 6330415M09  RGD1308384_predicted  similar to RIKEN cDNA 6330415M09 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308384_predicted  similar to RIKEN cDNA 6330415M09 (predicted)  LOC310697_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310697_predicted  similar to RIKEN cDNA 6330415M09 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL