Sirt3 (sirtuin 3) - Rat Genome Database

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Gene: Sirt3 (sirtuin 3) Rattus norvegicus
Analyze
Symbol: Sirt3
Name: sirtuin 3
RGD ID: 1308374
Description: Enables enzyme binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion and nucleus. Used to study metabolic dysfunction-associated steatotic liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,3,7,9-tetramethyluric acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC293615; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIRT3L mitochondrial; sirtuin; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Sirt3em25Mcwi ; Sirt3em4Mcwi ; Sirt3em35Mcwi ; Sirt3em30Mcwi
Genetic Models: SS-Sirt3em25Mcwi ; T2DN-Sirt3em30Mcwi ; T2DN-Sirt3em35Mcwi ; SS-Sirt3em4Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,371,703 - 205,394,145 (-)NCBIGRCr8
GRCr8 Ensembl1205,371,710 - 205,394,076 (-)EnsemblGRCr8 Ensembl
mRatBN7.21195,942,066 - 195,964,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,294,536 - 204,318,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,421,447 - 211,445,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,095,300 - 204,119,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1193,586,014 - 193,607,810 (-)NCBICelera
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,7,9-tetramethyluric acid  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
ADP  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-mangostin  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
arsenous acid  (EXP)
ATP  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisononyl phthalate  (ISO)
Diosbulbin B  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
erastin  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
ferrostatin-1  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
GSK-J4  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
linagliptin  (EXP)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP)
lycopene  (ISO)
mancozeb  (ISO)
maneb  (ISO)
melatonin  (EXP,ISO)
metformin  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nebivolol  (ISO)
nicotinamide  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
propionic acid  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
salvianolic acid B  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sodium sulfide (anhydrous)  (EXP)
Soman  (EXP)
sorafenib  (ISO)
stavudine  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trilobatin  (EXP)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vosaroxin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. Borengasser SJ, etal., PLoS One. 2011;6(8):e24068. doi: 10.1371/journal.pone.0024068. Epub 2011 Aug 25.
2. Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Caton PW, etal., Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Non-histone lysine acetylated proteins in heart failure. Grillon JM, etal., Biochim Biophys Acta. 2012 Apr;1822(4):607-14. doi: 10.1016/j.bbadis.2011.11.016. Epub 2011 Dec 3.
5. In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner. Gurd BJ, etal., Metabolism. 2012 May;61(5):733-41. doi: 10.1016/j.metabol.2011.09.016. Epub 2011 Nov 9.
6. Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis. Jiang HK, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):192-201. doi: 10.1111/1440-1681.12211.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
9. Pre-diabetes alters testicular PGC1-alpha/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress. Rato L, etal., Biochim Biophys Acta. 2014 Mar;1837(3):335-44. doi: 10.1016/j.bbabio.2013.12.008. Epub 2013 Dec 20.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Valdecantos MP, etal., Obesity (Silver Spring). 2012 Oct;20(10):1974-83. doi: 10.1038/oby.2012.32. Epub 2012 Feb 13.
14. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
15. CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. Weir HJ, etal., PLoS One. 2012;7(11):e48225. doi: 10.1371/journal.pone.0048225. Epub 2012 Nov 6.
16. Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model. Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.
Additional References at PubMed
PMID:11056054   PMID:12186850   PMID:12477932   PMID:16079181   PMID:16788062   PMID:16790548   PMID:17923681   PMID:18054327   PMID:18614015   PMID:19241369   PMID:19535340   PMID:20413424  
PMID:21419014   PMID:21867412   PMID:22309213   PMID:23201401   PMID:23283301   PMID:23576753   PMID:24239092   PMID:24535021   PMID:25210848   PMID:25284742   PMID:25433241   PMID:25483313  
PMID:25759382   PMID:25877446   PMID:25993470   PMID:26225774   PMID:26523980   PMID:26620563   PMID:26767982   PMID:27067422   PMID:27212443   PMID:27423420   PMID:27449933   PMID:27614093  
PMID:27888691   PMID:27890624   PMID:28003866   PMID:28053989   PMID:28296029   PMID:28396174   PMID:28579116   PMID:28760678   PMID:29445193   PMID:29857817   PMID:29863652   PMID:30132522  
PMID:30216853   PMID:30385301   PMID:30502252   PMID:30717220   PMID:30764676   PMID:30849417   PMID:31696493   PMID:32139662   PMID:32141452   PMID:32426865   PMID:32506069   PMID:32507768  
PMID:32805255   PMID:32818702   PMID:33127810   PMID:33522075   PMID:33565085   PMID:33665656   PMID:33823364   PMID:34082675   PMID:34296964   PMID:34330062   PMID:34360775   PMID:35192161  
PMID:35953459   PMID:36153454   PMID:36262283   PMID:36380567   PMID:36481985   PMID:36863620   PMID:36916106   PMID:36922709   PMID:37335200   PMID:37988067   PMID:38122862   PMID:38134189  
PMID:38139395   PMID:38301949   PMID:38408417   PMID:38572816   PMID:38767771   PMID:38950736   PMID:39048173   PMID:39168432   PMID:39261577  


Genomics

Comparative Map Data
Sirt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,371,703 - 205,394,145 (-)NCBIGRCr8
GRCr8 Ensembl1205,371,710 - 205,394,076 (-)EnsemblGRCr8 Ensembl
mRatBN7.21195,942,066 - 195,964,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,294,536 - 204,318,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,421,447 - 211,445,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,095,300 - 204,119,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1193,586,014 - 193,607,810 (-)NCBICelera
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Cytogenetic Map1q41NCBI
SIRT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811215,030 - 236,931 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11215,030 - 236,931 (-)EnsemblGRCh38hg38GRCh38
GRCh3711215,030 - 236,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611205,030 - 226,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411206,138 - 226,416NCBI
Celera11322,773 - 343,832 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef1135,047 - 56,030 (-)NCBIHuRef
CHM1_111213,704 - 234,799 (-)NCBICHM1_1
T2T-CHM13v2.011256,228 - 277,937 (-)NCBIT2T-CHM13v2.0
Sirt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,443,576 - 140,462,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,443,579 - 140,462,222 (-)EnsemblGRCm39 Ensembl
GRCm387140,863,663 - 140,882,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,863,666 - 140,882,309 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,049,562 - 148,068,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,714,990 - 140,733,629 (-)NCBIMGSCv36mm8
Celera7140,655,950 - 140,674,596 (-)NCBICelera
Cytogenetic Map7F4- F5NCBI
cM Map786.07NCBI
Sirt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,794,951 - 11,826,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,794,951 - 11,826,244 (+)NCBIChiLan1.0ChiLan1.0
SIRT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,582,959 - 2,605,626 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,737,925 - 1,761,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011210,052 - 233,969 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111255,191 - 863,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11255,191 - 278,732 (-)Ensemblpanpan1.1panPan2
SIRT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,369,183 - 25,388,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,369,382 - 25,388,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,019,130 - 25,038,115 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,895,720 - 25,914,839 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1825,895,722 - 25,914,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,463,734 - 25,482,834 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,108,512 - 25,127,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,721,366 - 25,740,351 (-)NCBIUU_Cfam_GSD_1.0
Sirt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,131 - 78,513 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688863,546 - 77,950 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493688863,131 - 78,536 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl238,464 - 55,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1238,465 - 55,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22162,169,820 - 162,186,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,740 - 49,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl126,927 - 48,944 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,040,657 - 97,063,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476622,199,601 - 22,233,933 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476622,199,741 - 22,233,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt3
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:48
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000018861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512205777982Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
RH133909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21195,942,227 - 195,942,434 (+)MAPPERmRatBN7.2
Rnor_6.01213,613,664 - 213,613,870NCBIRnor6.0
Rnor_5.01220,539,295 - 220,539,501UniSTSRnor5.0
RGSC_v3.41201,021,549 - 201,021,755UniSTSRGSC3.4
Celera1193,586,172 - 193,586,378UniSTS
Cytogenetic Map1q41UniSTS
Sirt3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21195,954,054 - 195,955,352 (+)MAPPERmRatBN7.2
Rnor_6.01213,625,491 - 213,626,788NCBIRnor6.0
Rnor_5.01220,551,122 - 220,552,419UniSTSRnor5.0
Celera1193,597,830 - 193,599,127UniSTS
Cytogenetic Map1q41UniSTS


Genetic Models
This gene Sirt3 is modified in the following models/strains:
SS-Sirt3em25Mcwi     T2DN-Sirt3em30Mcwi     T2DN-Sirt3em35Mcwi     SS-Sirt3em4Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU886468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000018861   ⟹   ENSRNOP00000018861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1205,371,710 - 205,393,635 (-)Ensembl
mRatBN7.2 Ensembl1195,942,077 - 195,964,071 (-)Ensembl
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095396   ⟹   ENSRNOP00000089047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,942,073 - 195,958,082 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116448   ⟹   ENSRNOP00000078101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1205,371,710 - 205,394,076 (-)Ensembl
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)Ensembl
RefSeq Acc Id: NM_001106313   ⟹   NP_001099783
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,601 (-)NCBI
mRatBN7.21195,942,070 - 195,963,970 (-)NCBI
Rnor_6.01213,613,506 - 213,635,512 (-)NCBI
Rnor_5.01220,539,132 - 220,561,380 (-)NCBI
RGSC_v3.41201,021,391 - 201,043,756 (-)RGD
Celera1193,586,014 - 193,607,810 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230526   ⟹   XP_006230588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,697 (-)NCBI
mRatBN7.21195,942,066 - 195,964,047 (-)NCBI
Rnor_6.01213,613,502 - 213,635,601 (-)NCBI
Rnor_5.01220,539,132 - 220,561,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107846   ⟹   XP_038963774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,103 (-)NCBI
mRatBN7.21195,942,068 - 195,964,472 (-)NCBI
RefSeq Acc Id: XM_039107856   ⟹   XP_038963784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,651 (-)NCBI
mRatBN7.21195,942,066 - 195,964,048 (-)NCBI
RefSeq Acc Id: XM_063286513   ⟹   XP_063142583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,877 (-)NCBI
RefSeq Acc Id: XM_063286515   ⟹   XP_063142585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,697 (-)NCBI
RefSeq Acc Id: XM_063286517   ⟹   XP_063142587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,113 (-)NCBI
RefSeq Acc Id: XM_063286519   ⟹   XP_063142589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,386,763 (-)NCBI
RefSeq Acc Id: XM_063286525   ⟹   XP_063142595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,145 (-)NCBI
RefSeq Acc Id: XM_063286528   ⟹   XP_063142598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,145 (-)NCBI
RefSeq Acc Id: XM_063286529   ⟹   XP_063142599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,145 (-)NCBI
RefSeq Acc Id: NP_001099783   ⟸   NM_001106313
- UniProtKB: B2RZ31 (UniProtKB/TrEMBL),   A0A8I6A7C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230588   ⟸   XM_006230526
- Peptide Label: isoform X2
- UniProtKB: F7EYD5 (UniProtKB/TrEMBL),   C6ZII9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018861   ⟸   ENSRNOT00000018861
RefSeq Acc Id: XP_038963784   ⟸   XM_039107856
- Peptide Label: isoform X5
- UniProtKB: A6HXL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963774   ⟸   XM_039107846
- Peptide Label: isoform X4
- UniProtKB: B2RZ31 (UniProtKB/TrEMBL),   A0A8I6A7C4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078101   ⟸   ENSRNOT00000116448
Ensembl Acc Id: ENSRNOP00000089047   ⟸   ENSRNOT00000095396
RefSeq Acc Id: XP_063142595   ⟸   XM_063286525
- Peptide Label: isoform X5
- UniProtKB: A6HXL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142599   ⟸   XM_063286529
- Peptide Label: isoform X5
- UniProtKB: A6HXL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142598   ⟸   XM_063286528
- Peptide Label: isoform X4
- UniProtKB: B2RZ31 (UniProtKB/TrEMBL),   A0A8I6A7C4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142583   ⟸   XM_063286513
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XWT5 (UniProtKB/TrEMBL),   C6ZII9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142585   ⟸   XM_063286515
- Peptide Label: isoform X3
- UniProtKB: C6ZII9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142587   ⟸   XM_063286517
- Peptide Label: isoform X4
- UniProtKB: B2RZ31 (UniProtKB/TrEMBL),   A0A8I6A7C4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142589   ⟸   XM_063286519
- Peptide Label: isoform X4
- UniProtKB: B2RZ31 (UniProtKB/TrEMBL),   A0A8I6A7C4 (UniProtKB/TrEMBL)
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-C6ZII9-F1-model_v2 AlphaFold C6ZII9 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690520
Promoter ID:EPDNEW_R1044
Type:multiple initiation site
Name:Sirt3_1
Description:sirtuin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,635,546 - 213,635,606EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308374 AgrOrtholog
BioCyc Gene G2FUF-57005 BioCyc
Ensembl Genes ENSRNOG00000013828 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018861 ENTREZGENE
  ENSRNOT00000018861.7 UniProtKB/TrEMBL
  ENSRNOT00000095396.1 UniProtKB/TrEMBL
  ENSRNOT00000116448 ENTREZGENE
  ENSRNOT00000116448.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314283 IMAGE-MGC_LOAD
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD-dep_deAcase_SIR2_euk UniProtKB/TrEMBL
  NAD-dep_histone_deAcase_SIR2 UniProtKB/TrEMBL
  NAD-dep_sirtuin_deacylases UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
KEGG Report rno:293615 UniProtKB/TrEMBL
MGC_CLONE MGC:189177 IMAGE-MGC_LOAD
NCBI Gene 293615 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PhenoGen Sirt3 PhenoGen
PIRSF SIR2_euk UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013828 RatGTEx
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A8I5XWT5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7C4 ENTREZGENE, UniProtKB/TrEMBL
  A6HXL1 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ31 ENTREZGENE, UniProtKB/TrEMBL
  C6ZII9 ENTREZGENE, UniProtKB/TrEMBL
  F7EYD5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt3  sirtuin 3  Sirt3  sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Sirt3  sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)  Sirt3  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sirt3  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)   Sirt3_predicted  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sirt3_predicted  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED