Sirt3 (sirtuin 3) - Rat Genome Database

Name: Sirt3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Sirt3 (sirtuin 3) Rattus norvegicus

Analyze

Symbol:

Sirt3

Name:

sirtuin 3

RGD ID:

1308374

Description:

Enables enzyme binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Used to study non-alcoholic fatty liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,3,7,9-tetramethyluric acid.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC293615; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIRT3L mitochondrial; sirtuin; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIRT3 (sirtuin 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SIRT3 (sirtuin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sirt3 (sirtuin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sirt3 (sirtuin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HST2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sirt3.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Sirt3^em25Mcwi Sirt3^em4Mcwi Sirt3^em35Mcwi Sirt3^em30Mcwi

Genetic Models:

SS-Sirt3^em25Mcwi T2DN-Sirt3^em30Mcwi T2DN-Sirt3^em35Mcwi SS-Sirt3^em4Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	195,942,066 - 195,964,472 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	195,942,073 - 195,964,808 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	204,294,536 - 204,318,293 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	211,421,447 - 211,445,196 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	204,095,300 - 204,119,047 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	213,613,502 - 213,636,061 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	213,613,513 - 213,635,546 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	220,539,132 - 220,561,380 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	201,021,391 - 201,043,756 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	201,172,601 - 201,193,816 (-)	NCBI
Celera	1	193,586,014 - 193,607,810 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal obesity-metabolic syndrome (ISS)

Alzheimer's disease (ISO)

congestive heart failure (IEP)

drug-induced hearing loss (ISO)

genetic disease (ISO)

gestational diabetes (ISO)

immunodeficiency 39 (ISO)

Mouth Neoplasms (ISO)

myocardial infarction (IEP)

non-alcoholic fatty liver disease (IDA)

obesity (IEP,ISO)

prediabetes syndrome (IEP)

Presbycusis (IEP)

squamous cell carcinoma (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(R)-lipoic acid (EXP)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1,3,7,9-tetramethyluric acid (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,5-diethoxycarbonyl-1,4-dihydrocollidine (ISO)

4-hydroxynon-2-enal (ISO)

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (EXP,ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

ADP (ISO)

aldehydo-D-glucose (ISO)

alpha-mangostin (ISO)

amitrole (EXP)

antimycin A (ISO)

arsenous acid (EXP)

ATP (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

berberine (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGS-21680 (ISO)

chloroquine (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (EXP,ISO)

copper(II) sulfate (ISO)

curcumin (EXP,ISO)

D-glucose (ISO)

deguelin (ISO)

diarsenic trioxide (EXP)

diazinon (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

diisononyl phthalate (ISO)

doxorubicin (EXP,ISO)

estriol (ISO)

ethanol (EXP,ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glucose (ISO)

hexadecanoic acid (ISO)

Honokiol (EXP)

hydrogen peroxide (EXP,ISO)

hydrogen sulfide (EXP,ISO)

hydroquinone (ISO)

icariin (EXP)

L-methionine (ISO)

lead diacetate (ISO)

linalool (ISO)

lipoic acid (EXP)

lipopolysaccharide (EXP)

mancozeb (ISO)

maneb (ISO)

metformin (EXP,ISO)

methimazole (EXP)

methotrexate (ISO)

metiram (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-acetyl-L-cysteine (EXP,ISO)

N-methyl-4-phenylpyridinium (EXP)

nebivolol (ISO)

nicotinamide (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

propionic acid (ISO)

reactive oxygen species (ISO)

resveratrol (EXP,ISO)

rotenone (EXP,ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sodium sulfide (anhydrous) (EXP)

Soman (EXP)

stavudine (ISO)

sulfadimethoxine (EXP)

tenofovir disoproxil fumarate (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trilobatin (EXP)

triptonide (ISO)

tris(2-chloroethyl) phosphate (ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aerobic respiration (ISO)

chromatin remodeling (IEA)

negative regulation of ERK1 and ERK2 cascade (IMP)

negative regulation of peptidyl-lysine acetylation (ISO)

negative regulation of reactive oxygen species metabolic process (IMP)

positive regulation of ceramide biosynthetic process (ISO)

positive regulation of insulin secretion (IMP)

positive regulation of mitochondrial transcription (ISO)

Cellular Component

cytoplasm (ISO)

membrane (ISO)

mitochondrial inner membrane (ISO)

mitochondrial matrix (ISO)

mitochondrion (ISO)

nucleus (IBA)

protein-containing complex (ISO)

Molecular Function

enzyme binding (IPI)

NAD+ binding (IBA)

NAD-dependent histone deacetylase activity (IBA)

NAD-dependent histone H3K14 deacetylase activity (ISO)

NAD-dependent protein deacetylase activity (ISO)

protein binding (ISO)

protein lysine deacetylase activity (ISO)

sequence-specific DNA binding (ISO)

transferase activity (IEA)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

Sirtuin mediated pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning.	Borengasser SJ, etal., PLoS One. 2011;6(8):e24068. doi: 10.1371/journal.pone.0024068. Epub 2011 Aug 25.
2.	Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.	Caton PW, etal., Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Non-histone lysine acetylated proteins in heart failure.	Grillon JM, etal., Biochim Biophys Acta. 2012 Apr;1822(4):607-14. doi: 10.1016/j.bbadis.2011.11.016. Epub 2011 Dec 3.
5.	In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner.	Gurd BJ, etal., Metabolism. 2012 May;61(5):733-41. doi: 10.1016/j.metabol.2011.09.016. Epub 2011 Nov 9.
6.	Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis.	Jiang HK, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):192-201. doi: 10.1111/1440-1681.12211.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Physical and functional HAT/HDAC interplay regulates protein acetylation balance.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
9.	Pre-diabetes alters testicular PGC1-alpha/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress.	Rato L, etal., Biochim Biophys Acta. 2014 Mar;1837(3):335-44. doi: 10.1016/j.bbabio.2013.12.008. Epub 2013 Dec 20.
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.	Valdecantos MP, etal., Obesity (Silver Spring). 2012 Oct;20(10):1974-83. doi: 10.1038/oby.2012.32. Epub 2012 Feb 13.
14.	NAD(+) in aging, metabolism, and neurodegeneration.	Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
15.	CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease.	Weir HJ, etal., PLoS One. 2012;7(11):e48225. doi: 10.1371/journal.pone.0048225. Epub 2012 Nov 6.
16.	Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model.	Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.

Additional References at PubMed

PMID:11056054	PMID:12186850	PMID:12477932	PMID:16079181	PMID:16788062	PMID:16790548	PMID:17923681	PMID:18054327	PMID:18614015	PMID:19241369	PMID:19535340	PMID:20413424
PMID:21419014	PMID:21867412	PMID:22309213	PMID:23201401	PMID:23283301	PMID:23576753	PMID:24239092	PMID:24535021	PMID:25210848	PMID:25284742	PMID:25433241	PMID:25483313
PMID:25759382	PMID:25877446	PMID:25993470	PMID:26225774	PMID:26523980	PMID:26620563	PMID:26767982	PMID:27067422	PMID:27212443	PMID:27423420	PMID:27449933	PMID:27614093
PMID:27888691	PMID:27890624	PMID:28003866	PMID:28053989	PMID:28296029	PMID:28396174	PMID:28579116	PMID:28760678	PMID:29445193	PMID:29857817	PMID:29863652	PMID:30132522
PMID:30216853	PMID:30385301	PMID:30502252	PMID:30717220	PMID:30764676	PMID:30849417	PMID:31696493	PMID:32139662	PMID:32141452	PMID:32426865	PMID:32506069	PMID:32507768
PMID:32805255	PMID:32818702	PMID:33127810	PMID:33522075	PMID:33565085	PMID:33665656	PMID:33823364	PMID:34082675	PMID:34296964	PMID:34330062	PMID:34360775	PMID:35192161
PMID:35953459	PMID:36153454	PMID:36262283	PMID:36380567	PMID:36481985	PMID:36863620	PMID:36916106	PMID:36922709	PMID:37335200

Genomics

Comparative Map Data

Sirt3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	195,942,066 - 195,964,472 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	195,942,073 - 195,964,808 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	204,294,536 - 204,318,293 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	211,421,447 - 211,445,196 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	204,095,300 - 204,119,047 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	213,613,502 - 213,636,061 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	213,613,513 - 213,635,546 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	220,539,132 - 220,561,380 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	201,021,391 - 201,043,756 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	201,172,601 - 201,193,816 (-)	NCBI
Celera	1	193,586,014 - 193,607,810 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

SIRT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	215,030 - 236,931 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	215,030 - 236,931 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	215,030 - 236,931 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	205,030 - 226,362 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	206,138 - 226,416	NCBI
Celera	11	322,773 - 343,832 (+)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	35,047 - 56,030 (-)	NCBI		HuRef
CHM1_1	11	213,704 - 234,799 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	256,228 - 277,937 (-)	NCBI		T2T-CHM13v2.0

Sirt3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,443,576 - 140,462,222 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	140,443,579 - 140,462,222 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	140,863,663 - 140,882,309 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	140,863,666 - 140,882,309 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	148,049,562 - 148,068,208 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	140,714,990 - 140,733,629 (-)	NCBI		MGSCv36	mm8
Celera	7	140,655,950 - 140,674,596 (-)	NCBI		Celera
Cytogenetic Map	7	F4- F5	NCBI
cM Map	7	86.07	NCBI

Sirt3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	11,794,951 - 11,826,237 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955476	11,794,951 - 11,826,244 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIRT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	11	1,737,925 - 1,761,366 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	210,052 - 233,969 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	255,191 - 863,031 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	255,191 - 278,732 (-)	Ensembl	panpan1.1		panPan2

SIRT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	25,369,183 - 25,388,126 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	25,369,382 - 25,388,118 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	25,019,130 - 25,038,115 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	25,895,720 - 25,914,839 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	25,895,722 - 25,914,795 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	25,463,734 - 25,482,834 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	25,108,512 - 25,127,612 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	25,721,366 - 25,740,351 (-)	NCBI		UU_Cfam_GSD_1.0

Sirt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	63,131 - 78,513 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936888	63,546 - 77,950 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936888	63,131 - 78,536 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIRT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	38,464 - 55,101 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	38,465 - 55,074 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	162,169,820 - 162,186,214 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIRT3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	25,740 - 49,471 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	26,927 - 48,944 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	97,040,657 - 97,063,458 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sirt3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	22,199,601 - 22,233,933 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	22,199,741 - 22,233,933 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sirt3
106 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	48
Interacting mature miRNAs:	53
Transcripts:	ENSRNOT00000018861
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169112897	197261052	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	169112897	197261052	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	174133260	196383668	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
61378	Bp43	Blood pressure QTL 43	22.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	181746937	196383668	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
1359018	Hrtrt20	Heart rate QTL 20	3.08		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	185356336	202902618	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
6480780	Insul18	Insulin level QTL 18	4.11		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	189607473	200611765	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
631260	Tcas2	Tongue tumor susceptibility QTL 2	4.93		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	192485903	199050587	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	193422268	214537671	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat

Markers in Region

RH133909

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	195,942,227 - 195,942,434 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	213,613,664 - 213,613,870	NCBI	Rnor6.0
Rnor_5.0	1	220,539,295 - 220,539,501	UniSTS	Rnor5.0
RGSC_v3.4	1	201,021,549 - 201,021,755	UniSTS	RGSC3.4
Celera	1	193,586,172 - 193,586,378	UniSTS
Cytogenetic Map	1	q41	UniSTS

Sirt3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	195,954,054 - 195,955,352 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	213,625,491 - 213,626,788	NCBI	Rnor6.0
Rnor_5.0	1	220,551,122 - 220,552,419	UniSTS	Rnor5.0
Celera	1	193,597,830 - 193,599,127	UniSTS
Cytogenetic Map	1	q41	UniSTS

Genetic Models

This gene Sirt3 is modified in the following models/strains

SS-Sirt3^em25Mcwi

T2DN-Sirt3^em30Mcwi

T2DN-Sirt3^em35Mcwi

SS-Sirt3^em4Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	16	41	3	6	74	35	41	11	3
Low					3		5	5					5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU886468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000018861 ⟹ ENSRNOP00000018861

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	195,942,077 - 195,964,071 (-)	Ensembl
Rnor_6.0 Ensembl	1	213,613,513 - 213,635,546 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095396 ⟹ ENSRNOP00000089047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	195,942,073 - 195,958,082 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116448 ⟹ ENSRNOP00000078101

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	195,942,073 - 195,964,808 (-)	Ensembl

RefSeq Acc Id:

NM_001106313 ⟹ NP_001099783

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	195,942,070 - 195,963,970 (-)	NCBI
Rnor_6.0	1	213,613,506 - 213,635,512 (-)	NCBI
Rnor_5.0	1	220,539,132 - 220,561,380 (-)	NCBI
RGSC_v3.4	1	201,021,391 - 201,043,756 (-)	RGD
Celera	1	193,586,014 - 193,607,810 (-)	RGD

Sequence:

show sequence

GGCCGCGCTCAGACTGTGGGGTCCGGGAGTATTACAGGTGGGAGAAGGCCCATATCCCTCTCTG
TGGGAGCCTCAGGCGGCTTTGGATGTGGAGGACACAGTGAGAAGAAGCTGTCTCTGCAGGACGT
AGCTGAGCTGCTTCGGACCAGAGCCTGCAGTAGGGTTGTGGTCATGGTGGGGGCTGGCATCAGC
ACACCCAGTGGTATCCCAGACTTCAGATCCCCAGGGAGTGGCCTCTACAGCAACCTTCAGCAGT
ATGACATCCCGTACCCTGAGGCCATCTTTGAACTAGGCTTCTTTTTTCACAACCCCAAGCCCTT
TTTCACGTTGGCCAAGGAGCTGTACCCTGGGCACTACAGGCCCAATGTCGCTCACTACTTCCTT
CGGCTGCTTCACGACAAGGAGCTGCTTCTGCGGCTCTACACACAGAACATCGACGGGCTTGAGA
GAGCATCTGGTATCCCTGCCTCAAAGCTGGTTGAAGCTCATGGGTCCTTTGTATCAGCTACGTG
CACGGTCTGTCGAAGGTCCTTCCCAGGGGAAGACATACGGGCTGACGTGATGGCAGACAGGGTG
CCCCGCTGCCCTGTCTGTACTGGCGTTGTGAAACCTGACATTGTGTTCTTTGGGGAGCAGCTGC
CAGCAAGGTTCTTACTACATGTGGCTGATTTCGCCTTGGCAGATCTGCTACTCATTCTTGGGAC
CTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGTCTGAATCGGTACAGAAATCAGTGCCCCGACTG
CTCATCAATCGAGACTTGGTGGGGTCCTTTGCTCTGAGTCCTCGAAGGAAAGATGTGGTCCAGC
TAGGGGATGTAGTCCAGGGTGTGGAAAGGCTGGTGGACCTCCTGGGGTGGACACAAGAGCTGCA
GGATCTCATCCAGCGGGAAAATGGAAAGCTGGATGGACAGGACGGATAAGACAGACTATGGCTT
ACTTCTTCACCTGCGGGAAAGTCGCACAGGAGATCATCCTATTCCCAGGGAGACCTCATGTCTG
AAAACAGCTCCGACAGGTTTACAAACATGGGCCAGACCACAACATGTGTCCTGGGCAGTAGTCC
CAAGGCTGCCTTTGTTAAGGCTGACCAGGGACCTTTACCCTTGGGGCCATGTGTTACCATACAA
AGGAGCTCCACGTGTGTGCTCTGTCCACCCATCACTGCTGAAGCTTGCAGTACAGTGCTGCTTT
CTGACAGAGGCCTTAGTTACCAAGAGGGCAGGGCAGCATGCCCATCGCTAGACAGCTGATACGC
TAGGCTAATCTAGCATGTTGGTCGGTAAAGTGGCATCTTTAACTGAAAAATCATTTTTCGCATG
AAATAAATTTAGTATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006230526 ⟹ XP_006230588

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	195,942,066 - 195,964,047 (-)	NCBI
Rnor_6.0	1	213,613,502 - 213,635,601 (-)	NCBI
Rnor_5.0	1	220,539,132 - 220,561,380 (-)	NCBI

Sequence:

show sequence

CCTACGGGGGCGGGGATTCGGATGGCACTTGACCCTCTAGGCGCCGTAAGCCTGCAGAGCATCA
TGGCGCTGAGCTGTCGACTGGTATTGGCCGCGCTCAGACTGTGGGGTCCGGGAGGTGGGAGAAG
GCCCATATCCCTCTCTGTGGGAGCCTCAGGCGGCTTTGGATGTGGAGGACACAGTGAGAAGAAG
CTGTCTCTGCAGGACGTAGCTGAGCTGCTTCGGACCAGAGCCTGCAGTAGGGTTGTGGTCATGG
TGGGGGCTGGCATCAGCACACCCAGTGGTATCCCAGACTTCAGATCCCCAGGGAGTGGCCTCTA
CAGCAACCTTCAGCAGTATGACATCCCGTACCCTGAGGCCATCTTTGAACTAGGCTTCTTTTTT
CACAACCCCAAGCCCTTTTTCACGTTGGCCAAGGAGCTGTACCCTGGGCACTACAGGCCCAATG
TCGCTCACTACTTCCTTCGGCTGCTTCACGACAAGGAGCTGCTTCTGCGGCTCTACACACAGAA
CATCGACGGGCTTGAGAGAGCATCTGGTATCCCTGCCTCAAAGCTGGTTGAAGCTCATGGGTCC
TTTGTATCAGCTACGTGCACGGTCTGTCGAAGGTCCTTCCCAGGGGAAGACATACGGGCTGACG
TGATGGCAGACAGGGTGCCCCGCTGCCCTGTCTGTACTGGCGTTGTGAAACCTGACATTGTGTT
CTTTGGGGAGCAGCTGCCAGCAAGGTTCTTACTACATGTGGCTGATTTCGCCTTGGCAGATCTG
CTACTCATTCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGTCTGAATCGGTACAGA
AATCAGTGCCCCGACTGCTCATCAATCGAGACTTGGTGGGGTCCTTTGCTCTGAGTCCTCGAAG
GAAAGATGTGGTCCAGCTAGGGGATGTAGTCCAGGGTGTGGAAAGGCTGGTGGACCTCCTGGGG
TGGACACAAGAGCTGCAGGATCTCATCCAGCGGGAAAATGGAAAGCTGGATGGACAGGACGGAT
AAGACAGACTATGGCTTACTTCTTCACCTGCGGGAAAGTCGCACAGGAGATCATCCTATTCCCA
GGGAGACCTCATGTCTGAAAACAGCTCCGACAGGTTTACAAACATGGGCCAGACCACAACATGT
GTCCTGGGCAGTAGTCCCAAGGCTGCCTTTGTTAAGGCTGACCAGGGACCTTTACCCTTGGGGC
CATGTGTTACCATACAAAGGAGCTCCACGTGTGTGCTCTGTCCACCCATCACTGCTGAAGCTTG
CAGTACAGTGCTGCTTTCTGACAGAGGCCTTAGTTACCAAGAGGGCAGGGCAGCATGCCCATCG
CTAGACAGCTGATACGCTAGGCTAATCTAGCATGTTGGTCGGTAAAGTGGCATCTTTAACTGAA
AAATCATTTTTCGCATGAAATAAATTTAGTATAAAAATGTG

hide sequence

RefSeq Acc Id:

XM_039107846 ⟹ XP_038963774

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	195,942,068 - 195,964,472 (-)	NCBI

RefSeq Acc Id:

XM_039107856 ⟹ XP_038963784

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	195,942,066 - 195,964,048 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099783	(Get FASTA)	NCBI Sequence Viewer
	XP_006230588	(Get FASTA)	NCBI Sequence Viewer
	XP_038963774	(Get FASTA)	NCBI Sequence Viewer
	XP_038963784	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67006	(Get FASTA)	NCBI Sequence Viewer
	ACJ70657	(Get FASTA)	NCBI Sequence Viewer
	EDM11942	(Get FASTA)	NCBI Sequence Viewer
	EDM11943	(Get FASTA)	NCBI Sequence Viewer
	EDM11944	(Get FASTA)	NCBI Sequence Viewer
	EDM11945	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001099783 ⟸ NM_001106313

- UniProtKB:

B2RZ31 (UniProtKB/TrEMBL), A0A8I6A7C4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFTLAKELYPGHYRP
NVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCTVCRRSFPGEDIRA
DVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHVADFALADLLLILGTSLEVEPFASLSESV
QKSVPRLLINRDLVGSFALSPRRKDVVQLGDVVQGVERLVDLLGWTQELQDLIQRENGKLDGQD
G

hide sequence

RefSeq Acc Id:	XP_006230588 ⟸ XM_006230526
- Peptide Label:	isoform X1
- UniProtKB:	F7EYD5 (UniProtKB/TrEMBL), C6ZII9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALDPLGAVSLQSIMALSCRLVLAALRLWGPGGGRRPISLSVGASGGFGCGGHSEKKLSLQDVA ELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFF TLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCT VCRRSFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHVADFALADLLLILGTS LEVEPFASLSESVQKSVPRLLINRDLVGSFALSPRRKDVVQLGDVVQGVERLVDLLGWTQELQD LIQRENGKLDGQDG hide sequence

RefSeq Acc Id:

ENSRNOP00000018861 ⟸ ENSRNOT00000018861

RefSeq Acc Id:	XP_038963784 ⟸ XM_039107856
- Peptide Label:	isoform X3
- UniProtKB:	A6HXL1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963774 ⟸ XM_039107846
- Peptide Label:	isoform X2
- UniProtKB:	B2RZ31 (UniProtKB/TrEMBL), A0A8I6A7C4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000078101 ⟸ ENSRNOT00000116448

RefSeq Acc Id:

ENSRNOP00000089047 ⟸ ENSRNOT00000095396

Protein Domains

Deacetylase sirtuin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-C6ZII9-F1-model_v2	AlphaFold	C6ZII9	1-320	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308374	AgrOrtholog
BioCyc Gene	G2FUF-57005	BioCyc
Ensembl Genes	ENSRNOG00000013828	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000018861	ENTREZGENE
	ENSRNOP00000018861.6	UniProtKB/TrEMBL
	ENSRNOP00000078101.1	UniProtKB/TrEMBL
	ENSRNOP00000089047	ENTREZGENE
	ENSRNOP00000089047.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018861	ENTREZGENE
	ENSRNOT00000018861.7	UniProtKB/TrEMBL
	ENSRNOT00000095396	ENTREZGENE
	ENSRNOT00000095396.1	UniProtKB/TrEMBL
	ENSRNOT00000116448.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1600.10	UniProtKB/TrEMBL
	TPP-binding domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7314283	IMAGE-MGC_LOAD
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/TrEMBL
	NAD-dep_deAcase_SIR2_euk	UniProtKB/TrEMBL
	NAD-dep_histone_deAcase_SIR2	UniProtKB/TrEMBL
	Sirtuin_cat_small_dom_sf	UniProtKB/TrEMBL
	Ssirtuin_cat_dom	UniProtKB/TrEMBL
KEGG Report	rno:293615	UniProtKB/TrEMBL
MGC_CLONE	MGC:189177	IMAGE-MGC_LOAD
NCBI Gene	293615	ENTREZGENE
PANTHER	NAD-DEPENDENT HISTONE DEACETYLASE HST4	UniProtKB/TrEMBL
	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	SIR2	UniProtKB/TrEMBL
PhenoGen	Sirt3	PhenoGen
PIRSF	SIR2_euk	UniProtKB/TrEMBL
PROSITE	SIRTUIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52467	UniProtKB/TrEMBL
UniProt	A0A8I5XWT5_RAT	UniProtKB/TrEMBL
	A0A8I6A7C4	ENTREZGENE, UniProtKB/TrEMBL
	A6HXL1	ENTREZGENE, UniProtKB/TrEMBL
	B2RZ31	ENTREZGENE, UniProtKB/TrEMBL
	C6ZII9	ENTREZGENE, UniProtKB/TrEMBL
	F7EYD5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Sirt3	sirtuin 3	Sirt3	sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Sirt3	sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)	Sirt3	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Sirt3	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)	Sirt3_predicted	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sirt3_predicted	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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