(+)-taxifolin multiple interactions EXP 6480464 Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]] more ... CTD PMID:35465754 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1318015 6480464 epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA], epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:36056792 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1318014 6480464 epigallocatechin gallate inhibits the reaction [bisphenol A results in increased expression of NLRP3 mRNA], epigallocatechin gallate inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein] CTD PMID:35439536 (20S)-ginsenoside Rg3 multiple interactions ISO RGD:1318015 6480464 ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:34423507 (20S)-ginsenoside Rg3 multiple interactions ISO RGD:1318014 6480464 3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]], ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:34423507 (S)-nicotine multiple interactions ISO RGD:1318014 6480464 CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein] CTD PMID:35131329 (S)-nicotine increases expression ISO RGD:1318014 6480464 Nicotine results in increased expression of NLRP3 protein CTD PMID:35131329 (S)-ropivacaine multiple interactions ISO RGD:1318014 6480464 Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein], NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]] CTD PMID:36858639 (S)-ropivacaine increases expression ISO RGD:1318014 6480464 Ropivacaine results in increased expression of NLRP3 protein CTD PMID:36858639 1,4-phenylenediamine increases expression ISO RGD:1318014 6480464 4-phenylenediamine results in increased expression of NLRP3 protein CTD PMID:31276767 1,4-phenylenediamine multiple interactions ISO RGD:1318014 6480464 4-phenylenediamine promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein] CTD PMID:31276767 1-chloro-2,4-dinitrobenzene multiple interactions ISO RGD:1318014 6480464 Dinitrochlorobenzene promotes the reaction [[NLRP12 protein binds to NLRP3 protein binds to CASP1 protein] which binds to PYCARD protein] CTD PMID:31276767 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:1318014 6480464 Dinitrochlorobenzene results in increased expression of NLRP3 protein CTD PMID:31276767 17beta-estradiol multiple interactions ISO RGD:1318014 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of NLRP3 mRNA CTD PMID:30165855 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NLRP3 mRNA CTD PMID:32741896 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NLRP3 mRNA CTD PMID:32741896 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1318015 6480464 KL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide more ... CTD PMID:29885354 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of NLRP3 mRNA CTD PMID:33387578 , PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1318015 6480464 Tetrachlorodibenzodioxin affects the expression of NLRP3 mRNA CTD PMID:28922406 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of NLRP3 protein CTD PMID:30365937 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP 6480464 bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NLRP3 protein] CTD PMID:30365937 2,4-D multiple interactions EXP 6480464 lycium barbarum polysaccharide inhibits the reaction [2 more ... CTD PMID:34464015 2,4-D increases expression ISO RGD:1318015 6480464 2 more ... CTD PMID:35099110 2,4-D multiple interactions ISO RGD:1318015 6480464 lycium barbarum polysaccharide inhibits the reaction [2 more ... CTD PMID:35099110 2,4-D increases expression EXP 6480464 2 more ... CTD PMID:34464015 2,5-hexanedione multiple interactions EXP 6480464 Glyburide inhibits the reaction [2, 5-hexanedione results in increased expression of NLRP3 protein] CTD PMID:32522579 , PMID:32860822 2,5-hexanedione increases expression EXP 6480464 2 more ... CTD PMID:32522579 , PMID:32860822 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions EXP 6480464 Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 mRNA], Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 protein] CTD PMID:35460826 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:1318015 6480464 [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NLRP3 protein, S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NLRP3 protein] CTD PMID:32453893 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of NLRP3 protein CTD PMID:33187795 3-chloropropane-1,2-diol multiple interactions EXP 6480464 alpha-Chlorohydrin promotes the reaction [glycidol results in increased expression of NLRP3 protein], glycidol promotes the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein] CTD PMID:33187795 3-mercaptopropanoic acid multiple interactions ISO RGD:1318015 6480464 [3-Mercaptopropionic Acid co-treated with cadmium telluride] results in increased expression of NLRP3 mRNA, [3-Mercaptopropionic Acid co-treated with cadmium telluride] results in increased expression of NLRP3 protein CTD PMID:29852215 3-methyladenine multiple interactions ISO RGD:1318014 6480464 3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]] more ... CTD PMID:30205151 more ... 4,4'-sulfonyldiphenol affects methylation ISO RGD:1318015 6480464 bis(4-hydroxyphenyl)sulfone affects the methylation of NLRP3 gene CTD PMID:31683443 4-hydroxynon-2-enal increases expression ISO RGD:1318015 6480464 4-hydroxy-2-nonenal results in increased expression of NLRP3 mRNA CTD PMID:19191707 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester multiple interactions ISO RGD:1318015 6480464 Carticaine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:32687258 4-phenylbutyric acid multiple interactions ISO RGD:1318015 6480464 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA], 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein] CTD PMID:30796460 4-phenylbutyric acid multiple interactions ISO RGD:1318014 6480464 4-phenylbutyric acid inhibits the reaction [7 more ... CTD PMID:35297523 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions EXP 6480464 Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]], Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:32418911 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of NLRP3 mRNA, Propylthiouracil results in increased expression of NLRP3 protein CTD PMID:37047793 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:1318014 6480464 [Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein more ... CTD PMID:18403674 , PMID:18604214 7,9-dihydro-1H-purine-2,6,8(3H)-trione decreases response to substance ISO RGD:1318015 6480464 NLRP3 gene mutant form results in decreased susceptibility to Uric Acid CTD PMID:23619996 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:1318015 6480464 [Lipopolysaccharides co-treated with Uric Acid] affects the localization of NLRP3 protein more ... CTD PMID:18403674 more ... 7-ketocholesterol multiple interactions ISO RGD:1318015 6480464 Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein] CTD PMID:28633109 7-ketocholesterol affects localization ISO RGD:1318015 6480464 7-ketocholesterol affects the localization of NLRP3 protein CTD PMID:28633109 acetamide increases expression EXP 6480464 acetamide results in increased expression of NLRP3 mRNA CTD PMID:31881176 acetic acid multiple interactions EXP 6480464 Plant Extracts inhibits the reaction [Acetic Acid results in increased expression of NLRP3 protein] more ... CTD PMID:30408459 , PMID:35595039 acetic acid increases expression EXP 6480464 Acetic Acid results in increased expression of NLRP3 mRNA, Acetic Acid results in increased expression of NLRP3 protein CTD PMID:30408459 , PMID:35595039 acetylsalicylic acid affects response to substance ISO RGD:1318014 6480464 NLRP3 SNP affects the susceptibility to Aspirin CTD PMID:19767079 aconitine increases expression EXP 6480464 Aconitine results in increased expression of NLRP3 protein CTD PMID:33236894 aconitine multiple interactions EXP 6480464 NLRP3 protein affects the reaction [Aconitine results in increased expression of CASP1 protein] more ... CTD PMID:33236894 aconitine increases expression ISO RGD:1318015 6480464 Aconitine results in increased expression of NLRP3 protein CTD PMID:33236894 acrolein multiple interactions EXP 6480464 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2 more ... CTD PMID:31639409 acrolein increases expression ISO RGD:1318014 6480464 Acrolein results in increased expression of NLRP3 protein CTD PMID:34238121 , PMID:36055550 acrolein multiple interactions ISO RGD:1318014 6480464 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein] more ... CTD PMID:30205151 more ... acrolein increases expression EXP 6480464 Acrolein results in increased expression of NLRP3 protein CTD PMID:31639409 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of NLRP3 mRNA CTD PMID:28959563 acrylamide affects response to substance ISO RGD:1318015 6480464 NLRP3 gene mutant form affects the susceptibility to Acrylamide CTD PMID:32014472 acrylamide multiple interactions ISO RGD:1318015 6480464 [NLRP3 gene mutant form affects the susceptibility to Acrylamide] which results in increased expression of HMOX1 protein more ... CTD PMID:31073625 , PMID:32014472 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of NLRP3 mRNA, Acrylamide results in increased expression of NLRP3 protein CTD PMID:31073625 acrylamide increases expression ISO RGD:1318015 6480464 Acrylamide results in increased expression of NLRP3 protein CTD PMID:31073625 , PMID:32014472 actinomycin D multiple interactions ISO RGD:1318014 6480464 Dactinomycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA] CTD PMID:23937860 aflatoxin B1 increases methylation ISO RGD:1318014 6480464 Aflatoxin B1 results in increased methylation of NLRP3 gene CTD PMID:27153756 aflatoxin B1 increases expression ISO RGD:1318015 6480464 Aflatoxin B1 results in increased expression of NLRP3 mRNA, Aflatoxin B1 results in increased expression of NLRP3 protein CTD PMID:35063475 aflatoxin B1 multiple interactions ISO RGD:1318015 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 mRNA], Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 protein] CTD PMID:35063475 aldehydo-D-glucose increases expression ISO RGD:1318014 6480464 Glucose results in increased expression of NLRP3 protein CTD PMID:23647015 , PMID:36066211 aldehydo-D-glucose increases response to substance ISO RGD:1318015 6480464 NLRP3 protein results in increased susceptibility to Glucose CTD PMID:27783111 aldehydo-D-glucose multiple interactions ISO RGD:1318015 6480464 NLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP1 protein] more ... CTD PMID:27783111 aldehydo-D-glucose multiple interactions ISO RGD:1318014 6480464 [Glucose co-treated with TGFB1 protein] results in increased expression of NLRP3 protein more ... CTD PMID:23647015 more ... aldehydo-D-glucose multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein more ... CTD PMID:23647015 more ... aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of NLRP3 protein CTD PMID:23647015 more ... all-trans-retinoic acid increases expression ISO RGD:1318014 6480464 Tretinoin results in increased expression of NLRP3 mRNA CTD PMID:33167477 allethrin increases expression ISO RGD:1318014 6480464 Allethrins results in increased expression of NLRP3 mRNA CTD PMID:36074087 allicin multiple interactions ISO RGD:1318015 6480464 allicin inhibits the reaction [Acetaminophen results in increased expression of NLRP3 protein] CTD PMID:32040233 allopurinol multiple interactions ISO RGD:1318014 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:23647015 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein] more ... CTD PMID:22426011 , PMID:23647015 aluminium hydroxide multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 aluminium sulfate (anhydrous) multiple interactions ISO RGD:1318015 6480464 NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased secretion of IL1B protein] CTD PMID:24158569 amitriptyline multiple interactions ISO RGD:1318015 6480464 Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein], Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of NLRP3 mRNA CTD PMID:30779732 amphibole asbestos decreases expression EXP 6480464 Asbestos, Amphibole results in decreased expression of NLRP3 mRNA CTD PMID:27083413 amphibole asbestos increases expression EXP 6480464 Asbestos, Amphibole results in increased expression of NLRP3 mRNA CTD PMID:22168577 anthocyanin multiple interactions ISO RGD:1318015 6480464 Anthocyanins inhibits the reaction [Dietary Fats results in increased expression of NLRP3 protein] CTD PMID:24795233 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1318014 6480464 pyrazolanthrone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein], pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein] CTD PMID:28004443 , PMID:34510229 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 antirheumatic drug decreases expression ISO RGD:1318014 6480464 Antirheumatic Agents results in decreased expression of NLRP3 mRNA CTD PMID:24449571 apigenin multiple interactions ISO RGD:1318014 6480464 Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]] more ... CTD PMID:36055550 apocynin multiple interactions ISO RGD:1318014 6480464 acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein] CTD PMID:26901245 aripiprazole multiple interactions ISO RGD:1318014 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of NLRP3 mRNA CTD PMID:31476115 aristolochic acid A increases expression ISO RGD:1318014 6480464 aristolochic acid I results in increased expression of NLRP3 mRNA CTD PMID:33212167 arsane affects methylation ISO RGD:1318014 6480464 Arsenic affects the methylation of NLRP3 gene CTD PMID:25304211 arsane multiple interactions ISO RGD:1318014 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein, bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein] CTD PMID:32645460 arsenic atom affects methylation ISO RGD:1318014 6480464 Arsenic affects the methylation of NLRP3 gene CTD PMID:25304211 arsenic atom multiple interactions ISO RGD:1318014 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein, bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein] CTD PMID:32645460 arsenite(3-) multiple interactions ISO RGD:1318015 6480464 [Arsenic Trioxide results in increased abundance of arsenite] which results in increased expression of NLRP3 mRNA CTD PMID:36791901 arsenous acid multiple interactions ISO RGD:1318015 6480464 [Arsenic Trioxide results in increased abundance of arsenite] which results in increased expression of NLRP3 mRNA more ... CTD PMID:30237538 more ... arsenous acid increases expression ISO RGD:1318014 6480464 Arsenic Trioxide results in increased expression of NLRP3 mRNA, Arsenic Trioxide results in increased expression of NLRP3 protein CTD PMID:35226250 arsenous acid multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein more ... CTD PMID:30660605 arsenous acid increases expression ISO RGD:1318015 6480464 Arsenic Trioxide results in increased expression of NLRP3 protein CTD PMID:30237538 , PMID:35226250 arsenous acid multiple interactions ISO RGD:1318014 6480464 [Arsenic Trioxide co-treated with lipopolysaccharide more ... CTD PMID:30237538 , PMID:35226250 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of NLRP3 protein CTD PMID:30660605 artesunate multiple interactions EXP 6480464 artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 asbestos affects response to substance ISO RGD:1318014 6480464 NLRP3 gene SNP affects the susceptibility to Asbestos CTD PMID:24142982 astragaloside IV multiple interactions EXP 6480464 astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:30842369 atorvastatin calcium multiple interactions EXP 6480464 [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NLRP3 protein] CTD PMID:34939712 ATP multiple interactions ISO RGD:1318014 6480464 [Adenosine Triphosphate co-treated with lipopolysaccharide more ... CTD PMID:18604214 more ... ATP multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein more ... CTD PMID:35962723 ATP multiple interactions ISO RGD:1318015 6480464 [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased expression of NLRP3 mRNA more ... CTD PMID:18604214 more ... atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of NLRP3 mRNA CTD PMID:36841081 atropine increases expression ISO RGD:1318014 6480464 Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 aucubin multiple interactions ISO RGD:1318014 6480464 aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of NLRP3 protein] CTD PMID:35961541 aucubin multiple interactions ISO RGD:1318015 6480464 aucubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein] CTD PMID:35961541 aurantio-obtusin increases expression ISO RGD:1318015 6480464 aurantio-obtusin results in increased expression of NLRP3 mRNA, aurantio-obtusin results in increased expression of NLRP3 protein CTD PMID:34718095 azathioprine increases expression ISO RGD:1318015 6480464 Azathioprine results in increased expression of NLRP3 mRNA CTD PMID:24184165 bafilomycin A1 multiple interactions ISO RGD:1318014 6480464 bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein] CTD PMID:32645460 bafilomycin A1 increases expression ISO RGD:1318014 6480464 bafilomycin A1 results in increased expression of NLRP3 protein CTD PMID:32645460 baicalin multiple interactions ISO RGD:1318015 6480464 baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] CTD PMID:29031535 BAPTA multiple interactions ISO RGD:1318015 6480464 1 more ... CTD PMID:36308466 benzo[a]pyrene affects methylation ISO RGD:1318014 6480464 Benzo(a)pyrene affects the methylation of NLRP3 3' UTR, Benzo(a)pyrene affects the methylation of NLRP3 promoter CTD PMID:27901495 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of NLRP3 protein CTD PMID:34999049 benzo[a]pyrene multiple interactions EXP 6480464 [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of NLRP3 protein] more ... CTD PMID:34999049 benzo[a]pyrene increases methylation ISO RGD:1318014 6480464 Benzo(a)pyrene results in increased methylation of NLRP3 5' UTR CTD PMID:27901495 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1318014 6480464 7 more ... CTD PMID:35297523 benzo[a]pyrene diol epoxide I multiple interactions ISO RGD:1318014 6480464 4-phenylbutyric acid inhibits the reaction [7 more ... CTD PMID:35297523 benzo[e]pyrene increases methylation ISO RGD:1318014 6480464 benzo(e)pyrene results in increased methylation of NLRP3 intron CTD PMID:30157460 berberine multiple interactions EXP 6480464 Berberine inhibits the reaction [Bortezomib results in increased expression of NLRP3 mRNA] CTD PMID:35121005 Bergenin multiple interactions EXP 6480464 bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NLRP3 protein] CTD PMID:30365937 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of NLRP3 mRNA, Diethylhexyl Phthalate results in increased expression of NLRP3 protein CTD PMID:35460826 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 4 more ... CTD PMID:35460826 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NLRP3 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1318014 6480464 bisphenol A results in increased expression of NLRP3 mRNA, bisphenol A results in increased expression of NLRP3 protein CTD PMID:35439536 bisphenol A multiple interactions ISO RGD:1318014 6480464 benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [bisphenol A results in increased expression of NLRP3 mRNA] more ... CTD PMID:35439536 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of NLRP3 protein CTD PMID:35465754 bisphenol A multiple interactions EXP 6480464 Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein] more ... CTD PMID:35465754 bisphenol A multiple interactions ISO RGD:1318015 6480464 [bisphenol A co-treated with Dietary Fats] results in increased expression of NLRP3 protein, bisphenol A promotes the reaction [Dietary Fats results in increased expression of NLRP3 mRNA] CTD PMID:33265944 bortezomib decreases expression ISO RGD:1318014 6480464 Bortezomib results in decreased expression of NLRP3 mRNA CTD PMID:17659339 bortezomib increases expression EXP 6480464 Bortezomib results in increased expression of NLRP3 mRNA CTD PMID:35121005 bortezomib multiple interactions EXP 6480464 Berberine inhibits the reaction [Bortezomib results in increased expression of NLRP3 mRNA] CTD PMID:35121005 buta-1,3-diene decreases expression ISO RGD:1318015 6480464 1, 3-butadiene results in decreased expression of NLRP3 mRNA CTD PMID:29038090 butanal increases expression ISO RGD:1318014 6480464 butyraldehyde results in increased expression of NLRP3 mRNA CTD PMID:26079696 cadmium atom increases expression ISO RGD:1318014 6480464 Cadmium results in increased expression of NLRP3 mRNA CTD PMID:33559965 cadmium atom multiple interactions ISO RGD:1318015 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein CTD PMID:33359024 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA more ... CTD PMID:34510229 , PMID:35384154 cadmium atom multiple interactions ISO RGD:1318014 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein] more ... CTD PMID:34510229 cadmium dichloride multiple interactions ISO RGD:1318015 6480464 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA] more ... CTD PMID:30796460 , PMID:33359024 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA more ... CTD PMID:34510229 , PMID:35384154 cadmium dichloride increases expression ISO RGD:1318015 6480464 Cadmium Chloride results in increased expression of NLRP3 protein CTD PMID:30796460 cadmium dichloride increases expression ISO RGD:1318014 6480464 Cadmium Chloride results in increased expression of NLRP3 mRNA, Cadmium Chloride results in increased expression of NLRP3 protein CTD PMID:30796460 cadmium dichloride multiple interactions ISO RGD:1318014 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein] more ... CTD PMID:26809137 more ... cannabidiol decreases expression ISO RGD:1318015 6480464 Cannabidiol results in decreased expression of NLRP3 protein CTD PMID:34269108 cannabidiol multiple interactions ISO RGD:1318014 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]] more ... CTD PMID:27932991 , PMID:34269108 cannabidiol decreases expression ISO RGD:1318014 6480464 Cannabidiol results in decreased expression of NLRP3 mRNA, Cannabidiol results in decreased expression of NLRP3 protein CTD PMID:27932991 , PMID:34269108 CCCP multiple interactions ISO RGD:1318014 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 CCCP multiple interactions ISO RGD:1318015 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 celastrol multiple interactions EXP 6480464 celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA] more ... CTD PMID:32470352 CGP 52608 multiple interactions ISO RGD:1318014 6480464 CGP 52608 promotes the reaction [RORA protein binds to NLRP3 gene] CTD PMID:28238834 chlorpyrifos multiple interactions ISO RGD:1318014 6480464 Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of NLRP3 protein] more ... CTD PMID:26435000 , PMID:30835941 chlorpyrifos increases expression ISO RGD:1318014 6480464 Chlorpyrifos results in increased expression of NLRP3 mRNA, Chlorpyrifos results in increased expression of NLRP3 protein CTD PMID:26435000 , PMID:30835941 chlorquinaldol multiple interactions ISO RGD:1318015 6480464 Chlorquinaldol inhibits the reaction [NLRP3 protein binds to PYCARD protein] CTD PMID:36002070 cholesterol multiple interactions ISO RGD:1318015 6480464 Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein], SMPD1 protein affects the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 cholesterol multiple interactions EXP 6480464 [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA more ... CTD PMID:25833014 cholesterol affects localization ISO RGD:1318015 6480464 Cholesterol analog affects the localization of NLRP3 protein CTD PMID:28633109 choline multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats co-treated with cyanoginosin LR] results in decreased expression of BCL2 protein] more ... CTD PMID:34416350 cisplatin multiple interactions ISO RGD:1318015 6480464 3-(5-(2 more ... CTD PMID:25308879 , PMID:34423507 cisplatin increases expression ISO RGD:1318014 6480464 Cisplatin results in increased expression of NLRP3 protein CTD PMID:34423507 cisplatin multiple interactions ISO RGD:1318014 6480464 3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]], ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:34423507 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of NLRP3 protein CTD PMID:30842369 , PMID:32418911 cisplatin multiple interactions EXP 6480464 astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] more ... CTD PMID:30842369 , PMID:32418911 cisplatin increases expression ISO RGD:1318015 6480464 Cisplatin results in increased expression of NLRP3 protein CTD PMID:25308879 more ... cobalt atom multiple interactions ISO RGD:1318014 6480464 [tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA more ... CTD PMID:18078969 , PMID:32805375 cobalt atom increases expression ISO RGD:1318014 6480464 Cobalt results in increased expression of NLRP3 protein CTD PMID:32805375 crocidolite asbestos multiple interactions ISO RGD:1318014 6480464 Dactinomycin inhibits the reaction [Asbestos more ... CTD PMID:18403674 more ... crocidolite asbestos multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [Asbestos more ... CTD PMID:18403674 crocidolite asbestos increases expression ISO RGD:1318014 6480464 Asbestos more ... CTD PMID:23937860 , PMID:24885895 Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of NLRP3 mRNA CTD PMID:27523638 curcumin multiple interactions ISO RGD:1318015 6480464 [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide more ... CTD PMID:34998855 , PMID:35063475 Curcumol decreases expression ISO RGD:1318014 6480464 curcumol results in decreased expression of NLRP3 protein CTD PMID:32344006 cycloheximide multiple interactions ISO RGD:1318014 6480464 Cycloheximide inhibits the reaction [tetrachlorobenzoquinone results in increased expression of NLRP3 protein] CTD PMID:26901245 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of NLRP3 protein CTD PMID:35762198 cyclophosphamide multiple interactions EXP 6480464 Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein]], Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein] CTD PMID:35762198 D-glucose increases response to substance ISO RGD:1318015 6480464 NLRP3 protein results in increased susceptibility to Glucose CTD PMID:27783111 D-glucose multiple interactions ISO RGD:1318015 6480464 NLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP1 protein] more ... CTD PMID:27783111 D-glucose multiple interactions ISO RGD:1318014 6480464 [Glucose co-treated with TGFB1 protein] results in increased expression of NLRP3 protein more ... CTD PMID:23647015 more ... D-glucose multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein more ... CTD PMID:23647015 more ... D-glucose increases expression EXP 6480464 Glucose results in increased expression of NLRP3 protein CTD PMID:23647015 more ... D-glucose increases expression ISO RGD:1318014 6480464 Glucose results in increased expression of NLRP3 protein CTD PMID:23647015 , PMID:36066211 dapagliflozin multiple interactions EXP 6480464 [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NLRP3 protein] CTD PMID:34939712 deoxynivalenol multiple interactions ISO RGD:1318015 6480464 deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of NLRP3 mRNA] more ... CTD PMID:36309173 deoxynivalenol increases expression ISO RGD:1318015 6480464 deoxynivalenol results in increased expression of NLRP3 mRNA, deoxynivalenol results in increased expression of NLRP3 protein CTD PMID:36309173 desipramine multiple interactions ISO RGD:1318014 6480464 Desipramine inhibits the reaction [Silicon Dioxide results in increased expression of NLRP3 protein] CTD PMID:34969174 dexamethasone multiple interactions ISO RGD:1318015 6480464 [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide more ... CTD PMID:30102002 more ... dexmedetomidine multiple interactions ISO RGD:1318014 6480464 Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein], NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]] CTD PMID:36858639 dexmedetomidine multiple interactions ISO RGD:1318015 6480464 Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:30102002 dextran sulfate increases expression EXP 6480464 Dextran Sulfate results in increased expression of NLRP3 mRNA CTD PMID:32470352 dextran sulfate increases expression ISO RGD:1318015 6480464 Dextran Sulfate results in increased expression of NLRP3 mRNA, Dextran Sulfate results in increased expression of NLRP3 protein CTD PMID:30270565 , PMID:37001609 dextran sulfate multiple interactions ISO RGD:1318015 6480464 [Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein more ... CTD PMID:27611972 more ... dextran sulfate multiple interactions EXP 6480464 celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA] more ... CTD PMID:32470352 diallyl disulfide multiple interactions ISO RGD:1318015 6480464 diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein] more ... CTD PMID:34896185 , PMID:35526736 diallyl trisulfide multiple interactions ISO RGD:1318015 6480464 diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] affects the localization of NLRP3 protein], diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]] CTD PMID:36796188 diarsenic trioxide multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein more ... CTD PMID:30660605 diarsenic trioxide increases expression ISO RGD:1318014 6480464 Arsenic Trioxide results in increased expression of NLRP3 mRNA, Arsenic Trioxide results in increased expression of NLRP3 protein CTD PMID:35226250 diarsenic trioxide multiple interactions ISO RGD:1318015 6480464 [Arsenic Trioxide results in increased abundance of arsenite] which results in increased expression of NLRP3 mRNA more ... CTD PMID:30237538 more ... diarsenic trioxide multiple interactions ISO RGD:1318014 6480464 [Arsenic Trioxide co-treated with lipopolysaccharide more ... CTD PMID:30237538 , PMID:35226250 diarsenic trioxide increases expression ISO RGD:1318015 6480464 Arsenic Trioxide results in increased expression of NLRP3 protein CTD PMID:30237538 , PMID:35226250 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of NLRP3 protein CTD PMID:30660605 dibutyl phthalate multiple interactions ISO RGD:1318014 6480464 KN 62 inhibits the reaction [Dibutyl Phthalate results in increased expression of NLRP3 protein] CTD PMID:26586371 dibutyl phthalate increases expression ISO RGD:1318014 6480464 Dibutyl Phthalate results in increased expression of NLRP3 protein CTD PMID:26586371 diclofenac increases expression ISO RGD:1318014 6480464 Diclofenac results in increased expression of NLRP3 mRNA CTD PMID:28138970 diclofenac increases expression ISO RGD:1318015 6480464 Diclofenac results in increased expression of NLRP3 mRNA CTD PMID:24747151 dicloxacillin increases expression ISO RGD:1318015 6480464 Dicloxacillin results in increased expression of NLRP3 mRNA CTD PMID:24747151 diethyldithiocarbamic acid multiple interactions ISO RGD:1318015 6480464 [Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein CTD PMID:25929180 diethyldithiocarbamic acid affects expression ISO RGD:1318015 6480464 Ditiocarb affects the expression of NLRP3 protein CTD PMID:25929180 dihydroartemisinin multiple interactions EXP 15036816 Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver] RGD dimethyldithiocarbamate affects expression ISO RGD:1318015 6480464 Dimethyldithiocarbamate affects the expression of NLRP3 protein CTD PMID:25929180 diosmetin multiple interactions EXP 6480464 diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein] CTD PMID:35191607 dioxygen multiple interactions EXP 6480464 [dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of NLRP3 mRNA] more ... CTD PMID:26464617 more ... doxorubicin multiple interactions ISO RGD:1318014 6480464 MAPK1 promotes the reaction [Doxorubicin results in increased expression of NLRP3 mRNA] CTD PMID:24885895 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of NLRP3 mRNA, Doxorubicin results in increased expression of NLRP3 protein CTD PMID:35764897 doxorubicin multiple interactions EXP 6480464 HDAC6 protein promotes the reaction [Doxorubicin results in increased expression of NLRP3 mRNA] more ... CTD PMID:35764897 doxorubicin increases expression ISO RGD:1318014 6480464 Doxorubicin results in increased expression of NLRP3 mRNA CTD PMID:24885895 elemental selenium increases expression ISO RGD:1318014 6480464 Selenium results in increased expression of NLRP3 mRNA CTD PMID:17293063 endosulfan increases expression ISO RGD:1318014 6480464 Endosulfan results in increased expression of NLRP3 mRNA CTD PMID:28108160 ergosterol multiple interactions EXP 6480464 [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA more ... CTD PMID:25833014 eriodictyol multiple interactions ISO RGD:1318015 6480464 eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:31860763 Erionite increases expression ISO RGD:1318014 6480464 erionite results in increased expression of NLRP3 mRNA CTD PMID:23937860 ethanol increases expression EXP 15036816 ethanol increases expression of Nrlp3 protein in liver RGD ethanol increases expression ISO RGD:1318015 6480464 Ethanol results in increased expression of NLRP3 protein CTD PMID:35526736 ethanol multiple interactions ISO RGD:1318015 6480464 [Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein more ... CTD PMID:35526736 ethanol increases expression ISO RGD:1318014 6480464 Ethanol results in increased expression of NLRP3 protein CTD PMID:34474091 ethanol multiple interactions ISO RGD:1318014 6480464 [Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein more ... CTD PMID:28964808 , PMID:34474091 flutamide increases expression ISO RGD:1318014 6480464 Flutamide results in increased expression of NLRP3 mRNA CTD PMID:28138970 flutamide increases expression ISO RGD:1318015 6480464 Flutamide results in increased expression of NLRP3 mRNA CTD PMID:28138970 fluvastatin multiple interactions EXP 6480464 Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein] more ... CTD PMID:35465754 formaldehyde decreases expression ISO RGD:1318014 6480464 Formaldehyde results in decreased expression of NLRP3 mRNA CTD PMID:28937961 fructose multiple interactions EXP 6480464 [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of NLRP3 protein] more ... CTD PMID:22426011 more ... fructose increases expression EXP 6480464 Fructose results in increased expression of NLRP3 protein CTD PMID:22426011 , PMID:24491314 fulvestrant multiple interactions ISO RGD:1318014 6480464 Fulvestrant inhibits the reaction [bisphenol A results in increased expression of NLRP3 mRNA], Fulvestrant inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein] CTD PMID:35439536 fumonisin B1 multiple interactions ISO RGD:1318015 6480464 deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of NLRP3 mRNA] more ... CTD PMID:36309173 fumonisin B1 increases expression ISO RGD:1318015 6480464 fumonisin B1 results in increased expression of NLRP3 mRNA, fumonisin B1 results in increased expression of NLRP3 protein CTD PMID:36309173 furan increases expression EXP 6480464 furan results in increased expression of NLRP3 mRNA CTD PMID:27387713 furan increases expression ISO RGD:1318015 6480464 furan results in increased expression of NLRP3 protein CTD PMID:34450210 furan multiple interactions ISO RGD:1318015 6480464 rhodioloside inhibits the reaction [furan results in increased expression of NLRP3 protein] CTD PMID:34450210 furosemide multiple interactions EXP 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein CTD PMID:29860548 Fusaric acid decreases expression ISO RGD:1318014 6480464 Fusaric Acid results in decreased expression of NLRP3 mRNA CTD PMID:30582969 galangin multiple interactions EXP 6480464 galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein] CTD PMID:35384154 genkwanin multiple interactions ISO RGD:1318014 6480464 genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein], TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]] CTD PMID:34481870 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of NLRP3 mRNA CTD PMID:33387578 glucose multiple interactions ISO RGD:1318015 6480464 NLRP3 protein promotes the reaction [Glucose results in decreased expression of TJP1 protein] more ... CTD PMID:27783111 glucose increases response to substance ISO RGD:1318015 6480464 NLRP3 protein results in increased susceptibility to Glucose CTD PMID:27783111 glucose increases expression EXP 6480464 Glucose results in increased expression of NLRP3 protein CTD PMID:23647015 more ... glucose multiple interactions ISO RGD:1318014 6480464 [Glucose co-treated with TGFB1 protein] results in increased expression of NLRP3 protein more ... CTD PMID:23647015 more ... glucose multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein more ... CTD PMID:23647015 more ... glucose increases expression ISO RGD:1318014 6480464 Glucose results in increased expression of NLRP3 protein CTD PMID:23647015 , PMID:36066211 glyburide multiple interactions EXP 6480464 Glyburide inhibits the reaction [2 more ... CTD PMID:25338942 more ... glyburide multiple interactions ISO RGD:1318015 6480464 Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein] more ... CTD PMID:32167222 more ... glycerol increases expression EXP 6480464 Glycerol results in increased expression of NLRP3 protein CTD PMID:36690085 glycerol multiple interactions EXP 6480464 Pentoxifylline inhibits the reaction [Glycerol results in increased expression of NLRP3 protein], Thiamine inhibits the reaction [Glycerol results in increased expression of NLRP3 protein] CTD PMID:36690085 glycidol multiple interactions EXP 6480464 alpha-Chlorohydrin promotes the reaction [glycidol results in increased expression of NLRP3 protein], glycidol promotes the reaction [alpha-Chlorohydrin results in increased expression of NLRP3 protein] CTD PMID:33187795 glycidol increases expression EXP 6480464 glycidol results in increased expression of NLRP3 protein CTD PMID:33187795 glyphosate increases methylation EXP 6480464 glyphosate results in increased methylation of NLRP3 gene CTD PMID:31011160 graphene oxide increases expression ISO RGD:1318014 6480464 graphene oxide results in increased expression of NLRP3 mRNA CTD PMID:33973267 guggulsterone multiple interactions EXP 15036816 Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver]] RGD hexadecanoic acid increases expression ISO RGD:1318015 6480464 Palmitic Acid results in increased expression of NLRP3 protein CTD PMID:29031535 hexadecanoic acid multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] more ... CTD PMID:30259999 hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of NLRP3 mRNA CTD PMID:30259999 hexadecanoic acid multiple interactions ISO RGD:1318015 6480464 baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] more ... CTD PMID:27689324 , PMID:29031535 HU-308 multiple interactions ISO RGD:1318015 6480464 [HU 308 co-treated with Dextran Sulfate] affects the expression of NLRP3 protein CTD PMID:27611972 hyaluronic acid increases expression EXP 6480464 Hyaluronic Acid results in increased expression of NLRP3 mRNA, Hyaluronic Acid results in increased expression of NLRP3 protein CTD PMID:33383130 hydrogen chloride increases expression ISO RGD:1318015 6480464 Hydrochloric Acid results in increased expression of NLRP3 protein CTD PMID:31900028 hydrogen peroxide decreases response to substance ISO RGD:1318015 6480464 NLRP3 gene mutant form results in decreased susceptibility to Hydrogen Peroxide CTD PMID:23619996 hydrogen sulfide multiple interactions EXP 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of NLRP3 protein], NFE2L2 protein affects the reaction [[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]] CTD PMID:32064027 hydroxysafflor yellow A multiple interactions ISO RGD:1318015 6480464 hydroxysafflor yellow A inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein] CTD PMID:37001609 icariin increases expression ISO RGD:1318014 6480464 icariin results in increased expression of NLRP3 mRNA, icariin results in increased expression of NLRP3 protein CTD PMID:35532261 iohexol multiple interactions EXP 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein CTD PMID:29860548 isoflurane multiple interactions ISO RGD:1318015 6480464 N-(1 more ... CTD PMID:35187972 isoflurane increases expression ISO RGD:1318015 6480464 Isoflurane results in increased expression of NLRP3 protein CTD PMID:35187972 ketoconazole increases expression ISO RGD:1318014 6480464 Ketoconazole results in increased expression of NLRP3 mRNA CTD PMID:28138970 ketoconazole increases expression ISO RGD:1318015 6480464 Ketoconazole results in increased expression of NLRP3 mRNA CTD PMID:28138970 L-methionine multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats co-treated with cyanoginosin LR] results in decreased expression of BCL2 protein] more ... CTD PMID:34416350 lead diacetate multiple interactions ISO RGD:1318015 6480464 1 more ... CTD PMID:36308466 lead(0) multiple interactions ISO RGD:1318015 6480464 1 more ... CTD PMID:36308466 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of NLRP3 mRNA, Lipopolysaccharides results in increased expression of NLRP3 protein CTD PMID:32418911 , PMID:34464015 lipopolysaccharide multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein more ... CTD PMID:30660605 more ... lipopolysaccharide multiple interactions ISO RGD:1318014 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]] more ... CTD PMID:18604214 more ... lipopolysaccharide increases expression ISO RGD:1318015 6480464 Lipopolysaccharides results in increased expression of NLRP3 mRNA, Lipopolysaccharides results in increased expression of NLRP3 protein CTD PMID:22147977 more ... lipopolysaccharide increases expression ISO RGD:1318014 6480464 Lipopolysaccharides results in increased expression of NLRP3 mRNA, Lipopolysaccharides results in increased expression of NLRP3 protein CTD PMID:24747151 more ... lipopolysaccharide multiple interactions ISO RGD:1318015 6480464 1-dodecylsulfonyl-5N more ... CTD PMID:18604214 more ... lithium carbonate increases expression ISO RGD:1318015 6480464 Lithium Carbonate results in increased expression of NLRP3 protein CTD PMID:34984798 lithocholic acid increases expression ISO RGD:1318015 6480464 Lithocholic Acid results in increased expression of NLRP3 mRNA, Lithocholic Acid results in increased expression of NLRP3 protein CTD PMID:29794447 lithocholic acid multiple interactions ISO RGD:1318015 6480464 Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 mRNA], Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 protein] CTD PMID:29794447 luteolin multiple interactions ISO RGD:1318014 6480464 Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein] CTD PMID:34217685 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of NLRP3 protein]] CTD PMID:36094782 , PMID:36898572 lysophosphatidylcholine multiple interactions ISO RGD:1318014 6480464 GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of NLRP3 protein] CTD PMID:34293432 lysophosphatidylcholine increases expression ISO RGD:1318014 6480464 Lysophosphatidylcholines results in increased expression of NLRP3 protein CTD PMID:34293432 magnesium dihydroxide multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 maneb multiple interactions ISO RGD:1318015 6480464 [Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein more ... CTD PMID:32375810 , PMID:34052309 mangiferin multiple interactions ISO RGD:1318014 6480464 mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of NLRP3 protein] CTD PMID:32420661 mebendazole increases expression ISO RGD:1318014 6480464 Mebendazole results in increased expression of NLRP3 mRNA CTD PMID:24747151 melatonin multiple interactions ISO RGD:1318015 6480464 [Nickel co-treated with Melatonin] results in decreased expression of NLRP3 protein more ... CTD PMID:36504304 melatonin decreases expression ISO RGD:1318015 6480464 Melatonin results in decreased expression of NLRP3 mRNA CTD PMID:36504304 memantine multiple interactions ISO RGD:1318015 6480464 Memantine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:34474083 mercury atom multiple interactions ISO RGD:1318015 6480464 N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of NLRP3 mRNA] CTD PMID:25237059 mercury atom increases expression ISO RGD:1318015 6480464 Mercury results in increased expression of NLRP3 mRNA CTD PMID:25237059 mercury dichloride multiple interactions ISO RGD:1318015 6480464 N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercuric Chloride results in increased expression of NLRP3 mRNA] CTD PMID:25237059 mercury dichloride increases expression ISO RGD:1318015 6480464 Mercuric Chloride results in increased expression of NLRP3 mRNA CTD PMID:25237059 mercury(0) multiple interactions ISO RGD:1318015 6480464 N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of NLRP3 mRNA] CTD PMID:25237059 mercury(0) increases expression ISO RGD:1318015 6480464 Mercury results in increased expression of NLRP3 mRNA CTD PMID:25237059 mesalamine multiple interactions ISO RGD:1318015 6480464 Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein] CTD PMID:37001609 methamphetamine multiple interactions ISO RGD:1318015 6480464 Methamphetamine promotes the reaction [PYCARD protein binds to NLRP3 protein] more ... CTD PMID:30394308 methamphetamine increases expression ISO RGD:1318015 6480464 Methamphetamine results in increased expression of NLRP3 protein CTD PMID:30394308 methapyrilene increases methylation ISO RGD:1318014 6480464 Methapyrilene results in increased methylation of NLRP3 intron CTD PMID:30157460 methimazole multiple interactions EXP 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of NLRP3 mRNA CTD PMID:26177832 microcystin-LR multiple interactions ISO RGD:1318015 6480464 FOXO1 affects the reaction [cyanoginosin LR results in increased expression of NLRP3 protein] more ... CTD PMID:33078829 , PMID:34416350 microcystin-LR increases expression ISO RGD:1318015 6480464 cyanoginosin LR results in increased expression of NLRP3 protein CTD PMID:33078829 mono(2-ethylhexyl) phthalate increases expression ISO RGD:1318015 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein CTD PMID:31016965 Morroniside multiple interactions ISO RGD:1318015 6480464 morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3] CTD PMID:33022338 Morroniside affects expression ISO RGD:1318015 6480464 morroniside affects the expression of NLRP3 CTD PMID:33022338 myrtenol multiple interactions EXP 6480464 myrtenol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA] CTD PMID:34477272 N-acetyl-L-cysteine multiple interactions ISO RGD:1318014 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:26435000 more ... N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of NLRP3 protein], Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 , PMID:36347317 N-acetyl-L-cysteine multiple interactions ISO RGD:1318015 6480464 Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 mRNA] more ... CTD PMID:26086368 more ... N-acetyl-L-cysteine increases expression ISO RGD:1318014 6480464 Acetylcysteine results in increased expression of NLRP3 mRNA CTD PMID:24885895 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1318014 6480464 genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein], TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]] CTD PMID:34481870 N-methyl-4-phenylpyridinium increases expression ISO RGD:1318014 6480464 1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein CTD PMID:34481870 N-nitrosodiethylamine increases expression ISO RGD:1318015 6480464 Diethylnitrosamine results in increased expression of NLRP3 mRNA CTD PMID:17942915 N-nitrosodiethylamine multiple interactions ISO RGD:1318015 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NLRP3 mRNA] CTD PMID:17942915 nickel atom increases expression ISO RGD:1318014 6480464 Nickel results in increased expression of NLRP3 mRNA CTD PMID:23195993 more ... nickel atom multiple interactions ISO RGD:1318015 6480464 [Nickel co-treated with Melatonin] results in decreased expression of NLRP3 protein more ... CTD PMID:36504304 nickel atom multiple interactions ISO RGD:1318014 6480464 [nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein, Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein] CTD PMID:31943712 nickel dichloride multiple interactions ISO RGD:1318015 6480464 NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein] CTD PMID:24158569 nickel dichloride multiple interactions ISO RGD:1318014 6480464 [nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein, Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein] CTD PMID:31943712 niclosamide multiple interactions ISO RGD:1318014 6480464 Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 niclosamide multiple interactions ISO RGD:1318015 6480464 Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 nicotine increases expression ISO RGD:1318014 6480464 Nicotine results in increased expression of NLRP3 protein CTD PMID:35131329 nicotine multiple interactions ISO RGD:1318014 6480464 CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein] CTD PMID:35131329 nigericin multiple interactions ISO RGD:1318014 6480464 NLRP3 protein affects the reaction [Nigericin results in increased secretion of IL1B protein] CTD PMID:18403674 nigericin multiple interactions EXP 6480464 Nigericin inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]] CTD PMID:36898572 NMN zwitterion multiple interactions ISO RGD:1318015 6480464 Nicotinamide Mononucleotide inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 protein] CTD PMID:30292833 NMN zwitterion multiple interactions EXP 6480464 Nicotinamide Mononucleotide inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 mRNA], Nicotinamide Mononucleotide inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 protein] CTD PMID:30292833 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of NLRP3 mRNA, nonylphenol results in increased expression of NLRP3 protein CTD PMID:35998786 Nonylphenol increases expression ISO RGD:1318014 6480464 nonylphenol results in increased expression of NLRP3 protein CTD PMID:35998786 obeticholic acid multiple interactions EXP 15036816 Obeticholic acid inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver] RGD ochratoxin A increases expression ISO RGD:1318015 6480464 ochratoxin A results in increased expression of NLRP3 mRNA, ochratoxin A results in increased expression of NLRP3 protein CTD PMID:33543323 omeprazole multiple interactions EXP 6480464 Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]], Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:32418911 ozone increases expression ISO RGD:1318014 6480464 Ozone results in increased expression of NLRP3 mRNA CTD PMID:31476115 ozone increases expression EXP 6480464 Ozone results in increased expression of NLRP3 mRNA CTD PMID:33383130 ozone multiple interactions ISO RGD:1318015 6480464 [Air Pollutants results in increased abundance of Ozone] which results in increased expression of NLRP3 protein, Glyburide inhibits the reaction [Ozone results in increased expression of NLRP3 protein] CTD PMID:26731380 , PMID:32167222 ozone increases expression ISO RGD:1318015 6480464 Ozone results in increased expression of NLRP3 protein CTD PMID:32167222 ozone multiple interactions ISO RGD:1318014 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of NLRP3 mRNA CTD PMID:31476115 Palbinone multiple interactions EXP 6480464 palbinone inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein] CTD PMID:32202043 paracetamol affects expression ISO RGD:1318015 6480464 Acetaminophen affects the expression of NLRP3 mRNA CTD PMID:17562736 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of NLRP3 mRNA CTD PMID:33387578 paracetamol multiple interactions ISO RGD:1318015 6480464 allicin inhibits the reaction [Acetaminophen results in increased expression of NLRP3 protein], PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of NLRP3 protein] CTD PMID:31444509 , PMID:32040233 paracetamol increases expression ISO RGD:1318015 6480464 Acetaminophen results in increased expression of NLRP3 mRNA, Acetaminophen results in increased expression of NLRP3 protein CTD PMID:24747151 more ... paracetamol increases expression ISO RGD:1318014 6480464 Acetaminophen results in increased expression of NLRP3 mRNA CTD PMID:26690555 paraquat multiple interactions EXP 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of NLRP3 protein] more ... CTD PMID:25338942 more ... paraquat multiple interactions ISO RGD:1318015 6480464 [Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein more ... CTD PMID:29054699 more ... paraquat increases expression ISO RGD:1318015 6480464 Paraquat results in increased expression of NLRP3 protein CTD PMID:29054699 paraquat increases expression EXP 6480464 Paraquat results in increased expression of NLRP3 mRNA, Paraquat results in increased expression of NLRP3 protein CTD PMID:25338942 more ... parthenolide multiple interactions EXP 6480464 parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 patulin increases expression ISO RGD:1318014 6480464 Patulin results in increased expression of NLRP3 protein CTD PMID:33217525 patulin multiple interactions ISO RGD:1318014 6480464 3-methyladenine inhibits the reaction [Patulin results in increased expression of NLRP3 protein] more ... CTD PMID:33217525 pentanal increases expression ISO RGD:1318014 6480464 pentanal results in increased expression of NLRP3 mRNA CTD PMID:26079696 Pentoxifylline multiple interactions EXP 6480464 Pentoxifylline inhibits the reaction [Glycerol results in increased expression of NLRP3 protein] CTD PMID:36690085 perfluorodecanoic acid multiple interactions ISO RGD:1318014 6480464 NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA] more ... CTD PMID:36423729 perfluorooctanoic acid increases expression ISO RGD:1318014 6480464 perfluorooctanoic acid results in increased expression of NLRP3 mRNA CTD PMID:36326898 permethrin multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [[Pyridostigmine Bromide co-treated with Permethrin] results in decreased expression of BDNF protein] more ... CTD PMID:32832901 phenytoin multiple interactions ISO RGD:1318015 6480464 [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA CTD PMID:23986454 phorbol 13-acetate 12-myristate increases expression ISO RGD:1318014 6480464 Tetradecanoylphorbol Acetate results in increased expression of NLRP3 mRNA CTD PMID:23937860 phosgene multiple interactions EXP 6480464 NLRP3 protein promotes the reaction [Phosgene results in increased expression of and results in increased activity of CASP1 protein] more ... CTD PMID:33012731 phosgene increases expression EXP 6480464 Phosgene results in increased expression of NLRP3 mRNA, Phosgene results in increased expression of NLRP3 protein CTD PMID:33012731 procyanidin B2 multiple interactions EXP 6480464 procyanidin B2 inhibits the reaction [Paraquat results in increased expression of NLRP3 protein] CTD PMID:30025709 propanal decreases expression ISO RGD:1318014 6480464 propionaldehyde results in decreased expression of NLRP3 mRNA CTD PMID:26079696 pterostilbene multiple interactions ISO RGD:1318014 6480464 pterostilbene inhibits the reaction [Ethanol results in increased expression of NLRP3 protein], RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of NLRP3 protein]] CTD PMID:34474091 puerarin multiple interactions ISO RGD:1318014 6480464 puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] CTD PMID:35331853 Pyridostigmine bromide multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [[Pyridostigmine Bromide co-treated with Permethrin] results in decreased expression of BDNF protein] more ... CTD PMID:32832901 pyrrolidine dithiocarbamate multiple interactions ISO RGD:1318014 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of NLRP3 protein] more ... CTD PMID:35190838 , PMID:36066211 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Fructose results in increased expression of NLRP3 protein] more ... CTD PMID:22426011 more ... quercetin multiple interactions ISO RGD:1318014 6480464 Quercetin inhibits the reaction [Glucose results in increased expression of NLRP3 protein] more ... CTD PMID:23647015 , PMID:34791735 raloxifene multiple interactions ISO RGD:1318014 6480464 [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA CTD PMID:19059307 resveratrol multiple interactions ISO RGD:1318014 6480464 [Lipopolysaccharides co-treated with Adenosine Triphosphate co-treated with Resveratrol] results in increased expression of NLRP3 mRNA, Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein] CTD PMID:24149798 , PMID:31943712 resveratrol multiple interactions ISO RGD:1318015 6480464 Resveratrol inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 mRNA], Resveratrol inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 protein] CTD PMID:34614429 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA] more ... CTD PMID:25833014 , PMID:26464617 resveratrol increases expression ISO RGD:1318014 6480464 resveratrol results in increased expression of NLRP3 mRNA CTD PMID:25436977 rifampicin multiple interactions ISO RGD:1318015 6480464 Rifampin inhibits the reaction [Rotenone results in increased expression of NLRP3 protein] CTD PMID:26086368 rimonabant multiple interactions ISO RGD:1318015 6480464 Rimonabant inhibits the reaction [3-(2-hydroxy-4-(1, 1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of NLRP3] CTD PMID:32832534 rimonabant multiple interactions ISO RGD:1318014 6480464 Rimonabant inhibits the reaction [Cannabidiol results in decreased expression of NLRP3 protein] CTD PMID:27932991 rosmarinic acid decreases expression ISO RGD:1318014 6480464 rosmarinic acid results in decreased expression of NLRP3 mRNA CTD PMID:36863647 rotenone multiple interactions ISO RGD:1318015 6480464 Acetylcysteine inhibits the reaction [Rotenone results in increased expression of NLRP3 protein] more ... CTD PMID:23619996 more ... rotenone increases expression EXP 6480464 Rotenone results in increased expression of NLRP3 protein CTD PMID:32088201 rotenone multiple interactions EXP 6480464 3-(2, 4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Rotenone results in increased expression of NLRP3 protein] CTD PMID:32088201 rotenone multiple interactions ISO RGD:1318014 6480464 [lipopolysaccharide more ... CTD PMID:30205151 , PMID:30927257 rotenone increases expression ISO RGD:1318015 6480464 Rotenone results in increased expression of NLRP3 protein CTD PMID:26086368 , PMID:28903492 rotenone increases response to substance ISO RGD:1318015 6480464 NLRP3 gene results in increased susceptibility to Rotenone CTD PMID:28903492 rotenone decreases response to substance ISO RGD:1318015 6480464 NLRP3 gene mutant form results in decreased susceptibility to Rotenone CTD PMID:28903492 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein] CTD PMID:22426011 S-allylcysteine multiple interactions ISO RGD:1318015 6480464 S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NLRP3 protein] CTD PMID:32453893 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:1318015 6480464 [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA CTD PMID:23986454 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of NLRP3 mRNA CTD PMID:26177832 Salidroside multiple interactions EXP 6480464 rhodioloside inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:29031534 Salidroside multiple interactions ISO RGD:1318015 6480464 rhodioloside inhibits the reaction [furan results in increased expression of NLRP3 protein] CTD PMID:34450210 SB 203580 multiple interactions ISO RGD:1318014 6480464 SB 203580 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein], SB 203580 inhibits the reaction [APP protein results in increased expression of NLRP3 protein] CTD PMID:28004443 , PMID:34510229 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Acrolein results in increased expression of NLRP3 protein] CTD PMID:31639409 selenium atom increases expression ISO RGD:1318014 6480464 Selenium results in increased expression of NLRP3 mRNA CTD PMID:17293063 serpentine asbestos multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [Asbestos more ... CTD PMID:18403674 sevoflurane multiple interactions EXP 6480464 PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of NLRP3 protein], WDR48 protein affects the reaction [Sevoflurane results in increased expression of NLRP3 protein] CTD PMID:36047109 , PMID:36155068 sevoflurane increases expression EXP 6480464 Sevoflurane results in increased expression of NLRP3 protein CTD PMID:36047109 , PMID:36155068 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of NLRP3 mRNA CTD PMID:21602193 silicon dioxide affects localization ISO RGD:1318014 6480464 Silicon Dioxide affects the localization of NLRP3 protein CTD PMID:34766707 silicon dioxide increases expression ISO RGD:1318014 6480464 Silicon Dioxide results in increased expression of NLRP3 mRNA, Silicon Dioxide results in increased expression of NLRP3 protein CTD PMID:33012733 more ... silicon dioxide multiple interactions ISO RGD:1318015 6480464 NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of CASP1 protein] more ... CTD PMID:18403674 , PMID:18604214 silicon dioxide multiple interactions ISO RGD:1318014 6480464 [Silicon Dioxide co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein more ... CTD PMID:18604214 more ... simvastatin multiple interactions EXP 6480464 Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein]] more ... CTD PMID:30408459 , PMID:35762198 sirolimus decreases expression ISO RGD:1318014 6480464 Sirolimus results in decreased expression of NLRP3 protein CTD PMID:32645460 sirolimus multiple interactions ISO RGD:1318015 6480464 Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein], Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of NLRP3 mRNA] CTD PMID:35405287 , PMID:36849104 sirolimus multiple interactions ISO RGD:1318014 6480464 Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein] CTD PMID:30205151 sodium arsenite multiple interactions ISO RGD:1318014 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein, bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein] CTD PMID:32645460 sodium arsenite multiple interactions EXP 6480464 [sodium arsenite co-treated with Lipopolysaccharides] promotes the reaction [SERPINH1 protein binds to NLRP3 protein] more ... CTD PMID:35963424 sodium arsenite increases expression ISO RGD:1318015 6480464 sodium arsenite results in increased expression of NLRP3 protein CTD PMID:33290778 sodium arsenite multiple interactions ISO RGD:1318015 6480464 SEMA4A protein promotes the reaction [sodium arsenite results in increased expression of NLRP3 protein] CTD PMID:33290778 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of NLRP3 protein CTD PMID:34920032 streptozocin multiple interactions ISO RGD:1318015 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein more ... CTD PMID:27783111 , PMID:35961541 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of NLRP3 mRNA, Streptozocin results in increased expression of NLRP3 protein CTD PMID:23647015 more ... streptozocin multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA] more ... CTD PMID:23647015 more ... succimer multiple interactions ISO RGD:1318015 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of NLRP3 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NLRP3 mRNA CTD PMID:21641980 , PMID:26378955 sulfasalazine multiple interactions EXP 6480464 Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA], Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 protein] CTD PMID:30408459 , PMID:35595039 tamoxifen multiple interactions ISO RGD:1318014 6480464 [Tamoxifen co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA CTD PMID:19059307 taurine multiple interactions EXP 6480464 Taurine inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein], Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein] CTD PMID:30660605 taurine multiple interactions ISO RGD:1318015 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of NLRP3 protein] CTD PMID:30237538 taurine multiple interactions ISO RGD:1318014 6480464 Taurine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein] CTD PMID:30237538 tauroursodeoxycholic acid multiple interactions ISO RGD:1318015 6480464 ursodoxicoltaurine inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] CTD PMID:29031535 testosterone multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NLRP3 mRNA CTD PMID:32741896 testosterone increases expression ISO RGD:1318014 6480464 Testosterone results in increased expression of NLRP3 mRNA CTD PMID:33359661 tetrachloromethane multiple interactions ISO RGD:1318015 6480464 NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]] more ... CTD PMID:27477297 , PMID:35405287 tetrachloromethane increases expression ISO RGD:1318015 6480464 Carbon Tetrachloride results in increased expression of NLRP3 protein CTD PMID:27477297 , PMID:35405287 tetramethylpyrazine multiple interactions ISO RGD:1318015 6480464 NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]], tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein] CTD PMID:27477297 thapsigargin increases expression ISO RGD:1318014 6480464 Thapsigargin results in increased expression of NLRP3 mRNA CTD PMID:30796460 thiamine(1+) chloride multiple interactions EXP 6480464 Thiamine inhibits the reaction [Glycerol results in increased expression of NLRP3 protein] CTD PMID:36690085 thioacetamide multiple interactions ISO RGD:1318015 6480464 3-(5-(2, 3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Thioacetamide results in increased expression of NLRP3 protein] CTD PMID:32721574 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of NLRP3 mRNA CTD PMID:34492290 thioacetamide increases expression ISO RGD:1318015 6480464 Thioacetamide results in increased expression of NLRP3 protein CTD PMID:32721574 thiram affects expression ISO RGD:1318015 6480464 Thiram affects the expression of NLRP3 protein CTD PMID:25929180 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of NLRP3 protein CTD PMID:32004531 toluene 2,4-diisocyanate multiple interactions ISO RGD:1318015 6480464 N-(1 more ... CTD PMID:31070765 trichloroethene increases expression ISO RGD:1318015 6480464 Trichloroethylene results in increased expression of NLRP3 mRNA CTD PMID:36849104 trichloroethene multiple interactions ISO RGD:1318015 6480464 Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of NLRP3 mRNA] CTD PMID:36849104 triclosan increases expression ISO RGD:1318015 6480464 Triclosan results in increased expression of NLRP3 mRNA CTD PMID:32321163 triptonide increases expression ISO RGD:1318015 6480464 triptonide results in increased expression of NLRP3 mRNA CTD PMID:33045310 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate increases expression ISO RGD:1318014 6480464 Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 Tungsten carbide multiple interactions ISO RGD:1318014 6480464 [tungsten carbide co-treated with Cobalt] results in increased expression of NLRP3 mRNA CTD PMID:18078969 ubiquinone-0 multiple interactions ISO RGD:1318014 6480464 ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein] CTD PMID:36847822 ubiquinone-0 decreases expression ISO RGD:1318014 6480464 ubiquinone-O results in decreased expression of NLRP3 protein CTD PMID:36847822 verapamil multiple interactions EXP 6480464 Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 mRNA], Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NLRP3 protein] CTD PMID:35460826 vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of NLRP3 gene CTD PMID:31079544 XL147 multiple interactions ISO RGD:1318015 6480464 [N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NLRP3 mRNA CTD PMID:27935865 zearalenone multiple interactions EXP 6480464 NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form] more ... CTD PMID:31586597 zearalenone multiple interactions ISO RGD:1318015 6480464 [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 mRNA more ... CTD PMID:30270565 zearalenone increases expression ISO RGD:1318015 6480464 Zearalenone results in increased expression of NLRP3 mRNA, Zearalenone results in increased expression of NLRP3 protein CTD PMID:30270565 zinc atom multiple interactions ISO RGD:1318015 6480464 [Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein CTD PMID:25929180 zinc(0) multiple interactions ISO RGD:1318015 6480464 [Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein CTD PMID:25929180 ziram decreases expression ISO RGD:1318015 6480464 Ziram results in decreased expression of NLRP3 protein CTD PMID:25929180
