Nxnl1 (nucleoredoxin-like 1) - Rat Genome Database

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Gene: Nxnl1 (nucleoredoxin-like 1) Rattus norvegicus
Analyze
Symbol: Nxnl1
Name: nucleoredoxin-like 1
RGD ID: 1308296
Description: Predicted to enable receptor ligand activity. Predicted to be involved in photoreceptor cell maintenance. Orthologous to human NXNL1 (nucleoredoxin like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; manganese(II) chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC108353096; LOC306342; nucleoredoxin-like protein 1; thioredoxin-like 6; Txnl6; uncharacterized LOC108353096; uncharacterized protein LOC108353096
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,303,454 - 18,311,510 (-)NCBIGRCr8
mRatBN7.21618,270,604 - 18,279,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,262,688 - 18,279,987 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,322,531 - 18,327,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,454,475 - 19,459,400 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,375,468 - 18,380,435 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,992,211 - 19,996,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,992,984 - 19,996,836 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,847,552 - 19,857,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,766,955 - 18,767,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,738,023 - 18,767,517 (-)NCBI
Celera1618,480,208 - 18,480,533 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14651853   PMID:26239254  


Genomics

Comparative Map Data
Nxnl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,303,454 - 18,311,510 (-)NCBIGRCr8
mRatBN7.21618,270,604 - 18,279,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,262,688 - 18,279,987 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,322,531 - 18,327,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,454,475 - 19,459,400 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,375,468 - 18,380,435 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,992,211 - 19,996,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,992,984 - 19,996,836 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,847,552 - 19,857,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,766,955 - 18,767,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,738,023 - 18,767,517 (-)NCBI
Celera1618,480,208 - 18,480,533 (-)NCBICelera
Cytogenetic Map16p14NCBI
NXNL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,455,425 - 17,460,926 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,455,425 - 17,460,926 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,566,234 - 17,571,735 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,427,234 - 17,432,725 (-)NCBINCBI36Build 36hg18NCBI36
Build 341917,427,235 - 17,432,725NCBI
Celera1917,467,985 - 17,473,494 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,131,793 - 17,137,523 (-)NCBIHuRef
CHM1_11917,565,780 - 17,571,275 (-)NCBICHM1_1
T2T-CHM13v2.01917,590,193 - 17,595,708 (-)NCBIT2T-CHM13v2.0
Nxnl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,013,211 - 72,019,291 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,013,199 - 72,019,245 (-)EnsemblGRCm39 Ensembl
GRCm38871,560,555 - 71,566,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,560,555 - 71,566,601 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,084,454 - 74,090,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,489,544 - 74,495,590 (-)NCBIMGSCv36mm8
Celera874,071,252 - 74,073,239 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Nxnl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524826,388 - 827,170 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955524825,818 - 827,167 (+)NCBIChiLan1.0ChiLan1.0
NXNL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,325,893 - 22,333,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,332,484 - 21,339,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01916,942,887 - 16,948,655 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11917,916,159 - 17,922,126 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,916,159 - 17,922,126 (-)Ensemblpanpan1.1panPan2
NXNL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,348,890 - 45,351,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,262,931 - 45,265,416 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,836,047 - 45,838,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,836,047 - 45,838,766 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,072,450 - 45,075,163 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,482,468 - 45,484,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,758,504 - 45,760,982 (+)NCBIUU_Cfam_GSD_1.0
NXNL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,244,646 - 60,251,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,244,592 - 60,249,696 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,863,727 - 59,869,499 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NXNL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,948,401 - 15,951,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl615,948,514 - 15,951,096 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,480,400 - 3,488,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nxnl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624908551,921 - 554,427 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624908549,989 - 554,902 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nxnl1
144 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:46
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000024434
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 49 113 62 61 31 20 31 6 179 91 93 44 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000024434   ⟹   ENSRNOP00000024434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,271,741 - 18,279,987 (-)Ensembl
Rnor_6.0 Ensembl1619,992,984 - 19,996,716 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080706   ⟹   ENSRNOP00000073212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,262,688 - 18,276,588 (-)Ensembl
Rnor_6.0 Ensembl1619,994,838 - 19,996,836 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116895   ⟹   ENSRNOP00000093815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,275,518 - 18,278,053 (-)Ensembl
RefSeq Acc Id: NM_001271341   ⟹   NP_001258270
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,304,587 - 18,310,644 (-)NCBI
mRatBN7.21618,270,604 - 18,276,661 (-)NCBI
Rnor_6.01619,992,984 - 19,996,716 (-)NCBI
Rnor_5.01619,847,552 - 19,857,599 (-)NCBI
Celera1618,480,208 - 18,480,533 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094485   ⟹   XP_038950413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,303,454 - 18,311,510 (-)NCBI
mRatBN7.21618,270,604 - 18,279,797 (-)NCBI
RefSeq Acc Id: XR_001841535
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,303,454 - 18,311,510 (-)NCBI
mRatBN7.21618,270,604 - 18,278,988 (-)NCBI
Rnor_6.01619,992,211 - 19,996,815 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258270 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950413 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACH42125 (Get FASTA)   NCBI Sequence Viewer  
  EDL90777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024434.6
  ENSRNOP00000073212.2
  ENSRNOP00000093815.1
RefSeq Acc Id: NP_001258270   ⟸   NM_001271341
- UniProtKB: A0A0G2K4X6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073212   ⟸   ENSRNOT00000080706
Ensembl Acc Id: ENSRNOP00000024434   ⟸   ENSRNOT00000024434
RefSeq Acc Id: XP_038950413   ⟸   XM_039094485
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4X6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093815   ⟸   ENSRNOT00000116895
Protein Domains
Thioredoxin   Thioredoxin-like fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LP37-F1-model_v2 AlphaFold F1LP37 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308296 AgrOrtholog
BioCyc Gene G2FUF-11839 BioCyc
Ensembl Genes ENSRNOG00000042658 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024434.6 UniProtKB/TrEMBL
  ENSRNOT00000080706.2 UniProtKB/TrEMBL
  ENSRNOT00000116895.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro RdCVF UniProtKB/TrEMBL
  Thioredoxin-like_fold UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report rno:306342 UniProtKB/TrEMBL
NCBI Gene 306342 ENTREZGENE
PANTHER NUCLEOREDOXIN-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR47109 UniProtKB/TrEMBL
Pfam Thioredoxin_8 UniProtKB/TrEMBL
PhenoGen Nxnl1 PhenoGen
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042658 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A0A0G2K4X6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJJ3_RAT UniProtKB/TrEMBL
  B5LNR2_RAT UniProtKB/TrEMBL
  F1LP37_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Nxnl1  nucleoredoxin-like 1  LOC108353096  uncharacterized LOC108353096  Data merged from RGD:11375317 737654 PROVISIONAL
2016-08-02 LOC108353096  uncharacterized LOC108353096      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-07 Nxnl1  nucleoredoxin-like 1  Txnl6_predicted  thioredoxin-like 6 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Txnl6_predicted  thioredoxin-like 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED