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Gene: Apc2 (APC regulator of WNT signaling pathway 2) Rattus norvegicus
Symbol: Apc2
Name: APC regulator of WNT signaling pathway 2
Description: Predicted to have beta-catenin binding activity and gamma-catenin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Localizes to postsynapse. Predicted to colocalize with cytoplasmic microtubule and filamentous actin. Human ortholog(s) of this gene implicated in Sotos syndrome and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2); PARTICIPATES IN basal cell carcinoma pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: INFERRED
Also known as: adenomatosis polyposis coli 2; adenomatous polyposis coli protein 2; APC2, WNT signaling pathway regulator; LOC299611
Homo sapiens (human) : APC2 (APC regulator of WNT signaling pathway 2)  HGNC  Alliance
Mus musculus (house mouse) : Apc2 (APC regulator of WNT signaling pathway 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apc2 (APC regulator of WNT signaling pathway 2)
Canis lupus familiaris (dog) : APC2 (APC regulator of WNT signaling pathway 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apc2 (APC regulator of WNT signaling pathway 2)
Sus scrofa (pig) : APC2 (APC regulator of WNT signaling pathway 2)
Chlorocebus sabaeus (African green monkey) : APC2 (APC regulator of WNT signaling pathway 2)
Heterocephalus glaber (naked mole-rat) : Apc2 (APC regulator of WNT signaling pathway 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0712,258,468 - 12,280,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,258,468 - 12,275,609 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,428,263 - 12,450,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,903,675 - 10,920,010 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,906,422 - 10,920,010 (-)NCBI
Celera77,569,129 - 7,585,464 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Apc2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308256
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.