Fign (fidgetin, microtubule severing factor) - Rat Genome Database

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Gene: Fign (fidgetin, microtubule severing factor) Rattus norvegicus
Analyze
Symbol: Fign
Name: fidgetin, microtubule severing factor
RGD ID: 1308174
Description: Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within locomotory behavior. Predicted to be located in nuclear matrix. Orthologous to human FIGN (fidgetin, microtubule severing factor); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fidgetin; LOC295649
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8369,045,918 - 69,169,148 (-)NCBIGRCr8
mRatBN7.2348,637,510 - 48,760,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl348,642,496 - 48,760,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx351,971,883 - 52,089,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0360,555,393 - 60,673,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0358,345,891 - 58,463,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0349,992,250 - 50,120,601 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl349,992,397 - 50,120,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0356,637,401 - 56,764,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4346,006,895 - 46,130,212 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1345,903,265 - 46,026,612 (-)NCBI
Celera348,260,684 - 48,378,383 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
melphalan  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentanal  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16751186   PMID:36586551  


Genomics

Comparative Map Data
Fign
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8369,045,918 - 69,169,148 (-)NCBIGRCr8
mRatBN7.2348,637,510 - 48,760,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl348,642,496 - 48,760,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx351,971,883 - 52,089,709 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0360,555,393 - 60,673,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0358,345,891 - 58,463,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0349,992,250 - 50,120,601 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl349,992,397 - 50,120,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0356,637,401 - 56,764,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4346,006,895 - 46,130,212 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1345,903,265 - 46,026,612 (-)NCBI
Celera348,260,684 - 48,378,383 (-)NCBICelera
Cytogenetic Map3q21NCBI
FIGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382163,602,611 - 163,736,008 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2163,593,396 - 163,736,012 (-)EnsemblGRCh38hg38GRCh38
GRCh372164,459,121 - 164,592,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362164,172,364 - 164,300,759 (-)NCBINCBI36Build 36hg18NCBI36
Build 342164,291,556 - 164,293,651NCBI
Celera2158,074,075 - 158,202,502 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2156,346,627 - 156,474,914 (-)NCBIHuRef
CHM1_12164,470,008 - 164,598,433 (-)NCBICHM1_1
T2T-CHM13v2.02164,059,859 - 164,193,293 (-)NCBIT2T-CHM13v2.0
Fign
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39263,801,852 - 63,928,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl263,801,851 - 63,928,382 (-)EnsemblGRCm39 Ensembl
GRCm38263,971,508 - 64,098,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl263,971,507 - 64,098,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv37263,815,418 - 63,936,064 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36263,778,670 - 63,898,827 (-)NCBIMGSCv36mm8
Celera265,662,900 - 65,783,578 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map237.19NCBI
Fign
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544910,271,014 - 10,393,859 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544910,271,125 - 10,400,631 (+)NCBIChiLan1.0ChiLan1.0
FIGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21366,279,486 - 66,407,932 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B66,289,122 - 66,600,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B50,889,187 - 51,022,435 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B168,259,440 - 168,387,036 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B168,258,315 - 168,385,768 (-)Ensemblpanpan1.1panPan2
FIGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1368,914,023 - 9,045,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl368,920,224 - 8,922,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha369,049,767 - 9,190,855 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0369,038,947 - 9,180,410 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl369,039,164 - 9,180,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1369,048,565 - 9,189,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,106,216 - 9,231,397 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0369,220,027 - 9,345,231 (-)NCBIUU_Cfam_GSD_1.0
Fign
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303126,059,464 - 126,183,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646915,434,127 - 15,553,438 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646915,434,150 - 15,556,167 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1570,262,091 - 70,394,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11570,255,270 - 70,394,095 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21578,089,130 - 78,245,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FIGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11049,035,120 - 49,453,559 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1049,052,032 - 49,178,962 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040150,341,369 - 150,475,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fign
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247321,770,852 - 1,899,842 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247321,770,794 - 1,904,398 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fign
736 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:61
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000006175
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
AU022255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2348,686,905 - 48,687,125 (+)MAPPERmRatBN7.2
Rnor_6.0350,037,242 - 50,037,461NCBIRnor6.0
Rnor_5.0356,680,974 - 56,681,193UniSTSRnor5.0
RGSC_v3.4346,050,510 - 46,050,729UniSTSRGSC3.4
Celera348,304,760 - 48,304,979UniSTS
Cytogenetic Map3q21UniSTS
FIGN__6723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2348,643,620 - 48,644,215 (+)MAPPERmRatBN7.2
Rnor_6.0349,993,126 - 49,993,720NCBIRnor6.0
Rnor_5.0356,637,905 - 56,638,499UniSTSRnor5.0
RGSC_v3.4346,007,561 - 46,008,155UniSTSRGSC3.4
Celera348,261,421 - 48,262,015UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006175   ⟹   ENSRNOP00000006175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl348,642,892 - 48,760,705 (-)Ensembl
Rnor_6.0 Ensembl349,992,397 - 50,120,392 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107158   ⟹   ENSRNOP00000081312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl348,642,496 - 48,760,787 (-)Ensembl
RefSeq Acc Id: NM_001106484   ⟹   NP_001099954
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,051,292 - 69,169,108 (-)NCBI
mRatBN7.2348,642,884 - 48,760,705 (-)NCBI
Rnor_6.0349,992,393 - 50,120,392 (-)NCBI
Rnor_5.0356,637,401 - 56,764,164 (-)NCBI
RGSC_v3.4346,006,895 - 46,130,212 (-)RGD
Celera348,260,684 - 48,378,383 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761888   ⟹   XP_008760110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,045,918 - 69,168,933 (-)NCBI
mRatBN7.2348,637,510 - 48,760,772 (-)NCBI
Rnor_6.0349,992,250 - 50,120,601 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761889   ⟹   XP_008760111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,045,918 - 69,168,933 (-)NCBI
mRatBN7.2348,637,510 - 48,713,087 (-)NCBI
Rnor_6.0349,992,250 - 50,049,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761890   ⟹   XP_008760112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,045,918 - 69,169,148 (-)NCBI
mRatBN7.2348,637,510 - 48,760,771 (-)NCBI
Rnor_6.0349,992,250 - 50,120,601 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283273   ⟹   XP_063139343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8369,045,918 - 69,168,933 (-)NCBI
RefSeq Acc Id: NP_001099954   ⟸   NM_001106484
- UniProtKB: D3ZYS4 (UniProtKB/TrEMBL),   A6HLW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760112   ⟸   XM_008761890
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZRP0 (UniProtKB/TrEMBL),   A6HLW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760110   ⟸   XM_008761888
- Peptide Label: isoform X1
- UniProtKB: D3ZYS4 (UniProtKB/TrEMBL),   A6HLW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760111   ⟸   XM_008761889
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZRP0 (UniProtKB/TrEMBL),   A6HLW5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006175   ⟸   ENSRNOT00000006175
Ensembl Acc Id: ENSRNOP00000081312   ⟸   ENSRNOT00000107158
RefSeq Acc Id: XP_063139343   ⟸   XM_063283273
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZRP0 (UniProtKB/TrEMBL),   A6HLW5 (UniProtKB/TrEMBL)
Protein Domains
AAA+ ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYS4-F1-model_v2 AlphaFold D3ZYS4 1-759 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308174 AgrOrtholog
BioCyc Gene G2FUF-49572 BioCyc
Ensembl Genes ENSRNOG00000004679 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006175.7 UniProtKB/TrEMBL
  ENSRNOT00000107158.1 UniProtKB/TrEMBL
  ENSRNOT00000129006 ENTREZGENE
  ENSRNOT00000166797 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro ATPase_AAA+_core UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/TrEMBL
  Fidgetin_ATPase UniProtKB/TrEMBL
  MT-severing_AAA_ATPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Vps4_C UniProtKB/TrEMBL
KEGG Report rno:295649 UniProtKB/TrEMBL
NCBI Gene 295649 ENTREZGENE
PANTHER AAA DOMAIN-CONTAINING UniProtKB/TrEMBL
  FIDGETIN UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  Vps4_C UniProtKB/TrEMBL
PhenoGen Fign PhenoGen
PROSITE AAA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004679 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZRP0 ENTREZGENE, UniProtKB/TrEMBL
  A6HLW4 ENTREZGENE, UniProtKB/TrEMBL
  A6HLW5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYS4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Fign  fidgetin, microtubule severing factor  Fign  fidgetin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fign  fidgetin   Fign_predicted  fidgetin (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fign_predicted  fidgetin (predicted)      Symbol and Name status set to approved 70820 APPROVED