Gmnn (geminin, DNA replication inhibitor)

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Gene: Gmnn (geminin, DNA replication inhibitor) Rattus norvegicus

Analyze

Symbol:

Gmnn

Name:

geminin, DNA replication inhibitor

RGD ID:

1308137

Description:

Predicted to enable several functions, including chromatin binding activity; histone deacetylase binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including DNA replication preinitiation complex assembly; regulation of mitotic cell cycle; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within animal organ morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

geminin; LOC291137

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GMNN (geminin DNA replication inhibitor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gmnn (geminin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gmnn (geminin DNA replication inhibitor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GMNN (geminin DNA replication inhibitor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GMNN (geminin DNA replication inhibitor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gmnn (geminin DNA replication inhibitor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GMNN (geminin DNA replication inhibitor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GMNN (geminin DNA replication inhibitor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gmnn (geminin DNA replication inhibitor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GMNN (geminin DNA replication inhibitor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Gmnn (geminin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gmnn (geminin DNA replication inhibitor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	geminin	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gmnn	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	40,301,771 - 40,310,054 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	40,301,808 - 40,310,054 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	40,369,865 - 40,378,099 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	41,973,905 - 41,982,139 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	40,257,144 - 40,265,376 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	42,302,523 - 42,310,783 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	42,302,540 - 42,310,783 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	44,170,109 - 44,178,377 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	47,372,316 - 47,380,559 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	47,375,179 - 47,383,393 (+)	NCBI
Celera	17	39,938,690 - 39,946,933 (+)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Meier-Gorlin syndrome (ISO)

Meier-Gorlin syndrome 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-methylcholanthrene (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

azathioprine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chlorpyrifos (ISO)

chromium(6+) (ISO)

chrysene (ISO)

cisplatin (ISO)

clofibrate (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

disodium selenite (ISO)

elemental selenium (ISO)

endosulfan (EXP)

Enterolactone (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

geraniol (ISO)

inulin (ISO)

lead diacetate (ISO)

lead(0) (ISO)

metacetamol (ISO)

methapyrilene (EXP)

methimazole (EXP)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (ISO)

nickel dichloride (EXP)

nocodazole (ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

pirinixic acid (EXP,ISO)

piroxicam (ISO)

progesterone (ISO)

propiconazole (ISO)

pyrimidifen (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

succimer (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (ISO)

DNA replication preinitiation complex assembly (ISO)

negative regulation of cell cycle (IBA,ISO)

negative regulation of DNA replication (IBA,ISO)

negative regulation of DNA-templated DNA replication (ISO)

negative regulation of DNA-templated transcription (ISO)

protein-containing complex assembly (ISO)

regulation of DNA replication (ISO)

regulation of DNA-templated DNA replication initiation (ISO)

regulation of mitotic cell cycle (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

transcription repressor complex (ISO)

Molecular Function

chromatin binding (ISO)

DNA-binding transcription factor binding (ISO)

histone deacetylase binding (ISO)

protein binding (ISO)

transcription cis-regulatory region binding (ISO)

transcription corepressor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9635433	PMID:9671596	PMID:11125146	PMID:12192004	PMID:16924111	PMID:17234884	PMID:21543332	PMID:23838810	PMID:24217620	PMID:25189787	PMID:28386846

Genomics

Comparative Map Data

Gmnn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	40,301,771 - 40,310,054 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	40,301,808 - 40,310,054 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	40,369,865 - 40,378,099 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	41,973,905 - 41,982,139 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	40,257,144 - 40,265,376 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	42,302,523 - 42,310,783 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	42,302,540 - 42,310,783 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	44,170,109 - 44,178,377 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	47,372,316 - 47,380,559 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	47,375,179 - 47,383,393 (+)	NCBI
Celera	17	39,938,690 - 39,946,933 (+)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

GMNN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	24,774,937 - 24,786,099 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	24,774,931 - 24,786,099 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	24,775,165 - 24,786,327 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	24,883,143 - 24,894,257 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	24,883,142 - 24,894,257	NCBI
Celera	6	26,008,534 - 26,019,648 (+)	NCBI		Celera
Cytogenetic Map	6	p22.3	NCBI
HuRef	6	24,724,596 - 24,735,764 (+)	NCBI		HuRef
CHM1_1	6	24,779,262 - 24,790,430 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	24,646,065 - 24,657,235 (+)	NCBI		T2T-CHM13v2.0

Gmnn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	24,935,828 - 24,954,222 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	24,935,828 - 24,945,906 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	24,751,845 - 24,761,937 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	24,751,845 - 24,761,923 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	24,843,714 - 24,853,806 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	24,759,311 - 24,769,322 (-)	NCBI		MGSCv36	mm8
Celera	13	24,982,510 - 24,992,603 (-)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	10.64	NCBI

Gmnn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955483	2,282,485 - 2,293,924 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955483	2,283,518 - 2,344,982 (-)	NCBI	ChiLan1.0	ChiLan1.0

GMNN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	35,425,780 - 35,436,978 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	24,612,864 - 24,624,010 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	24,944,377 - 24,955,575 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	24,944,377 - 24,955,575 (+)	Ensembl	panpan1.1		panPan2

GMNN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	22,796,558 - 22,805,961 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	22,798,386 - 22,805,959 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	22,764,295 - 22,773,899 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	22,918,761 - 22,928,353 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	22,919,066 - 22,928,351 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	22,723,808 - 22,733,378 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	22,771,634 - 22,781,238 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	24,208,088 - 24,217,477 (+)	NCBI		UU_Cfam_GSD_1.0

Gmnn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	2,594,324 - 2,603,971 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936671	1,018,124 - 1,026,968 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936671	1,017,621 - 1,027,224 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GMNN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	19,586,002 - 19,595,344 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	19,585,968 - 19,595,346 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	20,739,335 - 20,748,710 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GMNN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	47,462,647 - 47,474,445 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	47,461,645 - 47,474,417 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	24,706,853 - 24,718,372 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gmnn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	2,268,304 - 2,278,129 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	2,268,304 - 2,335,021 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gmnn
31 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	205
Count of miRNA genes:	154
Interacting mature miRNAs:	167
Transcripts:	ENSRNOT00000025389
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
7394837	Memor18	Memory QTL 18			exploratory behavior trait (VT:0010471)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	17	18640182	63640182	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
2313854	Bp343	Blood pressure QTL 343	3.9		life span trait (VT:0005372)	age at time of death (CMO:0001193)	17	31990784	50909196	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat

Markers in Region

RH128856

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	40,309,719 - 40,309,909 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	42,310,449 - 42,310,638	NCBI	Rnor6.0
Rnor_5.0	17	44,178,043 - 44,178,232	UniSTS	Rnor5.0
RGSC_v3.4	17	47,380,225 - 47,380,414	UniSTS	RGSC3.4
Celera	17	39,946,599 - 39,946,788	UniSTS
Cytogenetic Map	17	p11	UniSTS

RH142925

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	40,309,345 - 40,309,537 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	42,310,075 - 42,310,266	NCBI	Rnor6.0
Rnor_5.0	17	44,177,669 - 44,177,860	UniSTS	Rnor5.0
RGSC_v3.4	17	47,379,851 - 47,380,042	UniSTS	RGSC3.4
Celera	17	39,946,225 - 39,946,416	UniSTS
Cytogenetic Map	17	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	31	24	18	24			57	20	36	2
Low		17	25	16	1	16	8	11	17	15	5	9	8
Below cutoff			1	1		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000025389 ⟹ ENSRNOP00000025389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	40,301,808 - 40,310,054 (+)	Ensembl
Rnor_6.0 Ensembl	17	42,302,540 - 42,310,783 (+)	Ensembl

RefSeq Acc Id:

NM_001106112 ⟹ NP_001099582

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	40,301,808 - 40,310,054 (+)	NCBI
Rnor_6.0	17	42,302,540 - 42,310,783 (+)	NCBI
Rnor_5.0	17	44,170,109 - 44,178,377 (+)	NCBI
RGSC_v3.4	17	47,372,316 - 47,380,559 (+)	RGD
Celera	17	39,938,690 - 39,946,933 (+)	RGD

Sequence:

show sequence

CGACCGGGGCGGCGGGTTAGTCTGCAGGTTCGGGTCGTTTTGGCGCGGTTGGGTCCGGTGTGGT
GCCAGGGGCTTGTACGGCTCTCACGCTCGCTGGGAACGGAGCACTGCTGTCTGTGAGTCCGAGG
ACGCGGGGGGTCGGCGGGCGAGTGCAACTCCGGTATCGGCATAGCCGGGTTGGCCCGAAGCCAG
GCCTGCTTCTCAGCCACGGAGAACCGGCCGGTGGAGGCGAGGATATGAAGGGACCCAAGTCTGG
GGACTGGGGACTTGAAGGGACCCGAGTCTCGGCCCTACAGCCAGGCAAAGCTGGGCGAGCTGAG
ATGAGGGGCTGCGCCATTGGTGGGCTGAGAAATGAATCTCAGTATGAAGCAGAAACAGGAAGGA
GCCCAAGAGAACGTGAAGAGTAGTCCTGTCCCAAGGAGAACGCTGAAGATGATCCAGCCTTCTG
CAGCTGGGTCTCTTGTTGGCAGAGAAAATGAGTTGCCAAAAGGCTTGTCCAAAAGGAAACTTTG
GGATGACCAGTTAACATCTAAGATTTCAAGCTGTGGTCCTGAAGCCAATGAAAATAACAGTGTT
GGAGACCTCACCCAGGAAGCATGTGATCTTATGACTAAAGAAAACCCATCTTCTCAGTATTGGA
AAGAAGTGGCAGAACAACGGAGGAAAGCTCTCTATGAAGCACTTACGGAGAACGAGAAACTTCA
TAAAGAAATTGAGCAGAAGGACAGTGAGATTGCCCGCCTGAGAAAGGAGAATAAAGACCTGGCA
GAAGTGGCTGAGCACGTACAGTACATGGCAGAGGTAATCGAGAGGCTGAGTAATGAACCTCTGG
ATAACTTTGAATCACCGGATAGTCAAGAATTTGATTCTGAAAAAGAAACTGTTGAGTATTCTGA
ACCGGAAGACTCAGACACTGGGACATGTGCTGAAGAGACTGTGTCTTCCTCTTCCGATGGCACG
GCGTGTACATGAGATGTGACTGCCCTTTGGTATAGCTCTTGGTAAATTAACTACATGGTGCAAG
TGCTGGAATCCAGGAGTCCTGGGGTTACTAATACATTAAAAACAGATAGTATGTATTTTTAACC
TGTTTTATGTAAATAACATTTTCATTTTTGTCAGTGTCAGATGTGAATTGTGTATATTAAATAA
ACTTCAACTTCCTATTGAACATTTAT

hide sequence

RefSeq Acc Id:

XM_006253927 ⟹ XP_006253989

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	40,301,771 - 40,310,053 (+)	NCBI
Rnor_6.0	17	42,302,523 - 42,310,782 (+)	NCBI
Rnor_5.0	17	44,170,109 - 44,178,377 (+)	NCBI

Sequence:

show sequence

GCCTCTCAGTGCGTCAGCGACCGGGGCGGCGGGTTAGTCTGCAGGTTCGGGTCGTTTTGGCGCG
GTTGGGTCCGGTGTGGTGCCAGGGGCTTGTACGGCTCTCACGCTCGCTGGGAACGGAGCACTGC
TGTCTCTGAGAAATGAATCTCAGTATGAAGCAGAAACAGGAAGGAGCCCAAGAGAACGTGAAGA
GTAGTCCTGTCCCAAGGAGAACGCTGAAGATGATCCAGCCTTCTGCAGCTGGGTCTCTTGTTGG
CAGAGAAAATGAGTTGCCAAAAGGCTTGTCCAAAAGGAAACTTTGGGATGACCAGTTAACATCT
AAGATTTCAAGCTGTGGTCCTGAAGCCAATGAAAATAACAGTGTTGGAGACCTCACCCAGGAAG
CATGTGATCTTATGACTAAAGAAAACCCATCTTCTCAGTATTGGAAAGAAGTGGCAGAACAACG
GAGGAAAGCTCTCTATGAAGCACTTACGGAGAACGAGAAACTTCATAAAGAAATTGAGCAGAAG
GACAGTGAGATTGCCCGCCTGAGAAAGGAGAATAAAGACCTGGCAGAAGTGGCTGAGCACGTAC
AGTACATGGCAGAGGTAATCGAGAGGCTGAGTAATGAACCTCTGGATAACTTTGAATCACCGGA
TAGTCAAGAATTTGATTCTGAAAAAGAAACTGTTGAGTATTCTGAACCGGAAGACTCAGACACT
GGGACATGTGCTGAAGAGACTGTGTCTTCCTCTTCCGATGGCACGGCGTGTACATGAGATGTGA
CTGCCCTTTGGTATAGCTCTTGGTAAATTAACTACATGGTGCAAGTGCTGGAATCCAGGAGTCC
TGGGGTTACTAATACATTAAAAACAGATAGTATGTATTTTTAACCTGTTTTATGTAAATAACAT
TTTCATTTTTGTCAGTGTCAGATGTGAATTGTGTATATTAAATAAACTTCAACTTCCTATTGAA
CATTTA

hide sequence

RefSeq Acc Id:

XM_006253928 ⟹ XP_006253990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	40,302,305 - 40,310,053 (+)	NCBI
Rnor_6.0	17	42,302,985 - 42,310,782 (+)	NCBI
Rnor_5.0	17	44,170,109 - 44,178,377 (+)	NCBI

Sequence:

show sequence

GGATTGAATTGGTTATAGATCTTACGGCCAGCTCACCGACAGCAGCAAACGCTGCTCCTGGGAC
AAGGCCACTGAGAAATGAATCTCAGTATGAAGCAGAAACAGGAAGGAGCCCAAGAGAACGTGAA
GAGTAGTCCTGTCCCAAGGAGAACGCTGAAGATGATCCAGCCTTCTGCAGCTGGGTCTCTTGTT
GGCAGAGAAAATGAGTTGCCAAAAGGCTTGTCCAAAAGGAAACTTTGGGATGACCAGTTAACAT
CTAAGATTTCAAGCTGTGGTCCTGAAGCCAATGAAAATAACAGTGTTGGAGACCTCACCCAGGA
AGCATGTGATCTTATGACTAAAGAAAACCCATCTTCTCAGTATTGGAAAGAAGTGGCAGAACAA
CGGAGGAAAGCTCTCTATGAAGCACTTACGGAGAACGAGAAACTTCATAAAGAAATTGAGCAGA
AGGACAGTGAGATTGCCCGCCTGAGAAAGGAGAATAAAGACCTGGCAGAAGTGGCTGAGCACGT
ACAGTACATGGCAGAGGTAATCGAGAGGCTGAGTAATGAACCTCTGGATAACTTTGAATCACCG
GATAGTCAAGAATTTGATTCTGAAAAAGAAACTGTTGAGTATTCTGAACCGGAAGACTCAGACA
CTGGGACATGTGCTGAAGAGACTGTGTCTTCCTCTTCCGATGGCACGGCGTGTACATGAGATGT
GACTGCCCTTTGGTATAGCTCTTGGTAAATTAACTACATGGTGCAAGTGCTGGAATCCAGGAGT
CCTGGGGTTACTAATACATTAAAAACAGATAGTATGTATTTTTAACCTGTTTTATGTAAATAAC
ATTTTCATTTTTGTCAGTGTCAGATGTGAATTGTGTATATTAAATAAACTTCAACTTCCTATTG
AACATTTA

hide sequence

RefSeq Acc Id:

XM_039095515 ⟹ XP_038951443

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	17	40,301,805 - 40,310,053 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099582	(Get FASTA)	NCBI Sequence Viewer
	XP_006253989	(Get FASTA)	NCBI Sequence Viewer
	XP_006253990	(Get FASTA)	NCBI Sequence Viewer
	XP_038951443	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL86503	(Get FASTA)	NCBI Sequence Viewer
	EDL86504	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001099582 ⟸ NM_001106112

- UniProtKB:

D3ZWJ0 (UniProtKB/TrEMBL), A6KLF9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNLSMKQKQEGAQENVKSSPVPRRTLKMIQPSAAGSLVGRENELPKGLSKRKLWDDQLTSKISS
CGPEANENNSVGDLTQEACDLMTKENPSSQYWKEVAEQRRKALYEALTENEKLHKEIEQKDSEI
ARLRKENKDLAEVAEHVQYMAEVIERLSNEPLDNFESPDSQEFDSEKETVEYSEPEDSDTGTCA
EETVSSSSDGTACT

hide sequence

RefSeq Acc Id:	XP_006253989 ⟸ XM_006253927
- Peptide Label:	isoform X1
- UniProtKB:	D3ZWJ0 (UniProtKB/TrEMBL), A6KLF9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNLSMKQKQEGAQENVKSSPVPRRTLKMIQPSAAGSLVGRENELPKGLSKRKLWDDQLTSKISS CGPEANENNSVGDLTQEACDLMTKENPSSQYWKEVAEQRRKALYEALTENEKLHKEIEQKDSEI ARLRKENKDLAEVAEHVQYMAEVIERLSNEPLDNFESPDSQEFDSEKETVEYSEPEDSDTGTCA EETVSSSSDGTACT hide sequence

RefSeq Acc Id:	XP_006253990 ⟸ XM_006253928
- Peptide Label:	isoform X1
- UniProtKB:	D3ZWJ0 (UniProtKB/TrEMBL), A6KLF9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNLSMKQKQEGAQENVKSSPVPRRTLKMIQPSAAGSLVGRENELPKGLSKRKLWDDQLTSKISS CGPEANENNSVGDLTQEACDLMTKENPSSQYWKEVAEQRRKALYEALTENEKLHKEIEQKDSEI ARLRKENKDLAEVAEHVQYMAEVIERLSNEPLDNFESPDSQEFDSEKETVEYSEPEDSDTGTCA EETVSSSSDGTACT hide sequence

RefSeq Acc Id:

ENSRNOP00000025389 ⟸ ENSRNOT00000025389

RefSeq Acc Id:	XP_038951443 ⟸ XM_039095515
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZWJ0-F1-model_v2	AlphaFold	D3ZWJ0	1-206	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308137	AgrOrtholog
BioCyc Gene	G2FUF-9420	BioCyc
Ensembl Genes	ENSRNOG00000018782	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000025389	ENTREZGENE
	ENSRNOP00000025389.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025389	ENTREZGENE
	ENSRNOT00000025389.6	UniProtKB/TrEMBL
Gene3D-CATH	Geminin coiled-coil domain	UniProtKB/TrEMBL
InterPro	Geminin	UniProtKB/TrEMBL
KEGG Report	rno:291137	UniProtKB/TrEMBL
NCBI Gene	291137	ENTREZGENE
PANTHER	GEMININ	UniProtKB/TrEMBL
	PTHR13372:SF4	UniProtKB/TrEMBL
Pfam	Geminin	UniProtKB/TrEMBL
PhenoGen	Gmnn	PhenoGen
Superfamily-SCOP	Geminin coiled-coil domain	UniProtKB/TrEMBL
UniProt	A6KLF9	ENTREZGENE, UniProtKB/TrEMBL
	D3ZWJ0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-02-25	Gmnn	geminin, DNA replication inhibitor	Gmnn	geminin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gmnn	geminin	Gmnn_predicted	geminin (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gmnn_predicted	geminin (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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