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Gene: Actn2 (actinin alpha 2) Rattus norvegicus
Symbol: Actn2
Name: actinin alpha 2
Description: Predicted to have several functions, including cytoskeletal protein binding activity; ion channel binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including focal adhesion assembly; regulation of ion transmembrane transporter activity; and striated muscle cell development. Localizes to glutamatergic synapse; postsynaptic density membrane; and postsynaptic density, intracellular component. Colocalizes with cortical actin cytoskeleton. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-actinin-2; LOC291245
Homo sapiens (human) : ACTN2 (actinin alpha 2)  HGNC  Alliance
Mus musculus (house mouse) : Actn2 (actinin alpha 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actn2 (actinin alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTN2 (actinin alpha 2)
Canis lupus familiaris (dog) : ACTN2 (actinin alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actn2 (actinin alpha 2)
Sus scrofa (pig) : ACTN2 (actinin alpha 2)
Chlorocebus sabaeus (African green monkey) : ACTN2 (actinin alpha 2)
Heterocephalus glaber (naked mole-rat) : Actn2 (actinin alpha 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01766,304,530 - 66,397,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1766,304,501 - 66,397,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01768,050,946 - 68,143,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,705,160 - 68,773,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11768,681,756 - 68,784,094 (+)NCBI
Celera1762,323,048 - 62,390,681 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Actn2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308097
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.