Tp53bp1 (tumor protein p53 binding protein 1) - Rat Genome Database

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Gene: Tp53bp1 (tumor protein p53 binding protein 1) Rattus norvegicus
Analyze
Symbol: Tp53bp1
Name: tumor protein p53 binding protein 1
RGD ID: 1308039
Description: Predicted to enable several functions, including DNA binding activity; modification-dependent protein binding activity; and p53 binding activity. Involved in cellular response to X-ray. Predicted to be located in chromosome; cytoplasm; and nuclear body. Predicted to be part of DNA repair complex. Predicted to be active in nucleus and site of double-strand break. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296099; TP53-binding protein 1; transformation related protein 53 binding protein 1; Trp53bp1; tumor suppressor p53-binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,620,320 - 128,724,716 (-)NCBIGRCr8
mRatBN7.23108,166,574 - 108,270,229 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,169,980 - 108,269,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3111,845,501 - 111,918,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03120,441,084 - 120,514,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,101,485 - 118,174,840 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,160,030 - 113,259,701 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,160,000 - 113,231,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03119,697,122 - 119,799,485 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43107,994,425 - 108,071,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13107,897,216 - 107,968,850 (-)NCBI
Celera3107,073,150 - 107,144,062 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
acrolein  (ISO)
adenosine  (ISO)
adenosine 5'-monophosphate  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
CX-5461  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cyprodinil  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenthion  (ISO)
fludioxonil  (ISO)
folic acid  (ISO)
FR900359  (ISO)
GDP  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
glyphosate  (ISO)
GTP  (ISO)
guanosine  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
IDP  (ISO)
indometacin  (ISO)
inosine  (ISO)
iprodione  (ISO)
ivermectin  (ISO)
maneb  (ISO)
mercury dichloride  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
N-methyl-N-nitrosourea  (ISO)
nitric oxide  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pectolinarigenin  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinocembrin  (ISO)
potassium chromate  (ISO)
procymidone  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
UDP  (ISO)
UTP  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle. Casafont I, etal., Acta Neuropathol. 2011 Oct;122(4):481-93. doi: 10.1007/s00401-011-0869-0. Epub 2011 Sep 14.
2. Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer. Ding Y, etal., Clin Cancer Res. 2002 Oct;8(10):3290-7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Tudor: a versatile family of histone methylation 'readers'. Lu R and Wang GG, Trends Biochem Sci. 2013 Nov;38(11):546-55. doi: 10.1016/j.tibs.2013.08.002. Epub 2013 Sep 10.
6. Role for DNA damage signaling in pulmonary arterial hypertension. Meloche J, etal., Circulation. 2014 Feb 18;129(7):786-97. doi: 10.1161/CIRCULATIONAHA.113.006167. Epub 2013 Nov 22.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Double-strand break repair: 53BP1 comes into focus. Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
9. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
10. Suppression of replicative senescence by rapamycin in rodent embryonic cells. Pospelova TV, etal., Cell Cycle. 2012 Jun 15;11(12):2402-7. doi: 10.4161/cc.20882. Epub 2012 Jun 15.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. Wen Y, etal., Cancer Res. 2001 Oct 1;61(19):7142-7.
Additional References at PubMed
PMID:8889548   PMID:9748285   PMID:11801725   PMID:11934988   PMID:14985081   PMID:15077110   PMID:15149599   PMID:15159415   PMID:15364958   PMID:17053789   PMID:17500065   PMID:17805299  
PMID:19001091   PMID:20362325   PMID:21746928   PMID:22373579   PMID:23209566   PMID:23241889   PMID:23333305   PMID:23333306   PMID:23345425   PMID:23760478   PMID:24001775   PMID:24217620  
PMID:24625528   PMID:28241136  


Genomics

Comparative Map Data
Tp53bp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,620,320 - 128,724,716 (-)NCBIGRCr8
mRatBN7.23108,166,574 - 108,270,229 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,169,980 - 108,269,822 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3111,845,501 - 111,918,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03120,441,084 - 120,514,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,101,485 - 118,174,840 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,160,030 - 113,259,701 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,160,000 - 113,231,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03119,697,122 - 119,799,485 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43107,994,425 - 108,071,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13107,897,216 - 107,968,850 (-)NCBI
Celera3107,073,150 - 107,144,062 (-)NCBICelera
Cytogenetic Map3q35NCBI
TP53BP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381543,403,061 - 43,510,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1543,403,061 - 43,510,728 (-)EnsemblGRCh38hg38GRCh38
GRCh371543,695,259 - 43,802,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,486,699 - 41,590,028 (-)NCBINCBI36Build 36hg18NCBI36
Build 341541,486,698 - 41,590,028NCBI
Celera1520,470,061 - 20,573,379 (-)NCBICelera
Cytogenetic Map15q15.3NCBI
HuRef1520,547,443 - 20,650,644 (-)NCBIHuRef
CHM1_11543,818,081 - 43,921,400 (-)NCBICHM1_1
T2T-CHM13v2.01541,210,396 - 41,317,991 (-)NCBIT2T-CHM13v2.0
Trp53bp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,025,316 - 121,126,830 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,023,762 - 121,101,888 (-)EnsemblGRCm39 Ensembl
GRCm382121,194,835 - 121,296,354 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,193,281 - 121,271,407 (-)EnsemblGRCm38mm10GRCm38
MGSCv372121,022,463 - 121,097,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362120,889,692 - 120,962,561 (-)NCBIMGSCv36mm8
Celera2122,348,714 - 122,423,035 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.37NCBI
Tp53bp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554169,962,897 - 10,035,278 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554169,962,736 - 10,035,433 (-)NCBIChiLan1.0ChiLan1.0
TP53BP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21632,655,132 - 32,763,160 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11536,816,860 - 36,925,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01522,364,696 - 22,472,499 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11540,519,012 - 40,626,845 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,519,012 - 40,626,741 (-)Ensemblpanpan1.1panPan2
TP53BP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13010,263,650 - 10,362,646 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,263,650 - 10,336,134 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3010,322,230 - 10,419,975 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03010,399,747 - 10,497,632 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3010,399,747 - 10,497,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13010,316,018 - 10,388,325 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03010,437,331 - 10,535,512 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03010,557,080 - 10,655,185 (-)NCBIUU_Cfam_GSD_1.0
Tp53bp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864088,741,332 - 88,837,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364716,589,564 - 6,668,305 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364716,589,395 - 6,668,242 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53BP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1127,959,213 - 128,028,712 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11127,958,500 - 128,032,370 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21142,694,698 - 142,705,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TP53BP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12639,489,925 - 39,595,096 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2639,508,600 - 39,594,927 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048101,414,132 - 101,524,417 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp53bp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480410,517,696 - 10,591,688 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480410,517,531 - 10,612,238 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tp53bp1
552 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:319
Count of miRNA genes:194
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000019025, ENSRNOT00000033109, ENSRNOT00000067155
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
D3Rat259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,235,049 - 108,235,261 (+)MAPPERmRatBN7.2
Rnor_6.03113,223,783 - 113,223,994NCBIRnor6.0
Rnor_5.03119,763,585 - 119,763,796UniSTSRnor5.0
RGSC_v3.43108,063,213 - 108,063,425RGDRGSC3.4
RGSC_v3.43108,063,214 - 108,063,425UniSTSRGSC3.4
RGSC_v3.13107,961,584 - 107,961,796RGD
Celera3107,136,995 - 107,137,204UniSTS
SHRSP x BN Map352.9498RGD
SHRSP x BN Map352.9498UniSTS
Cytogenetic Map3q35UniSTS
BE108329  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,171,966 - 108,172,135 (+)MAPPERmRatBN7.2
Rnor_6.03113,162,019 - 113,162,187NCBIRnor6.0
Rnor_5.03119,701,820 - 119,701,988UniSTSRnor5.0
RGSC_v3.43108,001,450 - 108,001,618UniSTSRGSC3.4
Celera3107,075,139 - 107,075,307UniSTS
RH 3.4 Map3946.0UniSTS
Cytogenetic Map3q35UniSTS
AU049532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,209,356 - 108,209,608 (+)MAPPERmRatBN7.2
Rnor_6.03113,198,095 - 113,198,346NCBIRnor6.0
Rnor_5.03119,737,896 - 119,738,147UniSTSRnor5.0
RGSC_v3.43108,037,526 - 108,037,777UniSTSRGSC3.4
Cytogenetic Map3q35UniSTS
RH68009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,170,102 - 108,170,224 (+)MAPPERmRatBN7.2
Rnor_6.03113,160,155 - 113,160,276NCBIRnor6.0
Rnor_5.03119,699,956 - 119,700,077UniSTSRnor5.0
RGSC_v3.43107,999,586 - 107,999,707UniSTSRGSC3.4
Celera3107,073,275 - 107,073,396UniSTS
Cytogenetic Map3q35UniSTS
BI287966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,206,847 - 108,207,097 (+)MAPPERmRatBN7.2
Rnor_6.03113,195,586 - 113,195,835NCBIRnor6.0
Rnor_5.03119,735,387 - 119,735,636UniSTSRnor5.0
RGSC_v3.43108,035,017 - 108,035,266UniSTSRGSC3.4
Celera3107,109,563 - 107,109,812UniSTS
RH 3.4 Map3948.2UniSTS
Cytogenetic Map3q35UniSTS
RH139947  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map3946.0UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001371259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK840114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019025   ⟹   ENSRNOP00000019025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3108,169,984 - 108,269,822 (-)Ensembl
Rnor_6.0 Ensembl3113,160,000 - 113,231,790 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106843   ⟹   ENSRNOP00000090164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3108,169,984 - 108,242,316 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107143   ⟹   ENSRNOP00000093681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3108,169,980 - 108,243,008 (-)Ensembl
RefSeq Acc Id: NM_001371259   ⟹   NP_001358188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,623,724 - 128,696,747 (-)NCBI
mRatBN7.23108,169,978 - 108,243,008 (-)NCBI
RefSeq Acc Id: XM_006234865   ⟹   XP_006234927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,718,062 (-)NCBI
mRatBN7.23108,169,978 - 108,264,268 (-)NCBI
Rnor_6.03113,160,030 - 113,252,655 (-)NCBI
Rnor_5.03119,697,122 - 119,799,485 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592214   ⟹   XP_017447703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,716,837 (-)NCBI
mRatBN7.23108,169,978 - 108,263,089 (-)NCBI
Rnor_6.03113,160,030 - 113,251,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592215   ⟹   XP_017447704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,724,716 (-)NCBI
mRatBN7.23108,169,978 - 108,270,229 (-)NCBI
Rnor_6.03113,160,030 - 113,259,701 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104554   ⟹   XP_038960482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,655,444 (-)NCBI
mRatBN7.23108,169,978 - 108,201,286 (-)NCBI
RefSeq Acc Id: XM_063283318   ⟹   XP_063139388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,723,000 (-)NCBI
RefSeq Acc Id: XM_063283319   ⟹   XP_063139389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,716,837 (-)NCBI
RefSeq Acc Id: XM_063283320   ⟹   XP_063139390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,716,837 (-)NCBI
RefSeq Acc Id: XM_063283321   ⟹   XP_063139391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,620,320 - 128,716,837 (-)NCBI
RefSeq Acc Id: XP_006234927   ⟸   XM_006234865
- Peptide Label: isoform X1
- UniProtKB: F1M842 (UniProtKB/TrEMBL),   A0A8I6AB98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447704   ⟸   XM_017592215
- Peptide Label: isoform X1
- UniProtKB: F1M842 (UniProtKB/TrEMBL),   A0A8I6AB98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447703   ⟸   XM_017592214
- Peptide Label: isoform X1
- UniProtKB: F1M842 (UniProtKB/TrEMBL),   A0A8I6AB98 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019025   ⟸   ENSRNOT00000019025
RefSeq Acc Id: NP_001358188   ⟸   NM_001371259
- UniProtKB: A0A8I6AKV2 (UniProtKB/TrEMBL),   A0A8I6AB98 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960482   ⟸   XM_039104554
- Peptide Label: isoform X5
- UniProtKB: A6HPN0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090164   ⟸   ENSRNOT00000106843
Ensembl Acc Id: ENSRNOP00000093681   ⟸   ENSRNOT00000107143
RefSeq Acc Id: XP_063139388   ⟸   XM_063283318
- Peptide Label: isoform X1
- UniProtKB: F1M842 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139389   ⟸   XM_063283319
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139391   ⟸   XM_063283321
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063139390   ⟸   XM_063283320
- Peptide Label: isoform X3
Protein Domains
BRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M842-F1-model_v2 AlphaFold F1M842 1-1972 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692358
Promoter ID:EPDNEW_R2877
Type:multiple initiation site
Name:Tp53bp1_1
Description:tumor protein p53 binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03113,231,712 - 113,231,772EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308039 AgrOrtholog
BioCyc Gene G2FUF-48140 BioCyc
Ensembl Genes ENSRNOG00000013837 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019025.9 UniProtKB/TrEMBL
  ENSRNOT00000106843.1 UniProtKB/TrEMBL
  ENSRNOT00000107143.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
  2.30.30.30 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
InterPro 53-BP1_Tudor UniProtKB/TrEMBL
  BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  BRCT_p53bp1-like_rpt1 UniProtKB/TrEMBL
  BRCT_p53bp1-like_rpt2 UniProtKB/TrEMBL
  Rib_L2_dom2 UniProtKB/TrEMBL
  TP53BP1-like UniProtKB/TrEMBL
NCBI Gene 296099 ENTREZGENE
PANTHER TP53-BINDING PROTEIN 1 UniProtKB/TrEMBL
  TUMOR SUPPRESSOR P53-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam 53-BP1_Tudor UniProtKB/TrEMBL
  BRCT_3 UniProtKB/TrEMBL
PhenoGen Tp53bp1 PhenoGen
PROSITE BRCT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013837 RatGTEx
SMART BRCT UniProtKB/TrEMBL
Superfamily-SCOP BRCT UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8I6AB98 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKV2 ENTREZGENE, UniProtKB/TrEMBL
  A6HPN0 ENTREZGENE, UniProtKB/TrEMBL
  F1M842 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tp53bp1  tumor protein p53 binding protein 1  Trp53bp1  transformation related protein 53 binding protein 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Trp53bp1  transformation related protein 53 binding protein 1   Trp53bp1_predicted  transformation related protein 53 binding protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 Trp53bp1_predicted  transformation related protein 53 binding protein 1 (predicted)  LOC688035  similar to transformation related protein 53 binding protein 1  Data merged from RGD:1593627 1643240 APPROVED
2006-11-20 LOC688035  similar to transformation related protein 53 binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Trp53bp1_predicted  transformation related protein 53 binding protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED