Ptpn22 (protein tyrosine phosphatase, non-receptor type 22) - Rat Genome Database

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Gene: Ptpn22 (protein tyrosine phosphatase, non-receptor type 22) Rattus norvegicus
Analyze
Symbol: Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22
RGD ID: 1307992
Description: Enables protein tyrosine kinase binding activity. Involved in regulation of calcium ion transmembrane transport and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasmic side of plasma membrane and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); pulmonary tuberculosis; and systemic scleroderma. Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295338; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; Ptpn8; tyrosine-protein phosphatase non-receptor type 22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Iddm26 Iddm33 Iddm55
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22191,366,761 - 191,414,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,963,704 - 199,011,553 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02196,836,441 - 196,884,289 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02191,653,405 - 191,701,246 (+)NCBIRnor_WKY
Rnor_6.02206,342,066 - 206,390,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,765,744 - 225,814,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42199,083,186 - 199,144,309 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12199,045,987 - 199,095,515 (+)NCBI
Celera2183,836,919 - 183,884,957 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to muramyl dipeptide  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IBA,ISO)
negative regulation of p38MAPK cascade  (IBA,ISO)
negative regulation of T cell activation  (IBA,ISO,ISS)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (IBA,ISO)
peptidyl-tyrosine dephosphorylation  (IBA)
phosphoanandamide dephosphorylation  (ISO,ISS)
positive regulation of CD8-positive, alpha-beta T cell proliferation  (IBA,ISO)
positive regulation of defense response to virus by host  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of granzyme B production  (IBA,ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein K63-linked ubiquitination  (IBA,ISO)
positive regulation of toll-like receptor 3 signaling pathway  (IBA,ISO)
positive regulation of toll-like receptor 4 signaling pathway  (IBA,ISO)
positive regulation of toll-like receptor 7 signaling pathway  (IBA,ISO)
positive regulation of toll-like receptor 9 signaling pathway  (IBA,ISO)
positive regulation of type I interferon production  (ISO)
positive regulation of type II interferon production  (ISO)
protein dephosphorylation  (ISO,ISS)
regulation of antigen processing and presentation  (ISO)
regulation of calcium ion transmembrane transport  (IMP)
regulation of leukocyte migration  (ISO)
regulation of natural killer cell proliferation  (ISO,ISS)
regulation of NIK/NF-kappaB signaling  (IBA,ISO)
regulation of peptidyl-tyrosine phosphorylation  (IMP)
response to lipopolysaccharide  (ISO)
T cell differentiation  (IBA,ISO)
T cell receptor signaling pathway  (IBA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The role of PTPN22 gene polymorphism in childhood immune thrombocytopenic purpura. Anis SK, etal., Blood Coagul Fibrinolysis. 2011 Sep;22(6):521-5.
2. Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele. Balada E, etal., Tissue Antigens. 2006 Nov;68(5):432-8.
3. The association of the PTPN22 620W polymorphism with Behcet's disease. Baranathan V, etal., Ann Rheum Dis. 2007 Nov;66(11):1531-3. Epub 2007 Jul 27.
4. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Barrett JC, etal., Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
5. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Begovich AB, etal., Am J Hum Genet. 2004 Aug;75(2):330-7. Epub 2004 Jun 18.
6. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Bottini N, etal., Nat Genet. 2004 Apr;36(4):337-8. Epub 2004 Mar 7.
7. PTPN22 polymorphism presumably plays a role in the genetic background of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Dermatology. 2012;224(4):340-5. doi: 10.1159/000339332. Epub 2012 Jun 19.
8. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Canton I, etal., Genes Immun. 2005 Oct;6(7):584-7.
9. High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. Cao Y, etal., PLoS One. 2012;7(8):e42783. doi: 10.1371/journal.pone.0042783. Epub 2012 Aug 3.
10. The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients. Chinoy H, etal., Arthritis Rheum. 2008 Oct;58(10):3247-54. doi: 10.1002/art.23900.
11. The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis. Chuang WY, etal., Genes Immun. 2009 Dec;10(8):667-72. Epub 2009 Aug 20.
12. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Criswell LA, etal., Am J Hum Genet. 2005 Apr;76(4):561-71. Epub 2005 Feb 17.
13. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. Dai X, etal., J Clin Invest. 2013 May 1;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.
14. Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Diaz-Gallo LM, etal., Ann Rheum Dis. 2011 Mar;70(3):454-62. Epub 2010 Dec 3.
15. Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population. Douroudis K, etal., Tissue Antigens. 2008 Nov;72(5):425-30. Epub 2008 Aug 26.
16. Novel associations for hypothyroidism include known autoimmune risk loci. Eriksson N, etal., PLoS One. 2012;7(4):e34442. Epub 2012 Apr 6.
17. Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies. Espinoza JL, etal., Biol Blood Marrow Transplant. 2013 Feb;19(2):240-6. doi: 10.1016/j.bbmt.2012.09.014. Epub 2012 Sep 28.
18. PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Fousteri G, etal., Clin Immunol. 2015 Feb;156(2):98-108. doi: 10.1016/j.clim.2014.12.002. Epub 2014 Dec 13.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. PTPN22 C1858T polymorphism in women with endometriosis. Gomes FM, etal., Am J Reprod Immunol. 2010 Mar 1;63(3):227-32. Epub 2010 Jan 12.
22. PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases. Gomez LM, etal., Genes Immun. 2005 Oct;6(7):628-31.
23. Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis. Gonzalez-Gay MA, etal., J Rheumatol. 2005 Aug;32(8):1510-2.
24. Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. Hebbring SJ, etal., Blood. 2013 Jan 3;121(1):237-8. doi: 10.1182/blood-2012-08-450221.
25. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Hinks A, etal., Arthritis Rheum. 2005 Jun;52(6):1694-9.
26. Genetic analysis of adult-onset autoimmune diabetes. Howson JM, etal., Diabetes. 2011 Oct;60(10):2645-53. Epub 2011 Aug 26.
27. No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjogren's syndrome. Ittah M, etal., Genes Immun. 2005 Aug;6(5):457-8.
28. Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis. Juneblad K, etal., Arthritis Res Ther. 2011 Mar 16;13(2):R45.
29. The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. Kemp EH, etal., Hum Immunol. 2006 Jul;67(7):535-9. Epub 2006 May 4.
30. The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population. Laberge GS, etal., Pigment Cell Melanoma Res. 2008 Apr;21(2):206-8. doi: 10.1111/j.1755-148X.2008.00443.x.
31. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population. Lamsyah H, etal., Tissue Antigens. 2009 Sep;74(3):228-32. Epub 2009 Jun 25.
32. Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. Li Y, etal., J Invest Dermatol. 2009 Mar;129(3):629-34. doi: 10.1038/jid.2008.297. Epub 2008 Oct 16.
33. No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk of immune thrombocytopenia in French adult patients. Lioger B, etal., Thromb Res. 2016 Aug;144:76-8. doi: 10.1016/j.thromres.2016.04.013. Epub 2016 Apr 25.
34. Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease. Lopez-Escamez JA, etal., Laryngoscope. 2010 Jan;120(1):103-7. doi: 10.1002/lary.20650.
35. Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis. Luo L, etal., Endocr J. 2012 Feb 25.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. Namjou B, etal., PLoS One. 2013 Aug 7;8(8):e69404. doi: 10.1371/journal.pone.0069404. eCollection 2013.
38. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Negro R, etal., Blood. 2012 Jun 28;119(26):6278-87. doi: 10.1182/blood-2012-01-403162. Epub 2012 May 8.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Orru V, etal., Hum Mol Genet. 2009 Feb 1;18(3):569-79. doi: 10.1093/hmg/ddn363. Epub 2008 Nov 3.
41. GOA pipeline RGD automated data pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Comprehensive gene review and curation RGD comprehensive gene curation
45. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Rodriguez-Rodriguez L, etal., Arthritis Rheum. 2011 Feb;63(2):365-72. doi: 10.1002/art.30145.
46. Atherosclerosis and PTPN22: a study in coronary artery disease. Saccucci P, etal., Cardiology. 2011;119(1):54-6. Epub 2011 Aug 12.
47. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. Sarmiento J, etal., J Immunol. 2015 Jan 15;194(2):615-29. doi: 10.4049/jimmunol.1302689. Epub 2014 Dec 12.
48. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis. Serrano A, etal., Ann Rheum Dis. 2013 Nov 1;72(11):1882-6. doi: 10.1136/annrheumdis-2013-203641. Epub 2013 Aug 14.
49. Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. Skinningsrud B, etal., Eur J Hum Genet. 2008 Aug;16(8):977-82. Epub 2008 Feb 27.
50. Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Smith RL, etal., Br J Dermatol. 2008 May;158(5):962-8. doi: 10.1111/j.1365-2133.2008.08482.x. Epub 2008 Mar 13.
51. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Smyth D, etal., Diabetes. 2004 Nov;53(11):3020-3.
52. Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy. Syed AA, etal., Clin Endocrinol (Oxf). 2007 Nov;67(5):663-7. Epub 2007 Jul 3.
53. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Wang K, etal., Hum Mol Genet. 2010 May 15;19(10):2059-67. doi: 10.1093/hmg/ddq078. Epub 2010 Feb 22.
54. Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population. Wipff J, etal., Ann Rheum Dis. 2006 Sep;65(9):1230-2. Epub 2006 Feb 7.
55. Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats. Xu YB, etal., Chin Med Sci J. 2014 Jun;29(2):85-90.
56. [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. Yu ZY, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Aug;24(8):804-7.
57. The protein tyrosine phosphatase, non-receptor type 22 R620W polymorphism does not confer susceptibility to psoriasis in the genetic homogeneous population of Crete. Zervou MI, etal., Genet Test Mol Biomarkers. 2010 Feb;14(1):107-11. doi: 10.1089/gtmb.2009.0130.
58. No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations. Zhang Q, etal., PLoS One. 2012;7(3):e31230. doi: 10.1371/journal.pone.0031230. Epub 2012 Mar 2.
59. Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population. Zhebrun D, etal., Aging (Albany NY). 2011 Apr;3(4):368-73.
60. Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue. Zheng J, etal., Genes Immun. 2012 Dec;13(8):641-52. doi: 10.1038/gene.2012.46. Epub 2012 Oct 18.
Additional References at PubMed
PMID:8890164   PMID:10068674   PMID:10940933   PMID:14752163   PMID:16461343   PMID:16938887   PMID:18056643   PMID:18299186   PMID:20522204   PMID:21044313   PMID:23871208   PMID:23991106  


Genomics

Comparative Map Data
Ptpn22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22191,366,761 - 191,414,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,963,704 - 199,011,553 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02196,836,441 - 196,884,289 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02191,653,405 - 191,701,246 (+)NCBIRnor_WKY
Rnor_6.02206,342,066 - 206,390,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,765,744 - 225,814,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42199,083,186 - 199,144,309 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12199,045,987 - 199,095,515 (+)NCBI
Celera2183,836,919 - 183,884,957 (+)NCBICelera
Cytogenetic Map2q34NCBI
PTPN22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,813,811 - 113,871,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1113,813,811 - 113,871,753 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,356,433 - 114,414,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,157,960 - 114,215,857 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,068,480 - 114,126,376NCBI
Celera1112,585,654 - 112,643,598 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1112,214,556 - 112,272,493 (-)NCBIHuRef
CHM1_11114,471,278 - 114,529,225 (-)NCBICHM1_1
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBIT2T-CHM13v2.0
Ptpn22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,763,891 - 103,819,568 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3103,767,111 - 103,819,563 (+)EnsemblGRCm39 Ensembl
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)EnsemblGRCm38mm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBIMGSCv36mm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
Ptpn22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543517,082,762 - 17,139,067 (-)NCBIChiLan1.0ChiLan1.0
PTPN22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11106,067,591 - 106,123,889 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0188,685,736 - 88,743,164 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11123,734,511 - 123,790,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1123,734,511 - 123,790,830 (+)Ensemblpanpan1.1panPan2
PTPN22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11751,623,628 - 51,683,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1751,623,623 - 51,682,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1751,274,140 - 51,334,343 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01752,501,113 - 52,561,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1752,501,116 - 52,561,182 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11751,508,535 - 51,568,572 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01751,576,143 - 51,636,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01752,148,984 - 52,209,317 (-)NCBIUU_Cfam_GSD_1.0
Ptpn22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505815,244,798 - 15,296,846 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366902,181,047 - 2,232,958 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366902,180,804 - 2,232,869 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,686,604 - 106,758,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,897,216 - 116,927,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12019,792,807 - 19,855,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2019,793,083 - 19,855,827 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603822,562,918 - 22,626,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247729,472,913 - 9,550,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247729,472,869 - 9,552,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpn22
284 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:22
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000026556
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2190602746192625452Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2190602746192625452Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 1 4
Low 1 31 34 28 28 4 4 39 35 29 7 4
Below cutoff 12 15 13 13 4 7 31 10 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026556   ⟹   ENSRNOP00000026556
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)Ensembl
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120162   ⟹   ENSRNOP00000087016
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)Ensembl
RefSeq Acc Id: NM_001106460   ⟹   NP_001099930
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22191,366,808 - 191,414,779 (+)NCBI
Rnor_6.02206,342,066 - 206,390,348 (+)NCBI
Rnor_5.02225,765,744 - 225,814,130 (+)NCBI
RGSC_v3.42199,083,186 - 199,144,309 (+)RGD
Celera2183,836,919 - 183,884,957 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102072   ⟹   XP_038958000
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22191,366,763 - 191,414,782 (+)NCBI
RefSeq Acc Id: XM_039102073   ⟹   XP_038958001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22191,366,763 - 191,414,632 (+)NCBI
RefSeq Acc Id: XR_005500268
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22191,366,761 - 191,414,558 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099930 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958000 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958001 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85468 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099930   ⟸   NM_001106460
- UniProtKB: D4A2D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026556   ⟸   ENSRNOT00000026556
RefSeq Acc Id: XP_038958000   ⟸   XM_039102072
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958001   ⟸   XM_039102073
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000087016   ⟸   ENSRNOT00000120162
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2D5-F1-model_v2 AlphaFold D4A2D5 1-804 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691633
Promoter ID:EPDNEW_R2158
Type:single initiation site
Name:Ptpn22_1
Description:protein tyrosine phosphatase, non-receptor type 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02206,342,054 - 206,342,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307992 AgrOrtholog
BioCyc Gene G2FUF-51791 BioCyc
Ensembl Genes ENSRNOG00000019614 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026556 ENTREZGENE
  ENSRNOP00000026556.5 UniProtKB/TrEMBL
  ENSRNOP00000087016.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026556 ENTREZGENE
  ENSRNOT00000026556.6 UniProtKB/TrEMBL
  ENSRNOT00000120162.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp/Tyr_phosphatase UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTN12/18/22 UniProtKB/TrEMBL
  PTN22_cat UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:295338 UniProtKB/TrEMBL
NCBI Gene 295338 ENTREZGENE
PANTHER TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptpn22 PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8I6A706_RAT UniProtKB/TrEMBL
  D4A2D5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Ptpn22  protein tyrosine phosphatase, non-receptor type 22  Ptpn22  protein tyrosine phosphatase, non-receptor type 22 (lymphoid)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ptpn22  protein tyrosine phosphatase, non-receptor type 22 (lymphoid)   Ptpn22_predicted  protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ptpn22_predicted  protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (predicted)  Ptpn8_predicted  protein tyrosine phosphatase, non-receptor type 8 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ptpn8_predicted  protein tyrosine phosphatase, non-receptor type 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED