Def6 (DEF6 guanine nucleotide exchange factor) - Rat Genome Database

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Gene: Def6 (DEF6 guanine nucleotide exchange factor) Rattus norvegicus
Analyze
Symbol: Def6
Name: DEF6 guanine nucleotide exchange factor
RGD ID: 1307945
Description: Predicted to be involved in vesicle-mediated transport to the plasma membrane. Predicted to be located in cell-cell junction; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DEF6 (DEF6 guanine nucleotide exchange factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: differentially expressed in FDCP 6; differentially expressed in FDCP 6 homolog; differentially expressed in FDCP 6 homolog (mouse); LOC309642
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2206,268,614 - 6,290,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,268,601 - 6,289,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,981,182 - 7,002,247 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0206,343,008 - 6,364,079 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0206,822,253 - 6,843,219 (+)NCBIRnor_WKY
Rnor_6.0207,788,120 - 7,809,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,788,084 - 7,809,560 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,988,008 - 10,010,102 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,391,694 - 6,469,830 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,448,811 - 6,470,576 (+)NCBI
Celera207,825,022 - 7,845,913 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell-cell junction  (ISO)
cytoplasm  (IBA)
cytosol  (IEA)
cytosol  (ISO)
cytosol  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888   PMID:23793062  


Genomics

Comparative Map Data
Def6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2206,268,614 - 6,290,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,268,601 - 6,289,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,981,182 - 7,002,247 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0206,343,008 - 6,364,079 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0206,822,253 - 6,843,219 (+)NCBIRnor_WKY
Rnor_6.0207,788,120 - 7,809,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,788,084 - 7,809,560 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,988,008 - 10,010,102 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,391,694 - 6,469,830 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,448,811 - 6,470,576 (+)NCBI
Celera207,825,022 - 7,845,913 (+)NCBICelera
Cytogenetic Map20p12NCBI
DEF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,297,818 - 35,321,771 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl635,297,818 - 35,321,771 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,265,595 - 35,289,548 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,373,573 - 35,397,526 (+)NCBINCBI36Build 36hg18NCBI36
Build 34635,373,572 - 35,397,524NCBI
Celera636,819,554 - 36,843,506 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef634,986,813 - 35,010,534 (+)NCBIHuRef
CHM1_1635,267,635 - 35,291,597 (+)NCBICHM1_1
T2T-CHM13v2.0635,120,899 - 35,144,853 (+)NCBIT2T-CHM13v2.0
Def6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,426,752 - 28,447,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,426,752 - 28,447,582 (+)EnsemblGRCm39 Ensembl
GRCm381728,207,456 - 28,228,608 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,207,778 - 28,228,608 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,344,723 - 28,365,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,935,419 - 27,956,188 (+)NCBIMGSCv36mm8
Celera1728,761,659 - 28,782,259 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
Def6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,252,028 - 3,278,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,252,028 - 3,275,512 (+)NCBIChiLan1.0ChiLan1.0
DEF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1635,955,912 - 35,980,388 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl635,956,162 - 35,980,027 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0634,860,220 - 34,884,371 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DEF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,463,512 - 4,483,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,463,913 - 4,483,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,478,730 - 4,499,661 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,800,619 - 4,821,496 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,802,218 - 4,821,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,459,470 - 4,482,912 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,540,563 - 4,561,489 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,640,733 - 4,661,670 (+)NCBIUU_Cfam_GSD_1.0
Def6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,037,366 - 40,056,319 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,903,693 - 23,921,426 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647623,903,917 - 23,922,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DEF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,193,858 - 31,216,414 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,191,788 - 31,216,436 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,220,769 - 36,244,783 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DEF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,799,402 - 36,826,731 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,799,370 - 36,826,405 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,212,906 - 35,241,662 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Def6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475422,092,585 - 22,124,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475422,092,579 - 22,124,804 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Def6
146 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:95
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000000597
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

Markers in Region
D20Uia2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,232,172 - 6,232,338 (+)MAPPERmRatBN7.2
Rnor_6.0207,750,919 - 7,751,084NCBIRnor6.0
Rnor_5.0209,954,769 - 9,954,934UniSTSRnor5.0
RGSC_v3.4206,412,341 - 6,412,504RGDRGSC3.4
RGSC_v3.4206,412,339 - 6,412,504UniSTSRGSC3.4
RGSC_v3.1206,412,568 - 6,412,731RGD
Celera207,790,648 - 7,790,813UniSTS
Cytogenetic Map20p12UniSTS
D20Cebr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,282,240 - 6,282,558 (+)MAPPERmRatBN7.2
mRatBN7.2206,282,240 - 6,283,195 (+)MAPPERmRatBN7.2
Rnor_6.0207,801,746 - 7,802,699NCBIRnor6.0
Rnor_6.0207,801,746 - 7,802,063NCBIRnor6.0
Rnor_5.02010,001,921 - 10,002,874UniSTSRnor5.0
Rnor_5.02010,001,921 - 10,002,238UniSTSRnor5.0
RGSC_v3.4206,462,565 - 6,463,518UniSTSRGSC3.4
RGSC_v3.4206,462,565 - 6,462,882UniSTSRGSC3.4
Celera207,838,648 - 7,838,965UniSTS
Celera207,838,648 - 7,839,601UniSTS
Cytogenetic Map20p12UniSTS
RH128263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,230,798 - 6,230,993 (+)MAPPERmRatBN7.2
Rnor_6.0207,749,546 - 7,749,740NCBIRnor6.0
Rnor_5.0209,953,396 - 9,953,590UniSTSRnor5.0
RGSC_v3.4206,410,966 - 6,411,160UniSTSRGSC3.4
Celera207,789,275 - 7,789,469UniSTS
RH 3.4 Map2059.1UniSTS
Cytogenetic Map20p12UniSTS
RH132917  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,266,274 - 6,266,489 (+)MAPPERmRatBN7.2
Rnor_6.0207,785,783 - 7,785,997NCBIRnor6.0
Rnor_5.0209,985,671 - 9,985,885UniSTSRnor5.0
RGSC_v3.4206,446,261 - 6,446,475UniSTSRGSC3.4
Celera207,822,685 - 7,822,899UniSTS
RH 3.4 Map2075.93UniSTS
Cytogenetic Map20p12UniSTS
RH143313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,230,646 - 6,230,798 (+)MAPPERmRatBN7.2
Rnor_6.0207,749,394 - 7,749,545NCBIRnor6.0
Rnor_5.0209,953,244 - 9,953,395UniSTSRnor5.0
RGSC_v3.4206,410,814 - 6,410,965UniSTSRGSC3.4
Celera207,789,123 - 7,789,274UniSTS
RH 3.4 Map2060.9UniSTS
Cytogenetic Map20p12UniSTS
BF411261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,239,514 - 6,239,610 (+)MAPPERmRatBN7.2
Rnor_6.0207,758,261 - 7,758,356NCBIRnor6.0
Rnor_5.0209,960,631 - 9,960,726UniSTSRnor5.0
RGSC_v3.4206,419,650 - 6,419,745UniSTSRGSC3.4
Celera207,797,983 - 7,798,078UniSTS
RH 3.4 Map2078.14UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 26 18 19 18
Low 1 41 25 17 17 5 6 56 35 41 11 5
Below cutoff 6 6 6 3 5 18 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000597   ⟹   ENSRNOP00000000597
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,268,601 - 6,289,960 (+)Ensembl
Rnor_6.0 Ensembl207,788,084 - 7,809,560 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107870   ⟹   ENSRNOP00000079508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,268,601 - 6,289,507 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120154   ⟹   ENSRNOP00000082349
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,268,614 - 6,289,961 (+)Ensembl
RefSeq Acc Id: NM_001191717   ⟹   NP_001178646
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,268,614 - 6,289,507 (+)NCBI
Rnor_6.0207,788,120 - 7,809,011 (+)NCBI
Rnor_5.0209,988,008 - 10,010,102 (+)NCBI
Celera207,825,022 - 7,845,913 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098692   ⟹   XP_038954620
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,268,823 - 6,290,030 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178646 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954620 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178646   ⟸   NM_001191717
- UniProtKB: D3ZCK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000597   ⟸   ENSRNOT00000000597
RefSeq Acc Id: XP_038954620   ⟸   XM_039098692
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000082349   ⟸   ENSRNOT00000120154
RefSeq Acc Id: ENSRNOP00000079508   ⟸   ENSRNOT00000107870
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCK4-F1-model_v2 AlphaFold D3ZCK4 1-630 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701457
Promoter ID:EPDNEW_R11980
Type:multiple initiation site
Name:Def6_1
Description:DEF6 guanine nucleotide exchange factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0207,788,107 - 7,788,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307945 AgrOrtholog
BioCyc Gene G2FUF-4430 BioCyc
Ensembl Genes ENSRNOG00000000502 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000597 ENTREZGENE
  ENSRNOP00000000597.4 UniProtKB/TrEMBL
  ENSRNOP00000079508.1 UniProtKB/TrEMBL
  ENSRNOP00000082349.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000597 ENTREZGENE
  ENSRNOT00000000597.6 UniProtKB/TrEMBL
  ENSRNOT00000107870.1 UniProtKB/TrEMBL
  ENSRNOT00000120154.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:309642 UniProtKB/TrEMBL
NCBI Gene 309642 ENTREZGENE
PANTHER DIFFERENTIALLY EXPRESSED IN FDCP 6 HOMOLOG UniProtKB/TrEMBL
  SWAP-70 RECOMBINASE UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PhenoGen Def6 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A0A8I5ZMV4_RAT UniProtKB/TrEMBL
  A0A8I5ZUS6_RAT UniProtKB/TrEMBL
  D3ZCK4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-24 Def6  DEF6 guanine nucleotide exchange factor  Def6  differentially expressed in FDCP 6 homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Def6  differentially expressed in FDCP 6 homolog (mouse)  Def6  differentially expressed in FDCP 6   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Def6  differentially expressed in FDCP 6   Def6_predicted  differentially expressed in FDCP 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Def6_predicted  differentially expressed in FDCP 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED