Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Aff1 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AFF1 mRNA | CTD | PMID:22079256 | Aff1 | Rat | (-)-epigallocatechin 3-gallate | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | epigallocatechin gallate results in increased expression of AFF1 mRNA | CTD | PMID:22079256 | Aff1 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Aff1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AFF1 mRNA | CTD | PMID:36331819 | Aff1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Aff1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of AFF1 mRNA | CTD | PMID:22206623 | Aff1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of AFF1 mRNA | CTD | PMID:22206623 | Aff1 | Rat | 1,4-dichlorobenzene | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | 4-dichlorobenzene results in increased expression of AFF1 mRNA | CTD | PMID:26975756 | Aff1 | Rat | 17beta-estradiol | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of AFF1 mRNA | CTD | PMID:20404318 | Aff1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Aff1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of AFF1 mRNA | CTD | PMID:21570461 and PMID:24058054 | Aff1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of AFF1 mRNA | CTD | PMID:19770486 | Aff1 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of AFF1 mRNA | CTD | PMID:26251327 | Aff1 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AFF1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AFF1 mRNA | CTD | PMID:28628672 | Aff1 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AFF1 mRNA | CTD | PMID:28628672 | Aff1 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Aff1 (Mus musculus) | 6480464 | bisphenol S affects the methylation of AFF1 gene | CTD | PMID:31683443 | Aff1 | Rat | acrolein | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of AFF1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Aff1 | Rat | aflatoxin B1 | decreases methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of AFF1 gene | CTD | PMID:27153756 | Aff1 | Rat | aflatoxin B1 | increases methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of AFF1 intron | CTD | PMID:30157460 | Aff1 | Rat | all-trans-retinoic acid | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of AFF1 mRNA | CTD | PMID:33167477 | Aff1 | Rat | alpha-pinene | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of AFF1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of AFF1 mRNA | CTD | PMID:32699268 | Aff1 | Rat | aristolochic acid A | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of AFF1 mRNA | CTD | PMID:33212167 | Aff1 | Rat | arsane | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Arsenic results in increased expression of AFF1 mRNA | CTD | PMID:19945496 and PMID:30746931 | Aff1 | Rat | arsane | decreases methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of AFF1 gene | CTD | PMID:30746931 | Aff1 | Rat | arsane | affects methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of AFF1 gene | CTD | PMID:25304211 | Aff1 | Rat | arsenic atom | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Arsenic results in increased expression of AFF1 mRNA | CTD | PMID:19945496 and PMID:30746931 | Aff1 | Rat | arsenic atom | decreases methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Arsenic results in decreased methylation of AFF1 gene | CTD | PMID:30746931 | Aff1 | Rat | arsenic atom | affects methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of AFF1 gene | CTD | PMID:25304211 | Aff1 | Rat | arsenite(3-) | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to AFF1 mRNA] | CTD | PMID:32406909 | Aff1 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of AFF1 gene | CTD | PMID:28931070 and PMID:35440735 | Aff1 | Rat | benzo[a]pyrene | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of AFF1 mRNA | CTD | PMID:22228805 | Aff1 | Rat | benzo[a]pyrene | increases methylation | ISO | Aff1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of AFF1 3' UTR more ... | CTD | PMID:27901495 | Aff1 | Rat | benzo[a]pyrene | decreases methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of AFF1 5' UTR | CTD | PMID:27901495 | Aff1 | Rat | benzo[a]pyrene | affects methylation | ISO | AFF1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of AFF1 promoter | CTD | PMID:27901495 | Aff1 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20018196 | Aff1 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of AFF1 mRNA | CTD | PMID:19850644 | Aff1 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Aff1 (Mus musculus) | 6480464 | PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of AFF1 mRNA] | CTD | PMID:19850644 | Aff1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of AFF1 mRNA | CTD | PMID:25181051 | Aff1 | Rat | bisphenol A | increases methylation | ISO | AFF1 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of AFF1 gene | CTD | PMID:31601247 | Aff1 | Rat | bisphenol A | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of AFF1 gene | CTD | PMID:31601247 | Aff1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of AFF1 mRNA | CTD | PMID:32145629 | Aff1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of AFF1 gene | CTD | PMID:28505145 | Aff1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of AFF1 mRNA | CTD | PMID:30816183 and PMID:32528016 | Aff1 | Rat | bisphenol A | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of AFF1 mRNA | CTD | PMID:25594700 and PMID:35598803 | Aff1 | Rat | bisphenol F | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AFF1 mRNA | CTD | PMID:28628672 | Aff1 | Rat | bortezomib | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of AFF1 mRNA | CTD | PMID:20977926 | Aff1 | Rat | butanal | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of AFF1 mRNA | CTD | PMID:26079696 | Aff1 | Rat | cadmium atom | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AFF1 mRNA | CTD | PMID:35301059 | Aff1 | Rat | cadmium dichloride | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of AFF1 mRNA | CTD | PMID:38382870 and PMID:38568856 | Aff1 | Rat | cadmium dichloride | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AFF1 mRNA | CTD | PMID:35301059 | Aff1 | Rat | caffeine | affects phosphorylation | ISO | AFF1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of AFF1 protein | CTD | PMID:35688186 | Aff1 | Rat | carbon nanotube | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of AFF1 protein | CTD | PMID:33892499 | Aff1 | Rat | CGP 52608 | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to AFF1 gene] | CTD | PMID:28238834 | Aff1 | Rat | cisplatin | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of AFF1 mRNA | CTD | PMID:27594783 | Aff1 | Rat | cisplatin | decreases phosphorylation | ISO | Aff1 (Mus musculus) | 6480464 | Cisplatin results in decreased phosphorylation of AFF1 protein | CTD | PMID:22006019 | Aff1 | Rat | copper(II) sulfate | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of AFF1 mRNA | CTD | PMID:19549813 | Aff1 | Rat | coumarin | increases phosphorylation | ISO | AFF1 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of AFF1 protein | CTD | PMID:35688186 | Aff1 | Rat | CU-O LINKAGE | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of AFF1 mRNA | CTD | PMID:22077320 | Aff1 | Rat | cyclosporin A | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of AFF1 mRNA | CTD | PMID:25562108 | Aff1 | Rat | DDE | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of AFF1 mRNA | CTD | PMID:38568856 | Aff1 | Rat | dexamethasone | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of AFF1 mRNA | CTD | PMID:22733784 | Aff1 | Rat | dexamethasone | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AFF1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AFF1 mRNA | CTD | PMID:28628672 | Aff1 | Rat | Dibutyl phosphate | affects expression | ISO | AFF1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of AFF1 mRNA | CTD | PMID:37042841 | Aff1 | Rat | dicrotophos | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of AFF1 mRNA | CTD | PMID:28302478 | Aff1 | Rat | doxorubicin | affects methylation | EXP | | 6480464 | Doxorubicin affects the methylation of AFF1 gene | CTD | PMID:28962528 | Aff1 | Rat | doxorubicin | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of AFF1 mRNA | CTD | PMID:29803840 | Aff1 | Rat | epoxiconazole | affects expression | ISO | Aff1 (Mus musculus) | 6480464 | epoxiconazole affects the expression of AFF1 mRNA | CTD | PMID:35436446 | Aff1 | Rat | ethanol | affects expression | ISO | Aff1 (Mus musculus) | 6480464 | Ethanol affects the expression of AFF1 mRNA | CTD | PMID:30319688 | Aff1 | Rat | fenthion | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | Fenthion results in decreased expression of AFF1 mRNA | CTD | PMID:34813904 | Aff1 | Rat | fluoranthene | multiple interactions | ISO | Aff1 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of AFF1 mRNA | CTD | PMID:28329830 | Aff1 | Rat | folic acid | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of AFF1 mRNA | CTD | PMID:25629700 | Aff1 | Rat | folic acid | multiple interactions | ISO | Aff1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of AFF1 mRNA | CTD | PMID:22206623 | Aff1 | Rat | FR900359 | increases phosphorylation | ISO | AFF1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of AFF1 protein | CTD | PMID:37730182 | Aff1 | Rat | fulvestrant | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of AFF1 gene | CTD | PMID:31601247 | Aff1 | Rat | genistein | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of AFF1 gene | CTD | PMID:28505145 | Aff1 | Rat | hydrogen peroxide | affects expression | ISO | AFF1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of AFF1 mRNA | CTD | PMID:20044591 | Aff1 | Rat | indometacin | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AFF1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AFF1 mRNA | CTD | PMID:28628672 | Aff1 | Rat | malathion | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Malathion results in increased expression of AFF1 mRNA mutant form | CTD | PMID:28624474 | Aff1 | Rat | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of AFF1 mRNA | CTD | PMID:28801915 | Aff1 | Rat | methidathion | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | methidathion results in decreased expression of AFF1 mRNA | CTD | PMID:34813904 | Aff1 | Rat | methylmercury chloride | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of AFF1 mRNA | CTD | PMID:28001369 | Aff1 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of AFF1 gene | CTD | PMID:33148267 | Aff1 | Rat | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Aff1 (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of AFF1 gene | CTD | PMID:16724327 | Aff1 | Rat | ozone | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of AFF1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Aff1 | Rat | paraquat | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | Paraquat results in increased expression of AFF1 mRNA | CTD | PMID:21463325 | Aff1 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Aff1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AFF1 mRNA | CTD | PMID:36331819 | Aff1 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of AFF1 gene | CTD | PMID:33148267 | Aff1 | Rat | potassium chromate | decreases expression | ISO | AFF1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of AFF1 mRNA | CTD | PMID:22079256 | Aff1 | Rat | potassium chromate | multiple interactions | ISO | AFF1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AFF1 mRNA | CTD | PMID:22079256 | Aff1 | Rat | silicon dioxide | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of AFF1 mRNA | CTD | PMID:19073995 and PMID:33720480 | Aff1 | Rat | silicon dioxide | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of AFF1 mRNA | CTD | PMID:25351596 | Aff1 | Rat | sodium arsenite | affects expression | ISO | AFF1 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of AFF1 mRNA | CTD | PMID:29319823 | Aff1 | Rat | sodium arsenite | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of AFF1 mRNA | CTD | PMID:38568856 | Aff1 | Rat | sunitinib | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of AFF1 mRNA | CTD | PMID:31533062 | Aff1 | Rat | thiram | increases expression | ISO | AFF1 (Homo sapiens) | 6480464 | Thiram results in increased expression of AFF1 mRNA | CTD | PMID:38568856 | Aff1 | Rat | triptonide | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | triptonide results in increased expression of AFF1 mRNA | CTD | PMID:33045310 | Aff1 | Rat | tungsten | decreases expression | ISO | Aff1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of AFF1 mRNA | CTD | PMID:30912803 | Aff1 | Rat | valproic acid | increases expression | ISO | Aff1 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of AFF1 mRNA | CTD | PMID:19136453 and PMID:21427059 | | |||||||||||||||||||||||||||||||||||||||
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