Irf7 (interferon regulatory factor 7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Irf7 (interferon regulatory factor 7) Rattus norvegicus
Analyze
Symbol: Irf7
Name: interferon regulatory factor 7
RGD ID: 1307828
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of macromolecule biosynthetic process; and regulation of innate immune response. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC293624; MGC125013
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,796,956 - 205,800,543 (-)NCBIGRCr8
mRatBN7.21196,367,380 - 196,370,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,367,361 - 196,370,832 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,712,872 - 204,715,929 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,839,500 - 211,842,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,513,638 - 204,516,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,249,388 - 214,252,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,248,837 - 214,252,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,166,926 - 221,170,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,456,689 - 201,459,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,607,693 - 201,611,125 (-)NCBI
Celera1194,001,244 - 194,004,312 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
apilimod  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
chaetoglobosin A  (ISO)
chloroprene  (EXP)
cholesterol  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fentanyl  (EXP)
ferric oxide  (ISO)
finasteride  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydralazine  (ISO)
hydroxychloroquine  (ISO)
isoflavones  (ISO)
Licochalcone B  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
metam  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nitrates  (EXP)
Nutlin-3  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
pinostrobin  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP,ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
rotenone  (EXP)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zalcitabine  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. Li W, etal., J Virol. 2014 Jul;88(13):7578-88. doi: 10.1128/JVI.03117-13. Epub 2014 Apr 23.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12374802   PMID:12477932   PMID:15800576   PMID:16127453   PMID:17404045   PMID:17618271   PMID:19176627   PMID:21478870   PMID:22065573   PMID:23036922   PMID:23042151   PMID:23160154  
PMID:23729669   PMID:23956435   PMID:27129230   PMID:33152351   PMID:37946128  


Genomics

Comparative Map Data
Irf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,796,956 - 205,800,543 (-)NCBIGRCr8
mRatBN7.21196,367,380 - 196,370,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,367,361 - 196,370,832 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,712,872 - 204,715,929 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,839,500 - 211,842,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,513,638 - 204,516,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,249,388 - 214,252,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,248,837 - 214,252,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,166,926 - 221,170,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,456,689 - 201,459,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,607,693 - 201,611,125 (-)NCBI
Celera1194,001,244 - 194,004,312 (-)NCBICelera
Cytogenetic Map1q41NCBI
IRF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811612,555 - 615,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11612,553 - 615,983 (-)EnsemblGRCh38hg38GRCh38
GRCh3711612,555 - 615,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611602,555 - 605,999 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411602,590 - 605,650NCBI
Celera11677,701 - 681,146 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11427,860 - 431,281 (-)NCBIHuRef
CHM1_111611,595 - 615,009 (-)NCBICHM1_1
T2T-CHM13v2.011661,201 - 664,566 (-)NCBIT2T-CHM13v2.0
Irf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,843,096 - 140,846,412 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,842,619 - 140,846,394 (-)EnsemblGRCm39 Ensembl
GRCm387141,263,183 - 141,266,499 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,262,706 - 141,266,481 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,449,088 - 148,452,300 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,114,509 - 141,117,721 (-)NCBIMGSCv36mm8
Celera7141,056,921 - 141,060,133 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.57NCBI
Irf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,443,272 - 11,445,657 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,442,781 - 11,445,706 (+)NCBIChiLan1.0ChiLan1.0
IRF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,991,578 - 2,994,429 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,207,772 - 2,210,627 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl11647,827 - 651,314 (-)Ensemblpanpan1.1panPan2
IRF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,356,590 - 25,359,121 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,292,147 - 26,294,695 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11825,801,663 - 25,804,207 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,446,631 - 25,449,156 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,058,831 - 26,061,390 (-)NCBIUU_Cfam_GSD_1.0
Irf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947445,336 - 448,848 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888445,549 - 448,392 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888445,340 - 448,801 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2372,238 - 375,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12372,235 - 375,572 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22299,457 - 302,151 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11430,412 - 433,959 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1429,310 - 432,925 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,490,795 - 97,493,977 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,850,211 - 21,853,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irf7
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000023504
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
RH129676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,367,408 - 196,367,612 (+)MAPPERmRatBN7.2
Rnor_6.01214,249,417 - 214,249,620NCBIRnor6.0
Rnor_5.01221,166,955 - 221,167,158UniSTSRnor5.0
RGSC_v3.41201,456,718 - 201,456,921UniSTSRGSC3.4
Celera1194,001,273 - 194,001,476UniSTS
RH 3.4 Map11437.31UniSTS
Cytogenetic Map1q41UniSTS
PMC114617P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,368,918 - 196,369,940 (+)MAPPERmRatBN7.2
Rnor_6.01214,250,927 - 214,251,948NCBIRnor6.0
Rnor_5.01221,168,465 - 221,169,486UniSTSRnor5.0
RGSC_v3.41201,458,228 - 201,459,249UniSTSRGSC3.4
Celera1194,002,784 - 194,003,805UniSTS
Cytogenetic Map1q41UniSTS
PMC154027P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,367,663 - 196,368,131 (+)MAPPERmRatBN7.2
Rnor_6.01214,249,672 - 214,250,139NCBIRnor6.0
Rnor_5.01221,167,210 - 221,167,677UniSTSRnor5.0
RGSC_v3.41201,456,973 - 201,457,440UniSTSRGSC3.4
Celera1194,001,528 - 194,001,996UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 90 59 25 59 6 218 97 91 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023504   ⟹   ENSRNOP00000023504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,367,361 - 196,370,832 (-)Ensembl
Rnor_6.0 Ensembl1214,248,837 - 214,252,456 (-)Ensembl
RefSeq Acc Id: NM_001033691   ⟹   NP_001028863
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,796,956 - 205,800,023 (-)NCBI
mRatBN7.21196,367,380 - 196,370,447 (-)NCBI
Rnor_6.01214,249,388 - 214,252,455 (-)NCBI
Rnor_5.01221,166,926 - 221,170,447 (-)NCBI
RGSC_v3.41201,456,689 - 201,459,756 (-)RGD
Celera1194,001,244 - 194,004,312 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230540   ⟹   XP_006230602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,796,956 - 205,800,543 (-)NCBI
mRatBN7.21196,367,380 - 196,370,943 (-)NCBI
Rnor_6.01214,249,388 - 214,252,909 (-)NCBI
Rnor_5.01221,166,926 - 221,170,447 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230541   ⟹   XP_006230603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,796,956 - 205,800,519 (-)NCBI
mRatBN7.21196,367,380 - 196,370,943 (-)NCBI
Rnor_6.01214,249,388 - 214,252,909 (-)NCBI
Rnor_5.01221,166,926 - 221,170,447 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001028863   ⟸   NM_001033691
- UniProtKB: Q3SWU2 (UniProtKB/TrEMBL),   F7FGY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230603   ⟸   XM_006230541
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006230602   ⟸   XM_006230540
- Peptide Label: isoform X1
- UniProtKB: Q3SWU2 (UniProtKB/TrEMBL),   F7FGY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023504   ⟸   ENSRNOT00000023504
Protein Domains
Interferon regulatory factor-3   IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FGY2-F1-model_v2 AlphaFold F7FGY2 1-456 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307828 AgrOrtholog
BioCyc Gene G2FUF-56966 BioCyc
Ensembl Genes ENSRNOG00000017414 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023504.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7442863 IMAGE-MGC_LOAD
InterPro Interferon_regulatory_fac_CS UniProtKB/TrEMBL
  Interferon_regulatory_factor UniProtKB/TrEMBL
  Interferon_regulatory_factor-3 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:293624 UniProtKB/TrEMBL
MGC_CLONE MGC:125013 IMAGE-MGC_LOAD
NCBI Gene 293624 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/TrEMBL
  INTERFERON REGULATORY FACTOR 7 UniProtKB/TrEMBL
Pfam IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
PhenoGen Irf7 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF UniProtKB/TrEMBL
  IRF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017414 RatGTEx
SMART IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A6HXS3_RAT UniProtKB/TrEMBL
  A6HXS4_RAT UniProtKB/TrEMBL
  A6HXS5_RAT UniProtKB/TrEMBL
  A6HXS6_RAT UniProtKB/TrEMBL
  A6HXS7_RAT UniProtKB/TrEMBL
  A6HXS9_RAT UniProtKB/TrEMBL
  A6HXT0_RAT UniProtKB/TrEMBL
  F7FGY2 ENTREZGENE
  Q3SWU2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7FGY2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Irf7  interferon regulatory factor 7  Irf7_predicted  interferon regulatory factor 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Irf7_predicted  interferon regulatory factor 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED