Irf7 (interferon regulatory factor 7)

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Gene: Irf7 (interferon regulatory factor 7) Rattus norvegicus

Analyze

Symbol:

Irf7

Name:

interferon regulatory factor 7

RGD ID:

1307828

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of macromolecule biosynthetic process; and regulation of innate immune response. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC293624; MGC125013

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IRF7 (interferon regulatory factor 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Irf7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Irf7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IRF7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IRF7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Irf7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IRF7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IRF7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Irf7 (interferon regulatory factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MAP2K4 (mitogen-activated protein kinase kinase 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	IRF7 (interferon regulatory factor 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Irf7 (interferon regulatory factor 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	irf7 (interferon regulatory factor 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	irf7	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	196,367,380 - 196,370,943 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	196,367,361 - 196,370,832 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	204,712,872 - 204,715,929 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	211,839,500 - 211,842,700 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	204,513,638 - 204,516,838 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	214,249,388 - 214,252,909 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	214,248,837 - 214,252,456 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	221,166,926 - 221,170,447 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	201,456,689 - 201,459,756 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	201,607,693 - 201,611,125 (-)	NCBI
Celera	1	194,001,244 - 194,004,312 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chanarin-Dorfman syndrome (ISO)

COVID-19 (ISO)

delta beta-thalassemia (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

Human Influenza (ISO)

immunodeficiency 39 (ISO)

Inflammation (ISO)

lymphocytic choriomeningitis (ISO)

neuronal ceroid lipofuscinosis (ISO)

Segawa Syndrome, Autosomal Recessive (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (EXP,ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dichlorophenol (ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

4-(ethoxymethylene)-2-phenyloxazol-5-one (EXP)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

6alpha-methylprednisolone (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

C60 fullerene (EXP)

cadmium dichloride (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

ceric oxide (ISO)

chaetoglobosin A (ISO)

chloroprene (EXP)

cholesterol (ISO)

chromium(6+) (ISO)

copper atom (EXP)

copper(0) (EXP)

corn oil (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

diarsenic trioxide (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

dieldrin (EXP)

diethyl malate (ISO)

diethyl maleate (EXP)

diethylstilbestrol (EXP,ISO)

dioxygen (EXP)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (EXP,ISO)

ethyl methanesulfonate (ISO)

fenofibrate (ISO)

ferric oxide (ISO)

finasteride (EXP)

folic acid (ISO)

formaldehyde (ISO)

fructose (ISO)

fucoxanthin (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

geraniol (ISO)

glucose (ISO)

hydralazine (ISO)

hydroxychloroquine (ISO)

isoflavones (ISO)

Licochalcone B (ISO)

linuron (ISO)

lipopolysaccharide (ISO)

metam (ISO)

metformin (ISO)

methyl methanesulfonate (ISO)

mitoxantrone (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosomorpholine (EXP)

nickel atom (ISO)

nickel dichloride (ISO)

nicotine (ISO)

nitrates (EXP)

orphenadrine (EXP)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (EXP,ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP)

phenylephrine (EXP)

pirinixic acid (EXP,ISO)

poly(I:C) (EXP,ISO)

prednisolone (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

rac-lactic acid (ISO)

raloxifene (EXP)

rotenone (EXP)

ruxolitinib (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium aurothiomalate (ISO)

Soman (EXP)

succimer (ISO)

sulforaphane (ISO)

sulindac (EXP)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

theophylline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tofacitinib (ISO)

topotecan (EXP)

trichloroethene (EXP)

trimellitic anhydride (EXP)

triptonide (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

XL147 (ISO)

zalcitabine (EXP)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasmic pattern recognition receptor signaling pathway (ISO)

defense response to virus (ISO)

immune system process (IBA)

immunoglobulin mediated immune response (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of interferon-alpha production (ISO)

positive regulation of interferon-beta production (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of type I interferon production (ISO)

positive regulation of type I interferon-mediated signaling pathway (ISO)

regulation of adaptive immune response (ISO)

regulation of gene expression (ISO)

regulation of MyD88-dependent toll-like receptor signaling pathway (ISO)

regulation of MyD88-independent toll-like receptor signaling pathway (ISO)

regulation of transcription by RNA polymerase II (IBA)

type I interferon-mediated signaling pathway (ISO)

Cellular Component

chromatin (ISO)

cytoplasm (ISO)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

Molecular Function

cis-regulatory region sequence-specific DNA binding (ISO)

DNA binding (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific double-stranded DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway (IEA)

Toll-like receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.	Li W, etal., J Virol. 2014 Jul;88(13):7578-88. doi: 10.1128/JVI.03117-13. Epub 2014 Apr 23.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12374802	PMID:12477932	PMID:15800576	PMID:16127453	PMID:17404045	PMID:17618271	PMID:19176627	PMID:21478870	PMID:22065573	PMID:23036922	PMID:23042151	PMID:23160154
PMID:23729669	PMID:23956435	PMID:27129230	PMID:33152351

Genomics

Comparative Map Data

Irf7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	196,367,380 - 196,370,943 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	196,367,361 - 196,370,832 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	204,712,872 - 204,715,929 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	211,839,500 - 211,842,700 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	204,513,638 - 204,516,838 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	214,249,388 - 214,252,909 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	214,248,837 - 214,252,456 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	221,166,926 - 221,170,447 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	201,456,689 - 201,459,756 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	201,607,693 - 201,611,125 (-)	NCBI
Celera	1	194,001,244 - 194,004,312 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

IRF7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	612,555 - 615,950 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	612,553 - 615,983 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	612,555 - 615,950 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	602,555 - 605,999 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	602,590 - 605,650	NCBI
Celera	11	677,701 - 681,146 (-)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	427,860 - 431,281 (-)	NCBI		HuRef
CHM1_1	11	611,595 - 615,009 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	661,201 - 664,566 (-)	NCBI		T2T-CHM13v2.0

Irf7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,843,096 - 140,846,412 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	140,842,619 - 140,846,394 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	141,263,183 - 141,266,499 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	141,262,706 - 141,266,481 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	148,449,088 - 148,452,300 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	141,114,509 - 141,117,721 (-)	NCBI		MGSCv36	mm8
Celera	7	141,056,921 - 141,060,133 (-)	NCBI		Celera
Cytogenetic Map	7	F5	NCBI
cM Map	7	86.57	NCBI

Irf7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	11,443,272 - 11,445,657 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955476	11,442,781 - 11,445,706 (+)	NCBI	ChiLan1.0	ChiLan1.0

IRF7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	11	2,207,772 - 2,210,627 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1 Ensembl	11	647,827 - 651,314 (-)	Ensembl	panpan1.1		panPan2

IRF7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	18	25,356,590 - 25,359,121 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	26,292,147 - 26,294,695 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	25,801,663 - 25,804,207 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	25,446,631 - 25,449,156 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	26,058,831 - 26,061,390 (-)	NCBI		UU_Cfam_GSD_1.0

Irf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	445,336 - 448,848 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936888	445,549 - 448,392 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936888	445,340 - 448,801 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IRF7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	372,238 - 375,378 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	372,235 - 375,572 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	299,457 - 302,151 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IRF7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	430,412 - 433,959 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	429,310 - 432,925 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	97,490,795 - 97,493,977 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Irf7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624766	21,850,211 - 21,853,189 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Irf7
17 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	114
Count of miRNA genes:	87
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000023504
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169112897	197261052	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	169112897	197261052	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	174133260	196383668	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
61378	Bp43	Blood pressure QTL 43	22.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	181746937	196383668	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
1359018	Hrtrt20	Heart rate QTL 20	3.08		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	185356336	202902618	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
6480780	Insul18	Insulin level QTL 18	4.11		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	189607473	200611765	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
631260	Tcas2	Tongue tumor susceptibility QTL 2	4.93		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	192485903	199050587	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	193422268	214537671	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	0.00000081	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat

Markers in Region

RH129676

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	196,367,408 - 196,367,612 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	214,249,417 - 214,249,620	NCBI	Rnor6.0
Rnor_5.0	1	221,166,955 - 221,167,158	UniSTS	Rnor5.0
RGSC_v3.4	1	201,456,718 - 201,456,921	UniSTS	RGSC3.4
Celera	1	194,001,273 - 194,001,476	UniSTS
RH 3.4 Map	1	1437.31	UniSTS
Cytogenetic Map	1	q41	UniSTS

PMC114617P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	196,368,918 - 196,369,940 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	214,250,927 - 214,251,948	NCBI	Rnor6.0
Rnor_5.0	1	221,168,465 - 221,169,486	UniSTS	Rnor5.0
RGSC_v3.4	1	201,458,228 - 201,459,249	UniSTS	RGSC3.4
Celera	1	194,002,784 - 194,003,805	UniSTS
Cytogenetic Map	1	q41	UniSTS

PMC154027P4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	196,367,663 - 196,368,131 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	214,249,672 - 214,250,139	NCBI	Rnor6.0
Rnor_5.0	1	221,167,210 - 221,167,677	UniSTS	Rnor5.0
RGSC_v3.4	1	201,456,973 - 201,457,440	UniSTS	RGSC3.4
Celera	1	194,001,528 - 194,001,996	UniSTS
Cytogenetic Map	1	q41	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	13	26	12	19	12			2	11	7	11
Low		22	27	25		25	8	11	44	24	30		8
Below cutoff		8	4	4		4			26		4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC104686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000023504 ⟹ ENSRNOP00000023504

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	196,367,361 - 196,370,832 (-)	Ensembl
Rnor_6.0 Ensembl	1	214,248,837 - 214,252,456 (-)	Ensembl

RefSeq Acc Id:

NM_001033691 ⟹ NP_001028863

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	196,367,380 - 196,370,447 (-)	NCBI
Rnor_6.0	1	214,249,388 - 214,252,455 (-)	NCBI
Rnor_5.0	1	221,166,926 - 221,170,447 (-)	NCBI
RGSC_v3.4	1	201,456,689 - 201,459,756 (-)	RGD
Celera	1	194,001,244 - 194,004,312 (-)	RGD

Sequence:

show sequence

CAGGGTCCAGCCTGTGACAGCCCATCCAGGCCCGGACGCTGGATCAACACCTGTGACATCACAT
GTGCGCTCCCGCTGCTACATCTGTAGTCACATCTACAGCCACCTTGGCCTAGGAATCCACACTT
AAATTGGGAACCTAGGTGGCTATAAGTTCTCAAACCTCATCTGTGACCCTCAACACCCTAATAC
CTGGGTCACACTTGTGAAACTTCAATTCCCACCTGTGACCAACAATCCTAACGTTTAAAACATA
TTTATGAAACTTGGTTACACTATCTGTGGCTAAAACCATAAAGACACCCAAGGGACTCTTACCT
TATTTGTAATACTGCCTCAGTGACTGCAAGTCATCAGAGTAGTAGCACCTACTTTCTCCCAGAC
TGCCCGTGTAGAAGGAGCAATGGCCGAAGTGAGGGGGGTCCAGCGAGTGCTGTTCGGAGACTGG
CTCTTGGGTGAGGTCAGTAGTGGCCGGTACGAGGGGCTGCAGTGGCTGAATGAGGCTCACACAG
TCTTCCGTGTGCCCTGGAAGCATTTCAGCCGTAGGGATCTGGATGAAGCTGATGCACAGATCTT
CAAGGCCTGGGCTGTGGCCCGAGGGAGGTGGCCACCTAGTGGAGTTAACTTACCACCCCCAGAG
GCTGAGGCTGCTGAGCGAAGAGGCTGGAAGACCAACTTCCGATGTGCACTCCGCAGCACAGGGC
GCTTTATCTTGCGTCAAGACAACTCAGGGGACCCTGCTGATCCGCACAAGGTGTATGAACTTAG
CCCGGAGCTTGGATCTACAACTGGCCCAGCTCTGGAGAACAGGGAAGAAGTGACCCTCAGCAGT
GCCCTACCCACACAGGGTATGTCCCTAGGATCATTCCTGGCAAGAGGAAATGCTGGGTTGCAAA
CCCCAAGCCCTCTGCTTTCTGGTGATGCTGGGGACCTCTTGCTTCAGGTTCTGCAATACAGCCA
CCTACTGGACTCTGAGTCTAGGGCGGACTCAGTCCCACCACAGGCTTCTGGCCAGGAGCAAGAA
CACCTTCCTGAGGAGCCCCATGCAGCATGGCAGATGGAAGCTACCTCCAGCCCCAGGCTTCAAC
ACCCAGTTCTGATGACTGAGCGCAACCTTGGGTCCCTGGATGTGACCATCATGTACAAGGGCCG
CACAGTGCTACAGGCAATGGTGGGGCACCCCAGATGCGTGTTCCTGTATAGCCCCGTGGGCTCA
GCAATAAGAACTTCAGAGCCCCAGCCGGTGATTTTTCCGAGCCCCGCTGAGCTCCCAGATCAGA
AGCAGCTGCACTACACAGAGACTCTCCTACAGCATGTGTCTCCAGGCCTTCAGCTGGAGCTTCG
GGGGCCATCACTATGGGCCCTGCGAATGGGCAAGTGCAAGGTGTACTGGGAGGTGGGCAGCCCT
ATGGGCTCCACCAACCCCTCCACCCCAGCCCAGCTGCTGGAGCGCAACTGCCATACTCCCATCT
TTGACTTCAGCACTTTCTTCCGAGAACTGGAGGAGTTCCGGGCCCGGAGGCGACAAGGATCACC
ACATTACACCATCTACCTGGGTTTTGGGCAAGACTTGTCAGCAGGGAGGCCCAAGGAGAAGAGC
CTGATCCTGGTGAAGCTGGAGCCATGGCTGTGCAAGACACATCTGGAAGGCGTGCAGCGTGAGG
GTGTGTCCTCTCTGGACAGCAGCAGTCTTGGCCTGTGCTTGTCTAGCACCAATAGTCTCTACGA
TGACATTGAACACTTCCTCATGGACCTGGGTCAGTGGGCTTGATTCAGAACCCCAACTTCCAAT
AGAGTTCAGAACCACTGCTGCCCTGGCTCAGGCTTATTCCTTGGCTATATGTCATCTCTAGTGG
ACCTTGTGGAGTCCCTTGAAAGAAGGTGACCCCCCACTCCCTACACACTAGGCCTCCTTTGTAG
CACTCATCTTTACAATAAAGAATTGGTTGGGTTACCATAAAAAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_006230540 ⟹ XP_006230602

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	196,367,380 - 196,370,943 (-)	NCBI
Rnor_6.0	1	214,249,388 - 214,252,909 (-)	NCBI
Rnor_5.0	1	221,166,926 - 221,170,447 (-)	NCBI

Sequence:

show sequence

CACACCCTGCAGCATTCCACCCCGCCCCTGACCGAAGTACTATAAAAGCACGGCTACCTCCTTC
TCACTGAGATAAAACCGTCCCGGCGGCTCCGGTACCAGGGTCCAGCCTGTGACAGCCCATCCAG
GCCCGGACGCTGGATCAACACCTGTGACATCACATGTGCGCTCCCGCTGCTACATCTGTAGTCA
CATCTACAGCCACCTTGGCCTAGGAATCCACACTTAAATTGGGAACCTAGGTGGCTATAAGTTC
TCAAACCTCATCTGTGACCCTCAACACCCTAATACCTGGGTCACACTTGTGAAACTTCAATTCC
CACCTGTGACCAACAATCCTAACGTTTAAAACATATTTATGAAACTTGGTTACACTATCTGTGG
CTAAAACCATAAAGACACCCAAGGGACTCTTACCTTATTTGTAATACTGCCTCAGTGACTGCAA
GTCATCAGAGTAGTAGCACCTACTTTCTCCCAGACTGCCCGTGTAGAAGGAGCAATGGCCGAAG
TGAGGGGGGTCCAGCGAGTGCTGTTCGGAGACTGGCTCTTGGGTGAGGTCAGTAGTGGCCGGTA
CGAGGGGCTGCAGTGGCTGAATGAGGCTCACACAGTCTTCCGTGTGCCCTGGAAGCATTTCAGC
CGTAGGGATCTGGATGAAGCTGATGCACAGATCTTCAAGGCCTGGGCTGTGGCCCGAGGGAGGT
GGCCACCTAGTGGAGTTAACTTACCACCCCCAGAGGCTGAGGCTGCTGAGCGAAGAGGCTGGAA
GACCAACTTCCGATGTGCACTCCGCAGCACAGGGCGCTTTATCTTGCGTCAAGACAACTCAGGG
GACCCTGCTGATCCGCACAAGGTGTATGAACTTAGCCCGGAGCTTGGATCTACAACTGGCCCAG
CTCTGGAGAACAGGGAAGAAGTGACCCTCAGCAGTGCCCTACCCACACAGGGTATGTCCCTAGG
ATCATTCCTGGCAAGAGGAAATGCTGGGTTGCAAACCCCAAGCCCTCTGCTTTCTGGTGATGCT
GGGGACCTCTTGCTTCAGGTTCTGCAATACAGCCACCTACTGGACTCTGAGTCTAGGGCGGACT
CAGTCCCACCACAGGCTTCTGGCCAGGAGCAAGAACACCTTCCTGAGGAGCCCCATGCAGCATG
GCAGATGGAAGCTACCTCCAGCCCCAGGCTTCAACACCCAGTTCTGATGACTGAGCGCAACCTT
GGGTCCCTGGATGTGACCATCATGTACAAGGGCCGCACAGTGCTACAGGCAATGGTGGGGCACC
CCAGATGCGTGTTCCTGTATAGCCCCGTGGGCTCAGCAATAAGAACTTCAGAGCCCCAGCCGGT
GATTTTTCCGAGCCCCGCTGAGCTCCCAGATCAGAAGCAGCTGCACTACACAGAGACTCTCCTA
CAGCATGTGTCTCCAGGCCTTCAGCTGGAGCTTCGGGGGCCATCACTATGGGCCCTGCGAATGG
GCAAGTGCAAGGTGTACTGGGAGGTGGGCAGCCCTATGGGCTCCACCAACCCCTCCACCCCAGC
CCAGCTGCTGGAGCGCAACTGCCATACTCCCATCTTTGACTTCAGCACTTTCTTCCGAGAACTG
GAGGAGTTCCGGGCCCGGAGGCGACAAGGATCACCACATTACACCATCTACCTGGGTTTTGGGC
AAGACTTGTCAGCAGGGAGGCCCAAGGAGAAGAGCCTGATCCTGGTGAAGCTGGAGCCATGGCT
GTGCAAGACACATCTGGAAGGCGTGCAGCGTGAGGGTGTGTCCTCTCTGGACAGCAGCAGTCTT
GGCCTGTGCTTGTCTAGCACCAATAGTCTCTACGATGACATTGAACACTTCCTCATGGACCTGG
GTCAGTGGGCTTGATTCAGAACCCCAACTTCCAATAGAGTTCAGAACCACTGCTGCCCTGGCTC
AGGCTTATTCCTTGGCTATATGTCATCTCTAGTGGACCTTGTGGAGTCCCTTGAAAGAAGGTGA
CCCCCCACTCCCTACACACTAGGCCTCCTTTGTAGCACTCATCTTTACAATAAAGAATTGGTTG
GGTTACCATA

hide sequence

RefSeq Acc Id:

XM_006230541 ⟹ XP_006230603

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	196,367,380 - 196,370,943 (-)	NCBI
Rnor_6.0	1	214,249,388 - 214,252,909 (-)	NCBI
Rnor_5.0	1	221,166,926 - 221,170,447 (-)	NCBI

Sequence:

show sequence

CACACCCTGCAGCATTCCACCCCGCCCCTGACCGAAGTACTATAAAAGCACGGCTACCTCCTTC
TCACTGAGATAAAACCGTCCCGGCGGCTCCGGTACCAGGGTCCAGCCTGTGACAGCCCATCCAG
GCCCGGACGCTGGATCAACACCTGTGACATCACATGTGCGCTCCCGCTGCTACATCTGTAGTCA
CATCTACAGCCACCTTGGCCTAGGAATCCACACTTAAATTGGGAACCTAGGTGGCTATAAGTTC
TCAAACCTCATCTGTGACCCTCAACACCCTAATACCTGGGTCACACTTGTGAAACTTCAATTCC
CACCTGTGACCAACAATCCTAACGTTTAAAACATATTTATGAAACTTGGTTACACTATCTGTGG
CTAAAACCATAAAGACACCCAAGGGACTCTTACCTTATTTGTAATACTGCCTCAGTGACTGCAA
GTCATCAGAGTAGTAGCACCTACTTTCTCCCAGACTGCCCGTGTAGAAGGAGCAATGGCCGAAG
TGAGGGGGGTCCAGCGAGTGCTGTTCGGAGACTGGCTCTTGGGTGAGGTCAGTAGTGGCCGGTA
CGAGGGGCTGCAGTGGCTGAATGAGGCTCACACAGTCTTCCGTGTGCCCTGGAAGCATTTCAGC
CGTAGGGATCTGGATGAAGCTGATGCACAGATCTTCAAGGCCTGGGCTGTGGCCCGAGGGAGGT
GGCCACCTAGTGGAGTTAACTTACCACCCCCAGAGGCTGAGGCTGCTGAGCGAAGAGGCTGGAA
GACCAACTTCCGATGTGCACTCCGCAGCACAGGGCGCTTTATCTTGCGTCAAGACAACTCAGGG
GACCCTGCTGATCCGCACAAGGTGTATGAACTTAGCCCGGAGCTTGGATCTACAACTGGCCCAG
CTCTGGAGAACAGGGAAGAAGTGACCCTCAGCAGTGCCCTACCCACACAGGTTCTGCAATACAG
CCACCTACTGGACTCTGAGTCTAGGGCGGACTCAGTCCCACCACAGGCTTCTGGCCAGGAGCAA
GAACACCTTCCTGAGGAGCCCCATGCAGCATGGCAGATGGAAGCTACCTCCAGCCCCAGGCTTC
AACACCCAGTTCTGATGACTGAGCGCAACCTTGGGTCCCTGGATGTGACCATCATGTACAAGGG
CCGCACAGTGCTACAGGCAATGGTGGGGCACCCCAGATGCGTGTTCCTGTATAGCCCCGTGGGC
TCAGCAATAAGAACTTCAGAGCCCCAGCCGGTGATTTTTCCGAGCCCCGCTGAGCTCCCAGATC
AGAAGCAGCTGCACTACACAGAGACTCTCCTACAGCATGTGTCTCCAGGCCTTCAGCTGGAGCT
TCGGGGGCCATCACTATGGGCCCTGCGAATGGGCAAGTGCAAGGTGTACTGGGAGGTGGGCAGC
CCTATGGGCTCCACCAACCCCTCCACCCCAGCCCAGCTGCTGGAGCGCAACTGCCATACTCCCA
TCTTTGACTTCAGCACTTTCTTCCGAGAACTGGAGGAGTTCCGGGCCCGGAGGCGACAAGGATC
ACCACATTACACCATCTACCTGGGTTTTGGGCAAGACTTGTCAGCAGGGAGGCCCAAGGAGAAG
AGCCTGATCCTGGTGAAGCTGGAGCCATGGCTGTGCAAGACACATCTGGAAGGCGTGCAGCGTG
AGGGTGTGTCCTCTCTGGACAGCAGCAGTCTTGGCCTGTGCTTGTCTAGCACCAATAGTCTCTA
CGATGACATTGAACACTTCCTCATGGACCTGGGTCAGTGGGCTTGATTCAGAACCCCAACTTCC
AATAGAGTTCAGAACCACTGCTGCCCTGGCTCAGGCTTATTCCTTGGCTATATGTCATCTCTAG
TGGACCTTGTGGAGTCCCTTGAAAGAAGGTGACCCCCCACTCCCTACACACTAGGCCTCCTTTG
TAGCACTCATCTTTACAATAAAGAATTGGTTGGGTTACCATA

hide sequence

RefSeq Acc Id:

XM_039107968 ⟹ XP_038963896

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	196,367,380 - 196,370,162 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001028863	(Get FASTA)	NCBI Sequence Viewer
	XP_006230602	(Get FASTA)	NCBI Sequence Viewer
	XP_006230603	(Get FASTA)	NCBI Sequence Viewer
	XP_038963896	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI04687	(Get FASTA)	NCBI Sequence Viewer
	EDM12004	(Get FASTA)	NCBI Sequence Viewer
	EDM12005	(Get FASTA)	NCBI Sequence Viewer
	EDM12006	(Get FASTA)	NCBI Sequence Viewer
	EDM12007	(Get FASTA)	NCBI Sequence Viewer
	EDM12008	(Get FASTA)	NCBI Sequence Viewer
	EDM12009	(Get FASTA)	NCBI Sequence Viewer
	EDM12010	(Get FASTA)	NCBI Sequence Viewer
	EDM12011	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001028863 ⟸ NM_001033691

- UniProtKB:

Q3SWU2 (UniProtKB/TrEMBL), F7FGY2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEVRGVQRVLFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLDEADAQIFKAWAVA
RGRWPPSGVNLPPPEAEAAERRGWKTNFRCALRSTGRFILRQDNSGDPADPHKVYELSPELGST
TGPALENREEVTLSSALPTQGMSLGSFLARGNAGLQTPSPLLSGDAGDLLLQVLQYSHLLDSES
RADSVPPQASGQEQEHLPEEPHAAWQMEATSSPRLQHPVLMTERNLGSLDVTIMYKGRTVLQAM
VGHPRCVFLYSPVGSAIRTSEPQPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGPSLWA
LRMGKCKVYWEVGSPMGSTNPSTPAQLLERNCHTPIFDFSTFFRELEEFRARRRQGSPHYTIYL
GFGQDLSAGRPKEKSLILVKLEPWLCKTHLEGVQREGVSSLDSSSLGLCLSSTNSLYDDIEHFL
MDLGQWA

hide sequence

RefSeq Acc Id:

XP_006230603 ⟸ XM_006230541

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAEVRGVQRVLFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLDEADAQIFKAWAVA
RGRWPPSGVNLPPPEAEAAERRGWKTNFRCALRSTGRFILRQDNSGDPADPHKVYELSPELGST
TGPALENREEVTLSSALPTQVLQYSHLLDSESRADSVPPQASGQEQEHLPEEPHAAWQMEATSS
PRLQHPVLMTERNLGSLDVTIMYKGRTVLQAMVGHPRCVFLYSPVGSAIRTSEPQPVIFPSPAE
LPDQKQLHYTETLLQHVSPGLQLELRGPSLWALRMGKCKVYWEVGSPMGSTNPSTPAQLLERNC
HTPIFDFSTFFRELEEFRARRRQGSPHYTIYLGFGQDLSAGRPKEKSLILVKLEPWLCKTHLEG
VQREGVSSLDSSSLGLCLSSTNSLYDDIEHFLMDLGQWA

hide sequence

RefSeq Acc Id:	XP_006230602 ⟸ XM_006230540
- Peptide Label:	isoform X1
- UniProtKB:	Q3SWU2 (UniProtKB/TrEMBL), F7FGY2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEVRGVQRVLFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKHFSRRDLDEADAQIFKAWAVA RGRWPPSGVNLPPPEAEAAERRGWKTNFRCALRSTGRFILRQDNSGDPADPHKVYELSPELGST TGPALENREEVTLSSALPTQGMSLGSFLARGNAGLQTPSPLLSGDAGDLLLQVLQYSHLLDSES RADSVPPQASGQEQEHLPEEPHAAWQMEATSSPRLQHPVLMTERNLGSLDVTIMYKGRTVLQAM VGHPRCVFLYSPVGSAIRTSEPQPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGPSLWA LRMGKCKVYWEVGSPMGSTNPSTPAQLLERNCHTPIFDFSTFFRELEEFRARRRQGSPHYTIYL GFGQDLSAGRPKEKSLILVKLEPWLCKTHLEGVQREGVSSLDSSSLGLCLSSTNSLYDDIEHFL MDLGQWA hide sequence

RefSeq Acc Id:

ENSRNOP00000023504 ⟸ ENSRNOT00000023504

RefSeq Acc Id:	XP_038963896 ⟸ XM_039107968
- Peptide Label:	isoform X3

Protein Domains

Interferon regulatory factor-3 IRF tryptophan pentad repeat

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7FGY2-F1-model_v2	AlphaFold	F7FGY2	1-456	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307828	AgrOrtholog
BioCyc Gene	G2FUF-56966	BioCyc
Ensembl Genes	ENSRNOG00000017414	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000023504	ENTREZGENE
	ENSRNOP00000023504.6	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023504	ENTREZGENE
	ENSRNOT00000023504.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	2.60.200.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7442863	IMAGE-MGC_LOAD
InterPro	Interferon_regulatory_fac_CS	UniProtKB/TrEMBL
	Interferon_regulatory_factor	UniProtKB/TrEMBL
	Interferon_regulatory_factor-3	UniProtKB/TrEMBL
	SMAD_dom-like	UniProtKB/TrEMBL
	SMAD_FHA_domain	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:293624	UniProtKB/TrEMBL
MGC_CLONE	MGC:125013	IMAGE-MGC_LOAD
NCBI Gene	293624	ENTREZGENE
PANTHER	INTERFERON REGULATORY FACTOR	UniProtKB/TrEMBL
	INTERFERON REGULATORY FACTOR 7	UniProtKB/TrEMBL
Pfam	IRF	UniProtKB/TrEMBL
	IRF-3	UniProtKB/TrEMBL
PhenoGen	Irf7	PhenoGen
PRINTS	INTFRNREGFCT	UniProtKB/TrEMBL
PROSITE	IRF	UniProtKB/TrEMBL
	IRF_2	UniProtKB/TrEMBL
SMART	IRF	UniProtKB/TrEMBL
	IRF-3	UniProtKB/TrEMBL
Superfamily-SCOP	SMAD_FHA	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
UniProt	A6HXS3_RAT	UniProtKB/TrEMBL
	A6HXS4_RAT	UniProtKB/TrEMBL
	A6HXS5_RAT	UniProtKB/TrEMBL
	A6HXS6_RAT	UniProtKB/TrEMBL
	A6HXS7_RAT	UniProtKB/TrEMBL
	A6HXS9_RAT	UniProtKB/TrEMBL
	A6HXT0_RAT	UniProtKB/TrEMBL
	F7FGY2	ENTREZGENE
	Q3SWU2	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F7FGY2	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Irf7	interferon regulatory factor 7	Irf7_predicted	interferon regulatory factor 7 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Irf7_predicted	interferon regulatory factor 7 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)