Noxo1 (NADPH oxidase organizer 1) - Rat Genome Database

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Gene: Noxo1 (NADPH oxidase organizer 1) Rattus norvegicus
Analyze
Symbol: Noxo1
Name: NADPH oxidase organizer 1
RGD ID: 1307802
Description: Predicted to enable enzyme binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in extracellular matrix disassembly and superoxide anion generation. Predicted to act upstream of or within superoxide metabolic process. Predicted to be located in plasma membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Orthologous to human NOXO1 (NADPH oxidase organizer 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC302976
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,226,473 - 14,230,541 (+)NCBIGRCr8
GRCr8 Ensembl1014,228,205 - 14,230,541 (+)EnsemblGRCr8 Ensembl
mRatBN7.21013,723,253 - 13,726,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,721,473 - 13,726,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,470,370 - 18,472,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,959,223 - 17,961,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,458,425 - 13,460,760 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,062,331 - 14,066,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,062,331 - 14,066,918 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,873,396 - 13,883,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,949,293 - 13,953,880 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,401,215 - 13,405,802 (+)NCBICelera
RGSC_v3.11013,951,607 - 13,953,686 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
membrane  (IEA)
NADPH oxidase complex  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12473664   PMID:16636067   PMID:17126813   PMID:19755710   PMID:23957209  


Genomics

Comparative Map Data
Noxo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,226,473 - 14,230,541 (+)NCBIGRCr8
GRCr8 Ensembl1014,228,205 - 14,230,541 (+)EnsemblGRCr8 Ensembl
mRatBN7.21013,723,253 - 13,726,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,721,473 - 13,726,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,470,370 - 18,472,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,959,223 - 17,961,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,458,425 - 13,460,760 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,062,331 - 14,066,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,062,331 - 14,066,918 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,873,396 - 13,883,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,949,293 - 13,953,880 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,401,215 - 13,405,802 (+)NCBICelera
RGSC_v3.11013,951,607 - 13,953,686 (+)NCBI
Cytogenetic Map10q12NCBI
NOXO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,978,917 - 1,981,469 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,978,917 - 1,984,192 (-)EnsemblGRCh38hg38GRCh38
GRCh37162,028,918 - 2,031,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,968,919 - 1,971,441 (-)NCBINCBI36Build 36hg18NCBI36
Build 34161,969,041 - 1,971,185NCBI
Celera162,241,097 - 2,243,619 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,952,984 - 1,955,616 (-)NCBIHuRef
CHM1_1162,028,847 - 2,031,478 (-)NCBICHM1_1
T2T-CHM13v2.0161,998,875 - 2,001,427 (-)NCBIT2T-CHM13v2.0
Noxo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,915,208 - 24,919,504 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,915,208 - 24,919,503 (+)EnsemblGRCm39 Ensembl
GRCm381724,696,234 - 24,700,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,696,234 - 24,700,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,833,179 - 24,837,475 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,425,835 - 24,428,127 (+)NCBIMGSCv36mm8
Celera1725,219,149 - 25,223,451 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.49NCBI
Noxo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,288,602 - 15,290,418 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,288,495 - 15,290,601 (+)NCBIChiLan1.0ChiLan1.0
NOXO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,363,137 - 2,368,378 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,144,784 - 6,150,025 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016720,087 - 725,567 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,067,946 - 2,072,948 (-)NCBIpanpan1.1PanPan1.1panPan2
NOXO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,951,926 - 38,956,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,953,741 - 38,956,115 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,191,984 - 40,195,824 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,269,312 - 39,273,152 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,270,759 - 39,274,133 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,945,755 - 38,949,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,918,395 - 38,922,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,397,281 - 39,401,122 (+)NCBIUU_Cfam_GSD_1.0
Noxo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,649,365 - 104,655,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,057,836 - 2,059,891 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,054,429 - 2,060,098 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOXO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,987,384 - 39,989,548 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,987,340 - 39,989,640 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,192,077 - 42,196,619 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOXO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,874,801 - 1,878,557 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,874,937 - 1,877,044 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,188,043 - 29,193,093 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Noxo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913279,130 - 282,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913280,502 - 282,723 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Noxo1
39 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:372
Count of miRNA genes:191
Interacting mature miRNAs:237
Transcripts:ENSRNOT00000029652
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH135372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,725,784 - 13,725,983 (+)MAPPERmRatBN7.2
Rnor_6.01014,066,642 - 14,066,840NCBIRnor6.0
Rnor_5.01013,882,865 - 13,883,063UniSTSRnor5.0
RGSC_v3.41013,953,604 - 13,953,802UniSTSRGSC3.4
Celera1013,405,526 - 13,405,724UniSTS
RH 3.4 Map10173.1UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 7 19 110 67 66 35 25 35 6 156 64 1 90 41 60 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000029652   ⟹   ENSRNOP00000033263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,228,205 - 14,230,541 (+)Ensembl
mRatBN7.2 Ensembl1013,721,473 - 13,726,061 (+)Ensembl
Rnor_6.0 Ensembl1014,062,331 - 14,066,918 (+)Ensembl
RefSeq Acc Id: NM_001393998   ⟹   NP_001380927
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,228,205 - 14,230,541 (+)NCBI
mRatBN7.21013,723,671 - 13,726,008 (+)NCBI
RefSeq Acc Id: XM_039085858   ⟹   XP_038941786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,226,473 - 14,230,541 (+)NCBI
mRatBN7.21013,723,257 - 13,726,008 (+)NCBI
RefSeq Acc Id: XM_039085860   ⟹   XP_038941788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,226,473 - 14,230,541 (+)NCBI
mRatBN7.21013,723,255 - 13,725,771 (+)NCBI
RefSeq Acc Id: XM_039085863   ⟹   XP_038941791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,228,329 - 14,230,541 (+)NCBI
mRatBN7.21013,723,795 - 13,726,008 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380927 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941786 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941788 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941791 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03860 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033263
  ENSRNOP00000033263.4
Ensembl Acc Id: ENSRNOP00000033263   ⟸   ENSRNOT00000029652
RefSeq Acc Id: XP_038941788   ⟸   XM_039085860
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941786   ⟸   XM_039085858
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941791   ⟸   XM_039085863
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001380927   ⟸   NM_001393998
- UniProtKB: D4ACU5 (UniProtKB/TrEMBL)
Protein Domains
PX   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACU5-F1-model_v2 AlphaFold D4ACU5 1-235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307802 AgrOrtholog
BioCyc Gene G2FUF-25834 BioCyc
Ensembl Genes ENSRNOG00000025117 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029652 ENTREZGENE
  ENSRNOT00000029652.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1520.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro IPR001683 UniProtKB/TrEMBL
  NADPH_Oxidase/PX-Domain UniProtKB/TrEMBL
  NoxO1_SH3_2 UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 302976 ENTREZGENE
PANTHER NADPH OXIDASE ORGANIZER 1 UniProtKB/TrEMBL
  SH3 MULTIPLE DOMAIN UniProtKB/TrEMBL
Pfam PF00787 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Noxo1 PhenoGen
PROSITE PS50195 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025117 RatGTEx
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP 64268 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
UniProt D4ACU5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Noxo1  NADPH oxidase organizer 1   Noxo1_predicted  NADPH oxidase organizer 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Noxo1_predicted  NADPH oxidase organizer 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED