Anxa8 (annexin A8) - Rat Genome Database

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Gene: Anxa8 (annexin A8) Rattus norvegicus
Analyze
Symbol: Anxa8
Name: annexin A8
RGD ID: 1307719
Description: Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in endosomal transport and endosome organization. Predicted to be located in cytosol; late endosome membrane; and plasma membrane. Predicted to be active in cytoplasm; sarcolemma; and vesicle membrane. Orthologous to several human genes including ANXA8 (annexin A8); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: annexin VIII; annexin-8; LOC306283; MGC116246
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,403,267 - 9,418,317 (+)NCBIGRCr8
mRatBN7.2169,397,144 - 9,412,072 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,397,113 - 9,412,043 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,416,681 - 9,431,616 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,561,386 - 10,576,325 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,411,746 - 9,426,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,417,174 - 10,432,388 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,417,185 - 10,432,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,737,501 - 8,752,773 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,715,644 - 9,730,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,715,608 - 9,730,490 (+)NCBI
Celera165,797,809 - 5,812,655 (-)NCBICelera
Cytogenetic Map16p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cytarabine  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxifluridine  (ISO)
ethanol  (ISO)
folic acid  (ISO)
genistein  (ISO)
ibuprofen  (ISO)
isobutanol  (ISO)
lipopolysaccharide  (ISO)
methylarsonic acid  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8. Karanjawala ZE, etal., Am J Surg Pathol. 2008 Feb;32(2):188-96.
3. ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma. Lee MJ, etal., Gastroenterology. 2009 Sep;137(3):1138-50, 1150.e1-9. Epub 2009 Apr 16.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:2530088   PMID:12477932   PMID:15489334   PMID:15644210   PMID:16638567   PMID:18923148  


Genomics

Comparative Map Data
Anxa8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,403,267 - 9,418,317 (+)NCBIGRCr8
mRatBN7.2169,397,144 - 9,412,072 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,397,113 - 9,412,043 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,416,681 - 9,431,616 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,561,386 - 10,576,325 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,411,746 - 9,426,672 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,417,174 - 10,432,388 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,417,185 - 10,432,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,737,501 - 8,752,773 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,715,644 - 9,730,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,715,608 - 9,730,490 (+)NCBI
Celera165,797,809 - 5,812,655 (-)NCBICelera
Cytogenetic Map16p15NCBI
ANXA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381047,467,993 - 47,991,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1047,460,162 - 47,484,158 (-)EnsemblGRCh38hg38GRCh38
GRCh371048,255,247 - 48,271,369 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361047,875,231 - 47,891,375 (+)NCBINCBI36Build 36hg18NCBI36
Build 341047,217,012 - 47,233,044NCBI
Cytogenetic Map10q11.22NCBI
HuRef1043,018,066 - 43,029,984 (+)NCBIHuRef
CHM1_11048,417,242 - 48,433,403 (+)NCBICHM1_1
T2T-CHM13v2.01048,359,294 - 48,840,973 (-)NCBIT2T-CHM13v2.0
Anxa8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,807,936 - 33,822,528 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,807,938 - 33,822,528 (+)EnsemblGRCm39 Ensembl
GRCm381434,085,979 - 34,100,571 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,085,981 - 34,100,571 (+)EnsemblGRCm38mm10GRCm38
MGSCv371434,899,176 - 34,913,757 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,915,077 - 32,929,663 (+)NCBIMGSCv36mm8
MGSCv361429,195,890 - 29,210,476 (+)NCBIMGSCv36mm8
Celera1430,348,562 - 30,363,455 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI

Variants

.
Variants in Anxa8
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:330
Count of miRNA genes:205
Interacting mature miRNAs:233
Transcripts:ENSRNOT00000027464
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH141108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,411,680 - 9,411,860 (+)MAPPERmRatBN7.2
Rnor_6.01610,431,997 - 10,432,176NCBIRnor6.0
Rnor_5.0168,752,382 - 8,752,561UniSTSRnor5.0
RGSC_v3.4169,730,193 - 9,730,372UniSTSRGSC3.4
Celera165,798,021 - 5,798,200UniSTS
RH 3.4 Map10157.6UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 8 8 2 11
Low 23 21 17 5 17 5 5 26 29 19 5
Below cutoff 18 26 22 6 22 3 6 46 6 18 3

Sequence


RefSeq Acc Id: ENSRNOT00000082186   ⟹   ENSRNOP00000069969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,397,113 - 9,412,043 (+)Ensembl
Rnor_6.0 Ensembl1610,417,185 - 10,432,393 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111644   ⟹   ENSRNOP00000087636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,401,388 - 9,412,043 (+)Ensembl
RefSeq Acc Id: NM_001031654   ⟹   NP_001026824
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,403,387 - 9,418,317 (+)NCBI
mRatBN7.2169,397,144 - 9,412,072 (+)NCBI
Rnor_6.01610,417,275 - 10,432,388 (+)NCBI
Rnor_5.0168,737,501 - 8,752,773 (+)NCBI
RGSC_v3.4169,715,644 - 9,730,584 (+)RGD
Celera165,797,809 - 5,812,655 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094474   ⟹   XP_038950402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,403,332 - 9,417,846 (+)NCBI
mRatBN7.2169,397,616 - 9,412,072 (+)NCBI
RefSeq Acc Id: XM_063275365   ⟹   XP_063131435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,403,267 - 9,417,846 (+)NCBI
RefSeq Acc Id: NP_001026824   ⟸   NM_001031654
- UniProtKB: Q4FZU6 (UniProtKB/Swiss-Prot),   A0A8I6A7L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069969   ⟸   ENSRNOT00000082186
RefSeq Acc Id: XP_038950402   ⟸   XM_039094474
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A7L2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087636   ⟸   ENSRNOT00000111644
RefSeq Acc Id: XP_063131435   ⟸   XM_063275365
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7L2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZU6-F1-model_v2 AlphaFold Q4FZU6 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699954
Promoter ID:EPDNEW_R10478
Type:initiation region
Name:Anxa8_1
Description:annexin A8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,417,213 - 10,417,273EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307719 AgrOrtholog
BioCyc Gene G2FUF-12077 BioCyc
Ensembl Genes ENSRNOG00000060949 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010413 UniProtKB/Swiss-Prot
  ENSRNOG00060013185 UniProtKB/Swiss-Prot
  ENSRNOG00065014015 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082186.2 UniProtKB/Swiss-Prot
  ENSRNOT00000111644.1 UniProtKB/TrEMBL
  ENSRNOT00055017617 UniProtKB/Swiss-Prot
  ENSRNOT00060022468 UniProtKB/Swiss-Prot
  ENSRNOT00065023146 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460531 IMAGE-MGC_LOAD
InterPro Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANX8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306283 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116246 IMAGE-MGC_LOAD
NCBI Gene 306283 ENTREZGENE
PANTHER ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10502:SF133 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Anxa8 PhenoGen
PRINTS ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXINVIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060949 RatGTEx
  ENSRNOG00055010413 RatGTEx
  ENSRNOG00060013185 RatGTEx
  ENSRNOG00065014015 RatGTEx
SMART ANX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7L2 ENTREZGENE, UniProtKB/TrEMBL
  A6KFT2_RAT UniProtKB/TrEMBL
  ANXA8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Anxa8  annexin A8  Anxa8_predicted  annexin A8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Anxa8_predicted  annexin A8 (predicted)      Symbol and Name status set to approved 70820 APPROVED