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Gene: Ctsg (cathepsin G) Rattus norvegicus

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Symbol:

Ctsg

Name:

cathepsin G

RGD ID:

1307681

Description:

Predicted to enable several functions, including caspase binding activity; heparin binding activity; and serine-type endopeptidase activity. Predicted to be involved in several processes, including biofilm matrix disassembly; defense response to bacterium; and regulation of cell-cell adhesion. Predicted to act upstream of or within defense response to fungus; positive regulation of immune response; and response to bacterium. Predicted to be located in several cellular components, including cytoplasmic stress granule; lysosome; and secretory granule. Predicted to be active in extracellular space. Orthologous to human CTSG (cathepsin G); PARTICIPATES IN Entamoebiasis pathway; renin-angiotensin cascade pathway; systemic lupus erythematosus pathway; INTERACTS WITH anilines; bisphenol A; bortezomib.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC290257

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTSG (cathepsin G)	HGNC	EggNOG, Ensembl, HomoloGene, OrthoDB, Treefam
Mus musculus (house mouse):	Ctsg (cathepsin G)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CTSG (cathepsin G)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTSG (cathepsin G)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100154047 (cathepsin G)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTSG (cathepsin G)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UBA6 (ubiquitin like modifier activating enzyme 6)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CTSG (cathepsin G)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CTSG (cathepsin G)	Alliance	DIOPT (HGNC\|PhylomeDB)
Mus musculus (house mouse):	Ctsg (cathepsin G)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gzm3.2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ctsg	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,901,230 - 33,907,596 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	33,901,754 - 33,907,596 (-)	Ensembl				GRCr8
mRatBN7.2	15	29,930,988 - 29,937,353 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,931,003 - 29,937,353 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	31,780,745 - 31,783,332 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,927,946 - 32,930,533 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	31,186,079 - 31,188,666 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	35,107,333 - 35,113,678 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	35,111,091 - 35,113,678 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	38,994,558 - 39,000,903 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	34,622,211 - 34,624,798 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	29,509,460 - 29,512,047 (-)	NCBI		Celera
RGSC_v3.1	15	34,637,918 - 34,648,441 (-)	NCBI
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Reperfusion Injury (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

(-)-trans-epsilon-viniferin (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

anilines (EXP,ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bortezomib (EXP)

Butylbenzyl phthalate (ISO)

cannabidiol (ISO)

chlorpyrifos (ISO)

corn oil (EXP)

Cyclosporin H (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dimethylarsinic acid (ISO)

doxorubicin (ISO)

gallic acid (EXP)

genistein (ISO)

Honokiol (ISO)

methotrexate (ISO)

N-formyl-L-methionyl-L-leucyl-L-phenylalanine (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

potassium dichromate (ISO)

senecionine (ISO)

sulforaphane (ISO)

vanadyl sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibacterial humoral response (IEA)

biofilm matrix disassembly (IEA,ISO,ISS)

cellular response to lipopolysaccharide (IEA)

chemotaxis (IEA)

defense response to bacterium (IEA)

defense response to fungus (ISO)

defense response to Gram-negative bacterium (IEA,ISO,ISS)

defense response to Gram-positive bacterium (IEA,ISO,ISS)

monocyte chemotaxis (IEA,ISO,ISS)

negative regulation of T cell activation (IEA,ISO,ISS)

neutrophil activation (IEA,ISO,ISS)

neutrophil-mediated killing of gram-positive bacterium (ISO)

platelet activation (IEA,ISO,ISS)

positive regulation of immune response (ISO)

positive regulation of platelet aggregation (IEA,ISO,ISS)

protein maturation (IBA)

protein processing (IEA,ISO,ISS)

proteolysis (IEA,ISO,ISS)

response to lipopolysaccharide (ISO)

signal transduction (IEA)

Cellular Component

cytoplasmic stress granule (IEA,ISO)

cytosol (IEA,ISO,ISS)

extracellular region (IEA)

extracellular space (IBA,IEA,ISO,ISS)

lysosome (IEA,ISO,ISS)

membrane (IEA,ISO,ISS)

nucleus (IEA,ISO,ISS)

plasma membrane (IEA,ISO)

secretory granule (IEA,ISO)

Molecular Function

caspase binding (IEA,ISO,ISS)

heparin binding (IEA,ISO)

hydrolase activity (IEA)

peptidase activity (IEA,ISO)

protein binding (ISO)

receptor ligand activity (IEA,ISO,ISS)

serine-type endopeptidase activity (IBA,IEA,ISO,ISS)

serine-type peptidase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Entamoebiasis pathway (IEA)

renin-angiotensin cascade pathway (IEA)

systemic lupus erythematosus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cathepsin g is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys.	Shimoda N, etal., Am J Pathol. 2007 Mar;170(3):930-40.

Additional References at PubMed

PMID:1861080	PMID:1937776	PMID:2222858	PMID:8194606	PMID:8573071	PMID:10512690	PMID:10714686	PMID:11907569	PMID:12504904	PMID:16690621	PMID:17975113	PMID:19056867
PMID:20551380	PMID:21630459	PMID:21904640	PMID:23376485	PMID:23533145	PMID:26270939	PMID:27068509	PMID:27559042

Genomics

Comparative Map Data

Ctsg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,901,230 - 33,907,596 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	33,901,754 - 33,907,596 (-)	Ensembl				GRCr8
mRatBN7.2	15	29,930,988 - 29,937,353 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,931,003 - 29,937,353 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	31,780,745 - 31,783,332 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,927,946 - 32,930,533 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	31,186,079 - 31,188,666 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	35,107,333 - 35,113,678 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	35,111,091 - 35,113,678 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	38,994,558 - 39,000,903 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	34,622,211 - 34,624,798 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	29,509,460 - 29,512,047 (-)	NCBI		Celera
RGSC_v3.1	15	34,637,918 - 34,648,441 (-)	NCBI
Cytogenetic Map	15	p12	NCBI

CTSG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,573,518 - 24,576,250 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,573,518 - 24,576,250 (-)	Ensembl			hg38	GRCh38
GRCh37	14	25,042,724 - 25,045,456 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	24,112,564 - 24,115,306 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	24,112,563 - 24,115,306	NCBI
Celera	14	4,907,510 - 4,910,252 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	5,157,531 - 5,160,273 (-)	NCBI		HuRef
CHM1_1	14	25,041,620 - 25,044,362 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,772,405 - 18,775,137 (-)	NCBI		T2T-CHM13v2.0

Ctsg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	56,337,342 - 56,340,031 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	56,337,338 - 56,340,031 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	56,099,885 - 56,102,574 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	56,099,881 - 56,102,574 (-)	Ensembl			mm10	GRCm38
MGSCv37	14	56,718,718 - 56,721,411 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	55,053,952 - 55,056,645 (-)	NCBI		MGSCv36	mm8
Celera	14	53,905,080 - 53,907,773 (-)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

CTSG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,921,107 - 25,923,838 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	25,137,599 - 25,140,330 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,342,517 - 5,345,218 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,466,259 - 23,468,960 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,466,265 - 23,468,960 (-)	Ensembl			panPan2	panpan1.1

CTSG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,483,327 - 4,485,933 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,470,577 - 4,512,628 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,404,974 - 4,407,573 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,594,740 - 4,597,337 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,582,079 - 4,597,280 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,284,216 - 4,286,825 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,346,800 - 4,349,397 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,609,195 - 4,611,806 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC100154047
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	7	74,761,602 - 74,772,950 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	79,789,517 - 79,792,248 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTSG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,518,004 - 1,521,980 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,518,119 - 1,520,709 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666036	13,210,626 - 13,213,332 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Ctsg
31 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	102
Count of miRNA genes:	82
Interacting mature miRNAs:	86
Transcripts:	ENSRNOT00000059677
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2315759	47315759	Rat
5684946	Bss98	Bone structure and strength QTL 98	3.9	0.0026	tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	15	1	39411584	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	44836456	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2315759	53331089	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	31855803	92671517	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	22728353	42072050	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	28527732	73527732	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	25285835	104695021	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	22336351	52597086	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	25285835	104695021	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	19155762	87086765	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	2785923	47785923	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	14926594	71614418	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	22336351	67336351	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	25285835	104695021	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
8	2	8	24	48	52	36	28	36	1	111	48	11	12	18	37	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000059677 ⟹ ENSRNOP00000056429

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	33,901,754 - 33,907,596 (-)	Ensembl
mRatBN7.2 Ensembl	15	29,931,003 - 29,937,353 (-)	Ensembl
Rnor_6.0 Ensembl	15	35,111,091 - 35,113,678 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133635 ⟹ ENSRNOP00000098890

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	33,905,009 - 33,907,047 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000150390 ⟹ ENSRNOP00000098990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	33,905,009 - 33,907,596 (-)	Ensembl

RefSeq Acc Id:

NM_001106041 ⟹ NP_001099511

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,905,009 - 33,907,596 (-)	NCBI
mRatBN7.2	15	29,934,766 - 29,937,353 (-)	NCBI
Rnor_6.0	15	35,111,091 - 35,113,678 (-)	NCBI
Rnor_5.0	15	38,994,558 - 39,000,903 (-)	NCBI
RGSC_v3.4	15	34,622,211 - 34,624,798 (-)	RGD
Celera	15	29,509,460 - 29,512,047 (-)	RGD

Sequence:

show sequence

ACGAAACCTATCACGGGAGCAGGGAAATGGACCTGTGGTCCCTCAGCACACCCTTCCTTCCTCT
CCAGGGGAGGATAAAAGTCTGGCAGAGAAAAGTAAAAGCAGCAGCTGACTTAGCAACGGTTCTG
GAAAGATGCAGCCACTCCTGTTTCTGTTGATCTTTGTTCTATTCCAAGAAGATGAGGCAGGAAA
GATCATTGGAGGCCGAGAAGCCAGGCCAAATTCCCACCCCTACATGGCATTTCTTCTGATCCAG
AGTCCAGAAGGGCTGAGTGCTTGTGGAGGGTTTCTGGTGCGAGAAGACTTTGTCCTCACAGCAG
GTCACTGCTTTGGAAGCTCCATAAATGTTACCCTAGGGGCCCACAACATTCGAAGGCAAGAAGG
GACCCAGCAACACATCACTGTTCTCAGAGCCATCCGCCATCCTGATTACAATCCCCCGCCAGTC
ATCCAGAATGACATCATGCTACTGCAGCTGAGGAGTAGAGCCCGGAGGAGTCGAGCGGTGAAGC
CCGTGGCTCTGCCTCAAGCCACCAAGAGAGTACAACCAGGGGCTTTGTGCACAGTGGCTGGCTG
GGGCCTGGTGAGCCAGCGCAGGGGGACAAATGTACTCCAGGAGGTGAAGCTAAGAGTGCAGACG
GACCAAACGTGCGCCAATCGTTTCCAATTCTACAACAGCCAGACTCAGATCTGTGTGGGAAACC
CGAGAGAAAGGAAGTCTGCCTTCAAGGGTGATTCTGGTGGTCCTCTGGTATGTAATAATGTGGC
CCAGGGCATCGTCTCCTATGGAAGCAGCAGTGGTAACCCTCCAGCTGTGTTCACCAGAATCCAG
AGCTTCATGCCCTGGATCAAAAGAACAATGAGACGTCTTTCCTCAAGGTATTAGGGACTTGCTG
ACTCCCTGTCTCAGACGTAGACCAGCTTTAGGGAATTTCCATAGCCCTTATTAATGTCTCCTGG
ACAGTGTAAATTTTCATTTATTAAATATCATTTGGCACTGTCTTAA

hide sequence

RefSeq Acc Id:

XM_006252041 ⟹ XP_006252103

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,901,230 - 33,907,546 (-)	NCBI
mRatBN7.2	15	29,930,988 - 29,937,303 (-)	NCBI
Rnor_6.0	15	35,107,333 - 35,113,590 (-)	NCBI
Rnor_5.0	15	38,994,558 - 39,000,903 (-)	NCBI

Sequence:

show sequence

GAGAAAAGTAAAAGCAGCAGCTGACTTAGCAACGGTTCTGGAAAGATGCAGCCACTCCTGTTTC
TGTTGATCTTTGTTCTATTCCAAGAAGATGAGGCAGGAAAGATCATTGGAGGCCGAGAAGCCAG
GCCAAATTCCCACCCCTACATGGCATTTCTTCTGATCCAGAGTCCAGAAGGGCTGAGTGCTTGT
GGAGGGTTTCTGGTGCGAGAAGACTTTGTCCTCACAGCAGGTCACTGCTTTGGAAGCTCCATAA
ATGTTACCCTAGGGGCCCACAACATTCGAAGGCAAGAAGGGACCCAGCAACACATCACTGTTCT
CAGAGCCATCCGCCATCCTGATTACAATCCCCCGCCAGTCATCCAGAATGACATCATGCTACTG
CAGCTGAGGAGTAGAGCCCGGAGGAGTCGAGCGGTGAAGCCCGTGGCTCTGCCTCAAGCCACCA
AGAGAGTACAACCAGGGGCTTTGTGCACAGTGGCTGGCTGGGGCCTGGTGAGCCAGCGCAGGGG
GACAAATGTACTCCAGGAGGTGAAGCTAAGAGTGCAGACGGACCAAACGTGCGCCAATCGTTTC
CAATTCTACAACAGCCAGACTCAGATCTGTGTGGGAAACCCGAGAGAAAGGAAGTCTGCCTTCA
AGGGTGATTCTGGTGGTCCTCTGGTATGTAATAATGTGGCCCAGGGCATCGTCTCCTATGGAAG
CAGCAGTGGTAACCCTCCAGCTGTGTTCACCAGAATCCAGAGCTTCATGCCCTGGATCAAAAGA
ACAATGAGACGTCTTTCCTCAAGCAAAGAGGATTCTAAGCTGGATTCTAAGCAAGGTCCTGGGC
ATCCATCCAAGTTCAAAAGCAATGAAACCCTAACAAGACAAAAACTATCACTTTTAAAAGAGGA
TAATTAAGGATACAGGGTTATACACAGATGTGAGTCCCAGACAATGGAGTGATCATCGTAGGCC
TCAAGAACTCTACAGAACCAGGACTGCCTTGTCCACACTCCTCTACTAGAAAAATTTCCTTCTC
ACACTCATTTTTCTTCCAAATCTGTTTGTGTGGTCACCCAGGCCCCTCTGACATGGTCTGGGGA
GGATATTGCACGTGAGACCATGTGGTCTCACATCCTGCCCCTGAACTGATTATCACCCGCACAT
CTCCAGCAAGCGGTAGAATTTGAACGGCCTGTTATCTTCAGGAATCTATTGCTGCAACTCTCCA
CATTTGAACTACTCAGTTCTGGAACCTAAGGAGGAAGAGAAAAAGAAGAATGTGGGGACTTATA
TTGGCGCTGCAGTCACTCATATTGTGGGTGGGAGTGAGGCCCAGGAGATACAGCAGAGGTGACC
TCAAAAGTTCAAGGAAAGACCTCTGTCAAAAATAAAAGTTCAATAAATGTCTTACTGGCTAA

hide sequence

RefSeq Acc Id:

XM_039093138 ⟹ XP_038949066

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,901,230 - 33,907,546 (-)	NCBI
mRatBN7.2	15	29,930,988 - 29,937,303 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099511	(Get FASTA)	NCBI Sequence Viewer
	XP_006252103	(Get FASTA)	NCBI Sequence Viewer
	XP_038949066	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM14312	(Get FASTA)	NCBI Sequence Viewer
	EDM14313	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000056429
	ENSRNOP00000098990
GenBank Protein	P17977	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001099511 ⟸ NM_001106041
- Peptide Label:	precursor
- UniProtKB:	P17977 (UniProtKB/Swiss-Prot), G3V9Q7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQPLLFLLIFVLFQEDEAGKIIGGREARPNSHPYMAFLLIQSPEGLSACGGFLVREDFVLTAGH CFGSSINVTLGAHNIRRQEGTQQHITVLRAIRHPDYNPPPVIQNDIMLLQLRSRARRSRAVKPV ALPQATKRVQPGALCTVAGWGLVSQRRGTNVLQEVKLRVQTDQTCANRFQFYNSQTQICVGNPR ERKSAFKGDSGGPLVCNNVAQGIVSYGSSSGNPPAVFTRIQSFMPWIKRTMRRLSSRY hide sequence

RefSeq Acc Id:	XP_006252103 ⟸ XM_006252041
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5XFF7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQPLLFLLIFVLFQEDEAGKIIGGREARPNSHPYMAFLLIQSPEGLSACGGFLVREDFVLTAGH CFGSSINVTLGAHNIRRQEGTQQHITVLRAIRHPDYNPPPVIQNDIMLLQLRSRARRSRAVKPV ALPQATKRVQPGALCTVAGWGLVSQRRGTNVLQEVKLRVQTDQTCANRFQFYNSQTQICVGNPR ERKSAFKGDSGGPLVCNNVAQGIVSYGSSSGNPPAVFTRIQSFMPWIKRTMRRLSSSKEDSKLD SKQGPGHPSKFKSNETLTRQKLSLLKEDN hide sequence

Ensembl Acc Id:

ENSRNOP00000056429 ⟸ ENSRNOT00000059677

RefSeq Acc Id:	XP_038949066 ⟸ XM_039093138
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000098890 ⟸ ENSRNOT00000133635

Ensembl Acc Id:

ENSRNOP00000098990 ⟸ ENSRNOT00000150390

Protein Domains

Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P17977-F1-model_v2	AlphaFold	P17977	1-250	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307681	AgrOrtholog
BioCyc Gene	G2FUF-13662	BioCyc
Ensembl Genes	ENSRNOG00000020647	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000059677	ENTREZGENE
	ENSRNOT00000150390	ENTREZGENE
Gene3D-CATH	2.40.10.10	UniProtKB/Swiss-Prot
InterPro	Peptidase_S1_PA	UniProtKB/Swiss-Prot
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot
	Peptidase_S1A	UniProtKB/Swiss-Prot
	Trypsin_dom	UniProtKB/Swiss-Prot
	TRYPSIN_HIS	UniProtKB/Swiss-Prot
	TRYPSIN_SER	UniProtKB/Swiss-Prot
KEGG Report	rno:290257	UniProtKB/Swiss-Prot
NCBI Gene	290257	ENTREZGENE
PANTHER	CATHEPSIN G	UniProtKB/Swiss-Prot
	KALLIKREIN-RELATED	UniProtKB/Swiss-Prot
Pfam	Trypsin	UniProtKB/Swiss-Prot
PharmGKB	CTSG	RGD
PhenoGen	Ctsg	PhenoGen
PRINTS	CHYMOTRYPSIN	UniProtKB/Swiss-Prot
PROSITE	TRYPSIN_DOM	UniProtKB/Swiss-Prot
	TRYPSIN_HIS	UniProtKB/Swiss-Prot
	TRYPSIN_SER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000020647	RatGTEx
SMART	Tryp_SPc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50494	UniProtKB/Swiss-Prot
UniProt	A0A8I5XFF7	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LCH4_RAT	UniProtKB/TrEMBL
	CATG_RAT	UniProtKB/Swiss-Prot
	G3V9Q7	ENTREZGENE
	P17977	ENTREZGENE
UniProt Secondary	G3V9Q7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Ctsg	cathepsin G	Ctsg_predicted	cathepsin G (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ctsg_predicted	cathepsin G (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)