Hrnr (hornerin) - Rat Genome Database

Name: Hrnr
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Hrnr (hornerin) Rattus norvegicus

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Symbol:

Hrnr

Name:

hornerin

RGD ID:

1307660

Description:

Predicted to be involved in cell envelope organization and establishment of skin barrier. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in keratohyalin granule and perinuclear region of cytoplasm. Predicted to be active in cornified envelope. Orthologous to human HRNR (hornerin); INTERACTS WITH 1,2-dichloroethane (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 2-hydroxypropanoic acid (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC310587; RGD1307660; similar to hornerin

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HRNR (hornerin)	HGNC	NCBI
Mus musculus (house mouse):	Hrnr (hornerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HRNR (hornerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC119863999 (hornerin-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HRNR (hornerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HRNR (hornerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Hrnr (hornerin)	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HRNR (hornerin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	181,650,772 - 181,663,633 (+)	NCBI		GRCr8
Rnor_6.0	2	193,626,283 - 193,639,848 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	193,627,243 - 193,634,181 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	211,227,940 - 211,239,721 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	186,393,623 - 186,405,265 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	186,342,966 - 186,355,371 (+)	NCBI
Celera	2	171,314,820 - 171,318,755 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Epidermolysis Bullosa Simplex 5D with Nail Dystrophy (ISO)

gastrointestinal stromal tumor (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

benzo[a]pyrene (ISO)

beta-damascenone (ISO)

cadmium atom (ISO)

cisplatin (ISO)

dioxygen (ISO)

enzyme inhibitor (ISO)

folic acid (ISO)

glyphosate (ISO)

ivermectin (ISO)

lead(0) (ISO)

nickel atom (ISO)

potassium dichromate (ISO)

rac-lactic acid (ISO)

titanium dioxide (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell envelope organization (ISO)

establishment of skin barrier (ISO)

hematopoietic progenitor cell differentiation (ISO)

Cellular Component

cornified envelope (ISO)

cytoplasm (ISO)

keratohyalin granule (ISO)

perinuclear region of cytoplasm (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11572870	PMID:21282207	PMID:21362503	PMID:21630459	PMID:21700703	PMID:23403047	PMID:24029230

Genomics

Comparative Map Data

Hrnr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	181,650,772 - 181,663,633 (+)	NCBI		GRCr8
Rnor_6.0	2	193,626,283 - 193,639,848 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	193,627,243 - 193,634,181 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	211,227,940 - 211,239,721 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	186,393,623 - 186,405,265 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	186,342,966 - 186,355,371 (+)	NCBI
Celera	2	171,314,820 - 171,318,755 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

HRNR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	152,212,076 - 152,224,193 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	152,212,076 - 152,224,193 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	152,184,552 - 152,196,669 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	150,451,182 - 150,463,293 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	125,299,240 - 125,308,530 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	123,561,504 - 123,570,799 (-)	NCBI		HuRef
CHM1_1	1	153,579,878 - 153,592,041 (-)	NCBI		CHM1_1

Hrnr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	93,227,056 - 93,240,879 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	93,227,056 - 93,240,877 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	93,319,749 - 93,333,572 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	93,319,749 - 93,333,570 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	93,123,671 - 93,137,494 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	93,405,958 - 93,418,975 (+)	NCBI		MGSCv36	mm8
Celera	3	93,772,386 - 93,778,017 (-)	NCBI		Celera
Celera	3	95,066,507 - 95,070,752 (-)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.39	NCBI

HRNR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	97,599,034 - 97,614,267 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	97,350,236 - 97,362,876 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	127,570,653 - 127,583,285 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LOC119863999
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ROS_Cfam_1.0	17	62,211,458 - 62,220,185 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	17	61,039,431 - 61,048,151 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	61,126,410 - 61,133,175 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	61,854,570 - 61,863,299 (-)	NCBI		UU_Cfam_GSD_1.0

HRNR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	4	96,983,596 - 96,992,606 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

HRNR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	11,439,492 - 11,442,174 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	10,984,280 - 10,996,449 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
3	5	1	30	24	31	9	13	9	6	43	19	20	7	25	22

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001433676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000082934 ⟹ ENSRNOP00000072004

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	193,627,243 - 193,634,181 (+)	Ensembl

RefSeq Acc Id:

XM_063282905 ⟹ XP_063138975

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	181,650,772 - 181,663,633 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001420605	(Get FASTA)	NCBI Sequence Viewer
	XP_063138975	(Get FASTA)	NCBI Sequence Viewer

Ensembl Acc Id:

ENSRNOP00000072004 ⟸ ENSRNOT00000082934

RefSeq Acc Id:

XP_063138975 ⟸ XM_063282905

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K1V9-F1-model_v2	AlphaFold	A0A0G2K1V9	1-876	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307660	AgrOrtholog
Ensembl Genes	ENSRNOG00000053250	Ensembl
NCBI Gene	Hrnr	ENTREZGENE
PhenoGen	Hrnr	PhenoGen
RatGTEx	ENSRNOG00000053250	RatGTEx

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-09	Hrnr	hornerin	RGD1307660	similar to hornerin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1307660	similar to hornerin	RGD1307660_predicted	similar to hornerin (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1307660_predicted	similar to hornerin (predicted)	LOC310587_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC310587_predicted	similar to hornerin (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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