Brip1 (BRCA1 interacting helicase 1) - Rat Genome Database

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Gene: Brip1 (BRCA1 interacting helicase 1) Rattus norvegicus
Analyze
Symbol: Brip1
Name: BRCA1 interacting helicase 1
RGD ID: 1307659
Description: Enables chromatin binding activity. Involved in several processes, including cellular response to angiotensin; cellular response to hypoxia; and cellular response to vitamin. Predicted to be located in cytoplasm; nuclear membrane; and nucleoplasm. Predicted to be part of BRCA1-B complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Orthologous to human BRIP1 (BRCA1 interacting helicase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BRCA1 interacting protein C-terminal helicase 1; LOC360588
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,402,035 - 71,528,083 (-)NCBIGRCr8
mRatBN7.21070,907,266 - 71,031,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1070,907,371 - 71,030,324 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01073,507,009 - 73,632,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,507,100 - 73,629,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,408,318 - 73,533,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,313,004 - 74,436,532 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11074,327,690 - 74,448,583 (-)NCBI
Celera1069,829,617 - 69,953,629 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
FR900359  (ISO)
furan  (EXP)
Lasiocarpine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
monocrotaline  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenethyl isothiocyanate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
riddelliine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
BRCA1-B complex  (ISO)
cytoplasm  (ISO)
nuclear membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)
replication fork  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure. Balacescu O, etal., BMC Cancer. 2014 Apr 8;14:246. doi: 10.1186/1471-2407-14-246.
2. The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. Barroso E, etal., Breast Cancer Res Treat. 2009 Dec;118(3):655-60. doi: 10.1007/s10549-009-0439-5. Epub 2009 Jun 18.
3. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cantor SB, etal., Cell. 2001 Apr 6;105(1):149-60.
4. Mutation analysis of BRIP1/BACH1 in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives. Cao AY, etal., Breast Cancer Res Treat. 2009 May;115(1):51-5. doi: 10.1007/s10549-008-0052-z. Epub 2008 May 16.
5. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. Di Domenico F, etal., J Alzheimers Dis. 2015;44(4):1107-20. doi: 10.3233/JAD-141254.
6. Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy. Eelen G, etal., Oncogene. 2008 Jul 10;27(30):4233-41. doi: 10.1038/onc.2008.51. Epub 2008 Mar 17.
7. The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer. Esteban-Jurado C, etal., Eur J Hum Genet. 2016 May 11. doi: 10.1038/ejhg.2016.44.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Clinical characteristics and genetic subtypes of Fanconi anemia in Saudi patients. Ghazwani Y, etal., Cancer Genet. 2016 Apr;209(4):171-6. doi: 10.1016/j.cancergen.2016.02.003. Epub 2016 Feb 15.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Bach1 modulates heme oxygenase-1 expression in the neonatal mouse lung. Kassovska-Bratinova S, etal., Pediatr Res. 2009 Feb;65(2):145-9. doi: 10.1203/PDR.0b013e318191eedc.
12. Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. Kitamuro T, etal., J Biol Chem. 2003 Mar 14;278(11):9125-33. Epub 2003 Jan 2.
13. Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats. Kuroda K, etal., Mutagenesis. 2014 Jan;29(1):27-36. doi: 10.1093/mutage/get054. Epub 2013 Nov 16.
14. The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Levitus M, etal., Nat Genet. 2005 Sep;37(9):934-5. Epub 2005 Aug 21.
15. Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. Liang Y, etal., J Biol Chem. 2012 Sep 28;287(40):33533-44. Epub 2012 Aug 8.
16. Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension. Lopes RA, etal., Hypertension. 2015 Dec;66(6):1240-50. doi: 10.1161/HYPERTENSIONAHA.115.06163. Epub 2015 Oct 26.
17. FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer. Nakanishi R, etal., Ann Surg Oncol. 2012 Oct;19(11):3627-35. doi: 10.1245/s10434-012-2349-8. Epub 2012 Apr 12.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth. Palozza P, etal., Antioxid Redox Signal. 2006 May-Jun;8(5-6):1069-80.
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Seal S, etal., Nat Genet. 2006 Nov;38(11):1239-41. Epub 2006 Oct 8.
24. Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver? Shenvi SV, etal., Aging Cell. 2012 Apr;11(2):297-304. doi: 10.1111/j.1474-9726.2011.00788.x. Epub 2012 Feb 1.
25. Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer. Song H, etal., PLoS One. 2007 Mar 7;2(3):e268.
26. Haplotype analysis of eight genes of the monoubiquitinated FANCD2-DNA damage-repair pathway in breast cancer patients. Tang LL, etal., Cancer Epidemiol. 2013 Jun;37(3):311-7. doi: 10.1016/j.canep.2012.12.010. Epub 2013 Jan 26.
27. Induction of hepatic Bach1 mRNA expression by carbon tetrachloride-induced acute liver injury in rats. Tanioka N, etal., Biomed Rep. 2014 May;2(3):359-363. Epub 2014 Feb 7.
28. Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. Toki T, etal., Blood. 2005 Apr 15;105(8):3100-8. Epub 2004 Dec 21.
Additional References at PubMed
PMID:14504288   PMID:23585563   PMID:26490168  


Genomics

Comparative Map Data
Brip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,402,035 - 71,528,083 (-)NCBIGRCr8
mRatBN7.21070,907,266 - 71,031,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1070,907,371 - 71,030,324 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01073,507,009 - 73,632,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,507,100 - 73,629,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,408,318 - 73,533,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,313,004 - 74,436,532 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11074,327,690 - 74,448,583 (-)NCBI
Celera1069,829,617 - 69,953,629 (-)NCBICelera
Cytogenetic Map10q26NCBI
BRIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381761,679,139 - 61,863,528 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1761,679,139 - 61,863,559 (-)EnsemblGRCh38hg38GRCh38
GRCh371759,756,500 - 59,940,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361757,114,767 - 57,295,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 341757,114,766 - 57,295,537NCBI
Celera1758,857,566 - 59,042,100 (-)NCBICelera
Cytogenetic Map17q23.2NCBI
HuRef1755,122,899 - 55,306,703 (-)NCBIHuRef
CHM1_11759,821,037 - 60,005,473 (-)NCBICHM1_1
T2T-CHM13v2.01762,547,944 - 62,734,245 (-)NCBIT2T-CHM13v2.0
Brip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,948,957 - 86,092,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,948,964 - 86,092,019 (-)EnsemblGRCm39 Ensembl
GRCm381186,058,136 - 86,201,215 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,058,138 - 86,201,193 (-)EnsemblGRCm38mm10GRCm38
MGSCv371185,871,640 - 86,014,695 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,874,331 - 86,017,388 (-)NCBIMGSCv36mm8
Celera1195,685,510 - 95,821,501 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.61NCBI
Brip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554512,707,793 - 2,818,592 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554512,705,834 - 2,820,610 (-)NCBIChiLan1.0ChiLan1.0
BRIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21977,877,272 - 78,065,251 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11782,695,007 - 82,883,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01755,786,568 - 55,973,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11760,901,073 - 61,083,462 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1760,901,073 - 61,083,462 (-)Ensemblpanpan1.1panPan2
BRIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,804,285 - 34,984,640 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,806,535 - 34,983,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha934,033,470 - 34,213,752 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0935,614,312 - 35,794,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,614,404 - 35,793,717 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1934,396,970 - 34,580,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,682,046 - 34,865,676 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,768,817 - 34,949,171 (+)NCBIUU_Cfam_GSD_1.0
Brip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560233,935,468 - 34,073,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364903,003,484 - 3,137,479 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364903,001,445 - 3,139,538 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,498,205 - 36,635,973 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,498,138 - 36,639,847 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,871,343 - 37,957,493 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11632,909,226 - 33,085,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1632,910,693 - 33,082,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660773,666,211 - 3,849,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248712,052,863 - 2,198,165 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248712,051,044 - 2,195,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brip1
739 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:127
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000072755
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
D10Rat57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21070,982,628 - 70,982,751 (+)MAPPERmRatBN7.2
Rnor_6.01073,582,744 - 73,582,866NCBIRnor6.0
Rnor_5.01073,484,053 - 73,484,175UniSTSRnor5.0
RGSC_v3.41074,388,326 - 74,388,696RGDRGSC3.4
RGSC_v3.41074,388,383 - 74,388,505UniSTSRGSC3.4
RGSC_v3.11074,402,696 - 74,403,066RGD
Celera1069,904,849 - 69,904,971UniSTS
RH 2.0 Map10724.9RGD
FHH x ACI Map1059.2399RGD
Cytogenetic Map10q26UniSTS
D10Got226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21070,935,018 - 70,935,169 (+)MAPPERmRatBN7.2
Rnor_6.01073,534,759 - 73,534,909NCBIRnor6.0
Rnor_5.01073,436,068 - 73,436,218UniSTSRnor5.0
RGSC_v3.41074,340,760 - 74,340,910UniSTSRGSC3.4
Celera1069,857,288 - 69,857,438UniSTS
Cytogenetic Map10q26UniSTS
RH142049  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2676,052,672 - 76,052,858 (+)MAPPERmRatBN7.2
mRatBN7.21070,907,419 - 70,907,602 (+)MAPPERmRatBN7.2
Rnor_6.01073,507,163 - 73,507,345NCBIRnor6.0
Rnor_6.0679,473,759 - 79,473,944NCBIRnor6.0
Rnor_5.01073,408,472 - 73,408,654UniSTSRnor5.0
Rnor_5.0689,004,450 - 89,004,635UniSTSRnor5.0
RGSC_v3.4679,029,743 - 79,029,928UniSTSRGSC3.4
RGSC_v3.41074,313,164 - 74,313,346UniSTSRGSC3.4
Celera1069,829,771 - 69,829,953UniSTS
Celera674,823,659 - 74,823,844UniSTS
Cytogenetic Map6q23UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000091172   ⟹   ENSRNOP00000072934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1070,907,371 - 71,030,324 (-)Ensembl
Rnor_6.0 Ensembl1073,507,100 - 73,629,581 (-)Ensembl
RefSeq Acc Id: XM_006247063   ⟹   XP_006247125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,402,035 - 71,528,083 (-)NCBI
mRatBN7.21070,907,266 - 71,031,502 (-)NCBI
Rnor_6.01073,507,009 - 73,632,742 (-)NCBI
Rnor_5.01073,408,318 - 73,533,317 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001417159 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247125 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05558 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072934.1
RefSeq Acc Id: XP_006247125   ⟸   XM_006247063
- Sequence:
Ensembl Acc Id: ENSRNOP00000072934   ⟸   ENSRNOT00000091172
Protein Domains
Helicase ATP-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K475-F1-model_v2 AlphaFold A0A0G2K475 1-1166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307659 AgrOrtholog
BioCyc Gene G2FUF-23812 BioCyc
Ensembl Genes ENSRNOG00000059997 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091172.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ATP-dep_Helicase_C UniProtKB/TrEMBL
  DEAD_2 UniProtKB/TrEMBL
  DinG/Rad3-like UniProtKB/TrEMBL
  DNA_helicase_DNA-repair_Rad3 UniProtKB/TrEMBL
  Helic_SF1/SF2_ATP-bd_DinG/Rad3 UniProtKB/TrEMBL
  Helicase-like_DEXD_c2 UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:360588 UniProtKB/TrEMBL
NCBI Gene 360588 ENTREZGENE
PANTHER FANCONI ANEMIA GROUP J PROTEIN UniProtKB/TrEMBL
  PTHR11472 UniProtKB/TrEMBL
Pfam DEAD_2 UniProtKB/TrEMBL
  Helicase_C_2 UniProtKB/TrEMBL
PhenoGen Brip1 PhenoGen
PROSITE HELICASE_ATP_BIND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059997 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  DEXDc2 UniProtKB/TrEMBL
  HELICc2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K475 ENTREZGENE, UniProtKB/TrEMBL
  A6HHQ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Brip1  BRCA1 interacting helicase 1  Brip1  BRCA1 interacting protein C-terminal helicase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Brip1  BRCA1 interacting protein C-terminal helicase 1   Brip1_predicted  BRCA1 interacting protein C-terminal helicase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Brip1_predicted  BRCA1 interacting protein C-terminal helicase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED