Lpin1 (lipin 1) - Rat Genome Database

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Gene: Lpin1 (lipin 1) Rattus norvegicus
Analyze
Symbol: Lpin1
Name: lipin 1
RGD ID: 1307646
Description: Predicted to enable several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of myelination; and phosphatidic acid biosynthetic process. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of transcription regulator complex. Predicted to be active in several cellular components, including cytosol; endoplasmic reticulum membrane; and mitochondrial outer membrane. Biomarker of end stage renal disease. Orthologous to human LPIN1 (lipin 1); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313977; phosphatidate phosphatase LPIN1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lpin1em1Mcwi   Lpin1m1Hubr  
Genetic Models: SS-Lpin1em1Mcwi WI-Lpin1m1Hubr
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,039,110 - 45,145,845 (-)NCBIGRCr8
mRatBN7.2639,309,198 - 39,417,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,312,748 - 39,417,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx639,644,137 - 39,711,411 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0639,958,820 - 40,026,103 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,392,085 - 39,459,366 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0641,796,214 - 41,905,149 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl641,799,749 - 41,870,046 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,532,422 - 51,638,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,253,664 - 40,297,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1640,292,340 - 40,300,145 (-)NCBI
Celera638,623,057 - 38,690,436 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
baicalein  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
farnesol  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
FR900359  (ISO)
furan  (EXP)
gedunin  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
metronidazole  (ISO)
mitomycin C  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
neomycin  (ISO)
nevirapine  (EXP)
nitrofen  (EXP)
NMN zwitterion  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenytoin  (ISO)
phytosterols  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Hepatic Lipin 1{beta} Expression is Diminished in Insulin-Resistant Obese Subjects and is Reactivated by Marked Weight Loss. Croce MA, etal., Diabetes. 2007 Jun 11;.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Huffman TA, etal., Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1047-52. Epub 2002 Jan 15.
4. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. Lecker SH, etal., FASEB J. 2004 Jan;18(1):39-51.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat. Mul JD, etal., J Biol Chem. 2011 Jul 29;286(30):26781-93. doi: 10.1074/jbc.M110.197947. Epub 2011 Jun 1.
7. Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Nadra K, etal., Mol Cell Biol. 2012 Dec;32(23):4794-810. doi: 10.1128/MCB.00512-12. Epub 2012 Oct 1.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:2722772   PMID:10438476   PMID:11138012   PMID:12477932   PMID:14522948   PMID:16950137   PMID:17158099   PMID:18245816   PMID:18656451   PMID:18694939   PMID:19753306   PMID:20385772  
PMID:21397848   PMID:21549711   PMID:21911493   PMID:22134922   PMID:22231922   PMID:22337502   PMID:23505321   PMID:24788483   PMID:26475860   PMID:28653652   PMID:33123308   PMID:34435332  
PMID:36625880   PMID:38103341  


Genomics

Comparative Map Data
Lpin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,039,110 - 45,145,845 (-)NCBIGRCr8
mRatBN7.2639,309,198 - 39,417,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,312,748 - 39,417,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx639,644,137 - 39,711,411 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0639,958,820 - 40,026,103 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,392,085 - 39,459,366 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0641,796,214 - 41,905,149 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl641,799,749 - 41,870,046 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,532,422 - 51,638,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,253,664 - 40,297,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1640,292,340 - 40,300,145 (-)NCBI
Celera638,623,057 - 38,690,436 (-)NCBICelera
Cytogenetic Map6q16NCBI
LPIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38211,677,544 - 11,827,409 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl211,677,595 - 11,827,409 (+)EnsemblGRCh38hg38GRCh38
GRCh37211,817,670 - 11,967,535 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36211,804,191 - 11,884,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 34211,837,337 - 11,918,129NCBI
Celera211,803,878 - 11,884,673 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef211,669,235 - 11,818,856 (+)NCBIHuRef
CHM1_1211,747,316 - 11,897,077 (+)NCBICHM1_1
T2T-CHM13v2.0211,710,702 - 11,860,525 (+)NCBIT2T-CHM13v2.0
Lpin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391216,585,670 - 16,697,020 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1216,585,670 - 16,696,967 (-)EnsemblGRCm39 Ensembl
GRCm381216,535,669 - 16,653,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1216,535,669 - 16,646,966 (-)EnsemblGRCm38mm10GRCm38
MGSCv371216,542,475 - 16,596,576 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361216,562,116 - 16,615,250 (-)NCBIMGSCv36mm8
Celera1216,861,042 - 16,914,762 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map127.9NCBI
Lpin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554876,138,926 - 6,210,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554876,139,188 - 6,207,316 (+)NCBIChiLan1.0ChiLan1.0
LPIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212114,699,681 - 114,850,433 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A114,703,663 - 114,854,404 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A11,664,727 - 11,815,497 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A11,847,419 - 11,961,551 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A11,857,961 - 11,961,551 (+)Ensemblpanpan1.1panPan2
LPIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1178,348,860 - 8,480,447 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl178,348,886 - 8,478,863 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha178,279,917 - 8,411,687 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0178,451,896 - 8,584,013 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl178,451,917 - 8,584,010 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1178,382,241 - 8,466,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0178,340,808 - 8,472,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0178,359,796 - 8,491,836 (+)NCBIUU_Cfam_GSD_1.0
Lpin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,788,616 - 52,899,844 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365327,605,965 - 7,652,573 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365327,596,279 - 7,654,139 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3124,940,561 - 125,074,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13124,940,557 - 125,074,137 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23133,660,296 - 133,740,965 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q21-q27NCBI
LPIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11495,777,976 - 95,926,420 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1495,780,478 - 95,926,419 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604516,446,229 - 16,526,834 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,219,081 - 4,258,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,220,047 - 4,258,014 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lpin1
756 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:58
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000005863
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat


Genetic Models
This gene Lpin1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 45 31 15 31 8 11 56 13 5 8
Low 2 17 12 10 4 10 18 35 28 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000005863   ⟹   ENSRNOP00000005863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,312,748 - 39,380,176 (-)Ensembl
Rnor_6.0 Ensembl641,799,749 - 41,870,046 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084155   ⟹   ENSRNOP00000069689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,312,748 - 39,417,097 (-)Ensembl
Rnor_6.0 Ensembl641,799,788 - 41,842,817 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114735   ⟹   ENSRNOP00000080344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,312,748 - 39,417,097 (-)Ensembl
RefSeq Acc Id: NM_001012111   ⟹   NP_001012111
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,041,521 - 45,108,942 (-)NCBI
mRatBN7.2639,312,747 - 39,380,176 (-)NCBI
Rnor_6.0641,799,748 - 41,870,046 (-)NCBI
Rnor_5.0651,532,422 - 51,638,090 (-)NCBI
RGSC_v3.4640,253,664 - 40,297,195 (-)RGD
Celera638,623,057 - 38,690,436 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112195   ⟹   XP_038968123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,145,827 (-)NCBI
mRatBN7.2639,309,198 - 39,417,033 (-)NCBI
RefSeq Acc Id: XM_039112196   ⟹   XP_038968124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,145,812 (-)NCBI
mRatBN7.2639,309,198 - 39,417,033 (-)NCBI
RefSeq Acc Id: XM_039112197   ⟹   XP_038968125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,145,827 (-)NCBI
mRatBN7.2639,309,198 - 39,417,032 (-)NCBI
RefSeq Acc Id: XM_039112199   ⟹   XP_038968127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,145,845 (-)NCBI
mRatBN7.2639,309,198 - 39,417,033 (-)NCBI
RefSeq Acc Id: XM_039112200   ⟹   XP_038968128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,145,812 (-)NCBI
mRatBN7.2639,309,198 - 39,417,033 (-)NCBI
RefSeq Acc Id: XM_039112201   ⟹   XP_038968129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,094,990 (-)NCBI
mRatBN7.2639,309,198 - 39,366,226 (-)NCBI
RefSeq Acc Id: XM_039112202   ⟹   XP_038968130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,094,759 (-)NCBI
mRatBN7.2639,309,198 - 39,366,061 (-)NCBI
RefSeq Acc Id: XM_039112203   ⟹   XP_038968131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,145,811 (-)NCBI
mRatBN7.2639,309,198 - 39,417,033 (-)NCBI
RefSeq Acc Id: XM_039112204   ⟹   XP_038968132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,077,385 (-)NCBI
mRatBN7.2639,309,198 - 39,348,617 (-)NCBI
RefSeq Acc Id: XM_063261885   ⟹   XP_063117955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,108,959 (-)NCBI
RefSeq Acc Id: XM_063261886   ⟹   XP_063117956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,044,909 - 45,145,827 (-)NCBI
RefSeq Acc Id: XM_063261888   ⟹   XP_063117958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,039,110 - 45,094,754 (-)NCBI
RefSeq Acc Id: XR_010052085
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,048,896 - 45,108,973 (-)NCBI
RefSeq Acc Id: NP_001012111   ⟸   NM_001012111
- UniProtKB: Q5XIM8 (UniProtKB/TrEMBL),   A6HAS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069689   ⟸   ENSRNOT00000084155
RefSeq Acc Id: ENSRNOP00000005863   ⟸   ENSRNOT00000005863
RefSeq Acc Id: XP_038968131   ⟸   XM_039112203
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZPU6 (UniProtKB/TrEMBL),   A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968128   ⟸   XM_039112200
- Peptide Label: isoform X5
- UniProtKB: A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968127   ⟸   XM_039112199
- Peptide Label: isoform X4
- UniProtKB: A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968124   ⟸   XM_039112196
- Peptide Label: isoform X2
- UniProtKB: A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968123   ⟸   XM_039112195
- Peptide Label: isoform X1
- UniProtKB: A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968125   ⟸   XM_039112197
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JW03 (UniProtKB/TrEMBL),   A6HAS6 (UniProtKB/TrEMBL),   A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968129   ⟸   XM_039112201
- Peptide Label: isoform X6
- UniProtKB: F7FDH2 (UniProtKB/TrEMBL),   A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968130   ⟸   XM_039112202
- Peptide Label: isoform X6
- UniProtKB: F7FDH2 (UniProtKB/TrEMBL),   A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968132   ⟸   XM_039112204
- Peptide Label: isoform X11
RefSeq Acc Id: ENSRNOP00000080344   ⟸   ENSRNOT00000114735
RefSeq Acc Id: XP_063117955   ⟸   XM_063261885
- Peptide Label: isoform X7
- UniProtKB: A6HAS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117958   ⟸   XM_063261888
- Peptide Label: isoform X10
- UniProtKB: A6HAS7 (UniProtKB/TrEMBL),   Q5XIM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117956   ⟸   XM_063261886
- Peptide Label: isoform X9
- UniProtKB: A6HAS7 (UniProtKB/TrEMBL)
Protein Domains
LNS2/PITP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JW03-F1-model_v2 AlphaFold A0A0G2JW03 1-924 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694506
Promoter ID:EPDNEW_R5027
Type:single initiation site
Name:Lpin1_1
Description:lipin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0641,842,839 - 41,842,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307646 AgrOrtholog
BioCyc Gene G2FUF-38066 BioCyc
BioCyc Pathway PWY-7782 [plasmalogen biosynthesis] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
  PWY-8053 [anandamide biosynthesis II] BioCyc
  TRIGLSYN-PWY [diacylglycerol and triacylglycerol biosynthesis] BioCyc
BioCyc Pathway Image PWY-7782 BioCyc
  PWY-8052 BioCyc
  PWY-8053 BioCyc
  TRIGLSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000004377 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005863.7 UniProtKB/TrEMBL
  ENSRNOT00000084155.2 UniProtKB/TrEMBL
  ENSRNOT00000114735.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135110 IMAGE-MGC_LOAD
InterPro HAD-like_sf UniProtKB/TrEMBL
  LIPIN UniProtKB/TrEMBL
  Lipin_mid UniProtKB/TrEMBL
  Lipin_N UniProtKB/TrEMBL
  LNS2 UniProtKB/TrEMBL
  LNS2/PITP UniProtKB/TrEMBL
KEGG Report rno:313977 UniProtKB/TrEMBL
MGC_CLONE MGC:94481 IMAGE-MGC_LOAD
NCBI Gene 313977 ENTREZGENE
PANTHER PTHR12181 UniProtKB/TrEMBL
  PTHR12181:SF10 UniProtKB/TrEMBL
Pfam Lipin_mid UniProtKB/TrEMBL
  Lipin_N UniProtKB/TrEMBL
  LNS2 UniProtKB/TrEMBL
PhenoGen Lpin1 PhenoGen
RatGTEx ENSRNOG00000004377 RatGTEx
SMART LNS2 UniProtKB/TrEMBL
Superfamily-SCOP HAD-like_dom UniProtKB/TrEMBL
UniProt A0A0G2JW03 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPU6 ENTREZGENE, UniProtKB/TrEMBL
  A6HAS6 ENTREZGENE, UniProtKB/TrEMBL
  A6HAS7 ENTREZGENE, UniProtKB/TrEMBL
  F7FDH2 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIM8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Lpin1  lipin 1  Lpin1_predicted  lipin 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lpin1_predicted  lipin 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED