Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and sequence-specific double-stranded DNA binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to be part of chromatin. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA
[bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of HIC1 mRNA and [bisphenol F co-treated with Tretinoin] results in decreased expression of HIC1 mRNA
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA and Benzo(a)pyrene promotes the reaction [AHR protein binds to HIC1 promoter]
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA
[bisphenol F co-treated with Fulvestrant] results in increased methylation of HIC1 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA
[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA
E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA] and Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA
[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA]
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA