Predicted to enable interleukin-2 receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of gene expression; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to act upstream of or within positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH bisphenol A; D-penicillamine; 1-chloro-2,4-dinitrobenzene (ortholog).
[ITPR3 mutant form results in increased susceptibility to Cadmium] which results in increased expression of IL21 mRNA, Cadmium promotes the reaction [ITPR3 mutant form results in increased expression of IL21 mRNA]
Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein], Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein]
[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL21 protein, tamibarotene inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL21 protein]
Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein], Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein]
[Air Pollutants results in increased abundance of Ozone] which results in increased expression of IL21 mRNA, [MBL1 co-treated with MBL2] promotes the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of IL21 mRNA]
[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL21 protein, tamibarotene inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL21 protein]
tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT1 protein], tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT3 protein]
Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk.
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients.
Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease.
Interleukin-21 Is Associated with Early Antiviral Response in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease.
Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients.
Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer's Patches during Infection.
