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Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1) Rattus norvegicus
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
RGD ID: 1307313
Description: Predicted to have co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification and positive regulation of neuron death. Localizes to extracellular space. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; chlorpyrifos.
Type: protein-coding
Also known as: dickkopf 1 homolog; dickkopf 1 homolog (Xenopus laevis); dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf-like protein 1; dickkopf-related protein 1; LOC293897
Homo sapiens (human) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)  HGNC  Alliance
Mus musculus (house mouse) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Canis lupus familiaris (dog) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
Sus scrofa (pig) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Chlorocebus sabaeus (African green monkey) : DKK1 (dickkopf WNT signaling pathway inhibitor 1)
Heterocephalus glaber (naked mole-rat) : Dkk1 (dickkopf WNT signaling pathway inhibitor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Dkk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307313
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.